Details of the Probe

General Information of Probe

Probe ID
LDPC0323
Probe Name
C067
Synonyms
Z4225964065
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 331.33
Lipid-water partition coefficient (xlogp) 3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C15H20F3N3O2
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-4-(trifluoromethoxy)cyclohexane-1-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2CCC(CC2)OC(F)(F)F
InChI
InChI=1S/C15H20F3N3O2/c1-2-3-8-14(20-21-14)9-10-19-13(22)11-4-6-12(7-5-11)23-15(16,17)18/h1,11-12H,3-10H2,(H,19,22)
InChIKey
VHZBSUROFVEPFH-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

46 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 5.31  LDD1763 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 24.59  LDD1763 
Acid ceramidase (ASAH1) LDTP05905 6.41  LDD1763 
ADP-dependent glucokinase (ADPGK) LDTP11127 5.17  LDD1763 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 10.63  LDD1763 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 5.10  LDD1763 
Beta-galactosidase (GLB1) LDTP02837 7.41  LDD1763 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 5.58  LDD1763 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 5.43  LDD1763 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 6.59  LDD1763 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 7.31  LDD1763 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 6.63  LDD1763 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 7.16  LDD1763 
Cytochrome b5 type B (CYB5B) LDTP00697 13.00  LDD1763 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 6.59  LDD1763 
Delta(14)-sterol reductase TM7SF2 (TM7SF2) LDTP01389 16.00  LDD1763 
Delta(24)-sterol reductase (DHCR24) LDTP06375 12.13  LDD1763 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 5.39  LDD1763 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 5.90  LDD1763 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 5.24  LDD1763 
Heme oxygenase 1 (HMOX1) LDTP02359 6.19  LDD1763 
Heme oxygenase 2 (HMOX2) LDTP03540 13.93  LDD1763 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 5.03  LDD1763 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 5.03  LDD1763 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 7.52  LDD1763 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 17.75  LDD1763 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 5.03  LDD1763 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 6.41  LDD1763 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 5.50  LDD1763 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 4.96  LDD1763 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 5.82  LDD1763 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 6.68  LDD1763 
NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) LDTP01983 13.00  LDD1763 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 5.62  LDD1763 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 16.00  LDD1763 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 6.45  LDD1763 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 9.51  LDD1763 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 5.31  LDD1763 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 7.11  LDD1763 
Protein O-mannosyl-transferase TMTC3 (TMTC3) LDTP07868 4.96  LDD1763 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 7.31  LDD1763 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 6.45  LDD1763 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 6.92  LDD1763 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 5.62  LDD1763 
TLC domain-containing protein 1 (TLCD1) LDTP10182 32.67  LDD1763 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 6.59  LDD1763 
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⏷ Show the Full List of 46 Enzyme
36 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 6.36  LDD1763 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 8.11  LDD1763 
BRI3-binding protein (BRI3BP) LDTP15648 6.63  LDD1763 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 8.75  LDD1763 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 13.64  LDD1763 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 18.77  LDD1763 
Lysosome membrane protein 2 (SCARB2) LDTP06034 9.51  LDD1763 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 9.32  LDD1763 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 4.92  LDD1763 
Metaxin-1 (MTX1) LDTP05900 5.10  LDD1763 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 5.10  LDD1763 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 13.45  LDD1763 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 14.93  LDD1763 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 8.57  LDD1763 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.24  LDD1763 
Nucleoporin NDC1 (NDC1) LDTP11213 5.13  LDD1763 
Prosaposin (PSAP) LDTP02215 6.82  LDD1763 
Protein GPR107 (GPR107) LDTP07236 5.31  LDD1763 
Protein GPR108 (GPR108) LDTP12383 5.74  LDD1763 
Protein tweety homolog 3 (TTYH3) LDTP11615 7.94  LDD1763 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 5.35  LDD1763 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 8.94  LDD1763 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 8.06  LDD1763 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 18.51  LDD1763 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.10  LDD1763 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 7.52  LDD1763 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 6.02  LDD1763 
Tetraspanin-3 (TSPAN3) LDTP16813 8.57  LDD1763 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 11.16  LDD1763 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 6.59  LDD1763 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 5.28  LDD1763 
Transmembrane protein 126A (TMEM126A) LDTP15948 8.17  LDD1763 
Transmembrane protein 199 (TMEM199) LDTP08881 8.11  LDD1763 
Transmembrane protein 87A (TMEM87A) LDTP15481 5.10  LDD1763 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 9.92  LDD1763 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 9.06  LDD1763 
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⏷ Show the Full List of 36 Transporter and channel
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 9.99  LDD1763 
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22 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 21.26  LDD1763 
Centrin-2 (CETN2) LDTP03926 9.71  LDD1763 
Clustered mitochondria protein homolog (CLUH) LDTP14486 5.13  LDD1763 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 5.50  LDD1763 
DNA replication complex GINS protein SLD5 (GINS4) LDTP11134 7.06  LDD1763 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 11.79  LDD1763 
Galanin peptides (GAL) LDTP03175 5.86  LDD1763 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 5.74  LDD1763 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 5.62  LDD1763 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 9.00  LDD1763 
Mediator of RNA polymerase II transcription subunit 25 (MED25) LDTP07906 5.54  LDD1763 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 5.50  LDD1763 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 15.67  LDD1763 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 6.68  LDD1763 
Neuferricin (CYB5D2) LDTP15623 7.57  LDD1763 
Nucleobindin-2 (NUCB2) LDTP05160 11.47  LDD1763 
Protein CEBPZOS (CEBPZOS) LDTP18883 12.55  LDD1763 
Reticulon-3 (RTN3) LDTP01522 8.28  LDD1763 
Reticulon-4 (RTN4) LDTP12412 5.50  LDD1763 
Syntaxin-18 (STX18) LDTP13086 6.15  LDD1763 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 7.41  LDD1763 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 14.83  LDD1763 
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⏷ Show the Full List of 22 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1763 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587