Details of the Target

General Information of Target

Target ID LDTP17785
Target Name Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPR)
Gene Name PDPR
Gene ID 55066
Synonyms
KIAA1990; Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; PDPr
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAAMLPYACVLVLLGAHTAPAAGEAGGSCLRWEPHCQQPLPDRVPSTAILPPRLNGPWI
STGCEVRPGPEFLTRAYTFYPSRLFRAHQFYYEDPFCGEPAHSLLVKGKVRLRRASWVTR
GATEADYHLHKVGIVFHSRRALVDVTGRLNQTRAGRDCARRLPPARAWLPGALYELRSAR
AQGDCLEALGLTMHELSLVRVQRRLQPQPRASPRLVEELYLGDIHTDPAERRHYRPTGYQ
RPLQSALHHVQPCPACGLIARSDVHHPPVLPPPLALPLHLGGWWVSSGCEVRPAVLFLTR
LFTFHGHSRSWEGYYHHFSDPACRQPTFTVYAAGRYTRGTPSTRVRGGTELVFEVTRAHV
TPMDQVTTAMLNFSEPSSCGGAGAWSMGTERDVTATNGCLPLGIRLPHVEYELFKMEQDP
LGQSLLFIGQRPTDGSSPDTPEKRPTSYQAPLVLCHGEAPDFSRPPQHRPSLQKHPSTGG
LHIAPFPLLPLVLGLAFLHWL
Target Bioclass
Enzyme
Family
GcvT family
Subcellular location
Mitochondrion matrix
Function Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.
Uniprot ID
Q8NCN5
Ensemble ID
ENST00000288050.9
HGNC ID
HGNC:30264

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K765T DBIA    Probe Info 
HCT15 SNV: p.K854N .
IM95 SNV: p.Y847H DBIA    Probe Info 
MFE319 SNV: p.L781I DBIA    Probe Info 
OZ Substitution: p.G846Ter DBIA    Probe Info 
RL952 SNV: p.S712I DBIA    Probe Info 
VMRCRCW Deletion: p.D833IfsTer41 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K854(0.43)  LDD0277  [1]
Probe 1
 Probe Info  		Y660(16.29); Y847(17.94)  LDD3495  [2]
BTD
 Probe Info  		C85(1.10)  LDD2125  [3]
Curcusone 37
 Probe Info  		3.26  LDD0188  [4]
HHS-475
 Probe Info  		Y856(0.82)  LDD0264  [5]
DBIA
 Probe Info  		C85(1.28)  LDD0532  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C85(0.00); C735(0.00); C357(0.00); C598(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C653(0.00); C522(0.00); C85(0.00); C735(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C653(0.00); C522(0.00); C85(0.00); C735(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
HHS-465
 Probe Info  		Y708(0.00); Y856(0.00)  LDD2240  [14]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C303
 Probe Info  		11.00  LDD1972  [15]
C338
 Probe Info  		20.39  LDD2001  [15]
C383
 Probe Info  		11.71  LDD2042  [15]
C388
 Probe Info  		49.52  LDD2047  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C85(1.18)  LDD1093  [6]
 LDCM0215  AC10 HCT 116 C85(1.28)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C85(1.70)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C85(1.26)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C85(1.02)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C85(1.73)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C85(2.03)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C85(2.57)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C85(2.13)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C85(1.66)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C85(1.16)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C85(1.21)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C85(1.33)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C85(1.38)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C85(1.24)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C85(1.15)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C85(1.08)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C85(1.34)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C85(1.82)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C85(1.65)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C85(1.25)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C85(1.17)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C85(1.36)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C85(1.11)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C85(1.43)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C85(1.18)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C85(1.12)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C85(1.40)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C85(1.22)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C85(1.33)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C85(1.64)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C85(1.49)  LDD0562  [6]
 LDCM0246  AC128 PaTu 8988t C598(0.68); C85(0.95)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C598(0.73); C85(1.12)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C598(0.70); C85(1.06)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C598(0.87); C85(0.91)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C598(0.99); C85(1.14)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C598(0.91); C85(0.99)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C598(0.86); C85(1.17)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C598(0.77); C85(1.81)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C598(0.65); C85(1.41)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C598(0.74); C85(1.16)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C598(0.73); C85(1.26)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C598(0.59); C85(1.08)  LDD1137  [6]
 LDCM0259  AC14 HCT 116 C85(1.15)  LDD0576  [6]
 LDCM0260  AC140 PaTu 8988t C598(0.76); C85(0.87)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C598(0.88); C85(1.15)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C598(0.92); C85(1.34)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C85(1.57)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C85(1.34)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C85(1.20)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C85(1.24)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C85(1.87)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C85(1.56)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C85(1.53)  LDD1148  [6]
 LDCM0270  AC15 HCT 116 C85(1.22)  LDD0587  [6]
 LDCM0271  AC150 PaTu 8988t C85(1.65)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C85(1.65)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C85(1.22)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C85(1.78)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C85(1.86)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C85(1.20)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C85(1.74)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C85(1.34)  LDD2169  [6]
 LDCM0276  AC17 HCT 116 C85(1.12)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C85(1.58)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C85(1.67)  LDD0595  [6]
 LDCM0279  AC2 PaTu 8988t C85(1.09)  LDD1158  [6]
 LDCM0280  AC20 HCT 116 C85(1.11)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C85(1.68)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C85(1.13)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C85(1.59)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C85(1.06)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C85(1.37)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C85(1.42)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C85(1.58)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C85(1.59)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C85(1.40)  LDD0606  [6]
 LDCM0290  AC3 PaTu 8988t C85(1.15)  LDD1169  [6]
 LDCM0291  AC30 HCT 116 C85(1.38)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C85(1.51)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C85(1.49)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C85(1.10)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C85(1.26)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C85(0.90)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C85(0.93)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C85(0.93)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C85(1.04)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C85(1.16)  LDD0617  [6]
 LDCM0301  AC4 PaTu 8988t C85(1.02)  LDD1180  [6]
 LDCM0302  AC40 HCT 116 C85(1.11)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C85(1.29)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C85(1.04)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C85(1.08)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C85(1.07)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C85(1.17)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C85(0.91)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C85(1.00)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C85(1.07)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C85(1.13)  LDD0628  [6]
 LDCM0312  AC5 PaTu 8988t C85(1.35)  LDD1191  [6]
 LDCM0313  AC50 HCT 116 C85(1.19)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C85(0.95)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C85(1.11)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C85(1.23)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C85(1.25)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C85(1.30)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C85(0.90)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C85(1.54)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C85(1.57)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C85(1.65)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C85(1.35)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C85(1.60)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C85(1.70)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C85(1.72)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C85(1.67)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C85(1.60)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C85(2.03)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C85(2.00)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C85(1.85)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C85(0.99)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C85(0.98)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C85(1.21)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C85(0.87)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C85(1.07)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C85(1.24)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C85(1.04)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C85(1.28)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C85(0.74)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C85(1.09)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C85(1.19)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C85(0.90)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C85(0.98)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C85(1.23)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C85(1.42)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C85(0.77)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C85(0.74)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C85(2.09)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C85(1.71)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C85(1.32)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C85(1.51)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C85(1.20)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C85(1.25)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C85(1.38)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C85(1.08)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C85(2.02)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C85(2.22)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C85(1.23)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C85(1.39)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C85(1.28)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C85(1.32)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C85(1.52)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C85(1.03)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C85(1.00)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C85(1.05)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C85(1.20)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C85(1.95)  LDD0592  [6]
 LDCM0630  CCW28-3 231MFP C735(0.00)  LDD2214  [16]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 PaTu 8988t C85(1.48)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C85(2.42)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C85(1.13)  LDD1248  [6]
 LDCM0370  CL101 HCT 116 C85(1.50)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C85(1.26)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C85(1.55)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C85(1.30)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C85(1.49)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C85(2.08)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C85(1.61)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C85(1.75)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C85(1.84)  LDD0695  [6]
 LDCM0379  CL11 PaTu 8988t C85(1.44)  LDD1258  [6]
 LDCM0380  CL110 HCT 116 C85(1.95)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C85(1.53)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C85(1.24)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C85(1.30)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C85(1.61)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C85(1.36)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C85(1.43)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C85(1.34)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C85(1.26)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C85(1.07)  LDD0706  [6]
 LDCM0390  CL12 PaTu 8988t C85(1.69)  LDD1269  [6]
 LDCM0391  CL120 HCT 116 C85(1.06)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C85(0.63)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C85(1.24)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C85(2.05)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C85(1.39)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C85(1.35)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C85(1.43)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C85(1.30)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C85(1.64)  LDD0716  [6]
 LDCM0400  CL13 PaTu 8988t C85(1.49)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C85(1.78)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C85(2.49)  LDD1281  [6]
 LDCM0403  CL16 PaTu 8988t C598(0.90); C85(1.38)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C598(0.92); C85(1.36)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C598(0.71); C85(1.99)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C598(0.83); C85(1.26)  LDD1285  [6]
 LDCM0407  CL2 PaTu 8988t C85(1.11)  LDD1286  [6]
 LDCM0408  CL20 PaTu 8988t C598(0.38); C85(1.36)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C598(0.29); C85(1.57)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C598(0.71); C85(1.35)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C598(0.61); C85(1.19)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C598(0.79); C85(1.41)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C598(1.08); C85(1.45)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C598(0.51); C85(1.28)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C598(0.86); C85(1.35)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C598(0.24); C85(1.96)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C598(0.25); C85(1.20)  LDD1296  [6]
 LDCM0418  CL3 PaTu 8988t C85(1.31)  LDD1297  [6]
 LDCM0419  CL30 PaTu 8988t C598(1.16); C85(1.17)  LDD1298  [6]
 LDCM0420  CL31 HEK-293T C85(1.22); C357(0.90); C598(0.93); C735(0.84)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C85(1.08); C357(1.03); C598(0.95)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C85(2.24); C357(0.82); C598(0.78)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C85(1.19); C357(0.99); C598(1.07)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C85(1.08); C357(1.06); C598(0.91); C735(0.83)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C85(1.08); C357(0.87); C598(0.92)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C85(0.85); C357(1.10); C735(1.06)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C85(2.09); C357(1.20)  LDD1632  [17]
 LDCM0429  CL4 PaTu 8988t C85(1.36)  LDD1308  [6]
 LDCM0430  CL40 HEK-293T C85(0.99); C357(0.95); C653(0.98)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C85(0.98); C357(0.99); C598(0.84)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C85(0.99); C357(1.03); C598(1.18); C813(1.20)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C85(1.04); C357(1.10); C598(1.02); C735(0.91)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C85(1.16); C357(1.01); C598(0.95)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C85(1.17); C357(0.94); C598(0.79)  LDD1639  [17]
 LDCM0436  CL46 PaTu 8988t C598(0.99); C85(1.16)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C598(1.09); C85(1.15)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C598(0.98); C85(1.18)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C598(0.86); C85(1.19)  LDD1318  [6]
 LDCM0440  CL5 PaTu 8988t C85(1.28)  LDD1319  [6]
 LDCM0441  CL50 PaTu 8988t C598(0.84); C85(1.45)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C598(0.87); C85(2.15)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C598(1.05); C85(1.73)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C598(1.07); C85(1.80)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C598(1.33); C85(1.42)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C598(1.10); C85(1.40)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C598(0.26); C85(0.83)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C598(0.29); C85(1.90)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C598(1.19); C85(1.43)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C598(0.26); C85(1.42)  LDD1329  [6]
 LDCM0451  CL6 PaTu 8988t C85(1.58)  LDD1330  [6]
 LDCM0452  CL60 PaTu 8988t C598(0.65); C85(1.80)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C598(1.06); C85(1.11)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C598(1.11); C85(1.48)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C598(1.11); C85(1.69)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C598(1.31); C85(1.92)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C598(1.12); C85(1.24)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C598(1.14); C85(1.83)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C598(1.07); C85(1.38)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C598(1.00); C85(1.71)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C598(1.03); C85(2.22)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C85(1.21)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C598(0.90); C85(1.43)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C598(1.14); C85(1.16)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C598(1.11); C85(1.73)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C598(1.24); C85(2.61)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C598(1.25); C85(2.08)  LDD1346  [6]
 LDCM0469  CL76 HCT 116 C85(0.94)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C85(0.92)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C85(1.20)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C85(0.92)  LDD0789  [6]
 LDCM0473  CL8 PaTu 8988t C85(2.57)  LDD1352  [6]
 LDCM0474  CL80 HCT 116 C85(1.05)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C85(0.95)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C85(0.93)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C85(1.05)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C85(1.24)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C85(0.94)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C85(0.92)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C85(1.06)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C85(0.93)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C85(0.84)  LDD0800  [6]
 LDCM0484  CL9 PaTu 8988t C85(1.39)  LDD1363  [6]
 LDCM0485  CL90 HCT 116 C85(1.55)  LDD0802  [6]
 LDCM0486  CL91 PaTu 8988t C85(1.12)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C85(1.21)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C85(1.16)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C85(1.07)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C85(1.47)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C85(1.20)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C85(1.41)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C85(1.05)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C85(1.13)  LDD1373  [6]
 LDCM0033  Curcusone1d MCF-7 3.26  LDD0188  [4]
 LDCM0495  E2913 HEK-293T C85(0.94); C357(1.13)  LDD1698  [17]
 LDCM0468  Fragment33 PaTu 8988t C598(1.29); C85(1.48)  LDD1347  [6]
 LDCM0427  Fragment51 HEK-293T C85(0.90); C357(0.96)  LDD1631  [17]
 LDCM0116  HHS-0101 DM93 Y856(0.82)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y856(1.05)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y856(3.13)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y856(1.28)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y856(1.60)  LDD0268  [5]
 LDCM0022  KB02 HEK-293T C85(1.07); C357(0.95); C653(0.94); C735(1.15)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C85(1.08); C357(1.03); C653(0.90); C735(0.99)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C85(1.79)  LDD3310  [18]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C85(1.10)  LDD2125  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C85(1.22)  LDD2136  [3]

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD028853
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
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Mass spectrometry data entry: PXD039931
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840