Details of the Probe

General Information of Probe

Probe ID
LDPC0323
Probe Name
C067
Synonyms
Z4225964065
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 331.33
Lipid-water partition coefficient (xlogp) 3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C15H20F3N3O2
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-4-(trifluoromethoxy)cyclohexane-1-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2CCC(CC2)OC(F)(F)F
InChI
InChI=1S/C15H20F3N3O2/c1-2-3-8-14(20-21-14)9-10-19-13(22)11-4-6-12(7-5-11)23-15(16,17)18/h1,11-12H,3-10H2,(H,19,22)
InChIKey
VHZBSUROFVEPFH-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

92 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 5.31  LDD1763 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 5.31  LDD1763 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 24.59  LDD1763 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 24.59  LDD1763 
Acid ceramidase (ASAH1) LDTP05905 6.41  LDD1763 
Acid ceramidase (ASAH1) LDTP05905 6.41  LDD1763 
ADP-dependent glucokinase (ADPGK) LDTP11127 5.17  LDD1763 
ADP-dependent glucokinase (ADPGK) LDTP11127 5.17  LDD1763 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 10.63  LDD1763 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 10.63  LDD1763 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 5.10  LDD1763 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 5.10  LDD1763 
Beta-galactosidase (GLB1) LDTP02837 7.41  LDD1763 
Beta-galactosidase (GLB1) LDTP02837 7.41  LDD1763 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 5.58  LDD1763 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 5.58  LDD1763 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 5.43  LDD1763 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 5.43  LDD1763 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 6.59  LDD1763 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 6.59  LDD1763 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 7.31  LDD1763 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 7.31  LDD1763 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 6.63  LDD1763 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 6.63  LDD1763 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 7.16  LDD1763 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 7.16  LDD1763 
Cytochrome b5 type B (CYB5B) LDTP00697 13.00  LDD1763 
Cytochrome b5 type B (CYB5B) LDTP00697 13.00  LDD1763 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 6.59  LDD1763 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 6.59  LDD1763 
Delta(14)-sterol reductase TM7SF2 (TM7SF2) LDTP01389 16.00  LDD1763 
Delta(14)-sterol reductase TM7SF2 (TM7SF2) LDTP01389 16.00  LDD1763 
Delta(24)-sterol reductase (DHCR24) LDTP06375 12.13  LDD1763 
Delta(24)-sterol reductase (DHCR24) LDTP06375 12.13  LDD1763 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 5.39  LDD1763 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 5.39  LDD1763 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 5.90  LDD1763 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 5.90  LDD1763 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 5.24  LDD1763 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 5.24  LDD1763 
Heme oxygenase 1 (HMOX1) LDTP02359 6.19  LDD1763 
Heme oxygenase 1 (HMOX1) LDTP02359 6.19  LDD1763 
Heme oxygenase 2 (HMOX2) LDTP03540 13.93  LDD1763 
Heme oxygenase 2 (HMOX2) LDTP03540 13.93  LDD1763 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 5.03  LDD1763 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 5.03  LDD1763 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 5.03  LDD1763 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 5.03  LDD1763 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 7.52  LDD1763 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 7.52  LDD1763 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 17.75  LDD1763 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 17.75  LDD1763 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 5.03  LDD1763 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 5.03  LDD1763 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 6.41  LDD1763 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 6.41  LDD1763 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 5.50  LDD1763 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 5.50  LDD1763 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 4.96  LDD1763 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 4.96  LDD1763 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 5.82  LDD1763 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 5.82  LDD1763 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 6.68  LDD1763 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 6.68  LDD1763 
NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) LDTP01983 13.00  LDD1763 
NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) LDTP01983 13.00  LDD1763 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 5.62  LDD1763 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 5.62  LDD1763 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 16.00  LDD1763 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 16.00  LDD1763 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 6.45  LDD1763 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 6.45  LDD1763 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 9.51  LDD1763 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 9.51  LDD1763 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 5.31  LDD1763 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 5.31  LDD1763 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 7.11  LDD1763 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 7.11  LDD1763 
Protein O-mannosyl-transferase TMTC3 (TMTC3) LDTP07868 4.96  LDD1763 
Protein O-mannosyl-transferase TMTC3 (TMTC3) LDTP07868 4.96  LDD1763 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 7.31  LDD1763 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 7.31  LDD1763 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 6.45  LDD1763 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 6.45  LDD1763 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 6.92  LDD1763 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 6.92  LDD1763 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 5.62  LDD1763 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 5.62  LDD1763 
TLC domain-containing protein 1 (TLCD1) LDTP10182 32.67  LDD1763 
TLC domain-containing protein 1 (TLCD1) LDTP10182 32.67  LDD1763 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 6.59  LDD1763 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 6.59  LDD1763 
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⏷ Show the Full List of 92 Enzyme
72 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 6.36  LDD1763 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 6.36  LDD1763 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 8.11  LDD1763 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 8.11  LDD1763 
BRI3-binding protein (BRI3BP) LDTP15648 6.63  LDD1763 
BRI3-binding protein (BRI3BP) LDTP15648 6.63  LDD1763 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 8.75  LDD1763 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 8.75  LDD1763 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 13.64  LDD1763 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 13.64  LDD1763 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 18.77  LDD1763 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 18.77  LDD1763 
Lysosome membrane protein 2 (SCARB2) LDTP06034 9.51  LDD1763 
Lysosome membrane protein 2 (SCARB2) LDTP06034 9.51  LDD1763 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 9.32  LDD1763 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 9.32  LDD1763 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 4.92  LDD1763 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 4.92  LDD1763 
Metaxin-1 (MTX1) LDTP05900 5.10  LDD1763 
Metaxin-1 (MTX1) LDTP05900 5.10  LDD1763 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 5.10  LDD1763 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 5.10  LDD1763 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 13.45  LDD1763 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 13.45  LDD1763 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 14.93  LDD1763 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 14.93  LDD1763 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 8.57  LDD1763 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 8.57  LDD1763 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.24  LDD1763 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 5.24  LDD1763 
Nucleoporin NDC1 (NDC1) LDTP11213 5.13  LDD1763 
Nucleoporin NDC1 (NDC1) LDTP11213 5.13  LDD1763 
Prosaposin (PSAP) LDTP02215 6.82  LDD1763 
Prosaposin (PSAP) LDTP02215 6.82  LDD1763 
Protein GPR107 (GPR107) LDTP07236 5.31  LDD1763 
Protein GPR107 (GPR107) LDTP07236 5.31  LDD1763 
Protein GPR108 (GPR108) LDTP12383 5.74  LDD1763 
Protein GPR108 (GPR108) LDTP12383 5.74  LDD1763 
Protein tweety homolog 3 (TTYH3) LDTP11615 7.94  LDD1763 
Protein tweety homolog 3 (TTYH3) LDTP11615 7.94  LDD1763 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 5.35  LDD1763 
Proton-coupled amino acid transporter 1 (SLC36A1) LDTP08016 5.35  LDD1763 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 8.94  LDD1763 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 8.94  LDD1763 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 8.06  LDD1763 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 8.06  LDD1763 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 18.51  LDD1763 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 18.51  LDD1763 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.10  LDD1763 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.10  LDD1763 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 7.52  LDD1763 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 7.52  LDD1763 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 6.02  LDD1763 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 6.02  LDD1763 
Tetraspanin-3 (TSPAN3) LDTP16813 8.57  LDD1763 
Tetraspanin-3 (TSPAN3) LDTP16813 8.57  LDD1763 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 11.16  LDD1763 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 11.16  LDD1763 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 6.59  LDD1763 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 6.59  LDD1763 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 5.28  LDD1763 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 5.28  LDD1763 
Transmembrane protein 126A (TMEM126A) LDTP15948 8.17  LDD1763 
Transmembrane protein 126A (TMEM126A) LDTP15948 8.17  LDD1763 
Transmembrane protein 199 (TMEM199) LDTP08881 8.11  LDD1763 
Transmembrane protein 199 (TMEM199) LDTP08881 8.11  LDD1763 
Transmembrane protein 87A (TMEM87A) LDTP15481 5.10  LDD1763 
Transmembrane protein 87A (TMEM87A) LDTP15481 5.10  LDD1763 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 9.92  LDD1763 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 9.92  LDD1763 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 9.06  LDD1763 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 9.06  LDD1763 
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⏷ Show the Full List of 72 Transporter and channel
2 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 9.99  LDD1763 
Membrane progestin receptor alpha (PAQR7) LDTP15303 9.99  LDD1763 
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44 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 21.26  LDD1763 
Apolipoprotein L2 (APOL2) LDTP11076 21.26  LDD1763 
Centrin-2 (CETN2) LDTP03926 9.71  LDD1763 
Centrin-2 (CETN2) LDTP03926 9.71  LDD1763 
Clustered mitochondria protein homolog (CLUH) LDTP14486 5.13  LDD1763 
Clustered mitochondria protein homolog (CLUH) LDTP14486 5.13  LDD1763 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 5.50  LDD1763 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 5.50  LDD1763 
DNA replication complex GINS protein SLD5 (GINS4) LDTP11134 7.06  LDD1763 
DNA replication complex GINS protein SLD5 (GINS4) LDTP11134 7.06  LDD1763 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 11.79  LDD1763 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 11.79  LDD1763 
Galanin peptides (GAL) LDTP03175 5.86  LDD1763 
Galanin peptides (GAL) LDTP03175 5.86  LDD1763 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 5.74  LDD1763 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 5.74  LDD1763 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 5.62  LDD1763 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 5.62  LDD1763 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 9.00  LDD1763 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 9.00  LDD1763 
Mediator of RNA polymerase II transcription subunit 25 (MED25) LDTP07906 5.54  LDD1763 
Mediator of RNA polymerase II transcription subunit 25 (MED25) LDTP07906 5.54  LDD1763 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 5.50  LDD1763 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 5.50  LDD1763 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 15.67  LDD1763 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 15.67  LDD1763 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 6.68  LDD1763 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 6.68  LDD1763 
Neuferricin (CYB5D2) LDTP15623 7.57  LDD1763 
Neuferricin (CYB5D2) LDTP15623 7.57  LDD1763 
Nucleobindin-2 (NUCB2) LDTP05160 11.47  LDD1763 
Nucleobindin-2 (NUCB2) LDTP05160 11.47  LDD1763 
Protein CEBPZOS (CEBPZOS) LDTP18883 12.55  LDD1763 
Protein CEBPZOS (CEBPZOS) LDTP18883 12.55  LDD1763 
Reticulon-3 (RTN3) LDTP01522 8.28  LDD1763 
Reticulon-3 (RTN3) LDTP01522 8.28  LDD1763 
Reticulon-4 (RTN4) LDTP12412 5.50  LDD1763 
Reticulon-4 (RTN4) LDTP12412 5.50  LDD1763 
Syntaxin-18 (STX18) LDTP13086 6.15  LDD1763 
Syntaxin-18 (STX18) LDTP13086 6.15  LDD1763 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 7.41  LDD1763 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 7.41  LDD1763 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 14.83  LDD1763 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 14.83  LDD1763 
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⏷ Show the Full List of 44 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1763 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587