Details of the Target

General Information of Target

Target ID LDTP13973
Target Name WASH complex subunit 3 (WASHC3)
Gene Name WASHC3
Gene ID 51019
Synonyms
WASH complex subunit 3; Coiled-coil domain-containing protein 53
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLGGSLGSRLLRGVGGSHGRFGARGVREGGAAMAAGESMAQRMVWVDLEMTGLDIEKDQI
IEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQA
EYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWY
PEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENGENEKTVS
Target Bioclass
Transporter and channel
Family
CCDC53 family
Subcellular location
Early endosome
Function
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
Uniprot ID
Q9Y3C0
Ensemble ID
ENST00000240079.11
HGNC ID
HGNC:24256

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K24(5.83)  LDD0277  [1]
DBIA
 Probe Info  		C48(4.50)  LDD0209  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
AOyne
 Probe Info  		11.90  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		17.75  LDD1793  [6]
C129
 Probe Info  		6.32  LDD1811  [6]
C278
 Probe Info  		48.50  LDD1948  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C48(0.63)  LDD1093  [7]
 LDCM0215  AC10 PaTu 8988t C48(1.04)  LDD1094  [7]
 LDCM0226  AC11 PaTu 8988t C48(1.22)  LDD1105  [7]
 LDCM0230  AC113 PaTu 8988t C48(1.04)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C48(1.01)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C48(0.73)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C48(1.09)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C48(1.25)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C48(0.89)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C48(0.92)  LDD1115  [7]
 LDCM0237  AC12 PaTu 8988t C48(1.07)  LDD1116  [7]
 LDCM0238  AC120 PaTu 8988t C48(0.91)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C48(1.11)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C48(1.28)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C48(1.32)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C48(0.71)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C48(0.92)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C48(1.14)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C48(1.11)  LDD1124  [7]
 LDCM0259  AC14 PaTu 8988t C48(1.09)  LDD1138  [7]
 LDCM0263  AC143 PaTu 8988t C48(0.98)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C48(0.86)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C48(1.26)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C48(0.98)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C48(1.00)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C48(0.79)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C48(1.69)  LDD1148  [7]
 LDCM0270  AC15 PaTu 8988t C48(1.00)  LDD1149  [7]
 LDCM0271  AC150 PaTu 8988t C48(0.92)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C48(1.09)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C48(1.05)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C48(0.78)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C48(1.91)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C48(1.26)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C48(1.64)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C48(1.09)  LDD2169  [7]
 LDCM0276  AC17 PaTu 8988t C48(0.84)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C48(1.55)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C48(0.91)  LDD1157  [7]
 LDCM0279  AC2 PaTu 8988t C48(0.60)  LDD1158  [7]
 LDCM0280  AC20 PaTu 8988t C48(0.74)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C48(1.05)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C48(1.16)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C48(1.15)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C48(1.09)  LDD1163  [7]
 LDCM0285  AC25 PaTu 8988t C48(0.98)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C48(1.11)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C48(1.13)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C48(0.90)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C48(0.86)  LDD1168  [7]
 LDCM0290  AC3 PaTu 8988t C48(0.58)  LDD1169  [7]
 LDCM0291  AC30 PaTu 8988t C48(1.09)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C48(0.90)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C48(0.85)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C48(0.98)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C48(0.94)  LDD1174  [7]
 LDCM0298  AC37 HEK-293T C48(1.19)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C48(1.32)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C48(1.64)  LDD1539  [8]
 LDCM0301  AC4 PaTu 8988t C48(0.56)  LDD1180  [7]
 LDCM0302  AC40 HEK-293T C48(1.33)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C48(1.21)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C48(0.99)  LDD1543  [8]
 LDCM0307  AC45 HEK-293T C48(1.08)  LDD1546  [8]
 LDCM0308  AC46 PaTu 8988t C48(1.06)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C48(1.18)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C48(1.05)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C48(0.91)  LDD1190  [7]
 LDCM0312  AC5 PaTu 8988t C48(0.53)  LDD1191  [7]
 LDCM0313  AC50 PaTu 8988t C48(1.17)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C48(0.80)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C48(1.15)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C48(1.06)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C48(1.03)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C48(0.84)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C48(0.95)  LDD1198  [7]
 LDCM0320  AC57 HEK-293T C48(1.13)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C48(1.12)  LDD1560  [8]
 LDCM0323  AC6 PaTu 8988t C48(0.88)  LDD1202  [7]
 LDCM0325  AC61 HEK-293T C48(1.04)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C48(1.36)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C48(1.34)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C48(1.12)  LDD1567  [8]
 LDCM0334  AC7 PaTu 8988t C48(1.15)  LDD1213  [7]
 LDCM0345  AC8 PaTu 8988t C48(1.04)  LDD1224  [7]
 LDCM0349  AC83 PaTu 8988t C48(0.78)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C48(0.78)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C48(0.88)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C48(0.57)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C48(0.85)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C48(1.02)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C48(0.92)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C48(1.00)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C48(0.69)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C48(0.65)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C48(0.65)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C48(0.80)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C48(0.69)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C48(0.98)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C48(0.52)  LDD1243  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C48(1.19)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C48(1.19)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C48(1.07)  LDD1154  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C48(1.05)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C48(1.05)  LDD1572  [8]
 LDCM0369  CL100 PaTu 8988t C48(0.53)  LDD1248  [7]
 LDCM0370  CL101 PaTu 8988t C48(0.97)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C48(1.15)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C48(1.68)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C48(0.90)  LDD1252  [7]
 LDCM0374  CL105 PaTu 8988t C48(1.23)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C48(1.21)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C48(1.04)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C48(1.03)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C48(1.04)  LDD1257  [7]
 LDCM0379  CL11 HEK-293T C48(1.16)  LDD1583  [8]
 LDCM0380  CL110 PaTu 8988t C48(1.30)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C48(1.02)  LDD1260  [7]
 LDCM0382  CL112 PaTu 8988t C48(0.88)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C48(0.77)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C48(0.84)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C48(0.86)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C48(0.94)  LDD1265  [7]
 LDCM0387  CL117 HEK-293T C48(1.23)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C48(1.11)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C48(1.13)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C48(1.47)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C48(1.20)  LDD1595  [8]
 LDCM0392  CL121 PaTu 8988t C48(1.26)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C48(0.90)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C48(1.27)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C48(1.20)  LDD1274  [7]
 LDCM0396  CL125 HEK-293T C48(1.14)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C48(0.97)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C48(1.27)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C48(1.19)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C48(1.05)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C48(1.06)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C48(1.37)  LDD1606  [8]
 LDCM0403  CL16 PaTu 8988t C48(1.03)  LDD1282  [7]
 LDCM0404  CL17 PaTu 8988t C48(0.78)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C48(0.83)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C48(0.81)  LDD1285  [7]
 LDCM0407  CL2 HEK-293T C48(1.06)  LDD1611  [8]
 LDCM0408  CL20 PaTu 8988t C48(0.79)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C48(0.66)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C48(0.61)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C48(0.81)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C48(0.97)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C48(0.75)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C48(0.82)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C48(0.68)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C48(0.72)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C48(0.87)  LDD1296  [7]
 LDCM0418  CL3 HEK-293T C48(0.91)  LDD1622  [8]
 LDCM0419  CL30 PaTu 8988t C48(0.73)  LDD1298  [7]
 LDCM0420  CL31 PaTu 8988t C48(1.26)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C48(2.22)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C48(1.10)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C48(1.36)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C48(1.24)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C48(1.16)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C48(1.83)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C48(1.61)  LDD1307  [7]
 LDCM0429  CL4 HEK-293T C48(0.92)  LDD1633  [8]
 LDCM0430  CL40 PaTu 8988t C48(1.33)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C48(1.30)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C48(1.58)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C48(1.68)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C48(1.38)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C48(1.19)  LDD1314  [7]
 LDCM0436  CL46 HEK-293T C48(1.62)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C48(1.70)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C48(1.97)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C48(1.16)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C48(1.00)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C48(1.13)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C48(1.08)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C48(1.09)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C48(1.21)  LDD1648  [8]
 LDCM0448  CL57 HEK-293T C48(1.25)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C48(1.46)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C48(1.54)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C48(0.86)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C48(1.95)  LDD1655  [8]
 LDCM0453  CL61 PaTu 8988t C48(1.05)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C48(0.93)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C48(1.01)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C48(1.04)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C48(1.11)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C48(0.94)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C48(1.22)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C48(1.30)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C48(1.07)  LDD1340  [7]
 LDCM0463  CL70 PaTu 8988t C48(1.05)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C48(0.96)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C48(1.02)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C48(1.15)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C48(0.95)  LDD1346  [7]
 LDCM0469  CL76 PaTu 8988t C48(0.71)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C48(0.71)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C48(1.08)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C48(0.88)  LDD1351  [7]
 LDCM0474  CL80 PaTu 8988t C48(0.85)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C48(1.18)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C48(1.03)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C48(1.47)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C48(0.75)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C48(0.72)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C48(0.98)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C48(1.05)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C48(1.05)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C48(0.78)  LDD1362  [7]
 LDCM0484  CL9 HEK-293T C48(1.03)  LDD1687  [8]
 LDCM0485  CL90 PaTu 8988t C48(0.86)  LDD1364  [7]
 LDCM0486  CL91 PaTu 8988t C48(0.52)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C48(0.56)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C48(0.56)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C48(0.63)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C48(0.50)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C48(0.59)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C48(0.62)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C48(0.60)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C48(0.60)  LDD1373  [7]
 LDCM0495  E2913 HEK-293T C48(1.32)  LDD1698  [8]
 LDCM0468  Fragment33 PaTu 8988t C48(0.98)  LDD1347  [7]
 LDCM0427  Fragment51 PaTu 8988t C48(1.80)  LDD1306  [7]
 LDCM0022  KB02 HEK-293T C48(0.96)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C48(4.50)  LDD0209  [2]
 LDCM0024  KB05 Hs 936.T C48(2.72)  LDD3313  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2) PHOSPHO family Q8TCD6
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Pellino family Q96FA3
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Optineurin (OPTN) . Q96CV9
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) BLOC1S2 family Q6QNY1
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
Centromere protein K (CENPK) CENP-K/MCM22 family Q9BS16
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Dysbindin (DTNBP1) Dysbindin family Q96EV8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Heat shock factor-binding protein 1 (HSBP1) HSBP1 family O75506
Inhibitory synaptic factor 1 (INSYN1) INSYN1 family Q2T9L4
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type II cytoskeletal 71 (KRT71) Intermediate filament family Q3SY84
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Phakinin (BFSP2) Intermediate filament family Q13515
MOB kinase activator 1A (MOB1A) MOB1/phocein family Q9H8S9
MOB kinase activator 1B (MOB1B) MOB1/phocein family Q7L9L4
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Alpha-taxilin (TXLNA) Taxilin family P40222
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
Microspherule protein 1 (MCRS1) . Q96EZ8
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) . Q96AQ6
Small kinetochore-associated protein (KNSTRN) . Q9Y448
Uncharacterized protein C20orf202 (C20orf202) . A1L168
Uncharacterized protein CCDC197 (CCDC197) . Q8NCU1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840