Details of the Target

General Information of Target

Target ID LDTP04853
Target Name Eukaryotic translation initiation factor 3 subunit E (EIF3E)
Gene Name EIF3E
Gene ID 3646
Synonyms
EIF3S6; INT6; Eukaryotic translation initiation factor 3 subunit E; eIF3e; Eukaryotic translation initiation factor 3 subunit 6; Viral integration site protein INT-6 homolog; eIF-3 p48
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKN
LYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADK
HGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQ
NWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQP
QYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLY
VNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKL
NMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAM
NIEKKLNQNSRSEAPNWATQDSGFY
Target Bioclass
Other
Family
EIF-3 subunit E family
Subcellular location
Cytoplasm
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {|HAMAP-Rule:MF_03004}.
Uniprot ID
P60228
Ensemble ID
ENST00000220849.10
HGNC ID
HGNC:3277

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.21  LDD0402  [1]
A-EBA
 Probe Info  		3.01  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH216
 Probe Info  		Y401(15.78)  LDD0259  [4]
ONAyne
 Probe Info  		K120(7.68); K275(1.14)  LDD0274  [5]
STPyne
 Probe Info  		K275(9.98); K383(7.69); K407(3.66); K409(8.55)  LDD0277  [5]
IPM
 Probe Info  		N.A.  LDD0241  [6]
OPA-S-S-alkyne
 Probe Info  		K409(2.54)  LDD3494  [7]
Probe 1
 Probe Info  		Y62(11.19); Y127(9.73); Y132(13.81); Y286(222.35)  LDD3495  [8]
SAHA-CA-4PAP
 Probe Info  		4.00  LDD0361  [9]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [10]
BTD
 Probe Info  		C350(0.86)  LDD2092  [11]
HHS-475
 Probe Info  		Y62(2.33)  LDD0264  [12]
DBIA
 Probe Info  		C350(1.09)  LDD0078  [13]
ATP probe
 Probe Info  		K275(0.00); K82(0.00); K265(0.00); K424(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C250(0.00); C141(0.00); C350(0.00); C345(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		C250(0.00); C141(0.00); C350(0.00); C345(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
NAIA_4
 Probe Info  		C250(0.00); C345(0.00); C350(0.00)  LDD2226  [18]
1d-yne
 Probe Info  		K41(0.00); K387(0.00)  LDD0356  [19]
NHS
 Probe Info  		K35(0.00); K82(0.00); K265(0.00)  LDD0010  [20]
OSF
 Probe Info  		N.A.  LDD0029  [21]
SF
 Probe Info  		Y401(0.00); Y4(0.00); Y62(0.00)  LDD0028  [21]
TFBX
 Probe Info  		C345(0.00); C141(0.00)  LDD0148  [22]
1c-yne
 Probe Info  		K407(0.00); K387(0.00); K193(0.00); K409(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C350(0.00); C345(0.00); H12(0.00)  LDD0217  [23]
NAIA_5
 Probe Info  		C250(0.00); C345(0.00); C298(0.00); C328(0.00)  LDD2223  [18]
HHS-465
 Probe Info  		N.A.  LDD2240  [24]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C147
 Probe Info  		7.41  LDD1829  [25]
C161
 Probe Info  		9.99  LDD1841  [25]
C166
 Probe Info  		11.16  LDD1846  [25]
C220
 Probe Info  		12.82  LDD1894  [25]
C252
 Probe Info  		13.18  LDD1925  [25]
C289
 Probe Info  		37.53  LDD1959  [25]
FFF probe11
 Probe Info  		5.19  LDD0471  [26]
FFF probe13
 Probe Info  		7.72  LDD0475  [26]
FFF probe14
 Probe Info  		12.31  LDD0477  [26]
FFF probe2
 Probe Info  		6.37  LDD0463  [26]
FFF probe3
 Probe Info  		8.26  LDD0464  [26]
JN0003
 Probe Info  		13.25  LDD0469  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
OEA-DA
 Probe Info  		3.44  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C350(1.13)  LDD2117  [11]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C350(1.12)  LDD2103  [11]
 LDCM0025  4SU-RNA HEK-293T C298(8.42)  LDD0371  [30]
 LDCM0026  4SU-RNA+native RNA HEK-293T C298(2.34)  LDD0372  [30]
 LDCM0214  AC1 HCT 116 C141(0.74); C345(1.10); C350(0.95)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C141(0.97); C350(0.85)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C141(0.44); C350(0.95)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C141(0.42); C350(0.93)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C141(0.93); C350(0.97)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C141(0.53); C350(0.99)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C141(0.51); C350(0.88)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C141(0.48); C350(0.89)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C141(0.46); C350(0.78)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C141(0.46); C350(1.16)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C141(0.64); C350(1.01)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C141(0.89); C350(1.03)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C141(0.93); C350(0.93)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C141(0.75); C350(1.08)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C141(0.57); C350(0.92)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C141(0.50); C350(1.03)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C141(1.15); C350(0.90)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C141(0.82); C350(0.99)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C141(0.65); C350(1.05)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C141(0.64); C350(1.03)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C141(0.76); C350(1.01)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C141(0.76); C350(0.91)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C141(0.69); C350(0.85)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C141(0.99); C350(0.85)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C141(0.90); C350(1.03)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C141(0.61); C350(0.82)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C141(0.78); C350(0.80)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C141(0.82); C350(0.92)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C141(0.69); C350(0.87)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C141(0.86); C350(0.79)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C141(0.72); C350(0.75)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C141(0.72); C350(0.75)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C141(0.67); C350(1.21)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C141(0.84); C350(1.05)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C141(0.75); C350(1.15)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C141(1.16); C350(1.08)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C141(0.78); C350(1.00)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C141(0.62); C350(1.08)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C141(0.62); C350(1.27)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C141(0.67); C350(1.16)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C141(0.65); C350(1.20)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C141(0.80); C350(1.03)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C141(0.55); C350(1.13)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C141(0.69); C350(1.03)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C141(0.86); C350(0.96)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C141(0.68); C350(1.07)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C141(0.66); C350(1.04)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C141(0.85); C350(1.06)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C345(0.76); C350(0.91)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C345(0.53); C350(0.84)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C345(0.66); C350(0.94)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C345(0.54); C350(1.12)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C345(0.47); C350(0.89)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C345(0.63); C350(0.67)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C345(0.50); C350(0.89)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C141(0.89); C350(0.91)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C345(0.68); C350(0.85)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C345(0.69); C350(1.05)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C345(0.60); C350(0.80)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C345(0.58); C350(0.72)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C345(0.58); C350(0.93)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C345(0.45); C350(0.99)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C345(0.67); C350(1.03)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C345(0.78); C350(0.95)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C345(0.79); C350(0.85); C141(1.34)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C345(0.73); C350(1.30); C141(2.21)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C345(0.81); C350(0.86); C141(1.07)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C141(0.65); C345(0.97); C350(0.99)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C345(0.90); C350(0.94); C141(1.38)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C345(0.82); C350(1.00); C141(1.30)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C345(0.88); C350(0.93); C141(1.31)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C345(0.82); C350(0.90); C141(0.91)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C350(0.80); C345(0.94); C141(1.24)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C350(0.88); C141(0.89); C345(0.90)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C141(0.69); C345(0.84); C350(1.01)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C141(0.73); C345(0.87); C350(0.91)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C345(0.71); C141(0.77); C350(0.91)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C345(0.84); C350(0.90); C141(0.90)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C141(0.60); C350(0.85); C345(0.95)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C345(0.78); C141(0.86); C350(1.00)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C141(0.70); C350(0.95); C345(1.09)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C141(0.55); C345(0.72); C350(1.06)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C141(0.69); C345(0.88); C350(0.92)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C345(0.65); C141(0.79); C350(1.07)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C350(1.10); C141(1.53)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C350(0.93); C141(0.94)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C350(0.92); C141(1.03)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C350(0.93); C141(0.95)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C141(0.69); C350(0.81)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C141(0.62); C345(1.16); C350(1.20)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C350(1.02); C141(1.11)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C141(0.78); C350(0.94)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C141(0.76); C350(1.11)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C141(0.81); C350(0.99)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C141(0.73); C350(1.08)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C141(0.80); C350(0.94)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C350(0.96); C141(1.07)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C141(0.70); C350(0.95)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C141(0.70); C350(0.81)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C350(1.03); C141(1.05)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C141(0.59); C345(1.04); C350(1.10)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C141(0.86); C350(1.01)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C350(0.73); C141(0.88)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C141(0.67); C350(0.89)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C350(0.86); C141(0.90)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C141(0.82); C350(0.98)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C141(0.82); C350(1.00)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C350(1.03); C141(1.11)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C141(0.68); C345(0.79); C350(1.22)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C345(0.83); C141(0.94); C350(1.26)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C141(0.66); C345(0.70); C350(1.18)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C350(1.04); C141(1.06)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C141(0.70); C345(0.75); C350(1.10)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C141(0.52); C345(0.84); C350(1.08)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C141(0.69); C345(0.92); C350(1.36)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C141(0.70); C345(0.79); C350(1.06)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C141(0.62); C345(0.73); C350(1.15)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C141(0.45); C345(0.74); C350(0.95)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C141(0.47); C345(0.78); C350(0.98)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C141(0.61); C345(0.73); C350(1.13)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C345(0.86); C350(1.09); C141(1.19)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C345(0.88); C350(1.06); C141(1.15)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C350(0.96); C141(0.98)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C345(0.61); C141(0.86); C350(1.12)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C345(0.89); C350(1.00); C141(1.19)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C345(0.74); C141(0.96); C350(0.97)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C345(0.90); C141(1.12); C350(1.16)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C345(0.98); C350(1.25); C141(1.39)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C141(0.96); C345(1.05); C350(1.20)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C345(0.74); C350(0.96); C141(1.04)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C345(0.78); C350(1.05); C141(1.07)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C345(0.81); C350(0.91); C141(1.12)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C345(0.78); C350(0.99); C141(1.17)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C350(1.01); C141(1.25)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C345(0.81); C350(1.02); C141(1.28)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C345(1.05); C141(1.10); C350(1.16)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C345(0.93); C141(1.24); C350(1.29)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C345(0.63); C141(0.68); C350(1.21)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C345(0.60); C141(0.64); C350(1.15)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C345(0.61); C141(0.70); C350(1.04)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C345(0.67); C141(0.76); C350(0.91)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C141(0.81); C345(0.84); C350(0.93)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C345(0.68); C141(0.77); C350(0.84)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C345(0.59); C141(0.82); C350(1.01)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C350(0.69); C345(0.74); C141(1.91)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C345(0.56); C141(0.68); C350(1.01)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C345(0.51); C141(0.60); C350(0.84)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C345(0.66); C141(0.71); C350(0.82)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C345(0.63); C350(0.94); C141(1.19)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C345(0.68); C141(0.76); C350(0.87)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C345(0.55); C141(0.66); C350(0.97)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C345(0.53); C141(0.75); C350(0.91)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C141(0.24); C350(1.10)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C141(0.65); C350(0.77)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C141(0.94); C350(0.84)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C141(0.82); C350(0.95)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C141(0.81); C350(1.01)  LDD0592  [13]
 LDCM0020  ARS-1620 HCC44 C350(1.09)  LDD0078  [13]
 LDCM0630  CCW28-3 231MFP C350(1.45); C141(1.23); C345(0.57)  LDD2214  [31]
 LDCM0108  Chloroacetamide HeLa C350(0.00); H12(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C350(1.84)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C350(1.09); C345(1.12); C141(1.21)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C141(1.05); C345(1.19); C350(1.29)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C141(0.63); C350(0.90); C345(0.93)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C141(0.76); C350(1.12)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C350(0.94); C141(1.01)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C350(0.88); C141(1.19)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C350(0.91); C141(1.09)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C345(0.78); C350(0.94); C141(0.97)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C345(0.76); C141(0.93); C350(1.02)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C345(0.71); C141(0.74); C350(1.07)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C345(0.77); C350(1.06); C141(1.06)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C345(0.83); C350(0.84); C141(0.95)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C141(0.93); C350(1.16); C345(1.45)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C345(0.77); C141(0.85); C350(1.00)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C345(0.76); C350(0.90); C141(1.62)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C141(0.71); C345(0.90); C350(0.99)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C345(0.74); C141(0.75); C350(1.17)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C141(0.82); C345(0.88); C350(1.15)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C141(0.51); C345(0.76); C350(0.95)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C141(0.55); C345(0.73); C350(0.90)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C141(0.93); C350(1.20)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C141(0.66); C350(0.97)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C141(0.95); C350(0.98)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C141(0.85); C345(1.25); C350(1.35)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C141(0.68); C350(0.88)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C141(0.64); C350(0.94)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C141(0.66); C350(1.07)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C141(0.89); C350(0.90)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C141(0.65); C350(0.93)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C141(0.64); C350(0.96); C345(0.98)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C141(0.76); C345(0.89); C350(0.99)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C141(0.67); C345(0.93); C350(1.05)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C345(0.66); C141(0.69); C350(1.17)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C345(1.10); C141(1.16); C350(1.49)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C141(1.04); C350(1.22); C345(1.37)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C141(0.87); C345(0.97); C350(1.23)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C141(0.82); C350(1.28)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C141(0.75); C350(1.15)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C141(0.84); C350(1.45)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C141(0.78); C350(1.28)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C350(1.03); C141(1.07); C345(1.16)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C141(0.93); C350(1.44)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C141(1.02); C350(1.25)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C141(0.94); C350(1.31)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C350(1.01); C141(1.27)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C141(0.99); C350(1.23)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C141(0.82); C350(1.07)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C141(0.91); C350(1.08)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C141(0.71); C350(0.94)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C141(0.92); C350(1.13)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C141(0.93); C350(1.31)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C141(1.08); C345(1.32); C350(1.22)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C141(1.10); C350(1.23)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C141(1.12); C350(1.51)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C141(0.92); C350(1.81)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C141(1.03); C350(1.70)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C141(1.19); C350(2.00)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C141(1.37); C350(2.23)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C141(1.14); C350(1.98)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C141(1.31); C350(2.00)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C141(1.24); C350(1.70)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C141(1.02); C345(1.29); C350(1.10)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C141(1.08); C350(1.83)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C141(1.02); C350(1.90)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C141(1.14); C350(3.34)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C141(1.40); C350(2.19)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C141(1.33); C350(1.68)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C141(1.30); C350(1.48)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C141(1.31); C350(0.64)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C141(1.01); C350(0.85)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C141(1.62); C350(0.83)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C141(1.41); C350(0.78)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C141(1.14); C345(1.18); C350(1.06)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C141(1.30); C350(0.76)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C141(1.09); C350(0.77)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C141(0.82); C350(0.84)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C141(1.30); C350(1.01)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C141(2.18); C350(0.74)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C141(1.11); C350(0.89)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C141(0.80); C350(0.97)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C141(1.40); C350(0.75)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C141(1.46); C350(0.70)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C141(1.04); C350(0.72)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C141(0.89); C345(0.92); C350(1.10)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C141(1.20); C350(0.76)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C141(1.09); C345(1.31); C350(1.00)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C141(1.09); C345(1.08); C350(0.96)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C141(0.82); C345(1.00); C350(0.94)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C141(0.85); C345(1.24); C350(1.03)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C141(0.96); C345(1.33); C350(0.98)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C141(0.77); C345(1.10); C350(1.10)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C141(0.81); C345(1.22); C350(1.14)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C141(0.73); C345(1.36); C350(1.18)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C141(1.22); C345(1.24); C350(1.00)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C141(1.01); C345(0.76); C350(1.12)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C141(0.91); C345(1.15); C350(1.10)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C141(0.88); C345(1.10); C350(1.03)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C141(1.13); C345(1.19); C350(1.00)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C141(1.47); C345(1.26); C350(0.93)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C141(1.00); C345(1.31); C350(1.00)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C141(1.08); C350(1.13)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C141(2.05); C350(1.04)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C141(0.97); C350(1.09)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C141(0.95); C350(1.20)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C141(1.03); C345(0.95); C350(1.31)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C141(1.25); C350(1.38)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C141(1.01); C350(0.99)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C141(0.94); C350(1.36)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C141(0.97); C350(0.99)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C141(1.11); C350(1.12)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C141(0.99); C350(0.90)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C141(0.98); C350(0.94)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C141(0.90); C350(0.99)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C141(0.96); C350(0.89)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C141(1.15); C350(1.36)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C141(1.17); C345(0.86); C350(1.15)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C141(0.65); C350(0.96)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C141(0.60); C345(0.98); C350(1.08)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C141(0.68); C345(1.09); C350(1.13)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C141(0.83); C345(0.89); C350(1.13)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C141(0.72); C345(0.93); C350(1.10)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C141(0.60); C345(0.98); C350(1.13)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C141(0.73); C345(1.11); C350(1.06)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C141(0.69); C345(0.98); C350(1.10)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C141(0.51); C345(0.93); C350(1.11)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C141(0.62); C345(0.90); C350(1.02)  LDD0811  [13]
 LDCM0185  Compound 17 HEK-293T 4.39  LDD0512  [26]
 LDCM0191  Compound 21 HEK-293T 4.46  LDD0508  [26]
 LDCM0190  Compound 34 HEK-293T 4.89  LDD0510  [26]
 LDCM0192  Compound 35 HEK-293T 3.74  LDD0509  [26]
 LDCM0193  Compound 36 HEK-293T 4.26  LDD0511  [26]
 LDCM0495  E2913 HEK-293T C350(0.87); C141(0.96); C345(0.86); C250(0.87)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C345(1.60)  LDD1702  [11]
 LDCM0625  F8 Ramos C345(1.10)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C345(0.59)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C345(7.65)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C345(0.23)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C345(0.92)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C345(1.71); C350(1.17)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C345(0.45)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C345(0.66)  LDD2195  [33]
 LDCM0578  Fragment27 Ramos C345(0.48)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C345(0.84); C350(1.11)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C345(0.66)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C345(0.74)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C345(0.25)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C141(0.94); C345(1.25); C350(1.13)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C345(0.83)  LDD2203  [33]
 LDCM0427  Fragment51 HCT 116 C141(1.37); C350(1.61)  LDD0744  [13]
 LDCM0614  Fragment56 Ramos C345(0.47)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C350(0.60)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C345(2.42)  LDD2188  [33]
 LDCM0116  HHS-0101 DM93 Y62(2.33)  LDD0264  [12]
 LDCM0118  HHS-0301 DM93 Y62(0.60)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y62(2.66)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y62(1.65)  LDD0268  [12]
 LDCM0107  IAA HeLa H68(0.00); H12(0.00)  LDD0221  [23]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [10]
 LDCM0022  KB02 HCT 116 C345(1.48); C141(1.48); C350(1.08)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C345(2.83); C141(1.38); C350(1.74)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C345(2.06); C141(1.85); C350(1.37)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C350(1.09)  LDD2102  [11]
 LDCM0109  NEM HeLa H68(0.00); H12(0.00)  LDD0223  [23]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C350(0.86)  LDD2092  [11]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C350(1.31)  LDD2094  [11]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C350(1.10)  LDD2097  [11]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C350(1.16)  LDD2098  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C350(1.22)  LDD2099  [11]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C350(1.40)  LDD2105  [11]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C350(1.02)  LDD2107  [11]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C350(0.98)  LDD2109  [11]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C350(0.76)  LDD2123  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C350(1.01)  LDD2125  [11]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C350(1.42)  LDD2127  [11]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C350(1.12)  LDD2129  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C350(1.52)  LDD2135  [11]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C350(0.85)  LDD2137  [11]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C350(0.95)  LDD2140  [11]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C350(0.95)  LDD2146  [11]
 LDCM0628  OTUB2-COV-1 HEK-293T C345(1.30); C141(0.94)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C345(1.37); C141(1.33); C350(0.97)  LDD0304  [35]
 LDCM0096  SAHA K562 4.00  LDD0361  [9]
 LDCM0021  THZ1 HCT 116 C350(1.26); C345(1.25); C141(1.05)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Probable ATP-dependent RNA helicase DDX60 (DDX60) Helicase family Q8IY21
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
HLA class II histocompatibility antigen gamma chain (CD74) . P04233
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Endothelial PAS domain-containing protein 1 (EPAS1) . Q99814
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit B (EIF3B) EIF-3 subunit B family P55884
Eukaryotic translation initiation factor 3 subunit C (EIF3C) EIF-3 subunit C family Q99613
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Eukaryotic translation initiation factor 3 subunit K (EIF3K) EIF-3 subunit K family Q9UBQ5
Eukaryotic translation initiation factor 3 subunit L (EIF3L) EIF-3 subunit L family Q9Y262
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) HesB/IscA family Q86U28
MRN complex-interacting protein (MRNIP) MRNIP family Q6NTE8
RUN domain-containing protein 3A (RUNDC3A) RUNDC3 family Q59EK9
Keratinocyte proline-rich protein (KPRP) . Q5T749
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Uncharacterized protein C4orf19 (C4orf19) . Q8IY42

References

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Mass spectrometry data entry: PXD037665
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD038010
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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