Details of the Target

General Information of Target

Target ID LDTP01982
Target Name NADH-ubiquinone oxidoreductase chain 1 (MT-ND1)
Gene Name MT-ND1
Gene ID 4535
Synonyms
MTND1; NADH1; ND1; NADH-ubiquinone oxidoreductase chain 1; EC 7.1.1.2; NADH dehydrogenase subunit 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEP
LKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSG
WASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWP
LAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTT
IFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLAL
LMWYVSMPITISSIPPQT
Target Bioclass
Enzyme
Family
Complex I subunit 1 family
Subcellular location
Mitochondrion inner membrane
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Uniprot ID
P03886
Ensemble ID
ENST00000361390.2
HGNC ID
HGNC:7455
ChEMBL ID
CHEMBL2363065

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		2.23  LDD0120  [1]
PAL-AfBPP Probe
Click To Hide/Show 126 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		11.71  LDD1711  [2]
C004
 Probe Info  		10.06  LDD1714  [2]
C007
 Probe Info  		5.66  LDD1716  [2]
C027
 Probe Info  		11.00  LDD1733  [2]
C040
 Probe Info  		13.55  LDD1740  [2]
C041
 Probe Info  		12.73  LDD1741  [2]
C044
 Probe Info  		7.62  LDD1743  [2]
C053
 Probe Info  		5.35  LDD1751  [2]
C055
 Probe Info  		30.48  LDD1752  [2]
C056
 Probe Info  		29.45  LDD1753  [2]
C064
 Probe Info  		6.96  LDD1761  [2]
C070
 Probe Info  		18.38  LDD1766  [2]
C071
 Probe Info  		8.75  LDD1767  [2]
C072
 Probe Info  		11.79  LDD1768  [2]
C082
 Probe Info  		9.13  LDD1774  [2]
C085
 Probe Info  		10.56  LDD1777  [2]
C087
 Probe Info  		10.78  LDD1779  [2]
C089
 Probe Info  		8.82  LDD1781  [2]
C091
 Probe Info  		42.52  LDD1782  [2]
C092
 Probe Info  		67.65  LDD1783  [2]
C094
 Probe Info  		91.14  LDD1785  [2]
C102
 Probe Info  		5.03  LDD1790  [2]
C106
 Probe Info  		42.81  LDD1793  [2]
C107
 Probe Info  		17.51  LDD1794  [2]
C108
 Probe Info  		17.63  LDD1795  [2]
C112
 Probe Info  		76.11  LDD1799  [2]
C129
 Probe Info  		8.17  LDD1811  [2]
C130
 Probe Info  		17.15  LDD1812  [2]
C153
 Probe Info  		32.00  LDD1834  [2]
C156
 Probe Info  		5.13  LDD1836  [2]
C159
 Probe Info  		15.45  LDD1839  [2]
C160
 Probe Info  		22.47  LDD1840  [2]
C161
 Probe Info  		34.30  LDD1841  [2]
C176
 Probe Info  		6.06  LDD1855  [2]
C177
 Probe Info  		21.56  LDD1856  [2]
C178
 Probe Info  		63.12  LDD1857  [2]
C180
 Probe Info  		4.99  LDD1859  [2]
C182
 Probe Info  		6.45  LDD1860  [2]
C183
 Probe Info  		7.21  LDD1861  [2]
C185
 Probe Info  		5.78  LDD1863  [2]
C186
 Probe Info  		12.47  LDD1864  [2]
C187
 Probe Info  		20.97  LDD1865  [2]
C191
 Probe Info  		9.65  LDD1868  [2]
C201
 Probe Info  		99.73  LDD1877  [2]
C204
 Probe Info  		7.16  LDD1879  [2]
C206
 Probe Info  		37.27  LDD1881  [2]
C217
 Probe Info  		14.42  LDD1891  [2]
C218
 Probe Info  		27.86  LDD1892  [2]
C219
 Probe Info  		13.18  LDD1893  [2]
C220
 Probe Info  		32.00  LDD1894  [2]
C222
 Probe Info  		9.13  LDD1896  [2]
C225
 Probe Info  		36.25  LDD1898  [2]
C226
 Probe Info  		14.93  LDD1899  [2]
C228
 Probe Info  		68.12  LDD1901  [2]
C229
 Probe Info  		11.31  LDD1902  [2]
C231
 Probe Info  		23.10  LDD1904  [2]
C232
 Probe Info  		54.57  LDD1905  [2]
C233
 Probe Info  		25.11  LDD1906  [2]
C234
 Probe Info  		7.57  LDD1907  [2]
C235
 Probe Info  		45.89  LDD1908  [2]
C238
 Probe Info  		19.03  LDD1911  [2]
C239
 Probe Info  		8.11  LDD1912  [2]
C240
 Probe Info  		28.44  LDD1913  [2]
C242
 Probe Info  		7.73  LDD1915  [2]
C243
 Probe Info  		20.97  LDD1916  [2]
C244
 Probe Info  		17.51  LDD1917  [2]
C246
 Probe Info  		29.24  LDD1919  [2]
C249
 Probe Info  		18.00  LDD1922  [2]
C252
 Probe Info  		24.76  LDD1925  [2]
C264
 Probe Info  		28.25  LDD1935  [2]
C265
 Probe Info  		25.28  LDD1936  [2]
C269
 Probe Info  		9.92  LDD1939  [2]
C272
 Probe Info  		5.86  LDD1942  [2]
C273
 Probe Info  		20.68  LDD1943  [2]
C277
 Probe Info  		28.44  LDD1947  [2]
C278
 Probe Info  		48.84  LDD1948  [2]
C280
 Probe Info  		28.84  LDD1950  [2]
C282
 Probe Info  		23.75  LDD1952  [2]
C284
 Probe Info  		22.63  LDD1954  [2]
C285
 Probe Info  		29.04  LDD1955  [2]
C286
 Probe Info  		7.73  LDD1956  [2]
C287
 Probe Info  		37.27  LDD1957  [2]
C288
 Probe Info  		36.25  LDD1958  [2]
C289
 Probe Info  		77.71  LDD1959  [2]
C290
 Probe Info  		11.96  LDD1960  [2]
C292
 Probe Info  		5.17  LDD1962  [2]
C293
 Probe Info  		23.10  LDD1963  [2]
C296
 Probe Info  		16.11  LDD1966  [2]
C297
 Probe Info  		6.06  LDD1967  [2]
C307
 Probe Info  		8.17  LDD1975  [2]
C310
 Probe Info  		9.00  LDD1977  [2]
C314
 Probe Info  		19.29  LDD1981  [2]
C317
 Probe Info  		13.09  LDD1983  [2]
C348
 Probe Info  		25.46  LDD2009  [2]
C349
 Probe Info  		23.75  LDD2010  [2]
C350
 Probe Info  		68.59  LDD2011  [2]
C351
 Probe Info  		21.86  LDD2012  [2]
C353
 Probe Info  		7.31  LDD2014  [2]
C354
 Probe Info  		9.78  LDD2015  [2]
C362
 Probe Info  		95.67  LDD2023  [2]
C363
 Probe Info  		53.08  LDD2024  [2]
C364
 Probe Info  		32.90  LDD2025  [2]
C366
 Probe Info  		9.92  LDD2027  [2]
C367
 Probe Info  		10.34  LDD2028  [2]
C368
 Probe Info  		4.92  LDD2029  [2]
C376
 Probe Info  		26.54  LDD2036  [2]
C378
 Probe Info  		10.85  LDD2037  [2]
C379
 Probe Info  		5.24  LDD2038  [2]
C380
 Probe Info  		10.41  LDD2039  [2]
C382
 Probe Info  		31.78  LDD2041  [2]
C386
 Probe Info  		11.71  LDD2045  [2]
C387
 Probe Info  		6.19  LDD2046  [2]
C388
 Probe Info  		54.57  LDD2047  [2]
C389
 Probe Info  		7.73  LDD2048  [2]
C399
 Probe Info  		20.97  LDD2058  [2]
C403
 Probe Info  		32.67  LDD2061  [2]
C405
 Probe Info  		11.31  LDD2063  [2]
C407
 Probe Info  		21.56  LDD2064  [2]
C408
 Probe Info  		9.92  LDD2065  [2]
C424
 Probe Info  		22.63  LDD2079  [2]
C426
 Probe Info  		17.39  LDD2081  [2]
FFF probe11
 Probe Info  		17.45  LDD0471  [3]
FFF probe13
 Probe Info  		20.00  LDD0475  [3]
FFF probe14
 Probe Info  		20.00  LDD0477  [3]
JN0003
 Probe Info  		19.63  LDD0469  [3]
OEA-DA
 Probe Info  		20.00  LDD0046  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0071  Cisar_cp14 MDA-MB-231 2.41  LDD0121  [1]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.23  LDD0120  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nicotinamide phosphoribosyltransferase (NAMPT) NAPRTase family P43490

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Desflurane Small molecular drug DB01189
Halothane Small molecular drug DB01159
Isoflurane Small molecular drug DB00753
Methoxyflurane Small molecular drug DB01028
Nadh Small molecular drug DB00157
Sevoflurane Small molecular drug DB01236
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-formylmethionine Small molecular drug DB04464
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
4 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570