Details of the Target

General Information of Target

Target ID LDTP15303
Target Name Membrane progestin receptor alpha (PAQR7)
Gene Name PAQR7
Gene ID 164091
Synonyms
MRPA; Membrane progestin receptor alpha; mPR alpha; Membrane progesterone P4 receptor alpha; Membrane progesterone receptor alpha; Progesterone and adipoQ receptor family member 7; Progestin and adipoQ receptor family member 7; Progestin and adipoQ receptor family member VII
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADLLSCTGLGLQDVPAELP
AATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGRGVFVNASGLRLLDLSSNT
LRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGL
SATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLS
AVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSAPALGLERPEEHLYALVGRSLRLYC
NTSVPAMRIAWVSPQQELLRAPGSRDGSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLH
HNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCAVGLVLVLLYLFAPPCRCCRRACRCRRWP
QTPSPLQELSAQSSVLSTTPPDAPSRKASVHKHVVFLEPGRRGLNGRVQLAVAEEFDLYN
PGGLQLKAGSESASSIGSEGPMTT
Target Bioclass
GPCR
Family
ADIPOR family
Subcellular location
Cell membrane
Function
Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.
Uniprot ID
Q86WK9
Ensemble ID
ENST00000374296.4
HGNC ID
HGNC:23146

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		N.A.  LDD0148  [1]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		10.27  LDD1725  [2]
C055
 Probe Info  		28.64  LDD1752  [2]
C056
 Probe Info  		31.12  LDD1753  [2]
C063
 Probe Info  		14.52  LDD1760  [2]
C067
 Probe Info  		9.99  LDD1763  [2]
C070
 Probe Info  		45.89  LDD1766  [2]
C071
 Probe Info  		31.34  LDD1767  [2]
C072
 Probe Info  		44.94  LDD1768  [2]
C153
 Probe Info  		29.65  LDD1834  [2]
C187
 Probe Info  		64.00  LDD1865  [2]
C191
 Probe Info  		46.21  LDD1868  [2]
C193
 Probe Info  		27.86  LDD1869  [2]
C201
 Probe Info  		27.86  LDD1877  [2]
C206
 Probe Info  		27.10  LDD1881  [2]
C222
 Probe Info  		4.92  LDD1896  [2]
C225
 Probe Info  		19.84  LDD1898  [2]
C226
 Probe Info  		12.38  LDD1899  [2]
C228
 Probe Info  		28.44  LDD1901  [2]
C355
 Probe Info  		54.19  LDD2016  [2]
C356
 Probe Info  		18.90  LDD2017  [2]
C357
 Probe Info  		10.63  LDD2018  [2]
C361
 Probe Info  		28.25  LDD2022  [2]
C383
 Probe Info  		13.83  LDD2042  [2]
C386
 Probe Info  		6.96  LDD2045  [2]
C389
 Probe Info  		6.59  LDD2048  [2]
OEA-DA
 Probe Info  		20.00  LDD0046  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570