Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C347  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 23.9
 LDTP01803  Adenosine deaminase (ADA) 13.6
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 12.4
 LDTP01769  Dihydrofolate reductase (DHFR) 11.3
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 10.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 10.3
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 10.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.8
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 9.1
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) 8.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 8.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 8.1
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 6.6
 LDTP05917  Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) 6.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 6.2
 LDTP03001  E3 ubiquitin-protein ligase TRIM21 (TRIM21) 6.1
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 6.1
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 6.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 5.9
 LDTP09819  Unconventional myosin-XVIIIa (MYO18A) 5.9
 LDTP00813  5-hydroxymethyl-dUMP N-hydrolase (DNPH1) 5.7
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 5.7
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.7
 LDTP03150  Methylmalonyl-CoA mutase, mitochondrial (MMUT) 5.6
 LDTP10709  Pseudouridylate synthase 7 homolog (PUS7) 5.5
 LDTP06069  DNA polymerase alpha subunit B (POLA2) 5.5
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 5.4
 LDTP03842  Squalene synthase (FDFT1) 5.4
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 5.3
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 5.3
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 5.3
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 5.2
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.1
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 5.0
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 5.0
 LDTP03787  Choline kinase alpha (CHKA) 5.0
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 22.3
 LDTP14970  Metaxin-3 (MTX3) 16.3
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 11.2
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 10.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 7.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 7.6
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 7.1
 LDTP12383  Protein GPR108 (GPR108) 7.0
 LDTP07667  Transmembrane protein 205 (TMEM205) 6.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 6.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 6.3
 LDTP03952  Reduced folate transporter (SLC19A1) 5.5
 LDTP06198  Major facilitator superfamily domain-containing protein 10 (MFSD10) 5.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 5.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 5.3
 LDTP05900  Metaxin-1 (MTX1) 5.1
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) 5.0
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02870  Y-box-binding protein 3 (YBX3) 5.2
 LDTP05065  Y-box-binding protein 1 (YBX1) 5.1
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 5.0
Other
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15623  Neuferricin (CYB5D2) 26.5
 LDTP13630  Neudesin (NENF) 14.8
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 14.0
 LDTP16078  Heme-binding protein 1 (HEBP1) 11.6
 LDTP15057  TBC1 domain family member 9B (TBC1D9B) 11.3
 LDTP01171  Zinc finger protein ZPR1 (ZPR1) 9.6
 LDTP11328  Splicing factor 3B subunit 5 (SF3B5) 9.3
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 8.8
 LDTP09509  Rap guanine nucleotide exchange factor 6 (RAPGEF6) 8.8
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 8.6
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 8.4
 LDTP15714  Mdm2-binding protein (MTBP) 7.4
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 7.0
 LDTP14259  Testis-expressed protein 264 (TEX264) 6.9
 LDTP01652  Centrosomal protein 43 (CEP43) 6.9
 LDTP06097  Reticulocalbin-2 (RCN2) 6.7
 LDTP02297  Vimentin (VIM) 6.7
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 6.6
 LDTP05226  RNA-binding protein 3 (RBM3) 6.5
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 6.3
 LDTP05375  Nucleobindin-1 (NUCB1) 6.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 5.9
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 5.9
 LDTP01359  Dynactin subunit 3 (DCTN3) 5.7
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 5.6
 LDTP05113  T-complex protein 1 subunit beta (CCT2) 5.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 5.5
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 5.5
 LDTP04091  Adapter molecule crk (CRK) 5.5
 LDTP02180  Neurofilament light polypeptide (NEFL) 5.4
 LDTP01075  Protein CutA (CUTA) 5.3
 LDTP09297  Large ribosomal subunit protein mL64 (GADD45GIP1) 5.2
 LDTP00009  RNA-binding protein 47 (RBM47) 5.2
 LDTP01589  CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) 5.2
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 5.2
 LDTP05160  Nucleobindin-2 (NUCB2) 5.2
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 5.1
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 5.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 5.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 5.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 5.0
 LDTP00510  Spectrin beta chain, non-erythrocytic 2 (SPTBN2) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587