Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 200 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 36  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 60 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 19.0
 LDTP12851  UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) 18.3
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 16.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 14.5
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 13.7
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 13.0
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 12.6
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 12.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 10.9
 LDTP09569  Ras-related protein Rab-2B (RAB2B) 10.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 9.6
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.5
 LDTP06371  GTP-binding protein Rheb (RHEB) 9.3
 LDTP10020  Ras-related protein Rab-24 (RAB24) 9.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 8.9
 LDTP09388  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) 8.9
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 8.9
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 8.7
 LDTP00886  Nardilysin (NRDC) 8.5
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 8.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 8.2
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 8.1
 LDTP03682  DNA replication licensing factor MCM7 (MCM7) 8.1
 LDTP07015  Alanine--tRNA ligase, mitochondrial (AARS2) 8.0
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 7.8
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.5
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 7.5
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 7.4
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 7.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 7.3
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 7.3
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) 7.1
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 6.9
 LDTP06903  Ubiquitin carboxyl-terminal hydrolase 39 (USP39) 6.8
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 6.7
 LDTP04962  26S proteasome regulatory subunit 4 (PSMC1) 6.7
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 6.6
 LDTP06142  Squalene monooxygenase (SQLE) 6.5
 LDTP11127  ADP-dependent glucokinase (ADPGK) 6.3
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 6.2
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 6.1
 LDTP01986  NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) 5.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 5.9
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 5.8
 LDTP00988  Protein O-GlcNAcase (OGA) 5.3
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 4.9
 LDTP02868  Fumarylacetoacetase (FAH) 4.7
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 4.6
 LDTP04963  26S proteasome regulatory subunit 8 (PSMC5) 4.3
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 4.1
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) 4.0
 LDTP06849  Prolyl endopeptidase-like (PREPL) 4.0
 LDTP02743  Insulin-degrading enzyme (IDE) 3.9
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 3.8
 LDTP12610  Obg-like ATPase 1 (OLA1) 3.5
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 3.5
 LDTP06294  Lysine--tRNA ligase (KARS1) 3.2
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 3.2
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) 3.1
 LDTP02616  Creatine kinase B-type (CKB) 3.1
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 12.8
 LDTP00310  Syntenin-1 (SDCBP) 12.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 11.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 11.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 11.0
 LDTP09149  ATP-binding cassette sub-family F member 1 (ABCF1) 10.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 10.5
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 10.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 10.2
 LDTP11250  MICOS complex subunit MIC26 (APOO) 10.1
 LDTP05938  Sorting nexin-1 (SNX1) 9.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 9.4
 LDTP03405  Calnexin (CANX) 7.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 6.6
 LDTP04501  Importin subunit alpha-1 (KPNA2) 6.5
 LDTP16190  Protein FAM8A1 (FAM8A1) 6.1
 LDTP04597  Methylosome subunit pICln (CLNS1A) 4.4
 LDTP09949  Transportin-1 (TNPO1) 3.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02870  Y-box-binding protein 3 (YBX3) 16.6
Other
Click to Show/Hide to Show 52 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 13.7
 LDTP13044  Ribosome-binding protein 1 (RRBP1) 13.6
 LDTP13086  Syntaxin-18 (STX18) 13.1
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 12.3
 LDTP05160  Nucleobindin-2 (NUCB2) 12.0
 LDTP14085  Protein PRRC2C (PRRC2C) 11.1
 LDTP08594  Negative elongation factor C/D (NELFCD) 10.2
 LDTP04570  Coatomer subunit beta (COPB1) 10.1
 LDTP05375  Nucleobindin-1 (NUCB1) 10.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.7
 LDTP04558  Arfaptin-1 (ARFIP1) 9.4
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) 9.2
 LDTP16080  Protein FAM114A2 (FAM114A2) 9.2
 LDTP06121  Caprin-1 (CAPRIN1) 9.1
 LDTP05922  Dynactin subunit 2 (DCTN2) 9.1
 LDTP06268  Condensin complex subunit 2 (NCAPH) 9.0
 LDTP03030  Annexin A7 (ANXA7) 8.8
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) 8.7
 LDTP04199  Protein PRRC2A (PRRC2A) 8.7
 LDTP16006  Optic atrophy 3 protein (OPA3) 8.5
 LDTP13402  Dynactin subunit 4 (DCTN4) 8.5
 LDTP13532  Malignant T-cell-amplified sequence 1 (MCTS1) 8.2
 LDTP08224  Protein LYRIC (MTDH) 8.0
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 7.9
 LDTP01456  Pre-mRNA-processing factor 6 (PRPF6) 7.9
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 7.8
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 7.7
 LDTP00105  Protein unc-119 homolog B (UNC119B) 7.7
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 7.2
 LDTP14172  Sorting nexin-9 (SNX9) 6.6
 LDTP04092  Crk-like protein (CRKL) 6.4
 LDTP13908  AP-3 complex subunit mu-1 (AP3M1) 6.2
 LDTP02756  Junction plakoglobin (JUP) 6.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 6.2
 LDTP01522  Reticulon-3 (RTN3) 5.9
 LDTP15887  Lipase maturation factor 2 (LMF2) 5.8
 LDTP09069  Kinetochore protein Spc24 (SPC24) 5.7
 LDTP06181  Structural maintenance of chromosomes protein 1A (SMC1A) 5.6
 LDTP12412  Reticulon-4 (RTN4) 5.5
 LDTP02053  Heat shock protein beta-1 (HSPB1) 5.4
 LDTP13817  Nuclear migration protein nudC (NUDC) 5.0
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 4.6
 LDTP06280  Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) 4.6
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 4.3
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 4.3
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 4.1
 LDTP06281  Condensin complex subunit 1 (NCAPD2) 4.0
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 3.9
 LDTP05277  Protein SET (SET) 3.8
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 3.7
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 3.5
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 3.1

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.