Details of the Target

General Information of Target

Target ID LDTP06198
Target Name Major facilitator superfamily domain-containing protein 10 (MFSD10)
Gene Name MFSD10
Gene ID 10227
Synonyms
TETRAN; Major facilitator superfamily domain-containing protein 10; Tetracycline transporter-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGWGGGGGCTPRPPIHQQPPERRVVTVVFLGLLLDLLAFTLLLPLLPGLLESHGRAHDPL
YGSWQGGVDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVM
LLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVI
GVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFR
DAADLLSPLALLRFSAVARGQDPPSGDRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQR
FQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLP
VLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYW
LAGAQACFTTWSGLFLLPFFLLQKLSYPAQTLKAE
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily
Subcellular location
Nucleus inner membrane
Function
Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine.
Uniprot ID
Q14728
Ensemble ID
ENST00000329687.8
HGNC ID
HGNC:16894

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		22.16  LDD1733  [3]
C056
 Probe Info  		19.56  LDD1753  [3]
C070
 Probe Info  		9.99  LDD1766  [3]
C094
 Probe Info  		22.94  LDD1785  [3]
C158
 Probe Info  		44.94  LDD1838  [3]
C161
 Probe Info  		11.88  LDD1841  [3]
C169
 Probe Info  		21.41  LDD1849  [3]
C201
 Probe Info  		24.76  LDD1877  [3]
C269
 Probe Info  		8.88  LDD1939  [3]
C280
 Probe Info  		10.70  LDD1950  [3]
C282
 Probe Info  		21.86  LDD1952  [3]
C293
 Probe Info  		20.39  LDD1963  [3]
C296
 Probe Info  		15.03  LDD1966  [3]
C347
 Probe Info  		5.35  LDD2008  [3]
C361
 Probe Info  		24.59  LDD2022  [3]
C388
 Probe Info  		38.85  LDD2047  [3]
C396
 Probe Info  		5.21  LDD2055  [3]
C426
 Probe Info  		12.64  LDD2081  [3]
OEA-DA
 Probe Info  		6.13  LDD0046  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromobox protein homolog 5 (CBX5) . P45973

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570