Details of the Target

General Information of Target

Target ID LDTP15962
Target Name Protein-L-histidine N-pros-methyltransferase (METTL9)
Gene Name METTL9
Gene ID 51108
Synonyms
DREV; Protein-L-histidine N-pros-methyltransferase; EC 2.1.1.-; DORA reverse strand protein; DREV; DREV1; Methyltransferase-like protein 9; hMETTL9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAFTGSGLKRKFDDVDVGSSVSNSDDEISSSDSADSCDSLNPPTTASFTPTSILKRQKQ
LRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSVRSYTLCEFAQEQEVNHRE
ILREHLKEEKLHAKKMKLTKNGTVESVEADGLTLDDVSDEDIDVENVEVDDYFFLQPLPT
KRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCRLYCDPEACACSQAGIKCQVDRM
SFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKLELESKRQVSRPAAPDEEPSPTASC
SLTGAQGSETQDFQEFIAENETAVMHLQSAEELERLKAEEDSSGSSASLDSSIESLGVCI
LEEPLAVPEELCPGLTAPILIQAQLPPGSSVLCFTENSDHPTASTVNSPSYLNSGPLVYY
QVEQRPVLGVKGEPGTEEGSASFPKEKDLNVFSLPVTSLVACSSTDPAALCKSEVGKTPT
LEALLPEDCNPEEPENEDFHPSWSPSSLPFRTDNEEGCGMVKTSQQNEDRPPEDSSLELP
LAV
Target Bioclass
Enzyme
Family
METTL9 family
Subcellular location
Endoplasmic reticulum
Function
Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins. Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins. Constitutes the main methyltransferase for the 1-methylhistidine modification in cell.
Uniprot ID
Q9H1A3
Ensemble ID
ENST00000358154.8
HGNC ID
HGNC:24586

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1155 SNV: p.S207N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C215(1.27)  LDD0304  [1]
DBIA
 Probe Info  		C215(1.11)  LDD0531  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		19.84  LDD1782  [6]
C092
 Probe Info  		35.02  LDD1783  [6]
C094
 Probe Info  		44.63  LDD1785  [6]
C112
 Probe Info  		17.39  LDD1799  [6]
C218
 Probe Info  		14.22  LDD1892  [6]
C220
 Probe Info  		14.62  LDD1894  [6]
C246
 Probe Info  		14.93  LDD1919  [6]
C388
 Probe Info  		42.81  LDD2047  [6]
C420
 Probe Info  		26.54  LDD2075  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C215(1.11)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C215(1.13); C59(1.13)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C59(0.37)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C59(0.47)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C59(0.33)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C59(0.15)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C59(0.18)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C59(0.15)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C59(0.19)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C59(0.23)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C59(0.39)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C59(0.61)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C215(1.07); C59(1.07)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C59(0.38)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C59(0.45)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C59(0.30)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C59(0.73)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C59(0.32)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C59(0.12)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C59(0.13)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C59(0.32)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C59(0.40)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C59(0.30)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C215(1.03); C59(1.03)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C59(0.30)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C59(0.65)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C59(0.54)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C59(0.54)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C59(0.79)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C59(0.70)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C59(0.17)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C59(0.22)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C215(0.86); C59(0.42)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C215(1.22); C59(1.35)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C215(1.13); C59(0.55)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C215(1.05); C59(1.86)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C215(1.23); C59(1.62)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C215(1.09); C59(0.61)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C215(1.07); C59(0.44)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C215(1.10); C59(0.48)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C215(1.02); C59(0.62)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C215(0.96); C59(0.96)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C215(0.91); C59(0.52)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C215(1.22); C59(0.70)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C215(1.25); C59(1.25)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C215(1.13); C59(0.46)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C215(1.31); C59(0.64)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C215(0.97); C59(2.03)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C59(0.90)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C59(0.16)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C59(0.56)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C59(0.27)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C59(0.17)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C59(0.13)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C59(0.14)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C215(1.37); C59(1.37)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C59(0.59)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C59(0.75)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C59(0.14)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C59(0.15)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C59(0.23)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C59(0.20)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C59(1.01)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C59(0.91)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C59(1.45)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C59(1.46)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C59(1.00)  LDD0876  [2]
 LDCM0279  AC2 HCT 116 C215(1.18)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C59(1.87)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C59(0.95)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C59(2.74)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C59(1.77)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C59(1.51)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C59(0.76)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C59(0.51)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C59(0.50)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C59(0.45)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C59(0.45)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C215(1.14)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C59(0.38)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C59(0.48)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C59(0.35)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C59(0.78)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C59(1.04)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C215(0.91); C59(1.32)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C215(1.09); C59(1.48)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C215(0.85); C59(1.36)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C215(1.10); C59(1.16)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C59(0.86); C215(1.07)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C215(1.21)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C59(0.70); C215(1.06)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C215(0.97); C59(1.07)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C59(0.97); C215(1.08)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C59(1.08); C215(1.37)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C59(0.81); C215(0.91)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C59(0.76); C215(0.83)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C215(1.16); C59(1.38)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C59(0.69); C215(1.06)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C215(1.27); C59(1.28)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C59(0.81); C215(1.39)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C215(1.22)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C59(0.59); C215(1.31)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C215(1.22); C59(1.63)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C59(0.80); C215(1.27)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C59(0.69); C215(1.20)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C59(0.62); C215(1.20)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C59(0.60); C215(1.12)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C59(0.81); C215(1.35)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C59(0.22)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C59(0.36)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C59(0.20)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C215(1.09); C59(1.09)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C59(0.34)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C59(0.39)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C59(0.20)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C59(0.33)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C59(0.21)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C59(0.24)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C59(0.31)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C59(0.20)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C59(0.46)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C59(0.44)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C215(1.17); C59(1.17)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C59(0.47)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C59(0.78)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C59(0.39)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C59(0.41)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C59(0.43)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C59(0.44)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C59(0.33)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C59(0.29)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C59(0.85)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C59(0.54)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C215(1.25); C59(1.25)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C59(0.33)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C59(1.07)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C59(0.42)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C59(0.15); C215(1.09)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C59(0.17); C215(1.01)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C59(0.39); C215(0.96)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C59(0.35); C215(1.37)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C59(1.01); C215(1.16)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C59(0.44); C215(1.18)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C59(0.20); C215(1.13)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C215(1.22); C59(2.42)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C59(0.14); C215(0.95)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C59(0.16); C215(1.04)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C59(0.35); C215(1.07)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C59(0.65); C215(0.90)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C59(0.83); C215(1.22)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C59(0.26); C215(0.91)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C59(0.19); C215(1.25)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C59(0.11)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C59(0.72)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C215(1.17); C59(1.17)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C215(1.57); C59(1.57)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C215(1.32); C59(1.32)  LDD0873  [2]
 LDCM0367  CL1 HCT 116 C215(1.03); C59(1.35)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C59(0.40); C215(0.94)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C215(1.17)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C215(1.22); C59(1.22)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C215(2.14); C59(2.14)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C215(1.34); C59(1.34)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C215(1.42); C59(1.42)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C59(1.68)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C59(1.60)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C59(1.16)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C59(1.64)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C59(1.71)  LDD0976  [2]
 LDCM0379  CL11 HCT 116 C59(0.38); C215(0.98)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C59(1.39)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C59(1.12)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C59(0.75)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C59(0.43)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C59(0.44)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C59(0.75)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C59(0.83)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C59(0.94); C215(1.19)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C59(0.86); C215(1.11)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C59(0.72); C215(1.16)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C59(0.38); C215(1.10)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C59(0.95); C215(1.23)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C59(0.58); C215(1.08)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C59(0.93); C215(1.24)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C59(0.69); C215(1.25)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C59(0.67); C215(1.30)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C59(0.66)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C59(0.44)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C59(0.64)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C59(0.21)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C59(0.53); C215(1.02)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C59(0.75); C215(1.02)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C59(0.68); C215(1.15)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C59(0.49)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C59(0.59)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C59(0.70)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C59(0.43)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C215(1.04); C59(1.26)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C59(0.19)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C59(0.22)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C59(0.27)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C59(0.35)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C59(0.22)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C59(0.22)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C59(0.33)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C59(0.29)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C59(0.27)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C59(0.24)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C215(0.89); C59(0.94)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C59(0.64)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C215(0.92); C59(0.65)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C215(0.95); C59(0.88)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C215(1.05); C59(0.71)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C215(1.09); C59(0.42)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C215(0.94); C59(0.35)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C215(1.00); C59(0.38)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C215(0.87); C59(0.42)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C215(0.92); C59(0.37)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C215(1.14); C59(0.73)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C215(0.85); C59(0.36)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C215(1.00); C59(0.36)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C215(0.87); C59(0.46)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C215(1.01); C59(0.44)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C215(0.97); C59(0.51)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C215(1.08); C59(0.48)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C215(1.06)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C215(1.10)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C215(1.13)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C215(1.16)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C215(1.02); C59(0.62)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C215(1.06)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C215(1.11)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C215(1.22)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C215(1.05)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C215(1.03)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C215(1.18)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C215(1.23)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C215(1.25)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C215(1.29)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C215(1.14)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C215(1.13); C59(0.71)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C215(1.08)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C59(0.89)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C59(0.97)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C59(0.54)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C59(0.33)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C59(0.71)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C59(0.22)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C59(0.33)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C59(0.55)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C59(1.36)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C215(1.14); C59(0.45)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C59(0.67)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C59(0.51)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C59(0.85)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C59(1.11)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C59(0.66)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C59(0.67); C215(1.19)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C59(0.54); C215(1.13)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C59(0.32); C215(1.37)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C59(0.47); C215(1.04)  LDD1351  [2]
 LDCM0473  CL8 HCT 116 C215(1.16); C59(0.44)  LDD0790  [2]
 LDCM0474  CL80 PaTu 8988t C59(0.52); C215(1.35)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C59(0.26); C215(1.32)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C59(0.46); C215(1.26)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C59(0.34); C215(1.18)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C59(0.19); C215(1.47)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C59(0.45); C215(1.05)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C59(0.42); C215(1.34)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C59(0.20); C215(1.59)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C59(0.29); C215(1.40)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C59(0.20); C215(1.51)  LDD1362  [2]
 LDCM0484  CL9 HCT 116 C215(1.15); C59(0.54)  LDD0801  [2]
 LDCM0485  CL90 PaTu 8988t C59(0.21); C215(1.37)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C215(1.15)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C215(1.10)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C215(1.09)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C215(1.01)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C215(0.96)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C215(1.11)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C215(1.10)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C215(1.12)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C215(1.17)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C215(1.04)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C59(0.51)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C215(1.79); C59(0.42)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C215(0.99)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C215(1.04)  LDD1497  [7]
 LDCM0024  KB05 HMCB C215(19.83)  LDD3312  [8]
 LDCM0131  RA190 MM1.R C215(1.27)  LDD0304  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MYG1 exonuclease (MYG1) MYG1 family Q9HB07

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840