Details of the Target

General Information of Target

Target ID LDTP06515
Target Name Coiled-coil domain-containing protein 6 (CCDC6)
Gene Name CCDC6
Gene ID 8030
Synonyms
D10S170; TST1; Coiled-coil domain-containing protein 6; Papillary thyroid carcinoma-encoded protein; Protein H4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELT
NRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKI
QALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKK
LENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVS
APPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREE
NLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSP
SSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSP
DKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAHPSSQP
Target Bioclass
Other
Subcellular location
Cytoplasm
Uniprot ID
Q16204
Ensemble ID
ENST00000263102.7
HGNC ID
HGNC:18782

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBP2
 Probe Info  		2.07  LDD0323  [2]
ONAyne
 Probe Info  		K286(1.02)  LDD0274  [3]
STPyne
 Probe Info  		K148(6.56); K180(10.00); K234(10.00); K266(7.14)  LDD0277  [3]
Probe 1
 Probe Info  		Y80(14.86); Y290(31.52)  LDD3495  [4]
DBIA
 Probe Info  		C319(2.00)  LDD3407  [5]
DA-P3
 Probe Info  		6.37  LDD0179  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
IPM
 Probe Info  		C27(2.44)  LDD1701  [8]
Acrolein
 Probe Info  		N.A.  LDD0222  [9]
5E-2FA
 Probe Info  		H296(0.00); H375(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
VSF
 Probe Info  		N.A.  LDD0007  [13]
1d-yne
 Probe Info  		N.A.  LDD0357  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
HHS-465
 Probe Info  		K81(0.00); Y80(0.00)  LDD2240  [17]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		9.13  LDD1779  [18]
C158
 Probe Info  		9.45  LDD1838  [18]
C284
 Probe Info  		24.93  LDD1954  [18]
C296
 Probe Info  		14.22  LDD1966  [18]
C313
 Probe Info  		17.63  LDD1980  [18]
C314
 Probe Info  		11.55  LDD1981  [18]
C317
 Probe Info  		6.59  LDD1983  [18]
C338
 Probe Info  		11.63  LDD2001  [18]
C346
 Probe Info  		11.55  LDD2007  [18]
C348
 Probe Info  		11.39  LDD2009  [18]
C362
 Probe Info  		29.45  LDD2023  [18]
C364
 Probe Info  		15.67  LDD2025  [18]
C390
 Probe Info  		21.56  LDD2049  [18]
C391
 Probe Info  		17.39  LDD2050  [18]
C403
 Probe Info  		18.13  LDD2061  [18]
C407
 Probe Info  		15.24  LDD2064  [18]
FFF probe11
 Probe Info  		7.32  LDD0472  [19]
FFF probe12
 Probe Info  		20.00  LDD0473  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe2
 Probe Info  		20.00  LDD0463  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.00  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 111.68  LDD0185  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0192  Compound 35 HEK-293T 5.43  LDD0509  [19]
 LDCM0193  Compound 36 HEK-293T 7.75  LDD0511  [19]
 LDCM0028  Dobutamine HEK-293T 10.76  LDD0180  [6]
 LDCM0027  Dopamine HEK-293T 6.37  LDD0179  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C27(1.76)  LDD1702  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 90.26  LDD0183  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0022  KB02 786-O C319(0.99)  LDD2247  [5]
 LDCM0023  KB03 MDA-MB-231 C27(2.44)  LDD1701  [8]
 LDCM0024  KB05 RKO C319(2.00)  LDD3407  [5]
 LDCM0030  Luteolin HEK-293T 41.24  LDD0182  [6]
 LDCM0032  Oleacein HEK-293T 31.98  LDD0184  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 7 (MAPK7) CMGC Ser/Thr protein kinase family Q13164
Tripartite motif-containing protein 14 (TRIM14) TRIM/RBCC family Q14142
E3 ubiquitin-protein ligase LRSAM1 (LRSAM1) . Q6UWE0
F-box/WD repeat-containing protein 7 (FBXW7) . Q969H0
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
RalA-binding protein 1 (RALBP1) . Q15311
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) BZIP family Q9Y2D1
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
High mobility group protein 20A (HMG20A) . Q9NP66
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein Q (CENPQ) CENP-Q/OKP1 family Q7L2Z9
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
Cytohesin-4 (CYTH4) . Q9UIA0
Leucine zipper protein 4 (LUZP4) . Q9P127
snRNA-activating protein complex subunit 1 (SNAPC1) . Q16533
Vinexin (SORBS3) . O60504

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.