Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C135  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 90 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 48.8
 LDTP00697  Cytochrome b5 type B (CYB5B) 39.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 38.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 35.5
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 34.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 34.3
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 32.9
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 32.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 31.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 30.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 27.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 25.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 25.3
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 23.1
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 22.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 21.6
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 21.1
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 20.1
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 19.6
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 18.4
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 17.8
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 17.6
 LDTP11127  ADP-dependent glucokinase (ADPGK) 17.4
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 17.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 16.7
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 16.4
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 16.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 16.0
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 15.9
 LDTP10329  Ceramide synthase 2 (CERS2) 15.6
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 15.6
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 15.5
 LDTP00988  Protein O-GlcNAcase (OGA) 15.3
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 15.2
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 15.2
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 14.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 13.9
 LDTP02505  Lysosomal protective protein (CTSA) 13.8
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 13.8
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 13.7
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 13.6
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 13.5
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 13.5
 LDTP10780  Trimethylguanosine synthase (TGS1) 13.5
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 13.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 13.3
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 13.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 12.9
 LDTP12886  Glycerophosphodiester phosphodiesterase 1 (GDE1) 12.6
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 12.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 12.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 12.4
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 12.1
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) 12.1
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 12.0
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 12.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 11.9
 LDTP00836  ATPase GET3 (GET3) 11.8
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 11.6
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 11.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 11.5
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 11.3
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 11.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 11.3
 LDTP04531  Hexokinase-2 (HK2) 11.2
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 11.0
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 11.0
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 10.9
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 10.9
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 10.9
 LDTP05905  Acid ceramidase (ASAH1) 10.6
 LDTP02550  Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT) 10.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 10.6
 LDTP03145  Catechol O-methyltransferase (COMT) 10.5
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 10.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 10.4
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 10.3
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 10.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 9.8
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.8
 LDTP12494  Carbohydrate sulfotransferase 12 (CHST12) 9.8
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 9.8
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 9.7
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 9.7
 LDTP09251  Atlastin-2 (ATL2) 9.6
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 9.6
 LDTP12490  Sphingosine kinase 2 (SPHK2) 9.6
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 9.5
 LDTP03842  Squalene synthase (FDFT1) 9.5
Transporter and channel
Click to Show/Hide to Show 69 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP05900  Metaxin-1 (MTX1) 64.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 56.9
 LDTP12383  Protein GPR108 (GPR108) 50.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 41.4
 LDTP08881  Transmembrane protein 199 (TMEM199) 40.5
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 37.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 37.3
 LDTP15648  BRI3-binding protein (BRI3BP) 36.8
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 32.4
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 30.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 29.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 27.5
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 24.6
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 24.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 24.1
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 21.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 21.0
 LDTP07236  Protein GPR107 (GPR107) 20.0
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 19.3
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 18.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 18.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 18.8
 LDTP02215  Prosaposin (PSAP) 18.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 17.5
 LDTP16813  Tetraspanin-3 (TSPAN3) 17.5
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 17.5
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 17.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 16.8
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 16.7
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 16.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 15.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 14.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.1
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 14.0
 LDTP15481  Transmembrane protein 87A (TMEM87A) 13.8
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 13.7
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 13.6
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 13.5
 LDTP09288  Vang-like protein 1 (VANGL1) 13.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 13.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 13.1
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 12.7
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 11.8
 LDTP11615  Protein tweety homolog 3 (TTYH3) 11.6
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 11.5
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) 11.5
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 11.4
 LDTP07531  Sideroflexin-4 (SFXN4) 11.3
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 11.1
 LDTP14275  Sodium bicarbonate cotransporter 3 (SLC4A7) 10.9
 LDTP10065  Transmembrane protein 230 (TMEM230) 10.8
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 10.7
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 10.7
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 10.7
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 10.7
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 10.7
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 10.6
 LDTP11634  Derlin-2 (DERL2) 10.4
 LDTP13320  Prenylated Rab acceptor protein 1 (RABAC1) 10.4
 LDTP00310  Syntenin-1 (SDCBP) 10.3
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 10.1
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 9.9
 LDTP03380  Stomatin (STOM) 9.7
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.6
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 9.6
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 9.6
 LDTP16190  Protein FAM8A1 (FAM8A1) 9.5
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 17.3
Other
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 73.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 67.2
 LDTP11076  Apolipoprotein L2 (APOL2) 56.5
 LDTP18883  Protein CEBPZOS (CEBPZOS) 33.1
 LDTP11312  DET1- and DDB1-associated protein 1 (DDA1) 31.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 30.3
 LDTP05160  Nucleobindin-2 (NUCB2) 30.1
 LDTP05375  Nucleobindin-1 (NUCB1) 29.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 29.4
 LDTP01522  Reticulon-3 (RTN3) 23.9
 LDTP16080  Protein FAM114A2 (FAM114A2) 22.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 22.0
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.8
 LDTP13086  Syntaxin-18 (STX18) 20.7
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 20.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 20.0
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 19.4
 LDTP12412  Reticulon-4 (RTN4) 18.9
 LDTP10056  Protein FAM162A (FAM162A) 18.4
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 18.1
 LDTP09773  Protein FAM3C (FAM3C) 18.1
 LDTP18569  PRELI domain containing protein 3B (PRELID3B) 17.6
 LDTP19963  TraB domain-containing protein (TRABD) 17.3
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 16.6
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 16.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 14.8
 LDTP13630  Neudesin (NENF) 14.5
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 14.4
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 14.4
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 14.1
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 14.0
 LDTP00859  Synaptogyrin-2 (SYNGR2) 13.6
 LDTP07916  Protein MTSS 2 (MTSS2) 12.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.6
 LDTP13412  Anaphase-promoting complex subunit 2 (ANAPC2) 12.5
 LDTP09589  Charged multivesicular body protein 7 (CHMP7) 12.5
 LDTP01167  Reticulon-2 (RTN2) 12.5
 LDTP16285  Transducin beta-like protein 2 (TBL2) 12.5
 LDTP11167  Protein YIPF4 (YIPF4) 12.2
 LDTP13125  Protein UXT (UXT) 12.0
 LDTP06948  Protein YIF1B (YIF1B) 11.6
 LDTP04626  UV excision repair protein RAD23 homolog A (RAD23A) 11.5
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 11.3
 LDTP08606  Nurim (NRM) 11.1
 LDTP04946  Ubiquitin-fold modifier 1 (UFM1) 11.1
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 10.9
 LDTP08224  Protein LYRIC (MTDH) 10.9
 LDTP10703  Leukocyte receptor cluster member 8 (LENG8) 10.9
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 10.9
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 10.9
 LDTP05497  DNA repair protein RAD51 homolog 1 (RAD51) 10.8
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 10.6
 LDTP13656  Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) 10.5
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 10.3
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 10.3
 LDTP13664  Syntaxin-8 (STX8) 10.3
 LDTP08420  BLOC-2 complex member HPS6 (HPS6) 10.2
 LDTP15398  Protein FAM177A1 (FAM177A1) 10.1
 LDTP07031  Collectin-12 (COLEC12) 9.9
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 9.9
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 9.8
 LDTP13807  PRELI domain-containing protein 1, mitochondrial (PRELID1) 9.8
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 9.6
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 9.6
 LDTP14304  MAU2 chromatid cohesion factor homolog (MAU2) 9.6
 LDTP18272  Transmembrane protein 209 (TMEM209) 9.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 9.5
 LDTP01494  Protein YIF1A (YIF1A) 9.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587