Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Curcusone 37  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Curcusone1d  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Invasive breast carcinoma [ICD-11:2C60]
Model Name Human invasive breast carcinoma cells (MCF-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 9.0
 LDTP03676  ATP-binding cassette sub-family D member 1 (ABCD1) 6.0
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 5.6
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 5.5
 LDTP10038  Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) 5.3
 LDTP09053  Xyloside xylosyltransferase 1 (XXYLT1) 4.3
 LDTP09620  Soluble calcium-activated nucleotidase 1 (CANT1) 4.2
 LDTP13989  Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) 4.2
 LDTP13992  RNA-splicing ligase RtcB homolog (RTCB) 4.0
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 4.0
 LDTP07323  Acyl-coenzyme A thioesterase MBLAC2 (MBLAC2) 3.9
 LDTP09216  Serine palmitoyltransferase small subunit B (SPTSSB) 3.9
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 3.8
 LDTP09060  Ubiquitin-associated domain-containing protein 2 (UBAC2) 3.7
 LDTP00415  Acyl-coenzyme A thioesterase 8 (ACOT8) 3.5
 LDTP08559  Extracellular sulfatase Sulf-2 (SULF2) 3.4
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) 3.3
 LDTP17785  Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPR) 3.3
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 3.2
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) 3.1
 LDTP00654  Synaptobrevin homolog YKT6 (YKT6) 3.0
 LDTP01202  Serine/threonine-protein kinase ULK1 (ULK1) 3.0
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 3.0
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 2.7
 LDTP08855  D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2HGDH) 2.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 2.6
 LDTP13938  Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) 2.5
 LDTP04713  FAD-linked sulfhydryl oxidase ALR (GFER) 2.5
 LDTP02627  2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA) 2.4
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) 2.4
 LDTP10365  Methionine--tRNA ligase, mitochondrial (MARS2) 2.4
 LDTP05809  Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) 2.3
 LDTP15408  Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2) 2.3
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 2.2
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) 2.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 2.2
 LDTP13719  Ubiquitin carboxyl-terminal hydrolase 22 (USP22) 2.2
 LDTP10077  Patatin-like phospholipase domain-containing protein 2 (PNPLA2) 2.2
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 2.1
 LDTP00462  Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDK) 2.1
 LDTP03679  Dual specificity protein kinase TTK (TTK) 2.1
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 2.1
 LDTP15155  Thiol S-methyltransferase TMT1B (TMT1B) 2.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 2.0
 LDTP02096  Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB) 2.0
Transporter and channel
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 7.8
 LDTP06275  Lysosomal-associated transmembrane protein 4A (LAPTM4A) 5.5
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 5.4
 LDTP06490  Vesicle-associated membrane protein 3 (VAMP3) 4.7
 LDTP15924  Probable mitochondrial glutathione transporter SLC25A39 (SLC25A39) 4.5
 LDTP13320  Prenylated Rab acceptor protein 1 (RABAC1) 4.5
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 3.9
 LDTP05020  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) 3.4
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 3.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 3.1
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 3.0
 LDTP11406  Transmembrane protein 59 (TMEM59) 3.0
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) 2.7
 LDTP16008  Transmembrane protein 134 (TMEM134) 2.5
 LDTP00656  Insulin-induced gene 1 protein (INSIG1) 2.5
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 2.3
 LDTP05017  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) 2.3
 LDTP15838  Translocation protein SEC62 (SEC62) 2.3
 LDTP01060  PRA1 family protein 2 (PRAF2) 2.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 2.2
 LDTP17540  Transmembrane channel-like protein 4 (TMC4) 2.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 2.0
 LDTP07439  Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) 2.0
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09953  Interferon regulatory factor 7 (IRF7) 10.5
 LDTP06081  Zinc finger MYM-type protein 3 (ZMYM3) 4.8
 LDTP02500  Nuclear receptor subfamily 2 group F member 6 (NR2F6) 3.4
 LDTP02488  Androgen receptor (AR) 3.3
 LDTP05266  Interferon regulatory factor 9 (IRF9) 2.6
 LDTP01981  Estrogen receptor (ESR1) 2.1
Other
Click to Show/Hide to Show 49 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) 13.6
 LDTP11421  Fanconi anemia group D2 protein (FANCD2) 6.9
 LDTP09383  Protein CIP2A (CIP2A) 6.9
 LDTP19033  Uncharacterized protein C6orf47 (C6orf47) 5.9
 LDTP06870  Protein GREB1 (GREB1) 4.4
 LDTP12033  Zinc finger protein 703 (ZNF703) 4.3
 LDTP19958  Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) 4.3
 LDTP10357  RUS family member 1 (RUSF1) 4.0
 LDTP05269  Perilipin-5 (PLIN5) 3.6
 LDTP12724  Uncharacterized protein C14orf119 (C14orf119) 3.6
 LDTP08220  Suppressor APC domain-containing protein 2 (SAPCD2) 3.3
 LDTP07573  Proline/serine-rich coiled-coil protein 1 (PSRC1) 3.3
 LDTP07508  Polyamine-modulated factor 1 (PMF1) 3.0
 LDTP01381  Annexin A9 (ANXA9) 3.0
 LDTP04316  Tuberin (TSC2) 2.9
 LDTP06109  Guanine nucleotide-binding protein subunit alpha-13 (GNA13) 2.9
 LDTP05960  Trophoblast glycoprotein (TPBG) 2.9
 LDTP11330  Protein C1orf43 (C1orf43) 2.9
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 2.9
 LDTP10992  Myeloid differentiation primary response protein MyD88 (MYD88) 2.8
 LDTP15398  Protein FAM177A1 (FAM177A1) 2.7
 LDTP00632  Syntaxin-7 (STX7) 2.6
 LDTP09861  General transcription factor IIH subunit 4 (GTF2H4) 2.5
 LDTP02829  Integrin beta-4 (ITGB4) 2.5
 LDTP05846  Phosducin-like protein (PDCL) 2.5
 LDTP07625  Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) 2.4
 LDTP13394  Tubulin delta chain (TUBD1) 2.4
 LDTP08359  Condensin-2 complex subunit G2 (NCAPG2) 2.4
 LDTP19472  Protein NCBP2AS2 (NCBP2AS2) 2.4
 LDTP15278  Tubulin epsilon and delta complex protein 1 (TEDC1) 2.4
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 2.4
 LDTP13410  Anaphase-promoting complex subunit 5 (ANAPC5) 2.3
 LDTP06184  Genetic suppressor element 1 (GSE1) 2.3
 LDTP00519  NEDD4-binding protein 3 (N4BP3) 2.2
 LDTP01327  AP-1 complex subunit gamma-like 2 (AP1G2) 2.2
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 2.2
 LDTP09624  Protein POF1B (POF1B) 2.2
 LDTP01532  ZW10 interactor (ZWINT) 2.2
 LDTP01678  Tetratricopeptide repeat protein 4 (TTC4) 2.1
 LDTP00986  Syntaxin-10 (STX10) 2.1
 LDTP15333  Trafficking protein particle complex subunit 5 (TRAPPC5) 2.1
 LDTP19831  Protein THEM6 (THEM6) 2.1
 LDTP19963  TraB domain-containing protein (TRABD) 2.1
 LDTP17157  OCIA domain-containing protein 2 (OCIAD2) 2.1
 LDTP10419  Biorientation of chromosomes in cell division protein 1 (BOD1) 2.1
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 2.0
 LDTP05990  Plakophilin-1 (PKP1) 2.0
 LDTP13086  Syntaxin-18 (STX18) 2.0
 LDTP06066  Malectin (MLEC) 2.0

References

1 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.