Details of the Probe

General Information of Probe

Probe ID
LDPC0499
Probe Name
C269
Synonyms
Z3433408099
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 357.4
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C16H19N7OS
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-4-propan-2-yl-2-(1H-1,2,4-triazol-5-yl)-1,3-thiazole-5-carboxamide
Canonical SMILES
CC(C)C1=C(SC(=N1)C2=NC=NN2)C(=O)NCCC3(N=N3)CCC#C
InChI
InChI=1S/C16H19N7OS/c1-4-5-6-16(22-23-16)7-8-17-14(24)12-11(10(2)3)20-15(25-12)13-18-9-19-21-13/h1,9-10H,5-8H2,2-3H3,(H,17,24)(H,18,19,21)
InChIKey
FUIARXIAAVIRJA-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

48 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (OGFOD3) LDTP15132 6.15  LDD1939 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 25.11  LDD1939 
Adenosine 5'-monophosphoramidase HINT3 (HINT3) LDTP12415 6.73  LDD1939 
Adenosine deaminase (ADA) LDTP01803 84.45  LDD1939 
Adenosine kinase (ADK) LDTP04689 11.16  LDD1939 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 17.03  LDD1939 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 9.06  LDD1939 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 7.73  LDD1939 
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) LDTP03159 14.72  LDD1939 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 6.92  LDD1939 
Ceramide synthase 1 (CERS1) LDTP03394 6.73  LDD1939 
Choline kinase alpha (CHKA) LDTP03787 5.86  LDD1939 
DCN1-like protein 1 (DCUN1D1) LDTP10349 5.62  LDD1939 
Delta(24)-sterol reductase (DHCR24) LDTP06375 6.02  LDD1939 
Diacylglycerol lipase-beta (DAGLB) LDTP09095 5.98  LDD1939 
Diphthine methyl ester synthase (DPH5) LDTP11835 25.28  LDD1939 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 5.74  LDD1939 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 6.41  LDD1939 
Epoxide hydrolase 1 (EPHX1) LDTP02175 20.97  LDD1939 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 5.90  LDD1939 
Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) LDTP17305 5.90  LDD1939 
Heme oxygenase 1 (HMOX1) LDTP02359 16.56  LDD1939 
Heme oxygenase 2 (HMOX2) LDTP03540 8.75  LDD1939 
Holocytochrome c-type synthase (HCCS) LDTP04581 6.19  LDD1939 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 7.46  LDD1939 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 7.73  LDD1939 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 6.15  LDD1939 
Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) LDTP06810 64.89  LDD1939 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 6.11  LDD1939 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 9.92  LDD1939 
Nardilysin (NRDC) LDTP00886 5.86  LDD1939 
Nucleoside diphosphate kinase 3 (NME3) LDTP05795 5.98  LDD1939 
Nucleoside diphosphate kinase A (NME1) LDTP02796 9.00  LDD1939 
Oxidized purine nucleoside triphosphate hydrolase (NUDT1) LDTP03816 6.50  LDD1939 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 6.54  LDD1939 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 6.28  LDD1939 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 5.82  LDD1939 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 5.98  LDD1939 
Prostaglandin reductase 1 (PTGR1) LDTP06227 8.94  LDD1939 
Protein arginine N-methyltransferase 9 (PRMT9) LDTP07525 6.96  LDD1939 
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) LDTP04925 5.70  LDD1939 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 9.71  LDD1939 
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) LDTP00890 5.70  LDD1939 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 28.44  LDD1939 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 9.00  LDD1939 
Serine/threonine-protein kinase ULK3 (ULK3) LDTP07577 6.45  LDD1939 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 9.00  LDD1939 
sn-1-specific diacylglycerol lipase ABHD11 (ABHD11) LDTP09225 46.21  LDD1939 
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⏷ Show the Full List of 48 Enzyme
27 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit a (MT-ATP6) LDTP01804 11.71  LDD1939 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 6.28  LDD1939 
Gasdermin-E (GSDME) LDTP00970 5.82  LDD1939 
Major facilitator superfamily domain-containing protein 10 (MFSD10) LDTP06198 8.88  LDD1939 
Metaxin-1 (MTX1) LDTP05900 20.82  LDD1939 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 10.13  LDD1939 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 8.94  LDD1939 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 5.66  LDD1939 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 9.85  LDD1939 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 10.78  LDD1939 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 6.06  LDD1939 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 6.11  LDD1939 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 24.59  LDD1939 
Mpv17-like protein 2 (MPV17L2) LDTP14952 20.82  LDD1939 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 5.86  LDD1939 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 6.45  LDD1939 
Protein GPR107 (GPR107) LDTP07236 9.51  LDD1939 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 10.85  LDD1939 
Surfeit locus protein 4 (SURF4) LDTP00592 7.36  LDD1939 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 8.57  LDD1939 
Transmembrane protein 126A (TMEM126A) LDTP15948 13.64  LDD1939 
Transmembrane protein 160 (TMEM160) LDTP20002 10.13  LDD1939 
Transmembrane protein 199 (TMEM199) LDTP08881 25.11  LDD1939 
Transmembrane protein 205 (TMEM205) LDTP07667 30.48  LDD1939 
Transmembrane protein 87A (TMEM87A) LDTP15481 6.73  LDD1939 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 11.00  LDD1939 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 8.28  LDD1939 
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⏷ Show the Full List of 27 Transporter and channel
44 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 7.84  LDD1939 
AP-3 complex subunit mu-1 (AP3M1) LDTP13908 6.73  LDD1939 
Apolipoprotein L2 (APOL2) LDTP11076 18.25  LDD1939 
Clustered mitochondria protein homolog (CLUH) LDTP14486 24.25  LDD1939 
Dymeclin (DYM) LDTP08000 7.01  LDD1939 
Dynactin subunit 3 (DCTN3) LDTP01359 6.36  LDD1939 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 11.39  LDD1939 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 7.01  LDD1939 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 8.57  LDD1939 
GPI transamidase component PIG-T (PIGT) LDTP10015 5.94  LDD1939 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 8.34  LDD1939 
HIG1 domain family member 1A, mitochondrial (HIGD1A) LDTP13797 5.66  LDD1939 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 6.63  LDD1939 
Integrator complex subunit 14 (INTS14) LDTP15834 5.74  LDD1939 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 9.38  LDD1939 
Kinetochore protein Spc24 (SPC24) LDTP09069 7.06  LDD1939 
Leucine zipper putative tumor suppressor 2 (LZTS2) LDTP11115 7.16  LDD1939 
MAGUK p55 subfamily member 2 (MPP2) LDTP06068 7.16  LDD1939 
Membralin (TMEM259) LDTP14939 8.40  LDD1939 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 68.59  LDD1939 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 10.85  LDD1939 
Myomegalin (PDE4DIP) LDTP07221 5.94  LDD1939 
Nestin (NES) LDTP04206 6.23  LDD1939 
Neudesin (NENF) LDTP13630 8.11  LDD1939 
Neuferricin (CYB5D2) LDTP15623 16.56  LDD1939 
Neurofilament light polypeptide (NEFL) LDTP02180 9.32  LDD1939 
Nucleobindin-2 (NUCB2) LDTP05160 12.04  LDD1939 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 8.17  LDD1939 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 7.36  LDD1939 
Peroxisomal targeting signal 1 receptor (PEX5) LDTP04369 5.94  LDD1939 
Polyadenylate-binding protein-interacting protein 2 (PAIP2) LDTP11044 5.82  LDD1939 
Prefoldin subunit 2 (PFDN2) LDTP13309 5.66  LDD1939 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 6.06  LDD1939 
Protein CUSTOS (CUSTOS) LDTP18134 11.39  LDD1939 
Protein FAM114A2 (FAM114A2) LDTP16080 8.28  LDD1939 
Protein NipSnap homolog 1 (NIPSNAP1) LDTP19912 6.02  LDD1939 
Reticulocalbin-2 (RCN2) LDTP06097 7.62  LDD1939 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 6.23  LDD1939 
Splicing factor ESS-2 homolog (ESS2) LDTP10214 6.28  LDD1939 
T-complex protein 1 subunit beta (CCT2) LDTP05113 5.78  LDD1939 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 9.78  LDD1939 
TraB domain-containing protein (TRABD) LDTP19963 5.86  LDD1939 
Tubulin beta-2B chain (TUBB2B) LDTP11277 5.94  LDD1939 
Vimentin (VIM) LDTP02297 10.41  LDD1939 
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⏷ Show the Full List of 44 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1939 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587