Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name SAHA-CA-4PAP  Probe Info 
Probe concentration 0.3 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name SAHA  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cell lysate (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09865  Histone deacetylase 2 (HDAC2) 13.9
 LDTP05918  Histone deacetylase 1 (HDAC1) 13.6
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) 5.8
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) 4.0
 LDTP13136  Histone deacetylase 6 (HDAC6) .
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03104  V-type proton ATPase subunit B, brain isoform (ATP6V1B2) 4.3
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) .
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01414  Metastasis-associated protein MTA2 (MTA2) 4.0
Other
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 4.0
 LDTP05990  Plakophilin-1 (PKP1) 4.0
 LDTP06357  Keratin, type I cuticular Ha1 (KRT31) .
 LDTP01375  Keratin, type I cuticular Ha4 (KRT34) .
 LDTP01376  Keratin, type I cuticular Ha6 (KRT36) .
 LDTP12579  Keratin, type II cuticular Hb2 (KRT82) .
 LDTP12578  Keratin, type II cuticular Hb4 (KRT84) .
 LDTP05119  Keratin, type II cuticular Hb5 (KRT85) .
 LDTP00868  Keratin, type II cuticular Hb6 (KRT86) .
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) .

References

1 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.