Details of the Target

General Information of Target

Target ID LDTP01671
Target Name STARD3 N-terminal-like protein (STARD3NL)
Gene Name STARD3NL
Gene ID 83930
Synonyms
MENTHO; STARD3 N-terminal-like protein; MLN64 N-terminal domain homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNHLPEDMENALTGSQSSHASLRNIHSINPTQLMARIESYEGREKKGISDVRRTFCLFVT
FDLLFVTLLWIIELNVNGGIENTLEKEVMQYDYYSSYFDIFLLAVFRFKVLILAYAVCRL
RHWWAIALTTAVTSAFLLAKVILSKLFSQGAFGYVLPIISFILAWIETWFLDFKVLPQEA
EEENRLLIVQDASERAALIPGGLSDGQFYSPPESEAGSEEAEEKQDSEKPLLEL
Target Bioclass
Transporter and channel
Family
STARD3 family
Subcellular location
Late endosome membrane
Function
Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB.
Uniprot ID
O95772
Ensemble ID
ENST00000009041.12
HGNC ID
HGNC:19169

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JHH1 SNV: p.G217A .
NCIH1155 SNV: p.A221V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		6.86  LDD0318  [1]
PAL-AfBPP Probe
Click To Hide/Show 86 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C039
 Probe Info  		4.96  LDD1739  [2]
C040
 Probe Info  		20.11  LDD1740  [2]
C041
 Probe Info  		8.51  LDD1741  [2]
C055
 Probe Info  		14.22  LDD1752  [2]
C056
 Probe Info  		29.86  LDD1753  [2]
C059
 Probe Info  		6.28  LDD1756  [2]
C063
 Probe Info  		32.90  LDD1760  [2]
C064
 Probe Info  		9.45  LDD1761  [2]
C067
 Probe Info  		6.02  LDD1763  [2]
C070
 Probe Info  		24.76  LDD1766  [2]
C072
 Probe Info  		15.35  LDD1768  [2]
C106
 Probe Info  		31.78  LDD1793  [2]
C107
 Probe Info  		14.62  LDD1794  [2]
C108
 Probe Info  		9.45  LDD1795  [2]
C112
 Probe Info  		91.77  LDD1799  [2]
C129
 Probe Info  		23.43  LDD1811  [2]
C134
 Probe Info  		79.89  LDD1816  [2]
C135
 Probe Info  		21.86  LDD1817  [2]
C139
 Probe Info  		24.08  LDD1821  [2]
C140
 Probe Info  		12.30  LDD1822  [2]
C141
 Probe Info  		31.56  LDD1823  [2]
C143
 Probe Info  		68.12  LDD1825  [2]
C145
 Probe Info  		9.65  LDD1827  [2]
C147
 Probe Info  		12.30  LDD1829  [2]
C153
 Probe Info  		75.58  LDD1834  [2]
C159
 Probe Info  		24.08  LDD1839  [2]
C160
 Probe Info  		18.13  LDD1840  [2]
C161
 Probe Info  		62.25  LDD1841  [2]
C163
 Probe Info  		21.71  LDD1843  [2]
C165
 Probe Info  		31.34  LDD1845  [2]
C166
 Probe Info  		7.16  LDD1846  [2]
C173
 Probe Info  		5.50  LDD1853  [2]
C187
 Probe Info  		45.89  LDD1865  [2]
C215
 Probe Info  		5.03  LDD1889  [2]
C216
 Probe Info  		7.11  LDD1890  [2]
C217
 Probe Info  		5.90  LDD1891  [2]
C218
 Probe Info  		40.50  LDD1892  [2]
C219
 Probe Info  		20.53  LDD1893  [2]
C220
 Probe Info  		67.18  LDD1894  [2]
C221
 Probe Info  		5.50  LDD1895  [2]
C225
 Probe Info  		8.57  LDD1898  [2]
C228
 Probe Info  		34.06  LDD1901  [2]
C238
 Probe Info  		14.83  LDD1911  [2]
C240
 Probe Info  		16.00  LDD1913  [2]
C243
 Probe Info  		13.36  LDD1916  [2]
C246
 Probe Info  		22.16  LDD1919  [2]
C249
 Probe Info  		14.12  LDD1922  [2]
C277
 Probe Info  		8.34  LDD1947  [2]
C282
 Probe Info  		14.32  LDD1952  [2]
C285
 Probe Info  		33.36  LDD1955  [2]
C287
 Probe Info  		18.38  LDD1957  [2]
C288
 Probe Info  		10.63  LDD1958  [2]
C289
 Probe Info  		48.50  LDD1959  [2]
C290
 Probe Info  		6.06  LDD1960  [2]
C293
 Probe Info  		23.26  LDD1963  [2]
C296
 Probe Info  		13.27  LDD1966  [2]
C305
 Probe Info  		18.25  LDD1974  [2]
C307
 Probe Info  		6.63  LDD1975  [2]
C310
 Probe Info  		17.75  LDD1977  [2]
C314
 Probe Info  		29.24  LDD1981  [2]
C322
 Probe Info  		6.28  LDD1988  [2]
C326
 Probe Info  		9.58  LDD1990  [2]
C343
 Probe Info  		15.45  LDD2005  [2]
C362
 Probe Info  		55.33  LDD2023  [2]
C363
 Probe Info  		40.50  LDD2024  [2]
C364
 Probe Info  		31.12  LDD2025  [2]
C366
 Probe Info  		9.38  LDD2027  [2]
C367
 Probe Info  		9.38  LDD2028  [2]
C376
 Probe Info  		8.22  LDD2036  [2]
C378
 Probe Info  		6.63  LDD2037  [2]
C390
 Probe Info  		99.73  LDD2049  [2]
C391
 Probe Info  		31.12  LDD2050  [2]
C392
 Probe Info  		5.06  LDD2051  [2]
C393
 Probe Info  		5.10  LDD2052  [2]
C396
 Probe Info  		5.74  LDD2055  [2]
C407
 Probe Info  		12.47  LDD2064  [2]
C413
 Probe Info  		55.72  LDD2069  [2]
C424
 Probe Info  		11.24  LDD2079  [2]
C426
 Probe Info  		71.51  LDD2081  [2]
C429
 Probe Info  		25.11  LDD2084  [2]
C430
 Probe Info  		4.92  LDD2085  [2]
C431
 Probe Info  		47.84  LDD2086  [2]
C433
 Probe Info  		7.21  LDD2088  [2]
FFF probe11
 Probe Info  		20.00  LDD0471  [3]
FFF probe13
 Probe Info  		20.00  LDD0475  [3]
FFF probe14
 Probe Info  		20.00  LDD0477  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hematopoietic cell signal transducer (HCST) DAP10 family Q9UBK5
Motile sperm domain-containing protein 2 (MOSPD2) . Q8NHP6

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.