Details of the Target

General Information of Target

Target ID LDTP07891
Target Name Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP)
Gene Name IKBIP
Gene ID 121457
Synonyms
IKIP; Inhibitor of nuclear factor kappa-B kinase-interacting protein; I kappa-B kinase-interacting protein; IKBKB-interacting protein; IKK-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPRTCLSLLSLGTCLGLAW
FVFQQSEKFAKVENQYQLLKLETNEFQQLQSKISLISEKWQKSEAIMEQLKSFQIIAHLK
RLQEEINEVKTWSNRITEKQDILNNSLTTLSQDITKVDQSTTSMAKDVGLKITSVKTDIR
RISGLVTDVISLTDSVQELENKIEKVEKNTVKNIGDLLSSSIDRTATLRKTASENSQRIN
SVKKTLTELKSDFDKHTDRFLSLEGDRAKVLKTVTFANDLKPKVYNLKKDFSRLEPLVND
LTLRIGRLVTDLLQREKEIAFLSEKISNLTIVQAEIKDIKDEIAHISDMN
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function Target of p53/TP53 with pro-apoptotic function.
Uniprot ID
Q70UQ0
Ensemble ID
ENST00000299157.5
HGNC ID
HGNC:26430

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.Q197P .
EFO27 Insertion: p.I326NfsTer3 .
KYSE410 SNV: p.V274M .
LNCaP clone FGC SNV: p.E124D .
LS180 SNV: p.K283N .
MFE319 SNV: p.S146G .
OVCAR8 SNV: p.D252G .
RKO Deletion: p.N209IfsTer3 .
SW948 SNV: p.I343M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.29  LDD0318  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
FBP2
 Probe Info  		5.73  LDD0317  [1]
YN-4
 Probe Info  		100.00  LDD0445  [3]
ONAyne
 Probe Info  		K176(1.02)  LDD0274  [4]
STPyne
 Probe Info  		K13(3.33); K176(10.00); K212(5.00); K22(5.96)  LDD0277  [4]
m-APA
 Probe Info  		13.78  LDD0403  [5]
Curcusone 37
 Probe Info  		2.88  LDD0188  [6]
Acrolein
 Probe Info  		N.A.  LDD0233  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 76 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		8.94  LDD1725  [9]
C022
 Probe Info  		14.03  LDD1728  [9]
C040
 Probe Info  		8.94  LDD1740  [9]
C052
 Probe Info  		6.32  LDD1750  [9]
C053
 Probe Info  		5.74  LDD1751  [9]
C055
 Probe Info  		13.55  LDD1752  [9]
C056
 Probe Info  		21.71  LDD1753  [9]
C063
 Probe Info  		13.18  LDD1760  [9]
C070
 Probe Info  		9.71  LDD1766  [9]
C082
 Probe Info  		4.99  LDD1774  [9]
C087
 Probe Info  		9.25  LDD1779  [9]
C106
 Probe Info  		62.68  LDD1793  [9]
C107
 Probe Info  		6.15  LDD1794  [9]
C108
 Probe Info  		11.31  LDD1795  [9]
C112
 Probe Info  		39.40  LDD1799  [9]
C131
 Probe Info  		5.54  LDD1813  [9]
C134
 Probe Info  		31.34  LDD1816  [9]
C138
 Probe Info  		10.48  LDD1820  [9]
C143
 Probe Info  		22.94  LDD1825  [9]
C153
 Probe Info  		16.68  LDD1834  [9]
C158
 Probe Info  		11.31  LDD1838  [9]
C161
 Probe Info  		11.00  LDD1841  [9]
C169
 Probe Info  		22.78  LDD1849  [9]
C187
 Probe Info  		72.00  LDD1865  [9]
C191
 Probe Info  		28.05  LDD1868  [9]
C193
 Probe Info  		9.85  LDD1869  [9]
C201
 Probe Info  		53.45  LDD1877  [9]
C206
 Probe Info  		20.82  LDD1881  [9]
C210
 Probe Info  		64.00  LDD1884  [9]
C213
 Probe Info  		18.38  LDD1887  [9]
C218
 Probe Info  		16.22  LDD1892  [9]
C220
 Probe Info  		16.56  LDD1894  [9]
C228
 Probe Info  		15.35  LDD1901  [9]
C231
 Probe Info  		15.67  LDD1904  [9]
C232
 Probe Info  		37.79  LDD1905  [9]
C235
 Probe Info  		17.27  LDD1908  [9]
C238
 Probe Info  		13.18  LDD1911  [9]
C244
 Probe Info  		21.11  LDD1917  [9]
C246
 Probe Info  		14.93  LDD1919  [9]
C269
 Probe Info  		6.63  LDD1939  [9]
C282
 Probe Info  		14.93  LDD1952  [9]
C284
 Probe Info  		25.28  LDD1954  [9]
C289
 Probe Info  		31.34  LDD1959  [9]
C293
 Probe Info  		26.72  LDD1963  [9]
C296
 Probe Info  		22.63  LDD1966  [9]
C305
 Probe Info  		12.21  LDD1974  [9]
C313
 Probe Info  		13.74  LDD1980  [9]
C314
 Probe Info  		14.52  LDD1981  [9]
C317
 Probe Info  		10.06  LDD1983  [9]
C326
 Probe Info  		8.00  LDD1990  [9]
C338
 Probe Info  		16.80  LDD2001  [9]
C343
 Probe Info  		13.36  LDD2005  [9]
C348
 Probe Info  		10.34  LDD2009  [9]
C350
 Probe Info  		48.17  LDD2011  [9]
C355
 Probe Info  		40.79  LDD2016  [9]
C356
 Probe Info  		9.58  LDD2017  [9]
C357
 Probe Info  		5.82  LDD2018  [9]
C361
 Probe Info  		21.86  LDD2022  [9]
C362
 Probe Info  		88.65  LDD2023  [9]
C363
 Probe Info  		39.95  LDD2024  [9]
C364
 Probe Info  		29.04  LDD2025  [9]
C366
 Probe Info  		7.36  LDD2027  [9]
C367
 Probe Info  		8.11  LDD2028  [9]
C383
 Probe Info  		11.47  LDD2042  [9]
C388
 Probe Info  		71.51  LDD2047  [9]
C390
 Probe Info  		51.98  LDD2049  [9]
C391
 Probe Info  		34.06  LDD2050  [9]
C403
 Probe Info  		22.16  LDD2061  [9]
C407
 Probe Info  		17.27  LDD2064  [9]
C413
 Probe Info  		15.24  LDD2069  [9]
C420
 Probe Info  		16.56  LDD2075  [9]
C431
 Probe Info  		13.93  LDD2086  [9]
STS-2
 Probe Info  		N.A.  LDD0138  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]
Diazir
 Probe Info  		N.A.  LDD0011  [12]
OEA-DA
 Probe Info  		12.88  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.78  LDD0403  [5]
 LDCM0033  Curcusone1d MCF-7 2.88  LDD0188  [6]
 LDCM0109  NEM HeLa N.A.  LDD0233  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myogenin (MYOG) . P15173
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 25 (GPR25) G-protein coupled receptor 1 family O00155
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Lebercilin-like protein (LCA5L) LCA5 family O95447
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Bublin coiled-coil protein (BBLN) UPF0184 (EST00098) family Q9BUW7

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570