Details of the Target

General Information of Target

Target ID LDTP05990
Target Name Plakophilin-1 (PKP1)
Gene Name PKP1
Gene ID 5317
Synonyms
Plakophilin-1; Band 6 protein; B6P
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSS
TLSHSNRGSMYDGLADNYNYGTTSRSSYYSKFQAGNGSWGYPIYNGTLKREPDNRRFSSY
SQMENWSRHYPRGSCNTTGAGSDICFMQKIKASRSEPDLYCDPRGTLRKGTLGSKGQKTT
QNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVYIPPISCNKDLSFGHSRASSKICSEDI
ECSGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPN
QNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSST
DELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRKRLGMRELL
ALVPQRATSSRVNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLH
NLSYRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMNNNYDCPLPEEETNPKGS
GWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQI
ARLLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSS
ACYTVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAAEAARLLLSDMWSSKELQGV
LRQQGFDRNMLGTLAGANSLRNFTSRF
Target Bioclass
Other
Family
Beta-catenin family
Subcellular location
Nucleus; Cell junction, desmosome
Function Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. May facilitate the formation of intermediate filaments.
Uniprot ID
Q13835
Ensemble ID
ENST00000263946.7
HGNC ID
HGNC:9023
ChEMBL ID
CHEMBL4295817

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SAHA-CA-4PAP
 Probe Info  		4.00  LDD0361  [1]
DBIA
 Probe Info  		C290(2.57)  LDD3348  [2]
Curcusone 37
 Probe Info  		2.04  LDD0188  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0033  Curcusone1d MCF-7 2.04  LDD0188  [3]
 LDCM0022  KB02 A431 C568(1.22); C220(2.44); C290(1.72); C161(2.12)  LDD2258  [2]
 LDCM0023  KB03 A101D C290(2.41)  LDD2667  [2]
 LDCM0024  KB05 NCI-H1792 C290(2.57)  LDD3348  [2]
 LDCM0096  SAHA K562 4.00  LDD0361  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Desmoplakin (DSP) Plakin or cytolinker family P15924
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) TFII-I family Q9UHL9
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BICD family-like cargo adapter 2 (BICDL2) BICDR family A1A5D9
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 14 (KRT14) Intermediate filament family P02533
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type II cytoskeletal 5 (KRT5) Intermediate filament family P13647
Keratin, type II cytoskeletal 8 (KRT8) Intermediate filament family P05787
Vimentin (VIM) Intermediate filament family P08670
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Desmoglein-1 (DSG1) . Q02413
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.