Details of the Probe

General Information of Probe

Probe ID
LDPC0125
Probe Name
Curcusone 37
Synonyms
SCHEMBL24272208
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 392.5
Lipid-water partition coefficient (xlogp) 4.1
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C25H28O4
IUPAC Name
[(2S,6aR,7S)-2,5-dimethyl-10-methylidene-1,4-dioxo-7-prop-1-en-2-yl-3,6a,7,8,9,10a-hexahydrobenzo[e]azulen-2-yl] pent-4-ynoate
Canonical SMILES
CC1=CC2C(CCC(=C)C2C3=C(C1=O)CC(C3=O)(C)OC(=O)CCC#C)C(=C)C
InChI
InChI=1S/C25H28O4/c1-7-8-9-20(26)29-25(6)13-19-22(24(25)28)21-15(4)10-11-17(14(2)3)18(21)12-16(5)23(19)27/h1,12,17-18,21H,2,4,8-11,13H2,3,5-6H3/t17-,18-,21?,25+/m1/s1
InChIKey
ZPSNNKPOFQYHPI-YGQCNMQCSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

45 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA) LDTP02627 2.39  LDD0188 
Acyl-coenzyme A thioesterase 8 (ACOT8) LDTP00415 3.47  LDD0188 
Acyl-coenzyme A thioesterase MBLAC2 (MBLAC2) LDTP07323 3.88  LDD0188 
Alanine--tRNA ligase, cytoplasmic (AARS1) LDTP04262 2.21  LDD0188 
ATP synthase membrane subunit K, mitochondrial (ATP5MK) LDTP10432 3.79  LDD0188 
ATP-binding cassette sub-family D member 1 (ABCD1) LDTP03676 5.96  LDD0188 
Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDK) LDTP00462 2.11  LDD0188 
Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) LDTP11178 5.57  LDD0188 
Cytochrome b5 type B (CYB5B) LDTP00697 2.56  LDD0188 
D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2HGDH) LDTP08855 2.62  LDD0188 
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) LDTP05809 2.34  LDD0188 
Delta(14)-sterol reductase TM7SF2 (TM7SF2) LDTP01389 2.05  LDD0188 
Dual specificity protein kinase TTK (TTK) LDTP03679 2.10  LDD0188 
Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) LDTP02694 3.34  LDD0188 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 2.97  LDD0188 
Extracellular sulfatase Sulf-2 (SULF2) LDTP08559 3.44  LDD0188 
FAD-linked sulfhydryl oxidase ALR (GFER) LDTP04713 2.52  LDD0188 
Glutathione S-transferase 3, mitochondrial (MGST3) LDTP00464 2.39  LDD0188 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) LDTP10930 3.24  LDD0188 
Methionine--tRNA ligase, mitochondrial (MARS2) LDTP10365 2.39  LDD0188 
Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) LDTP10038 5.33  LDD0188 
NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) LDTP01219 2.72  LDD0188 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 3.99  LDD0188 
Neutral cholesterol ester hydrolase 1 (NCEH1) LDTP07591 9.03  LDD0188 
Patatin-like phospholipase domain-containing protein 2 (PNPLA2) LDTP10077 2.16  LDD0188 
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) LDTP13989 4.18  LDD0188 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 2.19  LDD0188 
Probable glutathione peroxidase 8 (GPX8) LDTP09495 2.13  LDD0188 
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB) LDTP02096 2.01  LDD0188 
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2) LDTP15408 2.34  LDD0188 
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPR) LDTP17785 3.26  LDD0188 
RNA-splicing ligase RtcB homolog (RTCB) LDTP13992 4.05  LDD0188 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 2.04  LDD0188 
Serine palmitoyltransferase small subunit B (SPTSSB) LDTP09216 3.86  LDD0188 
Serine/threonine-protein kinase ULK1 (ULK1) LDTP01202 2.98  LDD0188 
Soluble calcium-activated nucleotidase 1 (CANT1) LDTP09620 4.23  LDD0188 
Sulfhydryl oxidase 2 (QSOX2) LDTP07813 5.51  LDD0188 
Synaptobrevin homolog YKT6 (YKT6) LDTP00654 3.04  LDD0188 
Thiol S-methyltransferase TMT1B (TMT1B) LDTP15155 2.04  LDD0188 
Trimethyllysine dioxygenase, mitochondrial (TMLHE) LDTP12679 2.22  LDD0188 
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) LDTP13938 2.54  LDD0188 
Ubiquitin carboxyl-terminal hydrolase 22 (USP22) LDTP13719 2.17  LDD0188 
Ubiquitin-associated domain-containing protein 2 (UBAC2) LDTP09060 3.67  LDD0188 
Ubiquitin-conjugating enzyme E2 S (UBE2S) LDTP06621 3.08  LDD0188 
Xyloside xylosyltransferase 1 (XXYLT1) LDTP09053 4.28  LDD0188 
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⏷ Show the Full List of 45 Enzyme
23 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) LDTP12738 7.77  LDD0188 
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) LDTP08981 3.88  LDD0188 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 2.15  LDD0188 
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) LDTP05017 2.28  LDD0188 
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) LDTP05020 3.39  LDD0188 
Insulin-induced gene 1 protein (INSIG1) LDTP00656 2.48  LDD0188 
Lysosomal-associated transmembrane protein 4A (LAPTM4A) LDTP06275 5.48  LDD0188 
Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) LDTP07439 2.02  LDD0188 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 2.04  LDD0188 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 2.30  LDD0188 
Mpv17-like protein 2 (MPV17L2) LDTP14952 3.09  LDD0188 
PRA1 family protein 2 (PRAF2) LDTP01060 2.20  LDD0188 
Prenylated Rab acceptor protein 1 (RABAC1) LDTP13320 4.50  LDD0188 
Probable mitochondrial glutathione transporter SLC25A39 (SLC25A39) LDTP15924 4.54  LDD0188 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 3.23  LDD0188 
Store-operated calcium entry-associated regulatory factor (SARAF) LDTP10148 2.66  LDD0188 
Translocation protein SEC62 (SEC62) LDTP15838 2.25  LDD0188 
Transmembrane channel-like protein 4 (TMC4) LDTP17540 2.04  LDD0188 
Transmembrane emp24 domain-containing protein 1 (TMED1) LDTP05875 5.44  LDD0188 
Transmembrane protein 134 (TMEM134) LDTP16008 2.50  LDD0188 
Transmembrane protein 59 (TMEM59) LDTP11406 3.01  LDD0188 
Vesicle-associated membrane protein 3 (VAMP3) LDTP06490 4.69  LDD0188 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 3.03  LDD0188 
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⏷ Show the Full List of 23 Transporter and channel
6 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Androgen receptor (AR) LDTP02488 3.31  LDD0188 
Estrogen receptor (ESR1) LDTP01981 2.09  LDD0188 
Interferon regulatory factor 7 (IRF7) LDTP09953 10.54  LDD0188 
Interferon regulatory factor 9 (IRF9) LDTP05266 2.63  LDD0188 
Nuclear receptor subfamily 2 group F member 6 (NR2F6) LDTP02500 3.43  LDD0188 
Zinc finger MYM-type protein 3 (ZMYM3) LDTP06081 4.81  LDD0188 
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⏷ Show the Full List of 6 Transcription factor
49 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Anaphase-promoting complex subunit 5 (ANAPC5) LDTP13410 2.32  LDD0188 
Annexin A9 (ANXA9) LDTP01381 3.02  LDD0188 
AP-1 complex subunit gamma-like 2 (AP1G2) LDTP01327 2.21  LDD0188 
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) LDTP07625 2.43  LDD0188 
Biorientation of chromosomes in cell division protein 1 (BOD1) LDTP10419 2.05  LDD0188 
BRCA1-associated ATM activator 1 (BRAT1) LDTP07598 13.63  LDD0188 
Condensin-2 complex subunit G2 (NCAPG2) LDTP08359 2.40  LDD0188 
Fanconi anemia group D2 protein (FANCD2) LDTP11421 6.95  LDD0188 
General transcription factor IIH subunit 4 (GTF2H4) LDTP09861 2.54  LDD0188 
Genetic suppressor element 1 (GSE1) LDTP06184 2.31  LDD0188 
Guanine nucleotide-binding protein subunit alpha-13 (GNA13) LDTP06109 2.91  LDD0188 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 2.88  LDD0188 
Integrin beta-4 (ITGB4) LDTP02829 2.47  LDD0188 
Kelch-like ECH-associated protein 1 (KEAP1) LDTP06051 2.04  LDD0188 
Malectin (MLEC) LDTP06066 2.02  LDD0188 
Myeloid differentiation primary response protein MyD88 (MYD88) LDTP10992 2.76  LDD0188 
NEDD4-binding protein 3 (N4BP3) LDTP00519 2.24  LDD0188 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 2.17  LDD0188 
OCIA domain-containing protein 2 (OCIAD2) LDTP17157 2.05  LDD0188 
Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) LDTP19958 4.29  LDD0188 
Perilipin-5 (PLIN5) LDTP05269 3.64  LDD0188 
Phosducin-like protein (PDCL) LDTP05846 2.45  LDD0188 
Plakophilin-1 (PKP1) LDTP05990 2.04  LDD0188 
Polyamine-modulated factor 1 (PMF1) LDTP07508 3.02  LDD0188 
Proline/serine-rich coiled-coil protein 1 (PSRC1) LDTP07573 3.31  LDD0188 
Protein C1orf43 (C1orf43) LDTP11330 2.89  LDD0188 
Protein CIP2A (CIP2A) LDTP09383 6.87  LDD0188 
Protein FAM177A1 (FAM177A1) LDTP15398 2.66  LDD0188 
Protein GREB1 (GREB1) LDTP06870 4.36  LDD0188 
Protein NCBP2AS2 (NCBP2AS2) LDTP19472 2.39  LDD0188 
Protein POF1B (POF1B) LDTP09624 2.17  LDD0188 
Protein THEM6 (THEM6) LDTP19831 2.10  LDD0188 
RUS family member 1 (RUSF1) LDTP10357 3.96  LDD0188 
Suppressor APC domain-containing protein 2 (SAPCD2) LDTP08220 3.35  LDD0188 
Syntaxin-10 (STX10) LDTP00986 2.13  LDD0188 
Syntaxin-18 (STX18) LDTP13086 2.03  LDD0188 
Syntaxin-7 (STX7) LDTP00632 2.58  LDD0188 
Tetratricopeptide repeat protein 4 (TTC4) LDTP01678 2.15  LDD0188 
TraB domain-containing protein (TRABD) LDTP19963 2.07  LDD0188 
Trafficking protein particle complex subunit 5 (TRAPPC5) LDTP15333 2.11  LDD0188 
Trophoblast glycoprotein (TPBG) LDTP05960 2.91  LDD0188 
Tuberin (TSC2) LDTP04316 2.93  LDD0188 
Tubulin delta chain (TUBD1) LDTP13394 2.40  LDD0188 
Tubulin epsilon and delta complex protein 1 (TEDC1) LDTP15278 2.38  LDD0188 
Uncharacterized protein C14orf119 (C14orf119) LDTP12724 3.58  LDD0188 
Uncharacterized protein C6orf47 (C6orf47) LDTP19033 5.89  LDD0188 
UPF0729 protein C18orf32 (C18orf32) LDTP15599 2.37  LDD0188 
Zinc finger protein 703 (ZNF703) LDTP12033 4.35  LDD0188 
ZW10 interactor (ZWINT) LDTP01532 2.16  LDD0188 
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⏷ Show the Full List of 49 Other

Competitor(s) Related To This Probe

Competitor ID Name Concentration Cell-system Ref
 LDCM0033  Curcusone1d 30 uM Human invasive breast carcinoma cells (MCF-7) [1]

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
10 uM
Quantitative Method
LFQ
Competitor Name
Curcusone1d
 Competitor Info 
Competitor Concentration
30 uM
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Breast
Disease Model
Invasive breast carcinoma [ICD-11:2C60]
Model Name
Human invasive breast carcinoma cells (MCF-7)
Interaction Atlas ID
 LDD0188 
Download The Altas

References

1 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.