Details of the Probe

General Information of Probe

Probe ID
LDPC0394
Probe Name
C153
Synonyms
Z3426146472
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 315.4
Lipid-water partition coefficient (xlogp) 2.7
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C17H21N3OS
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-1-(5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyridin-6-yl)propan-1-one
Canonical SMILES
CC1(CC2=C(CN1C(=O)CCC3(N=N3)CCC#C)SC=C2)C
InChI
InChI=1S/C17H21N3OS/c1-4-5-8-17(18-19-17)9-6-15(21)20-12-14-13(7-10-22-14)11-16(20,2)3/h1,7,10H,5-6,8-9,11-12H2,2-3H3
InChIKey
MREOHSUCFBVHIO-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

139 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) LDTP13667 37.53  LDD1834 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 19.70  LDD1834 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 17.63  LDD1834 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 19.97  LDD1834 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 15.24  LDD1834 
Acid ceramidase (ASAH1) LDTP05905 39.67  LDD1834 
ADP-dependent glucokinase (ADPGK) LDTP11127 21.11  LDD1834 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 37.79  LDD1834 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 17.27  LDD1834 
Antigen peptide transporter 2 (TAP2) LDTP05409 30.27  LDD1834 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 18.13  LDD1834 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 15.56  LDD1834 
Atypical kinase COQ8A, mitochondrial (COQ8A) LDTP09285 17.15  LDD1834 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 15.89  LDD1834 
Beta-galactosidase (GLB1) LDTP02837 20.53  LDD1834 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 15.14  LDD1834 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 31.56  LDD1834 
Calcyclin-binding protein (CACYBP) LDTP12163 17.88  LDD1834 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 30.48  LDD1834 
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) LDTP04358 16.22  LDD1834 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 21.26  LDD1834 
Cartilage-associated protein (CRTAP) LDTP01300 16.68  LDD1834 
Catechol O-methyltransferase (COMT) LDTP03145 20.39  LDD1834 
Ceramide synthase 1 (CERS1) LDTP03394 22.63  LDD1834 
Ceramide synthase 2 (CERS2) LDTP10329 28.84  LDD1834 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 22.01  LDD1834 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 36.76  LDD1834 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 56.49  LDD1834 
Cytochrome b5 type B (CYB5B) LDTP00697 66.72  LDD1834 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 23.26  LDD1834 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 16.68  LDD1834 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 15.03  LDD1834 
Delta(24)-sterol reductase (DHCR24) LDTP06375 18.90  LDD1834 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 16.34  LDD1834 
Dihydrofolate reductase (DHFR) LDTP01769 21.86  LDD1834 
DNA helicase MCM8 (MCM8) LDTP13380 15.35  LDD1834 
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) LDTP11259 15.56  LDD1834 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 18.00  LDD1834 
E3 ubiquitin-protein ligase Itchy homolog (ITCH) LDTP10441 18.00  LDD1834 
E3 ubiquitin-protein ligase NEDD4 (NEDD4) LDTP04114 19.70  LDD1834 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 21.71  LDD1834 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 24.08  LDD1834 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 25.11  LDD1834 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 16.56  LDD1834 
Epididymis-specific alpha-mannosidase (MAN2B2) LDTP13853 19.03  LDD1834 
Epoxide hydrolase 1 (EPHX1) LDTP02175 23.10  LDD1834 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 32.22  LDD1834 
Glutathione hydrolase 7 (GGT7) LDTP13367 17.03  LDD1834 
GPI ethanolamine phosphate transferase 2 (PIGG) LDTP06977 18.00  LDD1834 
GTP-binding protein Rheb (RHEB) LDTP06371 17.39  LDD1834 
Heme A synthase COX15 (COX15) LDTP07931 33.59  LDD1834 
Heme oxygenase 1 (HMOX1) LDTP02359 56.49  LDD1834 
Heme oxygenase 2 (HMOX2) LDTP03540 42.22  LDD1834 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 26.72  LDD1834 
Holocytochrome c-type synthase (HCCS) LDTP04581 28.25  LDD1834 
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) LDTP06645 18.51  LDD1834 
Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) LDTP09056 14.72  LDD1834 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 34.54  LDD1834 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 15.56  LDD1834 
Kinesin-like protein KIF18B (KIF18B) LDTP08390 20.82  LDD1834 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 19.03  LDD1834 
Lathosterol oxidase (SC5D) LDTP01329 22.94  LDD1834 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 18.13  LDD1834 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 28.25  LDD1834 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 28.05  LDD1834 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 38.32  LDD1834 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 15.45  LDD1834 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 17.39  LDD1834 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 21.11  LDD1834 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 18.38  LDD1834 
Lysosomal protective protein (CTSA) LDTP02505 28.64  LDD1834 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 31.56  LDD1834 
Maleylacetoacetate isomerase (GSTZ1) LDTP00844 22.63  LDD1834 
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) LDTP00975 20.53  LDD1834 
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) LDTP02565 23.75  LDD1834 
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) LDTP05346 21.26  LDD1834 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 52.71  LDD1834 
Minor histocompatibility antigen H13 (HM13) LDTP09396 69.55  LDD1834 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 19.84  LDD1834 
Multidrug resistance-associated protein 1 (ABCC1) LDTP03671 39.67  LDD1834 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 31.34  LDD1834 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 18.64  LDD1834 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 22.47  LDD1834 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 19.03  LDD1834 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 93.05  LDD1834 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 32.00  LDD1834 
NADPH--cytochrome P450 reductase (POR) LDTP02848 16.34  LDD1834 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 28.64  LDD1834 
Nucleoredoxin (NXN) LDTP07367 24.42  LDD1834 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 54.57  LDD1834 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 21.41  LDD1834 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 32.00  LDD1834 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 24.25  LDD1834 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 15.67  LDD1834 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 29.86  LDD1834 
Phosphatidylserine synthase 2 (PTDSS2) LDTP11284 18.25  LDD1834 
Phospholipase A2 group XV (PLA2G15) LDTP09088 18.51  LDD1834 
Pirin (PIR) LDTP00325 20.82  LDD1834 
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) LDTP03024 20.25  LDD1834 
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) LDTP03249 21.71  LDD1834 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 17.27  LDD1834 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 64.89  LDD1834 
Presenilin-1 (PSEN1) LDTP04303 21.56  LDD1834 
Presequence protease, mitochondrial (PITRM1) LDTP07003 22.32  LDD1834 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 15.67  LDD1834 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 15.78  LDD1834 
Prostaglandin reductase 3 (PTGR3) LDTP15422 14.62  LDD1834 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 19.29  LDD1834 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 20.68  LDD1834 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 15.14  LDD1834 
Protein SCO2 homolog, mitochondrial (SCO2) LDTP00877 15.56  LDD1834 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 29.24  LDD1834 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 22.01  LDD1834 
Ras-related protein Rab-24 (RAB24) LDTP10020 16.91  LDD1834 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 48.50  LDD1834 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 33.59  LDD1834 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 28.84  LDD1834 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 15.03  LDD1834 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 21.56  LDD1834 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 28.44  LDD1834 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 41.93  LDD1834 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 14.72  LDD1834 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 17.39  LDD1834 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 18.38  LDD1834 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 24.08  LDD1834 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 22.16  LDD1834 
Squalene monooxygenase (SQLE) LDTP06142 20.39  LDD1834 
Squalene synthase (FDFT1) LDTP03842 18.00  LDD1834 
TLC domain-containing protein 1 (TLCD1) LDTP10182 26.17  LDD1834 
Transmembrane protein with metallophosphoesterase domain (TMPPE) LDTP07831 24.59  LDD1834 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 33.13  LDD1834 
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) LDTP14189 29.24  LDD1834 
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) LDTP11867 32.90  LDD1834 
Unconventional myosin-XVIIIa (MYO18A) LDTP09819 15.03  LDD1834 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 24.93  LDD1834 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 20.25  LDD1834 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 20.53  LDD1834 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 28.05  LDD1834 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) LDTP06320 19.43  LDD1834 
------------------------------------------------------------------------------------
⏷ Show the Full List of 139 Enzyme
101 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 21.56  LDD1834 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 22.16  LDD1834 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 15.03  LDD1834 
Anion exchange protein 2 (SLC4A2) LDTP02061 16.34  LDD1834 
Annexin A1 (ANXA1) LDTP02010 20.25  LDD1834 
Annexin A11 (ANXA11) LDTP04393 14.93  LDD1834 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 29.86  LDD1834 
ATP synthase subunit a (MT-ATP6) LDTP01804 37.01  LDD1834 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 48.50  LDD1834 
BRI3-binding protein (BRI3BP) LDTP15648 33.82  LDD1834 
Calcium uptake protein 2, mitochondrial (MICU2) LDTP08673 16.00  LDD1834 
CMP-sialic acid transporter (SLC35A1) LDTP05116 39.67  LDD1834 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 17.39  LDD1834 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 28.64  LDD1834 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 16.56  LDD1834 
Derlin-1 (DERL1) LDTP11245 17.75  LDD1834 
Derlin-2 (DERL2) LDTP11634 23.75  LDD1834 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 48.50  LDD1834 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 18.64  LDD1834 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 15.45  LDD1834 
Hsp90 co-chaperone Cdc37 (CDC37) LDTP06549 17.39  LDD1834 
Importin subunit alpha-1 (KPNA2) LDTP04501 21.56  LDD1834 
Importin subunit alpha-5 (KPNA1) LDTP04502 38.05  LDD1834 
Importin subunit alpha-7 (KPNA6) LDTP01031 15.03  LDD1834 
Integral membrane protein 2C (ITM2C) LDTP12451 18.38  LDD1834 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 17.51  LDD1834 
Lysosome membrane protein 2 (SCARB2) LDTP06034 40.79  LDD1834 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 27.10  LDD1834 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 17.27  LDD1834 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 28.84  LDD1834 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 52.35  LDD1834 
Metal cation symporter ZIP14 (SLC39A14) LDTP06293 14.62  LDD1834 
Metal transporter CNNM3 (CNNM3) LDTP09144 16.11  LDD1834 
Metal transporter CNNM4 (CNNM4) LDTP07537 15.03  LDD1834 
Metaxin-1 (MTX1) LDTP05900 26.72  LDD1834 
MICOS complex subunit MIC26 (APOO) LDTP11250 22.16  LDD1834 
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) LDTP07472 15.45  LDD1834 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 17.03  LDD1834 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 14.62  LDD1834 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 29.86  LDD1834 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 35.75  LDD1834 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 99.73  LDD1834 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD1834 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 42.22  LDD1834 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 15.35  LDD1834 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 31.78  LDD1834 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 18.38  LDD1834 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 32.90  LDD1834 
Mpv17-like protein 2 (MPV17L2) LDTP14952 27.47  LDD1834 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 19.03  LDD1834 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 18.13  LDD1834 
Nucleoporin NDC1 (NDC1) LDTP11213 17.03  LDD1834 
Nucleoporin NUP35 (NUP35) LDTP09204 16.22  LDD1834 
Pannexin-1 (PANX1) LDTP10754 15.45  LDD1834 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 18.51  LDD1834 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 25.63  LDD1834 
Prosaposin (PSAP) LDTP02215 15.89  LDD1834 
Protein FAM8A1 (FAM8A1) LDTP16190 21.26  LDD1834 
Protein GPR107 (GPR107) LDTP07236 37.53  LDD1834 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 19.03  LDD1834 
Protein spinster homolog 1 (SPNS1) LDTP11844 25.46  LDD1834 
Protein tweety homolog 3 (TTYH3) LDTP11615 62.68  LDD1834 
Protein YIPF3 (YIPF3) LDTP11626 18.77  LDD1834 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 18.77  LDD1834 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 26.54  LDD1834 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 20.82  LDD1834 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 50.56  LDD1834 
Sideroflexin-4 (SFXN4) LDTP07531 15.24  LDD1834 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 55.72  LDD1834 
Signal recognition particle subunit SRP68 (SRP68) LDTP13262 15.56  LDD1834 
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) LDTP10731 16.68  LDD1834 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 25.63  LDD1834 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 47.50  LDD1834 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 15.24  LDD1834 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 16.68  LDD1834 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 75.58  LDD1834 
Stomatin (STOM) LDTP03380 18.90  LDD1834 
Sugar transporter SWEET1 (SLC50A1) LDTP11136 39.12  LDD1834 
Surfeit locus protein 4 (SURF4) LDTP00592 15.45  LDD1834 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 16.80  LDD1834 
Tetraspanin-3 (TSPAN3) LDTP16813 32.67  LDD1834 
Thioredoxin-related transmembrane protein 2 (TMX2) LDTP13943 16.22  LDD1834 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 30.91  LDD1834 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 59.30  LDD1834 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 22.94  LDD1834 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 30.48  LDD1834 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 23.26  LDD1834 
Transmembrane protein 106B (TMEM106B) LDTP12635 15.67  LDD1834 
Transmembrane protein 126A (TMEM126A) LDTP15948 50.21  LDD1834 
Transmembrane protein 160 (TMEM160) LDTP20002 27.47  LDD1834 
Transmembrane protein 199 (TMEM199) LDTP08881 56.49  LDD1834 
Transmembrane protein 205 (TMEM205) LDTP07667 15.56  LDD1834 
Transmembrane protein 245 (TMEM245) LDTP15979 16.56  LDD1834 
Trimeric intracellular cation channel type B (TMEM38B) LDTP12695 17.03  LDD1834 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 14.93  LDD1834 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 19.84  LDD1834 
Vacuole membrane protein 1 (VMP1) LDTP10343 21.86  LDD1834 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 62.25  LDD1834 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 50.21  LDD1834 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 23.26  LDD1834 
Zinc transporter 7 (SLC30A7) LDTP09180 41.64  LDD1834 
------------------------------------------------------------------------------------
⏷ Show the Full List of 101 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 21.41  LDD1834 
Peregrin (BRPF1) LDTP04683 16.56  LDD1834 
------------------------------------------------------------------------------------
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 29.65  LDD1834 
------------------------------------------------------------------------------------
2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 25.63  LDD1834 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 16.00  LDD1834 
------------------------------------------------------------------------------------
85 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) LDTP06291 27.10  LDD1834 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 27.28  LDD1834 
Apolipoprotein L2 (APOL2) LDTP11076 99.73  LDD1834 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 15.45  LDD1834 
Clustered mitochondria protein homolog (CLUH) LDTP14486 19.16  LDD1834 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 74.54  LDD1834 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 21.26  LDD1834 
Dynactin subunit 2 (DCTN2) LDTP05922 18.77  LDD1834 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 23.92  LDD1834 
Emerin (EMD) LDTP04356 16.00  LDD1834 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 37.79  LDD1834 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 39.12  LDD1834 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 40.50  LDD1834 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 30.70  LDD1834 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 18.64  LDD1834 
Ferritin light chain (FTL) LDTP01973 18.13  LDD1834 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 16.80  LDD1834 
Galanin peptides (GAL) LDTP03175 26.35  LDD1834 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 18.90  LDD1834 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 26.17  LDD1834 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 19.97  LDD1834 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 17.75  LDD1834 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 15.56  LDD1834 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 16.68  LDD1834 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 17.27  LDD1834 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 16.56  LDD1834 
Large proline-rich protein BAG6 (BAG6) LDTP04094 17.88  LDD1834 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 17.63  LDD1834 
MAGUK p55 subfamily member 2 (MPP2) LDTP06068 19.56  LDD1834 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 26.54  LDD1834 
Mediator of RNA polymerase II transcription subunit 4 (MED4) LDTP12377 16.22  LDD1834 
Membralin (TMEM259) LDTP14939 39.95  LDD1834 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 24.08  LDD1834 
MICOS complex subunit MIC19 (CHCHD3) LDTP12764 17.39  LDD1834 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 65.34  LDD1834 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 14.62  LDD1834 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 83.29  LDD1834 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 41.36  LDD1834 
Negative elongation factor C/D (NELFCD) LDTP08594 18.13  LDD1834 
Nicastrin (NCSTN) LDTP09787 16.11  LDD1834 
Nucleobindin-1 (NUCB1) LDTP05375 43.11  LDD1834 
Nucleobindin-2 (NUCB2) LDTP05160 99.73  LDD1834 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 15.35  LDD1834 
Nurim (NRM) LDTP08606 21.26  LDD1834 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 18.90  LDD1834 
Optic atrophy 3 protein (OPA3) LDTP16006 35.02  LDD1834 
p53 and DNA damage-regulated protein 1 (PDRG1) LDTP16099 35.75  LDD1834 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 15.67  LDD1834 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 18.51  LDD1834 
Programmed cell death protein 5 (PDCD5) LDTP00417 22.01  LDD1834 
Proteasome activator complex subunit 3 (PSME3) LDTP04917 15.45  LDD1834 
Protein CEBPZOS (CEBPZOS) LDTP18883 68.59  LDD1834 
Protein FAM114A2 (FAM114A2) LDTP16080 37.27  LDD1834 
Protein FAM162A (FAM162A) LDTP10056 46.53  LDD1834 
Protein Hikeshi (HIKESHI) LDTP06892 53.45  LDD1834 
Protein SERAC1 (SERAC1) LDTP10487 16.22  LDD1834 
Protein unc-119 homolog B (UNC119B) LDTP00105 18.00  LDD1834 
Protein YIF1A (YIF1A) LDTP01494 15.67  LDD1834 
Receptor expression-enhancing protein 3 (REEP3) LDTP15095 17.88  LDD1834 
Reticulocalbin-2 (RCN2) LDTP06097 18.64  LDD1834 
Reticulon-3 (RTN3) LDTP01522 39.12  LDD1834 
Reticulon-4 (RTN4) LDTP12412 26.72  LDD1834 
RNA-binding protein FUS (FUS) LDTP03775 16.22  LDD1834 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 31.78  LDD1834 
SLC35A4 upstream open reading frame protein (SLC35A4) LDTP19005 20.82  LDD1834 
Small ribosomal subunit protein uS9m (MRPS9) LDTP14792 15.78  LDD1834 
Splicing factor U2AF 65 kDa subunit (U2AF2) LDTP03352 17.88  LDD1834 
Synaptogyrin-2 (SYNGR2) LDTP00859 22.16  LDD1834 
Syntaxin-18 (STX18) LDTP13086 43.71  LDD1834 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 16.00  LDD1834 
Tetraspanin-6 (TSPAN6) LDTP14458 40.22  LDD1834 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 25.28  LDD1834 
Thioredoxin domain-containing protein 15 (TXNDC15) LDTP10442 16.80  LDD1834 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 32.67  LDD1834 
TraB domain-containing protein (TRABD) LDTP19963 32.67  LDD1834 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 14.62  LDD1834 
Transmembrane protein 131 (TMEM131) LDTP18115 16.22  LDD1834 
Transmembrane protein 209 (TMEM209) LDTP18272 15.45  LDD1834 
Tubulin beta chain (TUBB) LDTP02205 18.64  LDD1834 
Tubulin beta-2A chain (TUBB2A) LDTP05998 16.91  LDD1834 
Tubulin beta-4A chain (TUBB4A) LDTP02037 15.24  LDD1834 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 32.22  LDD1834 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 44.32  LDD1834 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 16.45  LDD1834 
Vimentin (VIM) LDTP02297 19.03  LDD1834 
------------------------------------------------------------------------------------
⏷ Show the Full List of 85 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1834 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587