Details of the Probe

General Information of Probe

Probe ID
LDPC0452
Probe Name
C218
Synonyms
Z4282859646
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 383.8
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H18ClN7O
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[4-chloro-3-(5-cyclopropyltetrazol-1-yl)phenyl]propanamide
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)NC2=CC(=C(C=C2)Cl)N3C(=NN=N3)C4CC4
InChI
InChI=1S/C18H18ClN7O/c1-2-3-9-18(22-23-18)10-8-16(27)20-13-6-7-14(19)15(11-13)26-17(12-4-5-12)21-24-25-26/h1,6-7,11-12H,3-5,8-10H2,(H,20,27)
InChIKey
ZOIXHZFIBUJDEH-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

177 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) LDTP12639 14.42  LDD1892 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 12.47  LDD1892 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 12.38  LDD1892 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 13.45  LDD1892 
Acylglycerol kinase, mitochondrial (AGK) LDTP06905 11.79  LDD1892 
Adenosine 5'-monophosphoramidase HINT3 (HINT3) LDTP12415 14.62  LDD1892 
ADP-dependent glucokinase (ADPGK) LDTP11127 31.78  LDD1892 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 11.79  LDD1892 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 36.00  LDD1892 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 12.13  LDD1892 
Amidophosphoribosyltransferase (PPAT) LDTP05480 16.56  LDD1892 
Antigen peptide transporter 1 (TAP1) LDTP05408 38.85  LDD1892 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 33.13  LDD1892 
Atlastin-2 (ATL2) LDTP09251 21.41  LDD1892 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 12.91  LDD1892 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 11.96  LDD1892 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 14.12  LDD1892 
ATPase family AAA domain-containing protein 3B (ATAD3B) LDTP07154 13.18  LDD1892 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 34.30  LDD1892 
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) LDTP05920 14.12  LDD1892 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 19.84  LDD1892 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 23.43  LDD1892 
Cartilage-associated protein (CRTAP) LDTP01300 12.64  LDD1892 
Catechol O-methyltransferase (COMT) LDTP03145 17.63  LDD1892 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 18.77  LDD1892 
Ceramide glucosyltransferase (UGCG) LDTP06617 22.78  LDD1892 
Ceramide synthase 1 (CERS1) LDTP03394 13.18  LDD1892 
Ceramide synthase 2 (CERS2) LDTP10329 17.51  LDD1892 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 24.42  LDD1892 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 31.34  LDD1892 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 43.71  LDD1892 
Cytochrome b5 type B (CYB5B) LDTP00697 99.73  LDD1892 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 29.24  LDD1892 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 21.41  LDD1892 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 12.55  LDD1892 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 13.36  LDD1892 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 14.62  LDD1892 
Delta(24)-sterol reductase (DHCR24) LDTP06375 22.32  LDD1892 
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) LDTP04646 12.13  LDD1892 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 23.59  LDD1892 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 17.27  LDD1892 
Dihydrofolate reductase (DHFR) LDTP01769 54.95  LDD1892 
DNA replication licensing factor MCM2 (MCM2) LDTP04286 21.11  LDD1892 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 22.63  LDD1892 
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) LDTP11259 13.64  LDD1892 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 20.97  LDD1892 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 27.10  LDD1892 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 12.73  LDD1892 
E3 ubiquitin-protein ligase RNF139 (RNF139) LDTP09556 21.86  LDD1892 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 36.00  LDD1892 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 19.84  LDD1892 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 21.56  LDD1892 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 22.94  LDD1892 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 14.93  LDD1892 
Enoyl-CoA hydratase, mitochondrial (ECHS1) LDTP03518 13.45  LDD1892 
Exosome complex component RRP42 (EXOSC7) LDTP06283 10.85  LDD1892 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 10.78  LDD1892 
Farnesyl pyrophosphate synthase (FDPS) LDTP02721 11.88  LDD1892 
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) LDTP06721 14.42  LDD1892 
Glutathione S-transferase 3, mitochondrial (MGST3) LDTP00464 11.16  LDD1892 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 18.90  LDD1892 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 12.47  LDD1892 
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) LDTP04032 10.93  LDD1892 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 16.22  LDD1892 
GPI-anchor transamidase (PIGK) LDTP09835 11.00  LDD1892 
GTP-binding protein SAR1a (SAR1A) LDTP12470 10.93  LDD1892 
Heme oxygenase 1 (HMOX1) LDTP02359 19.97  LDD1892 
Heme oxygenase 2 (HMOX2) LDTP03540 45.57  LDD1892 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 20.68  LDD1892 
Hexokinase-2 (HK2) LDTP04531 14.32  LDD1892 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 22.32  LDD1892 
Holocytochrome c-type synthase (HCCS) LDTP04581 26.72  LDD1892 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 28.25  LDD1892 
L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) LDTP12105 14.62  LDD1892 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 20.53  LDD1892 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 16.00  LDD1892 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 27.86  LDD1892 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 22.94  LDD1892 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 18.25  LDD1892 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 12.64  LDD1892 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.38  LDD1892 
Mannose-1-phosphate guanyltransferase beta (GMPPB) LDTP14141 10.93  LDD1892 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) LDTP10930 11.00  LDD1892 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 41.64  LDD1892 
Microsomal glutathione S-transferase 2 (MGST2) LDTP10966 12.55  LDD1892 
Minor histocompatibility antigen H13 (HM13) LDTP09396 12.91  LDD1892 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 25.99  LDD1892 
Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) LDTP06810 11.31  LDD1892 
Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU) LDTP01284 15.56  LDD1892 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 14.93  LDD1892 
Mitofusin-1 (MFN1) LDTP08530 10.93  LDD1892 
Multidrug resistance-associated protein 1 (ABCC1) LDTP03671 22.01  LDD1892 
N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) LDTP07259 19.97  LDD1892 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 44.94  LDD1892 
NAD(P)H-hydrate epimerase (NAXE) LDTP09110 12.13  LDD1892 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 23.59  LDD1892 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 22.32  LDD1892 
NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) LDTP01219 21.86  LDD1892 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 17.03  LDD1892 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 36.00  LDD1892 
NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) LDTP00831 11.24  LDD1892 
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) LDTP01502 11.79  LDD1892 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 47.84  LDD1892 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 27.86  LDD1892 
NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) LDTP01983 16.80  LDD1892 
NADPH--cytochrome P450 reductase (POR) LDTP02848 10.93  LDD1892 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 23.92  LDD1892 
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) LDTP03813 11.39  LDD1892 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 18.13  LDD1892 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 37.79  LDD1892 
Palmitoyltransferase ZDHHC13 (ZDHHC13) LDTP08455 16.22  LDD1892 
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) LDTP08617 13.36  LDD1892 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 11.55  LDD1892 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 25.99  LDD1892 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 11.39  LDD1892 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 12.73  LDD1892 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 14.42  LDD1892 
Phenylalanine--tRNA ligase beta subunit (FARSB) LDTP12586 19.56  LDD1892 
Phenylalanine--tRNA ligase, mitochondrial (FARS2) LDTP01571 36.50  LDD1892 
Phosphatidate cytidylyltransferase 2 (CDS2) LDTP01649 19.70  LDD1892 
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) LDTP12608 11.96  LDD1892 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 10.78  LDD1892 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 12.47  LDD1892 
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) LDTP08859 16.56  LDD1892 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 37.53  LDD1892 
Presequence protease, mitochondrial (PITRM1) LDTP07003 16.00  LDD1892 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 46.21  LDD1892 
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 14.52  LDD1892 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 10.70  LDD1892 
Prostaglandin reductase 3 (PTGR3) LDTP15422 13.18  LDD1892 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 30.27  LDD1892 
Proteasome subunit beta type-7 (PSMB7) LDTP10862 12.13  LDD1892 
Protein disulfide-isomerase TMX3 (TMX3) LDTP10471 14.93  LDD1892 
Protein kinase C beta type (PRKCB) LDTP02123 13.83  LDD1892 
Protein O-GlcNAcase (OGA) LDTP00988 11.71  LDD1892 
Protein SCO2 homolog, mitochondrial (SCO2) LDTP00877 13.55  LDD1892 
Protein-L-histidine N-pros-methyltransferase (METTL9) LDTP15962 14.22  LDD1892 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 38.32  LDD1892 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 16.11  LDD1892 
RAC-beta serine/threonine-protein kinase (AKT2) LDTP03608 14.42  LDD1892 
Ras-related protein Rab-24 (RAB24) LDTP10020 19.03  LDD1892 
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) LDTP09666 15.45  LDD1892 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 14.12  LDD1892 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 12.30  LDD1892 
Retinol dehydrogenase 13 (RDH13) LDTP09061 17.03  LDD1892 
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) LDTP03592 11.24  LDD1892 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 22.63  LDD1892 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 16.34  LDD1892 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 11.16  LDD1892 
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) LDTP00890 11.00  LDD1892 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 26.91  LDD1892 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 11.71  LDD1892 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 18.64  LDD1892 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 16.91  LDD1892 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) LDTP06546 17.15  LDD1892 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 30.06  LDD1892 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 21.11  LDD1892 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 15.24  LDD1892 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 13.55  LDD1892 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 21.71  LDD1892 
Squalene monooxygenase (SQLE) LDTP06142 18.90  LDD1892 
Stearoyl-CoA desaturase (SCD) LDTP00344 14.42  LDD1892 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 23.10  LDD1892 
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) LDTP04438 16.91  LDD1892 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 16.56  LDD1892 
Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) LDTP07227 12.13  LDD1892 
Torsin-1B (TOR1B) LDTP00400 14.93  LDD1892 
Transmembrane protein with metallophosphoesterase domain (TMPPE) LDTP07831 74.03  LDD1892 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 11.31  LDD1892 
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) LDTP13957 11.88  LDD1892 
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) LDTP11867 19.70  LDD1892 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) LDTP07756 11.55  LDD1892 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 17.63  LDD1892 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 16.45  LDD1892 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 18.38  LDD1892 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 24.93  LDD1892 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 11.71  LDD1892 
------------------------------------------------------------------------------------
⏷ Show the Full List of 177 Enzyme
130 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 11.24  LDD1892 
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 18.90  LDD1892 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 14.22  LDD1892 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 17.51  LDD1892 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 11.24  LDD1892 
Anoctamin-10 (ANO10) LDTP12704 11.31  LDD1892 
Anoctamin-6 (ANO6) LDTP06855 23.43  LDD1892 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 17.03  LDD1892 
ATP synthase subunit a (MT-ATP6) LDTP01804 78.25  LDD1892 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 15.78  LDD1892 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 30.91  LDD1892 
ATP synthase subunit gamma, mitochondrial (ATP5F1C) LDTP03810 14.22  LDD1892 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 10.70  LDD1892 
BRI3-binding protein (BRI3BP) LDTP15648 99.73  LDD1892 
Calcium uptake protein 2, mitochondrial (MICU2) LDTP08673 12.91  LDD1892 
Calnexin (CANX) LDTP03405 14.62  LDD1892 
Chloride channel CLIC-like protein 1 (CLCC1) LDTP10804 16.11  LDD1892 
CMP-sialic acid transporter (SLC35A1) LDTP05116 12.73  LDD1892 
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) LDTP05510 10.85  LDD1892 
Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) LDTP08469 27.67  LDD1892 
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) LDTP08981 58.49  LDD1892 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 22.63  LDD1892 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 30.27  LDD1892 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 19.84  LDD1892 
Derlin-1 (DERL1) LDTP11245 11.31  LDD1892 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 12.04  LDD1892 
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) LDTP13393 12.04  LDD1892 
Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) LDTP12331 13.45  LDD1892 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 30.06  LDD1892 
ER membrane protein complex subunit 4 (EMC4) LDTP06994 11.31  LDD1892 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 17.88  LDD1892 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 11.47  LDD1892 
Integral membrane protein 2C (ITM2C) LDTP12451 11.24  LDD1892 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 17.63  LDD1892 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 20.11  LDD1892 
Lysosome membrane protein 2 (SCARB2) LDTP06034 13.36  LDD1892 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 11.88  LDD1892 
Magnesium transporter protein 1 (MAGT1) LDTP11732 12.13  LDD1892 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 16.45  LDD1892 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 26.91  LDD1892 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 41.93  LDD1892 
Metal cation symporter ZIP14 (SLC39A14) LDTP06293 13.93  LDD1892 
Metal transporter CNNM3 (CNNM3) LDTP09144 11.96  LDD1892 
Metaxin-1 (MTX1) LDTP05900 38.85  LDD1892 
Metaxin-2 (MTX2) LDTP01217 12.30  LDD1892 
MICOS complex subunit MIC26 (APOO) LDTP11250 13.83  LDD1892 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 27.10  LDD1892 
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) LDTP07472 12.55  LDD1892 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 22.78  LDD1892 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 19.29  LDD1892 
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) LDTP08279 13.09  LDD1892 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 35.51  LDD1892 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 27.28  LDD1892 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 99.73  LDD1892 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD1892 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 30.06  LDD1892 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 14.62  LDD1892 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 28.25  LDD1892 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 27.67  LDD1892 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 18.25  LDD1892 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 48.50  LDD1892 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 16.00  LDD1892 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 18.51  LDD1892 
Mpv17-like protein 2 (MPV17L2) LDTP14952 34.06  LDD1892 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 11.39  LDD1892 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 11.71  LDD1892 
Nucleoporin NDC1 (NDC1) LDTP11213 20.11  LDD1892 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 26.35  LDD1892 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 14.93  LDD1892 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 10.93  LDD1892 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 28.05  LDD1892 
Peroxisomal membrane protein PEX16 (PEX16) LDTP14181 11.39  LDD1892 
Prosaposin (PSAP) LDTP02215 15.89  LDD1892 
Protein GPR107 (GPR107) LDTP07236 29.86  LDD1892 
Protein Mpv17 (MPV17) LDTP03869 12.91  LDD1892 
Protein RER1 (RER1) LDTP00590 14.83  LDD1892 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 16.91  LDD1892 
Protein tweety homolog 3 (TTYH3) LDTP11615 17.39  LDD1892 
Protein YIPF3 (YIPF3) LDTP11626 25.63  LDD1892 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 14.52  LDD1892 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 45.57  LDD1892 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 24.08  LDD1892 
Rhomboid domain-containing protein 2 (RHBDD2) LDTP07467 30.06  LDD1892 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 11.08  LDD1892 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 11.47  LDD1892 
Sideroflexin-2 (SFXN2) LDTP10621 12.21  LDD1892 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 23.26  LDD1892 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 18.90  LDD1892 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 19.70  LDD1892 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 31.56  LDD1892 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 23.59  LDD1892 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 14.03  LDD1892 
Sorting nexin-5 (SNX5) LDTP14174 12.73  LDD1892 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 19.56  LDD1892 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 17.39  LDD1892 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 40.50  LDD1892 
Sugar transporter SWEET1 (SLC50A1) LDTP11136 20.97  LDD1892 
Surfeit locus protein 4 (SURF4) LDTP00592 15.35  LDD1892 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 20.39  LDD1892 
Syntaxin-5 (STX5) LDTP05780 18.25  LDD1892 
Tetraspanin-10 (TSPAN10) LDTP15967 13.93  LDD1892 
Tetraspanin-3 (TSPAN3) LDTP16813 19.56  LDD1892 
Thioredoxin-related transmembrane protein 2 (TMX2) LDTP13943 13.83  LDD1892 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 30.27  LDD1892 
Translocation protein SEC62 (SEC62) LDTP15838 13.09  LDD1892 
Translocator protein (TSPO) LDTP03546 24.76  LDD1892 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 49.87  LDD1892 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 12.30  LDD1892 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 32.90  LDD1892 
Transmembrane emp24 domain-containing protein 10 (TMED10) LDTP04293 11.47  LDD1892 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 17.63  LDD1892 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 10.93  LDD1892 
Transmembrane protein 126A (TMEM126A) LDTP15948 46.21  LDD1892 
Transmembrane protein 160 (TMEM160) LDTP20002 30.70  LDD1892 
Transmembrane protein 199 (TMEM199) LDTP08881 71.01  LDD1892 
Transmembrane protein 201 (TMEM201) LDTP07058 15.78  LDD1892 
Transmembrane protein 205 (TMEM205) LDTP07667 27.86  LDD1892 
Transmembrane protein 214 (TMEM214) LDTP07477 12.64  LDD1892 
Transmembrane protein 230 (TMEM230) LDTP10065 32.00  LDD1892 
Transmembrane protein 33 (TMEM33) LDTP04787 10.85  LDD1892 
Transmembrane protein 59 (TMEM59) LDTP11406 12.30  LDD1892 
Transmembrane protein 87A (TMEM87A) LDTP15481 35.75  LDD1892 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 17.03  LDD1892 
Vang-like protein 1 (VANGL1) LDTP09288 11.47  LDD1892 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 54.19  LDD1892 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 38.32  LDD1892 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 22.78  LDD1892 
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) LDTP11281 11.47  LDD1892 
Wolframin (WFS1) LDTP01380 17.75  LDD1892 
Zinc transporter 6 (SLC30A6) LDTP07490 25.28  LDD1892 
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⏷ Show the Full List of 130 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 13.18  LDD1892 
Zinc finger protein 512B (ZNF512B) LDTP10507 10.85  LDD1892 
------------------------------------------------------------------------------------
2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 14.52  LDD1892 
Leukocyte surface antigen CD47 (CD47) LDTP05572 15.35  LDD1892 
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133 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Actin-related protein 3 (ACTR3) LDTP04902 11.08  LDD1892 
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 17.15  LDD1892 
ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) LDTP15434 16.91  LDD1892 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 17.15  LDD1892 
AP-3 complex subunit mu-1 (AP3M1) LDTP13908 13.93  LDD1892 
Apolipoprotein L2 (APOL2) LDTP11076 27.67  LDD1892 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 13.00  LDD1892 
BLOC-2 complex member HPS6 (HPS6) LDTP08420 13.09  LDD1892 
BRCA1-associated ATM activator 1 (BRAT1) LDTP07598 17.15  LDD1892 
BSD domain-containing protein 1 (BSDC1) LDTP16116 14.22  LDD1892 
Calumenin (CALU) LDTP00887 16.11  LDD1892 
Centrosomal protein 43 (CEP43) LDTP01652 11.88  LDD1892 
Chromatin remodeling regulator CECR2 (CECR2) LDTP11373 11.71  LDD1892 
Clustered mitochondria protein homolog (CLUH) LDTP14486 11.55  LDD1892 
COMM domain-containing protein 1 (COMMD1) LDTP08919 34.30  LDD1892 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 77.17  LDD1892 
DENN domain-containing protein 11 (DENND11) LDTP16577 12.91  LDD1892 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 10.70  LDD1892 
Dymeclin (DYM) LDTP08000 11.00  LDD1892 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 34.06  LDD1892 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 16.11  LDD1892 
ELMO domain-containing protein 2 (ELMOD2) LDTP17659 13.00  LDD1892 
Emerin (EMD) LDTP04356 16.00  LDD1892 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 14.32  LDD1892 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 47.18  LDD1892 
Engulfment and cell motility protein 2 (ELMO2) LDTP10469 13.55  LDD1892 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 31.56  LDD1892 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 10.70  LDD1892 
Extracellular glycoprotein lacritin (LACRT) LDTP11674 99.73  LDD1892 
Fanconi anemia group D2 protein (FANCD2) LDTP11421 14.22  LDD1892 
Far upstream element-binding protein 3 (FUBP3) LDTP10408 10.85  LDD1892 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 11.55  LDD1892 
Gamma-tubulin complex component 2 (TUBGCP2) LDTP11159 11.96  LDD1892 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 11.96  LDD1892 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 32.45  LDD1892 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 16.00  LDD1892 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 14.52  LDD1892 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 13.36  LDD1892 
HEAT repeat-containing protein 3 (HEATR3) LDTP15253 17.39  LDD1892 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 17.27  LDD1892 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 12.82  LDD1892 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 11.47  LDD1892 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 12.73  LDD1892 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 11.88  LDD1892 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 12.55  LDD1892 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 11.16  LDD1892 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 11.79  LDD1892 
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) LDTP05530 11.79  LDD1892 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 16.22  LDD1892 
Iron-sulfur cluster transfer protein NUBPL (NUBPL) LDTP09325 13.64  LDD1892 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 18.25  LDD1892 
Kinetochore protein Spc24 (SPC24) LDTP09069 18.51  LDD1892 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 22.63  LDD1892 
Large proline-rich protein BAG6 (BAG6) LDTP04094 11.08  LDD1892 
Large ribosomal subunit protein mL40 (MRPL40) LDTP12395 29.04  LDD1892 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 60.13  LDD1892 
Lipase maturation factor 2 (LMF2) LDTP15887 11.88  LDD1892 
Lipocalin-1 (LCN1) LDTP03571 99.73  LDD1892 
LYR motif-containing protein 2 (LYRM2) LDTP18467 34.54  LDD1892 
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) LDTP15240 26.54  LDD1892 
m-AAA protease-interacting protein 1, mitochondrial (MAIP1) LDTP09644 12.38  LDD1892 
Membralin (TMEM259) LDTP14939 27.28  LDD1892 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 18.13  LDD1892 
Mitochondrial calcium uniporter regulator 1 (MCUR1) LDTP10093 19.29  LDD1892 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 25.63  LDD1892 
Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B) LDTP14125 11.47  LDD1892 
Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13) LDTP14136 11.39  LDD1892 
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) LDTP16322 12.73  LDD1892 
Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) LDTP14126 15.89  LDD1892 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 53.45  LDD1892 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 50.21  LDD1892 
Mitochondrial import receptor subunit TOM7 homolog (TOMM7) LDTP12982 19.43  LDD1892 
Neuferricin (CYB5D2) LDTP15623 13.55  LDD1892 
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) LDTP13622 13.09  LDD1892 
NLR family member X1 (NLRX1) LDTP08248 24.25  LDD1892 
Nucleobindin-1 (NUCB1) LDTP05375 19.70  LDD1892 
Nucleobindin-2 (NUCB2) LDTP05160 39.95  LDD1892 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 15.45  LDD1892 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 15.03  LDD1892 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 18.51  LDD1892 
Opiorphin prepropeptide (OPRPN) LDTP11009 34.54  LDD1892 
Optic atrophy 3 protein (OPA3) LDTP16006 29.86  LDD1892 
Peroxisomal targeting signal 1 receptor (PEX5) LDTP04369 11.71  LDD1892 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 18.64  LDD1892 
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) LDTP04015 16.68  LDD1892 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 31.56  LDD1892 
Polyadenylate-binding protein-interacting protein 2 (PAIP2) LDTP11044 11.08  LDD1892 
Protein CEBPZOS (CEBPZOS) LDTP18883 20.82  LDD1892 
Protein FAM114A2 (FAM114A2) LDTP16080 25.63  LDD1892 
Protein FAM162A (FAM162A) LDTP10056 99.73  LDD1892 
Protein FAM177A1 (FAM177A1) LDTP15398 13.83  LDD1892 
Protein FAM210A (FAM210A) LDTP15793 10.70  LDD1892 
Protein jagunal homolog 1 (JAGN1) LDTP08904 16.00  LDD1892 
Protein LYRIC (MTDH) LDTP08224 44.02  LDD1892 
Protein SET (SET) LDTP05277 11.00  LDD1892 
Protein SYS1 homolog (SYS1) LDTP08796 23.10  LDD1892 
Protein unc-119 homolog A (UNC119) LDTP05868 86.82  LDD1892 
Protein unc-119 homolog B (UNC119B) LDTP00105 32.00  LDD1892 
Protein YIF1A (YIF1A) LDTP01494 11.79  LDD1892 
Protein YIPF4 (YIPF4) LDTP11167 11.96  LDD1892 
Rab9 effector protein with kelch motifs (RABEPK) LDTP08130 22.94  LDD1892 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 14.93  LDD1892 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 12.04  LDD1892 
Reticulocalbin-2 (RCN2) LDTP06097 29.86  LDD1892 
Reticulon-2 (RTN2) LDTP01167 28.25  LDD1892 
Reticulon-3 (RTN3) LDTP01522 82.71  LDD1892 
Reticulon-4 (RTN4) LDTP12412 60.55  LDD1892 
Reticulophagy regulator 3 (RETREG3) LDTP08300 11.47  LDD1892 
RING finger and SPRY domain-containing protein 1 (RSPRY1) LDTP15712 22.32  LDD1892 
RUS family member 1 (RUSF1) LDTP10357 27.67  LDD1892 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 46.85  LDD1892 
SLC35A4 upstream open reading frame protein (SLC35A4) LDTP19005 13.18  LDD1892 
Survival motor neuron protein (SMN1; SMN2) LDTP06587 12.55  LDD1892 
Synaptogyrin-2 (SYNGR2) LDTP00859 18.00  LDD1892 
Syntaxin-10 (STX10) LDTP00986 30.06  LDD1892 
Syntaxin-18 (STX18) LDTP13086 50.91  LDD1892 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 11.88  LDD1892 
TBC1 domain family member 2B (TBC1D2B) LDTP13721 10.93  LDD1892 
Tetraspanin-6 (TSPAN6) LDTP14458 32.67  LDD1892 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 35.26  LDD1892 
TraB domain-containing protein (TRABD) LDTP19963 45.57  LDD1892 
Transducin beta-like protein 3 (TBL3) LDTP05647 11.96  LDD1892 
Transmembrane protein 209 (TMEM209) LDTP18272 12.30  LDD1892 
Tubulin beta chain (TUBB) LDTP02205 12.38  LDD1892 
Tubulin beta-2A chain (TUBB2A) LDTP05998 11.55  LDD1892 
Tubulin beta-2B chain (TUBB2B) LDTP11277 13.36  LDD1892 
Tubulin beta-4B chain (TUBB4B) LDTP05076 13.18  LDD1892 
Tudor and KH domain-containing protein (TDRKH) LDTP13922 12.13  LDD1892 
U6 snRNA-associated Sm-like protein LSm7 (LSM7) LDTP13425 27.67  LDD1892 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 52.35  LDD1892 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 15.45  LDD1892 
Vimentin (VIM) LDTP02297 13.93  LDD1892 
WW domain-binding protein 2 (WBP2) LDTP10033 11.24  LDD1892 
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⏷ Show the Full List of 133 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1892 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587