Details of the Target

General Information of Target

Target ID LDTP13320
Target Name Prenylated Rab acceptor protein 1 (RABAC1)
Gene Name RABAC1
Gene ID 10567
Synonyms
PRA1; PRAF1; Prenylated Rab acceptor protein 1; PRA1 family protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSPE
EKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKN
TAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGS
GVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQ
YQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERE
TRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELK
SGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRH
YPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAA
ARS
Target Bioclass
Transporter and channel
Family
PRA1 family
Subcellular location
Cell membrane
Function
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Uniprot ID
Q9UI14
Ensemble ID
ENST00000222008.11
HGNC ID
HGNC:9794

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		6.91  LDD0196  [1]
IA-alkyne
 Probe Info  		C64(10.00)  LDD2157  [2]
Curcusone 37
 Probe Info  		4.50  LDD0188  [3]
DBIA
 Probe Info  		C64(0.97)  LDD0532  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
W1
 Probe Info  		N.A.  LDD0236  [8]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		26.35  LDD1785  [9]
C106
 Probe Info  		16.11  LDD1793  [9]
C134
 Probe Info  		32.00  LDD1816  [9]
C135
 Probe Info  		10.41  LDD1817  [9]
C177
 Probe Info  		8.75  LDD1856  [9]
C178
 Probe Info  		18.38  LDD1857  [9]
C246
 Probe Info  		12.91  LDD1919  [9]
C278
 Probe Info  		49.87  LDD1948  [9]
C289
 Probe Info  		37.27  LDD1959  [9]
C350
 Probe Info  		25.63  LDD2011  [9]
C355
 Probe Info  		24.42  LDD2016  [9]
C362
 Probe Info  		83.29  LDD2023  [9]
C363
 Probe Info  		20.82  LDD2024  [9]
C364
 Probe Info  		24.93  LDD2025  [9]
C366
 Probe Info  		7.78  LDD2027  [9]
C367
 Probe Info  		6.68  LDD2028  [9]
C390
 Probe Info  		41.07  LDD2049  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C64(0.89)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C64(0.97)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C64(1.21)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C64(0.87)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C64(1.22)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C64(1.35)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C64(1.39)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C64(1.33)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C64(1.44)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C64(1.01)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C64(1.26)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C64(1.11)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C64(1.28)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C64(1.23)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C64(1.33)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C64(1.19)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C64(1.09)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C64(1.19)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C64(1.19)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C64(0.95)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C64(0.92)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C64(0.99)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C64(0.95)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C64(1.08)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C64(1.04)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C64(1.06)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C64(1.06)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C64(1.34)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C64(1.06)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C64(1.09)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C64(1.01)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C64(1.00)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C64(1.13)  LDD0576  [4]
 LDCM0270  AC15 HCT 116 C64(0.96)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C64(1.20)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C64(1.02)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C64(0.99)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C64(0.99)  LDD1518  [10]
 LDCM0280  AC20 HCT 116 C64(1.10)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C64(1.04)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C64(0.87)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C64(0.94)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C64(1.01)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C64(0.98)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C64(0.99)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C64(0.94)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C64(1.02)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C64(0.94)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C64(0.91)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C64(0.93)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C64(0.97)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C64(1.01)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C64(0.93)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C64(0.94)  LDD1534  [10]
 LDCM0296  AC35 HCT 116 C64(0.93)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C64(0.79)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C64(0.80)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C64(0.93)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C64(0.87)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C64(0.93)  LDD1540  [10]
 LDCM0302  AC40 HCT 116 C64(0.86)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C64(1.04)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C64(0.80)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C64(0.99)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C64(0.81)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C64(0.70)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C64(0.94)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C64(0.96)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C64(0.93)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C64(0.94)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C64(1.01)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C64(1.05)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C64(1.01)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C64(0.97)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C64(1.00)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C64(0.99)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C64(1.02)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C64(1.00)  LDD1558  [10]
 LDCM0320  AC57 HCT 116 C64(0.92)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C64(1.00)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C64(0.96)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C64(1.25)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C64(1.03)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C64(0.91)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C64(1.03)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C64(1.20)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C64(1.17)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C64(1.07)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C64(1.03)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C64(1.06)  LDD0648  [4]
 LDCM0334  AC7 HCT 116 C64(1.18)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C64(1.13)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C64(1.09)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C64(0.90)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C64(1.09)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C64(1.03)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C64(1.13)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C64(1.02)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C64(0.99)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C64(1.13)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C64(1.01)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C64(0.79)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C64(1.18)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C64(1.10)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C64(1.00)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C64(1.06)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C64(1.16)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C64(1.36)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C64(1.41)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C64(1.02)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C64(1.12)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C64(1.08)  LDD0592  [4]
 LDCM0367  CL1 HEK-293T C64(1.11)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C64(0.82)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C64(1.04)  LDD1573  [10]
 LDCM0370  CL101 HCT 116 C64(0.94)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C64(0.90)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C64(1.04)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C64(1.09)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C64(1.22)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C64(1.08)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C64(0.99)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C64(1.18)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C64(0.95)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C64(0.81)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C64(1.17)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C64(1.01)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C64(1.04)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C64(1.10)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C64(0.92)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C64(0.93)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C64(1.02)  LDD1590  [10]
 LDCM0387  CL117 HCT 116 C64(0.94)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C64(1.21)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C64(0.93)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C64(0.97)  LDD1594  [10]
 LDCM0391  CL120 HCT 116 C64(1.09)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C64(0.96)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C64(0.94)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C64(0.94)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C64(1.15)  LDD1599  [10]
 LDCM0396  CL125 HCT 116 C64(1.12)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C64(0.95)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C64(0.83)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C64(0.80)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C64(1.03)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C64(0.91)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C64(0.92)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C64(1.21)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C64(0.81)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C64(1.01)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C64(0.90)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C64(0.93)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C64(1.00)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C64(1.02)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C64(0.97)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C64(0.93)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C64(1.06)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C64(1.06)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C64(0.98)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C64(1.02)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C64(1.03)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C64(1.01)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C64(0.98)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C64(1.02)  LDD1623  [10]
 LDCM0420  CL31 HCT 116 C64(0.89)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C64(0.76)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C64(1.00)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C64(1.01)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C64(1.43)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C64(1.11)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C64(1.10)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C64(1.05)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C64(0.97)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C64(1.06)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C64(1.24)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C64(0.84)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C64(1.06)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C64(0.86)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C64(1.32)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C64(0.98)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C64(0.96)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C64(1.06)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C64(1.10)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C64(0.90)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C64(1.00)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C64(1.13)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C64(0.89)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C64(0.94)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C64(0.98)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C64(0.92)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C64(1.02)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C64(1.11)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C64(1.02)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C64(1.01)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C64(0.98)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C64(1.02)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C64(0.99)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C64(0.96)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C64(0.94)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C64(0.94)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C64(1.05)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C64(0.92)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C64(1.19)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C64(1.10)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C64(0.91)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C64(1.03)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C64(1.00)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C64(1.02)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C64(1.04)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C64(0.98)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C64(1.24)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C64(0.82)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C64(1.09)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C64(1.03)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C64(0.95)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C64(1.02)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C64(1.15)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C64(1.02)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C64(0.94)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C64(1.00)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C64(0.98)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C64(1.00)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C64(1.08)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C64(1.21)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C64(0.97)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C64(1.06)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C64(0.76)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C64(0.94)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C64(0.92)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C64(1.03)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C64(0.96)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C64(0.89)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C64(0.93)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C64(0.99)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C64(0.99)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C64(1.07)  LDD1697  [10]
 LDCM0033  Curcusone1d MCF-7 4.50  LDD0188  [3]
 LDCM0495  E2913 HEK-293T C64(1.00)  LDD1698  [10]
 LDCM0625  F8 Ramos C64(0.83)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C64(0.28)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C64(1.64)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C64(0.29)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C64(1.41)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C64(0.75)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C64(0.49)  LDD2194  [11]
 LDCM0582  Fragment23 Ramos C64(0.54)  LDD2196  [11]
 LDCM0588  Fragment30 Ramos C64(3.76)  LDD2199  [11]
 LDCM0590  Fragment32 Ramos C64(0.21)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C64(1.13)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C64(1.13)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C64(0.69)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C64(1.92)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C64(0.44)  LDD2204  [11]
 LDCM0569  Fragment7 Ramos C64(0.81)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C64(0.54)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C64(0.93)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C64(1.01)  LDD1497  [10]
 LDCM0024  KB05 HEK-293T C64(0.87)  LDD1502  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C64(0.58)  LDD2207  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Protein NDRG4 (NDRG4) NDRG family Q9ULP0
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
8-oxo-dGDP phosphatase NUDT18 (NUDT18) Nudix hydrolase family Q6ZVK8
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) Peptidase S33 family Q8TB40
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Dual specificity protein phosphatase 12 (DUSP12) Protein-tyrosine phosphatase family Q9UNI6
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Ras-related protein Rab-33A (RAB33A) Rab family Q14088
E3 ubiquitin-protein ligase TRIM32 (TRIM32) TRIM/RBCC family Q13049
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin-like protein 2, mitochondrial (STOML2) Band 7/mec-2 family Q9UJZ1
Etoposide-induced protein 2.4 homolog (EI24) EI24 family O14681
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Sorting nexin-10 (SNX10) Sorting nexin family Q9Y5X0
Sorting nexin-11 (SNX11) Sorting nexin family Q9Y5W9
Sorting nexin-15 (SNX15) Sorting nexin family Q9NRS6
Sorting nexin-17 (SNX17) Sorting nexin family Q15036
Sorting nexin-8 (SNX8) Sorting nexin family Q9Y5X2
Alpha-synuclein (SNCA) Synuclein family P37840
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Stromal interaction molecule 1 (STIM1) . Q13586
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
SLAM family member 6 (SLAMF6) . Q96DU3
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 3 (LTBR) . P36941
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 2 (REEP2) DP1 family Q9BRK0
RNA-binding protein FXR1 (FXR1) FMR1 family P51114
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Mitochondrial dynamics protein MID49 (MIEF2) MID49/MID51 family Q96C03
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
Transmembrane protein 115 (TMEM115) TMEM115 family Q12893
Translocon-associated protein subunit gamma (SSR3) TRAP-gamma family Q9UNL2
WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) WD repeat PROPPIN family Q9Y4P8
Inner nuclear membrane protein Man1 (LEMD3) . Q9Y2U8
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Transmembrane protein 42 (TMEM42) . Q69YG0
Uncharacterized protein C6orf47 (C6orf47) . O95873
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.