Details of the Target

General Information of Target

Target ID LDTP15095
Target Name Receptor expression-enhancing protein 3 (REEP3)
Gene Name REEP3
Gene ID 221035
Synonyms
C10orf74; Receptor expression-enhancing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLCALLLLPSLLGATRASPTSGPQECAKGSTVWCQDLQTAARCGAVGYCQGAVWNKPTAK
SLPCDVCQDIAAAAGNGLNPDATESDILALVMKTCEWLPSQESSAGCKWMVDAHSSAILS
MLRGAPDSAPAQVCTALSLCEPLQRHLATLRPLSKEDTFEAVAPFMANGPLTFHPRQAPE
GALCQDCVRQVSRLQEAVRSNLTLADLNIQEQCESLGPGLAVLCKNYLFQFFVPADQALR
LLPPQELCRKGGFCEELGAPARLTQVVAMDGVPSLELGLPRKQSEMQMKAGVTCEVCMNV
VQKLDHWLMSNSSELMITHALERVCSVMPASITKECIILVDTYSPSLVQLVAKITPEKVC
KFIRLCGNRRRARAVHDAYAIVPSPEWDAENQGSFCNGCKRLLTVSSHNLESKSTKRDIL
VAFKGGCSILPLPYMIQCKHFVTQYEPVLIESLKDMMDPVAVCKKVGACHGPRTPLLGTD
QCALGPSFWCRSQEAAKLCNAVQHCQKHVWKEMHLHAGEHA
Target Bioclass
Other
Family
DP1 family
Subcellular location
Endoplasmic reticulum membrane
Function
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes.
Uniprot ID
Q6NUK4
Ensemble ID
ENST00000373758.5
HGNC ID
HGNC:23711

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K111(6.36); K90(3.70)  LDD0277  [1]
PAL-AfBPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.94  LDD1725  [2]
C055
 Probe Info  		27.28  LDD1752  [2]
C056
 Probe Info  		30.91  LDD1753  [2]
C091
 Probe Info  		16.91  LDD1782  [2]
C092
 Probe Info  		31.34  LDD1783  [2]
C094
 Probe Info  		58.89  LDD1785  [2]
C106
 Probe Info  		28.25  LDD1793  [2]
C107
 Probe Info  		5.90  LDD1794  [2]
C108
 Probe Info  		8.82  LDD1795  [2]
C112
 Probe Info  		23.75  LDD1799  [2]
C134
 Probe Info  		41.64  LDD1816  [2]
C135
 Probe Info  		10.85  LDD1817  [2]
C141
 Probe Info  		9.58  LDD1823  [2]
C143
 Probe Info  		13.09  LDD1825  [2]
C153
 Probe Info  		17.88  LDD1834  [2]
C159
 Probe Info  		10.70  LDD1839  [2]
C161
 Probe Info  		14.83  LDD1841  [2]
C169
 Probe Info  		28.84  LDD1849  [2]
C210
 Probe Info  		54.19  LDD1884  [2]
C228
 Probe Info  		34.54  LDD1901  [2]
C243
 Probe Info  		13.27  LDD1916  [2]
C246
 Probe Info  		23.10  LDD1919  [2]
C278
 Probe Info  		67.65  LDD1948  [2]
C282
 Probe Info  		22.78  LDD1952  [2]
C285
 Probe Info  		19.43  LDD1955  [2]
C289
 Probe Info  		55.72  LDD1959  [2]
C293
 Probe Info  		28.64  LDD1963  [2]
C296
 Probe Info  		11.96  LDD1966  [2]
C343
 Probe Info  		22.47  LDD2005  [2]
C373
 Probe Info  		4.92  LDD2033  [2]
C388
 Probe Info  		88.03  LDD2047  [2]
C407
 Probe Info  		19.56  LDD2064  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TPA-induced transmembrane protein (TTMP) . Q5BVD1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587