Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C112  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 184 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 99.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 99.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 99.7
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 99.7
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 99.7
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 99.7
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 81.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 79.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 79.3
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 76.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 71.5
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 64.0
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 64.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 63.1
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 62.7
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 61.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 53.8
 LDTP05905  Acid ceramidase (ASAH1) 53.1
 LDTP08171  Stearoyl-CoA desaturase 5 (SCD5) 52.7
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 51.6
 LDTP11438  Signal peptidase complex catalytic subunit SEC11C (SEC11C) 51.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 49.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 49.2
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 48.5
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 47.8
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 46.9
 LDTP11127  ADP-dependent glucokinase (ADPGK) 46.5
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 46.5
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 44.3
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 44.0
 LDTP03842  Squalene synthase (FDFT1) 41.9
 LDTP10329  Ceramide synthase 2 (CERS2) 41.6
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 41.4
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 40.8
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 40.8
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 39.9
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 39.9
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 39.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 38.6
 LDTP16258  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (PIGL) 37.5
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 37.0
 LDTP07931  Heme A synthase COX15 (COX15) 36.8
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 34.5
 LDTP11867  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) 34.3
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 33.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 33.1
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 32.2
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 31.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 30.9
 LDTP06802  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) 30.9
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 30.7
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 30.5
 LDTP01065  E3 ubiquitin-protein ligase TRIM13 (TRIM13) 30.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 29.7
 LDTP10020  Ras-related protein Rab-24 (RAB24) 29.7
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 29.2
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 29.0
 LDTP14305  Bis(5'-adenosyl)-triphosphatase ENPP4 (ENPP4) 28.6
 LDTP04374  Dynamin-2 (DNM2) 28.6
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 28.6
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 28.4
 LDTP06142  Squalene monooxygenase (SQLE) 28.4
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 28.4
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 28.2
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 27.7
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 27.7
 LDTP03394  Ceramide synthase 1 (CERS1) 27.3
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 27.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 27.1
 LDTP01329  Lathosterol oxidase (SC5D) 26.9
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 26.7
 LDTP05137  Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) 26.5
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 26.5
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 26.4
 LDTP11284  Phosphatidylserine synthase 2 (PTDSS2) 26.4
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 26.0
 LDTP03145  Catechol O-methyltransferase (COMT) 26.0
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 25.8
 LDTP03676  ATP-binding cassette sub-family D member 1 (ABCD1) 25.5
 LDTP00836  ATPase GET3 (GET3) 25.5
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 25.5
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 25.5
 LDTP13744  Dynamin-3 (DNM3) 25.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 24.8
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 24.6
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 24.3
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 23.9
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 23.9
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 23.9
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 23.4
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 23.4
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 23.4
 LDTP06617  Ceramide glucosyltransferase (UGCG) 23.3
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 23.3
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 23.3
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 23.3
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 23.3
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 23.3
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 23.1
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 23.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 22.9
 LDTP12303  ATP-binding cassette sub-family B member 6 (ABCB6) 22.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 22.6
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 22.6
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 22.5
 LDTP09251  Atlastin-2 (ATL2) 22.3
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 22.3
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 22.3
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 22.3
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 22.2
 LDTP07756  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) 22.0
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 21.9
 LDTP08378  Serine/threonine-protein kinase VRK2 (VRK2) 21.9
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 21.7
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 21.7
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 21.7
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 21.6
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 21.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 21.6
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 21.6
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 21.4
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 21.3
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 21.3
 LDTP00400  Torsin-1B (TOR1B) 21.3
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 21.0
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 20.8
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 20.4
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.4
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 20.4
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 20.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 20.4
 LDTP01710  Pseudouridylate synthase TRUB2, mitochondrial (TRUB2) 20.4
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 20.4
 LDTP03822  Activin receptor type-1B (ACVR1B) 20.3
 LDTP05408  Antigen peptide transporter 1 (TAP1) 20.3
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 20.3
 LDTP09814  Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) 20.1
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 20.1
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 20.1
 LDTP07966  COP9 signalosome complex subunit 6 (COPS6) 20.0
 LDTP01515  NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) 20.0
 LDTP01513  NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) 19.8
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 19.8
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 19.7
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 19.6
 LDTP11268  Acireductone dioxygenase (ADI1) 19.4
 LDTP14075  AFG3-like protein 2 (AFG3L2) 19.3
 LDTP05958  Ras-related protein Rab-32 (RAB32) 19.2
 LDTP00344  Stearoyl-CoA desaturase (SCD) 19.2
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 19.0
 LDTP02505  Lysosomal protective protein (CTSA) 19.0
 LDTP00577  Dihydroxyacetone phosphate acyltransferase (GNPAT) 18.9
 LDTP08416  E3 ubiquitin-protein ligase MIB1 (MIB1) 18.9
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 18.9
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 18.8
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 18.6
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 18.5
 LDTP00975  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) 18.5
 LDTP07290  Lysophospholipid acyltransferase LPCAT4 (LPCAT4) 18.4
 LDTP12752  NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) 18.4
 LDTP06849  Prolyl endopeptidase-like (PREPL) 18.4
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 18.4
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 18.4
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 18.4
 LDTP04263  Cysteine--tRNA ligase, cytoplasmic (CARS1) 18.3
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 18.1
 LDTP01514  NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4) 18.0
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 18.0
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 17.9
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 17.9
 LDTP01769  Dihydrofolate reductase (DHFR) 17.8
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 17.8
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 17.6
 LDTP01986  NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) 17.6
 LDTP00994  Beta-1,4-galactosyltransferase 3 (B4GALT3) 17.5
 LDTP09620  Soluble calcium-activated nucleotidase 1 (CANT1) 17.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 17.4
 LDTP15962  Protein-L-histidine N-pros-methyltransferase (METTL9) 17.4
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 17.3
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 17.3
 LDTP02539  Lysosomal acid phosphatase (ACP2) 17.1
 LDTP05337  Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH) 17.0
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) 17.0
 LDTP11733  Ras-related protein Rab-1B (RAB1B) 17.0
Transporter and channel
Click to Show/Hide to Show 159 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 99.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 99.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 99.7
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 91.8
 LDTP02215  Prosaposin (PSAP) 91.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 90.5
 LDTP15648  BRI3-binding protein (BRI3BP) 88.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 78.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 77.2
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 75.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 75.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 68.1
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 67.6
 LDTP03546  Translocator protein (TSPO) 67.6
 LDTP07236  Protein GPR107 (GPR107) 58.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 55.7
 LDTP10065  Transmembrane protein 230 (TMEM230) 55.3
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 52.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 52.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 50.2
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 48.5
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 48.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 47.8
 LDTP05900  Metaxin-1 (MTX1) 47.8
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 47.2
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 47.2
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 46.5
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 46.2
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 44.9
 LDTP10343  Vacuole membrane protein 1 (VMP1) 44.3
 LDTP11245  Derlin-1 (DERL1) 43.7
 LDTP11250  MICOS complex subunit MIC26 (APOO) 42.2
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 41.9
 LDTP03380  Stomatin (STOM) 39.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 39.1
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 38.9
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 38.6
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 38.1
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 38.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 37.8
 LDTP20002  Transmembrane protein 160 (TMEM160) 37.0
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 36.8
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 36.8
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) 36.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 36.3
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 36.0
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 35.0
 LDTP11812  Protein ARV1 (ARV1) 35.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 35.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 34.1
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 33.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 33.4
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 32.9
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 32.4
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 32.2
 LDTP16813  Tetraspanin-3 (TSPAN3) 32.2
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 31.3
 LDTP09278  Multiple coagulation factor deficiency protein 2 (MCFD2) 30.9
 LDTP09028  Mitoguardin 1 (MIGA1) 30.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 30.7
 LDTP06928  Coiled-coil domain-containing protein 93 (CCDC93) 30.1
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 30.1
 LDTP07667  Transmembrane protein 205 (TMEM205) 30.1
 LDTP12451  Integral membrane protein 2C (ITM2C) 29.4
 LDTP10398  Receptor expression-enhancing protein 6 (REEP6) 29.4
 LDTP00358  Succinate dehydrogenase cytochrome b small subunit, mitochondrial (SDHD) 29.4
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 29.0
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 28.4
 LDTP05474  ATP synthase F(0) complex subunit C2, mitochondrial (ATP5MC2) 28.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 28.2
 LDTP11116  45 kDa calcium-binding protein (SDF4) 27.9
 LDTP11634  Derlin-2 (DERL2) 27.7
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 27.7
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 26.9
 LDTP12704  Anoctamin-10 (ANO10) 26.4
 LDTP07156  Protein wntless homolog (WLS) 26.2
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 26.2
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 26.0
 LDTP01380  Wolframin (WFS1) 26.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 25.6
 LDTP07439  Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) 24.9
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 24.9
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 24.9
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 24.8
 LDTP09789  Transmembrane 9 superfamily member 4 (TM9SF4) 24.4
 LDTP13256  SUN domain-containing protein 2 (SUN2) 24.1
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 23.6
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 23.3
 LDTP15979  Transmembrane protein 245 (TMEM245) 23.3
 LDTP00592  Surfeit locus protein 4 (SURF4) 23.1
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 23.1
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 22.9
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 22.9
 LDTP13953  Endophilin-B1 (SH3GLB1) 22.8
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 22.8
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 22.8
 LDTP07537  Metal transporter CNNM4 (CNNM4) 22.6
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 22.6
 LDTP05811  Syntaxin-3 (STX3) 22.6
 LDTP04787  Transmembrane protein 33 (TMEM33) 22.3
 LDTP16190  Protein FAM8A1 (FAM8A1) 22.2
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 21.9
 LDTP07531  Sideroflexin-4 (SFXN4) 21.9
 LDTP11229  Transmembrane protein 70, mitochondrial (TMEM70) 21.9
 LDTP11213  Nucleoporin NDC1 (NDC1) 21.3
 LDTP07058  Transmembrane protein 201 (TMEM201) 21.3
 LDTP14717  ATP synthase subunit e, mitochondrial (ATP5ME) 21.1
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 21.1
 LDTP07467  Rhomboid domain-containing protein 2 (RHBDD2) 21.1
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 21.1
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 21.1
 LDTP01217  Metaxin-2 (MTX2) 21.0
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 20.8
 LDTP13833  Integral membrane protein 2B (ITM2B) 20.8
 LDTP16201  B-cell receptor-associated protein 29 (BCAP29) 20.7
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 20.7
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 20.5
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 20.4
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 20.3
 LDTP05780  Syntaxin-5 (STX5) 20.1
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 20.0
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 20.0
 LDTP09788  Sorting nexin-19 (SNX19) 20.0
 LDTP01366  Flotillin-1 (FLOT1) 19.7
 LDTP03405  Calnexin (CANX) 19.6
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 19.4
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 19.3
 LDTP10754  Pannexin-1 (PANX1) 19.3
 LDTP10621  Sideroflexin-2 (SFXN2) 19.3
 LDTP12979  Transmembrane protein 14C (TMEM14C) 19.2
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 19.0
 LDTP05934  Stromal interaction molecule 1 (STIM1) 19.0
 LDTP01060  PRA1 family protein 2 (PRAF2) 18.9
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 18.8
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 18.8
 LDTP11291  Transmembrane emp24 domain-containing protein 9 (TMED9) 18.8
 LDTP04723  ATP synthase subunit f, mitochondrial (ATP5MF) 18.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 18.6
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 18.5
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 18.5
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 18.4
 LDTP04501  Importin subunit alpha-1 (KPNA2) 18.3
 LDTP14275  Sodium bicarbonate cotransporter 3 (SLC4A7) 18.3
 LDTP11041  Calcium uptake protein 1, mitochondrial (MICU1) 18.1
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 18.1
 LDTP03717  Prohibitin 1 (PHB1) 18.0
 LDTP09515  Importin-4 (IPO4) 17.6
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 17.6
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 17.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 17.5
 LDTP01301  Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) 17.4
 LDTP00590  Protein RER1 (RER1) 17.4
 LDTP07477  Transmembrane protein 214 (TMEM214) 17.3
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 17.1
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 17.1
 LDTP10036  BOS complex subunit NCLN (NCLN) 17.0
 LDTP10804  Chloride channel CLIC-like protein 1 (CLCC1) 17.0
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 38.1
 LDTP01198  Nuclear receptor corepressor 1 (NCOR1) 33.1
 LDTP05307  Transcription factor AP-4 (TFAP4) 23.4
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 26.7
Other
Click to Show/Hide to Show 147 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 99.7
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 99.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 99.7
 LDTP10113  Mitochondrial import receptor subunit TOM6 homolog (TOMM6) 99.7
 LDTP18145  Small integral membrane protein 19 (SMIM19) 99.7
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 97.7
 LDTP05160  Nucleobindin-2 (NUCB2) 87.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 81.0
 LDTP08606  Nurim (NRM) 75.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 72.0
 LDTP10056  Protein FAM162A (FAM162A) 72.0
 LDTP01522  Reticulon-3 (RTN3) 70.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 67.6
 LDTP16006  Optic atrophy 3 protein (OPA3) 62.7
 LDTP00859  Synaptogyrin-2 (SYNGR2) 61.0
 LDTP13086  Syntaxin-18 (STX18) 59.7
 LDTP08000  Dymeclin (DYM) 58.9
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 57.7
 LDTP14458  Tetraspanin-6 (TSPAN6) 55.7
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 54.2
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 53.4
 LDTP12412  Reticulon-4 (RTN4) 52.0
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 51.3
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 51.3
 LDTP14939  Membralin (TMEM259) 51.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 50.6
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 47.8
 LDTP00986  Syntaxin-10 (STX10) 47.8
 LDTP15110  Protein C3orf33 (C3orf33) 47.5
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 46.2
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 44.9
 LDTP03926  Centrin-2 (CETN2) 43.7
 LDTP18883  Protein CEBPZOS (CEBPZOS) 41.6
 LDTP01494  Protein YIF1A (YIF1A) 41.6
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 41.1
 LDTP06097  Reticulocalbin-2 (RCN2) 40.8
 LDTP05277  Protein SET (SET) 40.5
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 39.4
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 39.1
 LDTP10924  Prohibitin-2 (PHB2) 39.1
 LDTP09773  Protein FAM3C (FAM3C) 39.1
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 38.9
 LDTP08224  Protein LYRIC (MTDH) 38.9
 LDTP01167  Reticulon-2 (RTN2) 38.6
 LDTP11143  Centromere protein K (CENPK) 38.1
 LDTP06948  Protein YIF1B (YIF1B) 37.8
 LDTP02927  Ganglioside GM2 activator (GM2A) 37.3
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 37.3
 LDTP05375  Nucleobindin-1 (NUCB1) 37.3
 LDTP08594  Negative elongation factor C/D (NELFCD) 36.0
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 34.8
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 33.1
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 32.7
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 32.0
 LDTP19963  TraB domain-containing protein (TRABD) 31.8
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 31.3
 LDTP02297  Vimentin (VIM) 31.3
 LDTP01387  SEC14-like protein 2 (SEC14L2) 30.5
 LDTP11670  Mitochondrial fission factor (MFF) 30.1
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 29.4
 LDTP01236  Transcription initiation protein SPT3 homolog (SUPT3H) 29.4
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 29.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 28.4
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 28.1
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 28.1
 LDTP01359  Dynactin subunit 3 (DCTN3) 27.5
 LDTP13901  Ragulator complex protein LAMTOR2 (LAMTOR2) 27.1
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 26.9
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 26.9
 LDTP09080  Reticulophagy regulator 2 (RETREG2) 26.0
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 25.1
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 24.8
 LDTP15398  Protein FAM177A1 (FAM177A1) 24.8
 LDTP14716  ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) 24.6
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 24.4
 LDTP10116  Lipid droplet assembly factor 1 (LDAF1) 24.4
 LDTP15741  Cytochrome c oxidase assembly protein COX14 (COX14) 24.1
 LDTP10275  Mitochondrial potassium channel (CCDC51) 24.1
 LDTP13982  Mitochondrial fission 1 protein (FIS1) 23.9
 LDTP13630  Neudesin (NENF) 23.9
 LDTP00887  Calumenin (CALU) 23.8
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 23.8
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 23.8
 LDTP02181  Neurofilament medium polypeptide (NEFM) 23.4
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 23.3
 LDTP10442  Thioredoxin domain-containing protein 15 (TXNDC15) 23.3
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 23.1
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 22.9
 LDTP02180  Neurofilament light polypeptide (NEFL) 22.9
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 22.8
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 22.8
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 22.8
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 22.6
 LDTP05960  Trophoblast glycoprotein (TPBG) 22.5
 LDTP10184  HAUS augmin-like complex subunit 1 (HAUS1) 22.3
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 21.9
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 21.7
 LDTP15778  Protein PRRC1 (PRRC1) 21.7
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) 21.0
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 20.8
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 20.8
 LDTP01652  Centrosomal protein 43 (CEP43) 20.7
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 20.7
 LDTP04356  Emerin (EMD) 20.5
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 20.5
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 20.3
 LDTP08795  GH3 domain-containing protein (GHDC) 20.3
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 20.3
 LDTP09324  Ganglioside-induced differentiation-associated protein 1 (GDAP1) 20.1
 LDTP13967  Transmembrane emp24 domain-containing protein 5 (TMED5) 20.1
 LDTP04703  Tumor protein D52 (TPD52) 20.1
 LDTP06527  Alpha-internexin (INA) 20.0
 LDTP00397  Golgi SNAP receptor complex member 2 (GOSR2) 20.0
 LDTP03065  Lamin-B1 (LMNB1) 20.0
 LDTP15623  Neuferricin (CYB5D2) 20.0
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 19.8
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 19.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 19.0
 LDTP16285  Transducin beta-like protein 2 (TBL2) 19.0
 LDTP07476  RAD50-interacting protein 1 (RINT1) 18.9
 LDTP01225  Mediator of RNA polymerase II transcription subunit 24 (MED24) 18.6
 LDTP07031  Collectin-12 (COLEC12) 18.5
 LDTP08248  NLR family member X1 (NLRX1) 18.5
 LDTP05685  Transmembrane protein 115 (TMEM115) 18.5
 LDTP04621  Heat shock-related 70 kDa protein 2 (HSPA2) 18.4
 LDTP08761  NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) 18.4
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 18.4
 LDTP14277  Cytochrome c oxidase assembly protein COX11, mitochondrial (COX11) 18.1
 LDTP05741  Large ribosomal subunit protein bL28m (MRPL28) 18.1
 LDTP12729  Required for meiotic nuclear division protein 1 homolog (RMND1) 18.1
 LDTP15712  RING finger and SPRY domain-containing protein 1 (RSPRY1) 18.1
 LDTP06868  Angiomotin (AMOT) 18.0
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 18.0
 LDTP09069  Kinetochore protein Spc24 (SPC24) 18.0
 LDTP05641  WASH complex subunit 5 (WASHC5) 17.8
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 17.6
 LDTP14164  Immediate early response 3-interacting protein 1 (IER3IP1) 17.6
 LDTP14259  Testis-expressed protein 264 (TEX264) 17.6
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 17.6
 LDTP00417  Programmed cell death protein 5 (PDCD5) 17.5
 LDTP13863  DnaJ homolog subfamily C member 16 (DNAJC16) 17.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 17.3
 LDTP14239  Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) 17.3
 LDTP01932  Prelamin-A/C (LMNA) 17.3
 LDTP06128  RNA-binding protein 39 (RBM39) 17.3
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 17.3
 LDTP18272  Transmembrane protein 209 (TMEM209) 17.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587