Details of the Probe

General Information of Probe

Probe ID
LDPC0371
Probe Name
C129
Synonyms
Z4282860401
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 361.4
Lipid-water partition coefficient (xlogp) 2.2
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H19N5O2
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[[2-(4-cyanophenyl)-1,3-oxazol-4-yl]methyl]-N-methylpropanamide
Canonical SMILES
CN(CC1=COC(=N1)C2=CC=C(C=C2)C#N)C(=O)CCC3(N=N3)CCC#C
InChI
InChI=1S/C20H19N5O2/c1-3-4-10-20(23-24-20)11-9-18(26)25(2)13-17-14-27-19(22-17)16-7-5-15(12-21)6-8-16/h1,5-8,14H,4,9-11,13H2,2H3
InChIKey
RPIARMSJPBUARB-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

57 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
4'-phosphopantetheine phosphatase (PANK4) LDTP12673 7.73  LDD1811 
Abasic site processing protein HMCES (HMCES) LDTP10322 10.85  LDD1811 
Acid ceramidase (ASAH1) LDTP05905 8.00  LDD1811 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 6.92  LDD1811 
Arginyl-tRNA--protein transferase 1 (ATE1) LDTP14534 5.17  LDD1811 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 8.69  LDD1811 
Beta-galactosidase (GLB1) LDTP02837 6.54  LDD1811 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 9.65  LDD1811 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 9.32  LDD1811 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 5.94  LDD1811 
Catechol O-methyltransferase (COMT) LDTP03145 5.24  LDD1811 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 7.01  LDD1811 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 9.38  LDD1811 
Cytochrome b5 type B (CYB5B) LDTP00697 12.38  LDD1811 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 6.77  LDD1811 
Delta(24)-sterol reductase (DHCR24) LDTP06375 10.63  LDD1811 
Dihydrofolate reductase (DHFR) LDTP01769 16.34  LDD1811 
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) LDTP06511 6.45  LDD1811 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 6.87  LDD1811 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 5.46  LDD1811 
Farnesyl pyrophosphate synthase (FDPS) LDTP02721 18.90  LDD1811 
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) LDTP04032 7.11  LDD1811 
Glyoxalase domain-containing protein 4 (GLOD4) LDTP16040 10.93  LDD1811 
Heme oxygenase 1 (HMOX1) LDTP02359 9.65  LDD1811 
Heme oxygenase 2 (HMOX2) LDTP03540 15.56  LDD1811 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 9.19  LDD1811 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 5.90  LDD1811 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 14.42  LDD1811 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 7.73  LDD1811 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 15.78  LDD1811 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 6.32  LDD1811 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 7.41  LDD1811 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 7.31  LDD1811 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 7.01  LDD1811 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 29.24  LDD1811 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 9.65  LDD1811 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 5.78  LDD1811 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 8.17  LDD1811 
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) LDTP03813 5.06  LDD1811 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 10.56  LDD1811 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 10.06  LDD1811 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 5.86  LDD1811 
Phenylalanine--tRNA ligase alpha subunit (FARSA) LDTP13831 4.99  LDD1811 
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) LDTP02679 5.03  LDD1811 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 8.11  LDD1811 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 7.36  LDD1811 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 15.89  LDD1811 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 13.93  LDD1811 
SET and MYND domain-containing protein 4 (SMYD4) LDTP08664 9.65  LDD1811 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 7.06  LDD1811 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 9.38  LDD1811 
TLC domain-containing protein 1 (TLCD1) LDTP10182 5.35  LDD1811 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 6.36  LDD1811 
Trimethyllysine dioxygenase, mitochondrial (TMLHE) LDTP12679 17.03  LDD1811 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 5.24  LDD1811 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 5.74  LDD1811 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 4.99  LDD1811 
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⏷ Show the Full List of 57 Enzyme
43 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 6.32  LDD1811 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 11.00  LDD1811 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 15.67  LDD1811 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 5.13  LDD1811 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 18.00  LDD1811 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 5.90  LDD1811 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 8.75  LDD1811 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 19.03  LDD1811 
Metaxin-1 (MTX1) LDTP05900 5.94  LDD1811 
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) LDTP05384 5.70  LDD1811 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 6.54  LDD1811 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 46.21  LDD1811 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 36.50  LDD1811 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 26.17  LDD1811 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 6.50  LDD1811 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 6.11  LDD1811 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 20.39  LDD1811 
Mpv17-like protein 2 (MPV17L2) LDTP14952 10.70  LDD1811 
Nucleoporin NDC1 (NDC1) LDTP11213 9.58  LDD1811 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 9.45  LDD1811 
Protein FAM8A1 (FAM8A1) LDTP16190 5.46  LDD1811 
Protein GPR107 (GPR107) LDTP07236 6.68  LDD1811 
Protein GPR108 (GPR108) LDTP12383 6.06  LDD1811 
Protein tweety homolog 3 (TTYH3) LDTP11615 6.59  LDD1811 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 5.66  LDD1811 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 5.54  LDD1811 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 16.22  LDD1811 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 15.78  LDD1811 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 11.71  LDD1811 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 10.48  LDD1811 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 23.43  LDD1811 
Surfeit locus protein 4 (SURF4) LDTP00592 6.92  LDD1811 
Tetraspanin-3 (TSPAN3) LDTP16813 8.06  LDD1811 
THO complex subunit 1 (THOC1) LDTP10317 5.03  LDD1811 
Transferrin receptor protein 1 (TFRC) LDTP01969 11.16  LDD1811 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 10.20  LDD1811 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 8.51  LDD1811 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 6.02  LDD1811 
Transmembrane protein 199 (TMEM199) LDTP08881 14.12  LDD1811 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 14.62  LDD1811 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 16.22  LDD1811 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 14.72  LDD1811 
WASH complex subunit 3 (WASHC3) LDTP13973 6.32  LDD1811 
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⏷ Show the Full List of 43 Transporter and channel
30 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 7.41  LDD1811 
Apolipoprotein L2 (APOL2) LDTP11076 42.22  LDD1811 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 15.67  LDD1811 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 17.63  LDD1811 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 7.06  LDD1811 
GATOR2 complex protein MIOS (MIOS) LDTP12775 6.32  LDD1811 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 8.69  LDD1811 
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) LDTP10962 4.96  LDD1811 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 5.86  LDD1811 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 6.41  LDD1811 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 5.82  LDD1811 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 4.99  LDD1811 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.41  LDD1811 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 5.70  LDD1811 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 13.83  LDD1811 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 7.57  LDD1811 
Negative elongation factor C/D (NELFCD) LDTP08594 9.45  LDD1811 
Nucleobindin-1 (NUCB1) LDTP05375 8.11  LDD1811 
Nucleobindin-2 (NUCB2) LDTP05160 7.31  LDD1811 
Protein FAM114A2 (FAM114A2) LDTP16080 6.87  LDD1811 
Protein jagunal homolog 1 (JAGN1) LDTP08904 5.86  LDD1811 
Protein unc-119 homolog B (UNC119B) LDTP00105 7.84  LDD1811 
Protein YIF1A (YIF1A) LDTP01494 5.50  LDD1811 
Reticulon-3 (RTN3) LDTP01522 6.59  LDD1811 
Syntaxin-18 (STX18) LDTP13086 6.59  LDD1811 
Testis-expressed protein 264 (TEX264) LDTP14259 6.92  LDD1811 
Tetraspanin-6 (TSPAN6) LDTP14458 9.85  LDD1811 
Tetratricopeptide repeat protein 21B (TTC21B) LDTP08073 7.21  LDD1811 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 5.46  LDD1811 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 9.06  LDD1811 
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⏷ Show the Full List of 30 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1811 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587