Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C129 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP08265 | N-alpha-acetyltransferase 40 (NAA40) | 29.2 | ||||
| LDTP02721 | Farnesyl pyrophosphate synthase (FDPS) | 18.9 | ||||
| LDTP12679 | Trimethyllysine dioxygenase, mitochondrial (TMLHE) | 17.0 | ||||
| LDTP01769 | Dihydrofolate reductase (DHFR) | 16.3 | ||||
| LDTP05758 | S-methyl-5'-thioadenosine phosphorylase (MTAP) | 15.9 | ||||
| LDTP16007 | Lipid droplet-associated hydrolase (LDAH) | 15.8 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 15.6 | ||||
| LDTP06648 | Lanosterol 14-alpha demethylase (CYP51A1) | 14.4 | ||||
| LDTP06333 | Serum paraoxonase/arylesterase 2 (PON2) | 13.9 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 12.4 | ||||
| LDTP16040 | Glyoxalase domain-containing protein 4 (GLOD4) | 10.9 | ||||
| LDTP10322 | Abasic site processing protein HMCES (HMCES) | 10.9 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 10.6 | ||||
| LDTP04388 | Palmitoyl-protein thioesterase 1 (PPT1) | 10.6 | ||||
| LDTP14218 | Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) | 10.1 | ||||
| LDTP01328 | CAAX prenyl protease 1 homolog (ZMPSTE24) | 9.6 | ||||
| LDTP02359 | Heme oxygenase 1 (HMOX1) | 9.6 | ||||
| LDTP11273 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) | 9.6 | ||||
| LDTP08664 | SET and MYND domain-containing protein 4 (SMYD4) | 9.6 | ||||
| LDTP13189 | Cytochrome b-c1 complex subunit 9 (UQCR10) | 9.4 | ||||
| LDTP03139 | Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) | 9.4 | ||||
| LDTP09096 | Carbohydrate sulfotransferase 14 (CHST14) | 9.3 | ||||
| LDTP05396 | Histone-lysine N-methyltransferase 2A (KMT2A) | 9.2 | ||||
| LDTP06618 | ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) | 8.7 | ||||
| LDTP01982 | NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) | 8.2 | ||||
| LDTP01039 | Protein-S-isoprenylcysteine O-methyltransferase (ICMT) | 8.1 | ||||
| LDTP05905 | Acid ceramidase (ASAH1) | 8.0 | ||||
| LDTP12673 | 4'-phosphopantetheine phosphatase (PANK4) | 7.7 | ||||
| LDTP02385 | Leukotriene A-4 hydrolase (LTA4H) | 7.7 | ||||
| LDTP02005 | Lysosomal acid glucosylceramidase (GBA1) | 7.4 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 7.4 | ||||
| LDTP06477 | Methylsterol monooxygenase 1 (MSMO1) | 7.3 | ||||
| LDTP04032 | Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) | 7.1 | ||||
| LDTP01613 | Sphingosine-1-phosphate lyase 1 (SGPL1) | 7.1 | ||||
| LDTP00486 | Cytochrome b-c1 complex subunit 8 (UQCRQ) | 7.0 | ||||
| LDTP05632 | Mitochondrial-processing peptidase subunit alpha (PMPCA) | 7.0 | ||||
| LDTP04437 | Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) | 6.9 | ||||
| LDTP12279 | Endoplasmic reticulum transmembrane helix translocase (ATP13A1) | 6.9 | ||||
| LDTP01773 | Cytochrome c oxidase subunit 2 (MT-CO2) | 6.8 | ||||
| LDTP02837 | Beta-galactosidase (GLB1) | 6.5 | ||||
| LDTP06511 | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) | 6.5 | ||||
| LDTP03912 | Trifunctional enzyme subunit alpha, mitochondrial (HADHA) | 6.4 | ||||
| LDTP09188 | Lysophosphatidylcholine acyltransferase 1 (LPCAT1) | 6.3 | ||||
| LDTP03257 | Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) | 5.9 | ||||
| LDTP06787 | Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) | 5.9 | ||||
| LDTP06307 | Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) | 5.9 | ||||
| LDTP00832 | NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) | 5.8 | ||||
| LDTP14030 | V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) | 5.7 | ||||
| LDTP10188 | FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) | 5.5 | ||||
| LDTP10182 | TLC domain-containing protein 1 (TLCD1) | 5.4 | ||||
| LDTP03145 | Catechol O-methyltransferase (COMT) | 5.2 | ||||
| LDTP00428 | Tripeptidyl-peptidase 1 (TPP1) | 5.2 | ||||
| LDTP14534 | Arginyl-tRNA--protein transferase 1 (ATE1) | 5.2 | ||||
| LDTP03813 | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) | 5.1 | ||||
| LDTP02679 | Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) | 5.0 | ||||
| LDTP13831 | Phenylalanine--tRNA ligase alpha subunit (FARSA) | 5.0 | ||||
| LDTP08728 | Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) | 5.0 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP10913 | Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) | 46.2 | ||||
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 36.5 | ||||
| LDTP14099 | Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) | 26.2 | ||||
| LDTP01671 | STARD3 N-terminal-like protein (STARD3NL) | 23.4 | ||||
| LDTP07885 | Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) | 20.4 | ||||
| LDTP00562 | Membrane-associated progesterone receptor component 2 (PGRMC2) | 19.0 | ||||
| LDTP03277 | ER lumen protein-retaining receptor 1 (KDELR1) | 18.0 | ||||
| LDTP11813 | Solute carrier family 25 member 32 (SLC25A32) | 16.2 | ||||
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 16.2 | ||||
| LDTP11162 | Solute carrier family 25 member 33 (SLC25A33) | 15.8 | ||||
| LDTP02724 | Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) | 15.7 | ||||
| LDTP04071 | Voltage-dependent anion-selective channel protein 2 (VDAC2) | 14.7 | ||||
| LDTP09968 | V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) | 14.6 | ||||
| LDTP08881 | Transmembrane protein 199 (TMEM199) | 14.1 | ||||
| LDTP06221 | StAR-related lipid transfer protein 3 (STARD3) | 11.7 | ||||
| LDTP01969 | Transferrin receptor protein 1 (TFRC) | 11.2 | ||||
| LDTP14511 | ATP synthase subunit g, mitochondrial (ATP5MG) | 11.0 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 10.7 | ||||
| LDTP18459 | StAR-related lipid transfer protein 7, mitochondrial (STARD7) | 10.5 | ||||
| LDTP06426 | Translocating chain-associated membrane protein 1 (TRAM1) | 10.2 | ||||
| LDTP11213 | Nucleoporin NDC1 (NDC1) | 9.6 | ||||
| LDTP16069 | Peroxisomal membrane protein 2 (PXMP2) | 9.4 | ||||
| LDTP03559 | High affinity cationic amino acid transporter 1 (SLC7A1) | 8.8 | ||||
| LDTP04033 | Translocon-associated protein subunit alpha (SSR1) | 8.5 | ||||
| LDTP16813 | Tetraspanin-3 (TSPAN3) | 8.1 | ||||
| LDTP00592 | Surfeit locus protein 4 (SURF4) | 6.9 | ||||
| LDTP07236 | Protein GPR107 (GPR107) | 6.7 | ||||
| LDTP11615 | Protein tweety homolog 3 (TTYH3) | 6.6 | ||||
| LDTP13174 | Mitochondrial dicarboxylate carrier (SLC25A10) | 6.5 | ||||
| LDTP06308 | Mitochondrial inner membrane protein OXA1L (OXA1L) | 6.5 | ||||
| LDTP09328 | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) | 6.3 | ||||
| LDTP13973 | WASH complex subunit 3 (WASHC3) | 6.3 | ||||
| LDTP14200 | Mitochondrial ornithine transporter 1 (SLC25A15) | 6.1 | ||||
| LDTP12383 | Protein GPR108 (GPR108) | 6.1 | ||||
| LDTP18448 | Transmembrane 9 superfamily member 3 (TM9SF3) | 6.0 | ||||
| LDTP05900 | Metaxin-1 (MTX1) | 5.9 | ||||
| LDTP08878 | ER membrane protein complex subunit 5 (MMGT1) | 5.9 | ||||
| LDTP05384 | Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) | 5.7 | ||||
| LDTP09294 | Proton-coupled zinc antiporter SLC30A5 (SLC30A5) | 5.7 | ||||
| LDTP12207 | Putative divalent cation/proton antiporter TMEM165 (TMEM165) | 5.5 | ||||
| LDTP16190 | Protein FAM8A1 (FAM8A1) | 5.5 | ||||
| LDTP05511 | Cytoskeleton-associated protein 4 (CKAP4) | 5.1 | ||||
| LDTP10317 | THO complex subunit 1 (THOC1) | 5.0 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP11076 | Apolipoprotein L2 (APOL2) | 42.2 | ||||
| LDTP03678 | ER lumen protein-retaining receptor 2 (KDELR2) | 17.6 | ||||
| LDTP13828 | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) | 15.7 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 13.8 | ||||
| LDTP14458 | Tetraspanin-6 (TSPAN6) | 9.8 | ||||
| LDTP08594 | Negative elongation factor C/D (NELFCD) | 9.4 | ||||
| LDTP15067 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) | 9.1 | ||||
| LDTP00281 | Golgi integral membrane protein 4 (GOLIM4) | 8.7 | ||||
| LDTP05375 | Nucleobindin-1 (NUCB1) | 8.1 | ||||
| LDTP00105 | Protein unc-119 homolog B (UNC119B) | 7.8 | ||||
| LDTP15420 | Mitochondrial import receptor subunit TOM5 homolog (TOMM5) | 7.6 | ||||
| LDTP08364 | Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) | 7.4 | ||||
| LDTP13606 | Mammalian ependymin-related protein 1 (EPDR1) | 7.4 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 7.3 | ||||
| LDTP08073 | Tetratricopeptide repeat protein 21B (TTC21B) | 7.2 | ||||
| LDTP04652 | Eukaryotic translation initiation factor 5 (EIF5) | 7.1 | ||||
| LDTP14259 | Testis-expressed protein 264 (TEX264) | 6.9 | ||||
| LDTP16080 | Protein FAM114A2 (FAM114A2) | 6.9 | ||||
| LDTP01522 | Reticulon-3 (RTN3) | 6.6 | ||||
| LDTP13086 | Syntaxin-18 (STX18) | 6.6 | ||||
| LDTP03614 | Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) | 6.4 | ||||
| LDTP12775 | GATOR2 complex protein MIOS (MIOS) | 6.3 | ||||
| LDTP00500 | Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) | 5.9 | ||||
| LDTP08904 | Protein jagunal homolog 1 (JAGN1) | 5.9 | ||||
| LDTP00991 | Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) | 5.8 | ||||
| LDTP16192 | Mitochondrial fission process protein 1 (MTFP1) | 5.7 | ||||
| LDTP01494 | Protein YIF1A (YIF1A) | 5.5 | ||||
| LDTP18373 | Thioredoxin-related transmembrane protein 4 (TMX4) | 5.5 | ||||
| LDTP00756 | Heterogeneous nuclear ribonucleoprotein R (HNRNPR) | 5.0 | ||||
| LDTP10962 | Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) | 5.0 | ||||