Details of the Probe

General Information of Probe

Probe ID
LDPC0266
Probe Name
FFF probe12
Synonyms
SCHEMBL20400125;AKOS034129677;Z3026367292
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 353.5
Lipid-water partition coefficient (xlogp) 1.9
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C20H27N5O
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]propanamide
Canonical SMILES
CN1CCN(CC1)CC2=CC=C(C=C2)NC(=O)CCC3(N=N3)CCC#C
InChI
InChI=1S/C20H27N5O/c1-3-4-10-20(22-23-20)11-9-19(26)21-18-7-5-17(6-8-18)16-25-14-12-24(2)13-15-25/h1,5-8H,4,9-16H2,2H3,(H,21,26)
InChIKey
CJJPDILNQHPZQV-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

143 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 7.07  LDD0473 
26S proteasome regulatory subunit 7 (PSMC2) LDTP03797 20.00  LDD0473 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 20.00  LDD0473 
Acid ceramidase (ASAH1) LDTP05905 20.00  LDD0473 
Adenine phosphoribosyltransferase (APRT) LDTP02220 19.45  LDD0473 
Adenosylhomocysteinase (AHCY) LDTP03242 5.39  LDD0473 
ADP-ribosylation factor 1 (ARF1) LDTP05192 5.06  LDD0473 
ADP-ribosylation factor 3 (ARF3) LDTP04907 5.06  LDD0473 
ADP-ribosylation factor 4 (ARF4) LDTP02942 5.33  LDD0473 
ADP-ribosylation factor 5 (ARF5) LDTP05193 8.09  LDD0473 
Alanine--tRNA ligase, cytoplasmic (AARS1) LDTP04262 5.37  LDD0473 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 6.12  LDD0474 
Alpha-adducin (ADD1) LDTP03770 17.75  LDD0473 
Alpha-galactosidase A (GLA) LDTP02141 20.00  LDD0473 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 20.00  LDD0473 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 13.86  LDD0473 
Aspartate--tRNA ligase, mitochondrial (DARS2) LDTP07581 14.70  LDD0473 
Atlastin-3 (ATL3) LDTP07362 20.00  LDD0473 
ATP-dependent DNA/RNA helicase DHX36 (DHX36) LDTP11841 20.00  LDD0473 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 20.00  LDD0473 
Beta-galactosidase (GLB1) LDTP02837 20.00  LDD0473 
Beta-glucuronidase (GUSB) LDTP02260 20.00  LDD0473 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 20.00  LDD0473 
Beta-hexosaminidase subunit beta (HEXB) LDTP02216 20.00  LDD0473 
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) LDTP02706 20.00  LDD0473 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 20.00  LDD0473 
Bleomycin hydrolase (BLMH) LDTP05992 18.54  LDD0473 
Calcyclin-binding protein (CACYBP) LDTP12163 5.33  LDD0473 
Calpain-2 catalytic subunit (CAPN2) LDTP02911 12.03  LDD0473 
Carboxypeptidase D (CPD) LDTP01372 20.00  LDD0473 
Casein kinase II subunit alpha' (CSNK2A2) LDTP03011 7.62  LDD0473 
Cathepsin B (CTSB) LDTP02223 20.00  LDD0473 
Cathepsin D (CTSD) LDTP02198 17.41  LDD0473 
Creatine kinase B-type (CKB) LDTP02616 6.01  LDD0473 
CTP synthase 1 (CTPS1) LDTP02922 6.16  LDD0473 
Cyclin-dependent kinase 2 (CDK2) LDTP03299 20.00  LDD0473 
Cystathionine gamma-lyase (CTH) LDTP03656 12.02  LDD0473 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 15.13  LDD0473 
Damage-control phosphatase ARMT1 (ARMT1) LDTP12085 6.59  LDD0473 
Delta(24)-sterol reductase (DHCR24) LDTP06375 20.00  LDD0487 
Deoxyribonuclease-2-alpha (DNASE2) LDTP00185 20.00  LDD0473 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 20.00  LDD0473 
E3 ubiquitin-protein ligase CHIP (STUB1) LDTP13655 16.02  LDD0473 
EH domain-containing protein 4 (EHD4) LDTP11788 10.97  LDD0473 
Electron transfer flavoprotein subunit beta (ETFB) LDTP03849 20.00  LDD0473 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 11.18  LDD0473 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 20.00  LDD0473 
Epididymis-specific alpha-mannosidase (MAN2B2) LDTP13853 20.00  LDD0473 
Exonuclease 1 (EXO1) LDTP13751 13.44  LDD0473 
Gamma-glutamyl hydrolase (GGH) LDTP09886 20.00  LDD0473 
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) LDTP02651 20.00  LDD0473 
Glucosidase 2 subunit beta (PRKCSH) LDTP02718 11.82  LDD0473 
Glutathione S-transferase kappa 1 (GSTK1) LDTP13900 20.00  LDD0473 
Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) LDTP17305 20.00  LDD0473 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 20.00  LDD0473 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 5.34  LDD0473 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 20.00  LDD0473 
Histone-lysine N-methyltransferase SMYD3 (SMYD3) LDTP12020 20.00  LDD0473 
Holocytochrome c-type synthase (HCCS) LDTP04581 5.35  LDD0473 
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) LDTP01782 5.00  LDD0473 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 18.93  LDD0487 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 5.77  LDD0473 
Legumain (LGMN) LDTP10888 20.00  LDD0473 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 20.00  LDD0473 
Lysine--tRNA ligase (KARS1) LDTP06294 8.07  LDD0473 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 15.46  LDD0473 
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) LDTP03858 14.24  LDD0473 
Lysosomal acid phosphatase (ACP2) LDTP02539 20.00  LDD0473 
Lysosomal alpha-glucosidase (GAA) LDTP02486 20.00  LDD0473 
Lysosomal alpha-mannosidase (MAN2B1) LDTP00338 20.00  LDD0473 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 20.00  LDD0487 
Lysosomal protective protein (CTSA) LDTP02505 18.35  LDD0473 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 20.00  LDD0473 
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) LDTP03677 20.00  LDD0473 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 20.00  LDD0473 
Myosin-10 (MYH10) LDTP03765 8.34  LDD0473 
Myosin-9 (MYH9) LDTP03764 7.25  LDD0473 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 20.00  LDD0473 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 20.00  LDD0473 
NAD kinase 2, mitochondrial (NADK2) LDTP06839 17.27  LDD0473 
NAD(P)H-hydrate epimerase (NAXE) LDTP09110 12.25  LDD0473 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 20.00  LDD0473 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 12.10  LDD0473 
NADH-cytochrome b5 reductase 3 (CYB5R3) LDTP01770 12.14  LDD0473 
Nardilysin (NRDC) LDTP00886 13.81  LDD0473 
Nucleotide triphosphate diphosphatase NUDT15 (NUDT15) LDTP12657 13.74  LDD0473 
Pachytene checkpoint protein 2 homolog (TRIP13) LDTP06432 9.62  LDD0473 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 20.00  LDD0473 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 6.91  LDD0473 
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) LDTP05372 20.00  LDD0487 
Peroxiredoxin-2 (PRDX2) LDTP03626 6.14  LDD0473 
Peroxiredoxin-4 (PRDX4) LDTP05773 8.80  LDD0473 
Phospholipase A2 group XV (PLA2G15) LDTP09088 20.00  LDD0473 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 20.00  LDD0473 
Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) LDTP05623 20.00  LDD0473 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 13.35  LDD0473 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 18.28  LDD0473 
Proliferation-associated protein 2G4 (PA2G4) LDTP13750 5.35  LDD0473 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 20.00  LDD0473 
Prolyl endopeptidase-like (PREPL) LDTP06849 14.38  LDD0473 
Prostaglandin reductase 2 (PTGR2) LDTP08979 20.00  LDD0487 
Proteasome subunit alpha type-2 (PSMA2) LDTP03331 6.58  LDD0473 
Proteasome subunit alpha type-3 (PSMA3) LDTP03332 5.96  LDD0473 
Proteasome subunit alpha type-6 (PSMA6) LDTP04884 7.87  LDD0473 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 6.45  LDD0473 
Proteasome subunit beta type-3 (PSMB3) LDTP04284 5.25  LDD0473 
Proteasome subunit beta type-4 (PSMB4) LDTP03417 7.73  LDD0473 
Proteasome subunit beta type-5 (PSMB5) LDTP03419 10.20  LDD0473 
Proteasome subunit beta type-7 (PSMB7) LDTP10862 14.26  LDD0473 
Protein disulfide-isomerase (P4HB) LDTP02188 7.90  LDD0473 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 12.22  LDD0473 
Protein O-GlcNAcase (OGA) LDTP00988 8.12  LDD0473 
Protein-glutamine gamma-glutamyltransferase E (TGM3) LDTP05548 20.00  LDD0474 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 12.64  LDD0473 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 20.00  LDD0473 
Ras-related protein Rab-5B (RAB5B) LDTP04893 7.12  LDD0473 
Ras-related protein Rab-7a (RAB7A) LDTP04399 5.04  LDD0473 
Ras-related protein Rab-9A (RAB9A) LDTP04400 5.34  LDD0473 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 20.00  LDD0473 
Rho-related GTP-binding protein RhoC (RHOC) LDTP02248 20.00  LDD0473 
Ribonuclease T2 (RNASET2) LDTP00316 20.00  LDD0473 
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) LDTP03592 20.00  LDD0473 
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) LDTP06384 12.29  LDD0473 
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) LDTP06363 20.00  LDD0473 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 5.66  LDD0474 
RuvB-like 2 (RUVBL2) LDTP13787 5.32  LDD0473 
Sialate O-acetylesterase (SIAE) LDTP12135 20.00  LDD0473 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 6.50  LDD0473 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 20.00  LDD0473 
Thioredoxin (TXN) LDTP02502 5.96  LDD0473 
Thioredoxin-like protein 1 (TXNL1) LDTP00758 16.14  LDD0473 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 20.00  LDD0473 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 20.00  LDD0473 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 6.81  LDD0473 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 6.88  LDD0473 
Tubulin alpha-8 chain (TUBA8) LDTP12810 6.35  LDD0473 
Tubulin--tyrosine ligase-like protein 12 (TTLL12) LDTP06067 5.65  LDD0473 
Tyrosine--tRNA ligase, cytoplasmic (YARS1) LDTP04617 6.12  LDD0473 
Ubiquitin carboxyl-terminal hydrolase 14 (USP14) LDTP04618 7.35  LDD0473 
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) LDTP02383 5.63  LDD0473 
Ubiquitin thioesterase OTUB1 (OTUB1) LDTP10318 12.70  LDD0473 
UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) LDTP12851 13.25  LDD0473 
V-type proton ATPase catalytic subunit A (ATP6V1A) LDTP03859 12.09  LDD0473 
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⏷ Show the Full List of 143 Enzyme
62 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 5.56  LDD0473 
14-3-3 protein theta (YWHAQ) LDTP03385 5.54  LDD0473 
14-3-3 protein zeta/delta (YWHAZ) LDTP05043 5.38  LDD0473 
45 kDa calcium-binding protein (SDF4) LDTP11116 20.00  LDD0473 
Amino acid transporter heavy chain SLC3A2 (SLC3A2) LDTP02256 11.16  LDD0473 
Amyloid-beta precursor protein (APP) LDTP02071 20.00  LDD0473 
Calnexin (CANX) LDTP03405 12.52  LDD0473 
Calreticulin (CALR) LDTP03402 13.57  LDD0473 
Cellular tumor antigen p53 (TP53) LDTP02048 6.36  LDD0473 
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) LDTP05510 12.15  LDD0473 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 20.00  LDD0473 
Desmoplakin (DSP) LDTP02815 20.00  LDD0474 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST) LDTP03870 6.08  LDD0487 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 5.50  LDD0487 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) LDTP02058 12.46  LDD0473 
EH domain-containing protein 1 (EHD1) LDTP11934 13.97  LDD0473 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 13.71  LDD0473 
Exocyst complex component 4 (EXOC4) LDTP10069 20.00  LDD0473 
Extended synaptotagmin-1 (ESYT1) LDTP11161 12.37  LDD0473 
Flotillin-1 (FLOT1) LDTP01366 20.00  LDD0473 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 5.64  LDD0473 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 12.56  LDD0473 
Hsp90 co-chaperone Cdc37 (CDC37) LDTP06549 12.06  LDD0473 
Hypoxia up-regulated protein 1 (HYOU1) LDTP14066 12.91  LDD0473 
Importin subunit beta-1 (KPNB1) LDTP06242 5.52  LDD0473 
Integral membrane protein 2B (ITM2B) LDTP13833 20.00  LDD0473 
Lysosome membrane protein 2 (SCARB2) LDTP06034 20.00  LDD0473 
Lysosome-associated membrane glycoprotein 2 (LAMP2) LDTP02655 20.00  LDD0473 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 5.57  LDD0473 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 7.06  LDD0473 
Metaxin-1 (MTX1) LDTP05900 5.04  LDD0473 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 20.00  LDD0487 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 20.00  LDD0473 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 20.00  LDD0473 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 20.00  LDD0473 
Neutral amino acid transporter B(0) (SLC1A5) LDTP06462 20.00  LDD0473 
NPC intracellular cholesterol transporter 2 (NPC2) LDTP04940 20.00  LDD0473 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 8.97  LDD0473 
Phosphatidylinositol transfer protein beta isoform (PITPNB) LDTP04213 6.55  LDD0473 
Prosaposin (PSAP) LDTP02215 20.00  LDD0473 
Protein ERGIC-53 (LMAN1) LDTP04237 20.00  LDD0473 
Protein SEC13 homolog (SEC13) LDTP04707 12.29  LDD0473 
Proton-activated chloride channel (PACC1) LDTP12042 17.88  LDD0473 
Reduced folate transporter (SLC19A1) LDTP03952 15.91  LDD0473 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 14.39  LDD0473 
Secretory carrier-associated membrane protein 3 (SCAMP3) LDTP00451 12.90  LDD0473 
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) LDTP10731 16.01  LDD0473 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 20.00  LDD0487 
Sortilin (SORT1) LDTP10885 20.00  LDD0473 
Sorting nexin-27 (SNX27) LDTP10533 12.52  LDD0473 
Surfeit locus protein 4 (SURF4) LDTP00592 11.34  LDD0473 
Syntenin-1 (SDCBP) LDTP00310 20.00  LDD0473 
Transferrin receptor protein 1 (TFRC) LDTP01969 18.84  LDD0473 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 6.83  LDD0473 
Transmembrane 9 superfamily member 4 (TM9SF4) LDTP09789 20.00  LDD0473 
Transmembrane emp24 domain-containing protein 10 (TMED10) LDTP04293 9.79  LDD0473 
Transmembrane protein 59 (TMEM59) LDTP11406 20.00  LDD0473 
Transmembrane protein 87A (TMEM87A) LDTP15481 20.00  LDD0473 
Ubiquilin-4 (UBQLN4) LDTP12533 12.22  LDD0473 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 13.06  LDD0473 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 19.59  LDD0487 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 7.23  LDD0487 
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⏷ Show the Full List of 62 Transporter and channel
4 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
FACT complex subunit SSRP1 (SSRP1) LDTP05577 5.31  LDD0473 
High mobility group protein B3 (HMGB3) LDTP00612 20.00  LDD0473 
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 5.75  LDD0473 
Splicing factor, proline- and glutamine-rich (SFPQ) LDTP03212 5.12  LDD0473 
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5 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 7.88  LDD0473 
Cell adhesion molecule 1 (CADM1) LDTP11441 15.59  LDD0473 
HLA class I histocompatibility antigen, A alpha chain (HLA-A) LDTP02040 20.00  LDD0473 
HLA class I histocompatibility antigen, C alpha chain (HLA-C) LDTP02491 17.64  LDD0473 
Junctional adhesion molecule A (F11R) LDTP14203 20.00  LDD0473 
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119 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein beta/alpha (YWHAB) LDTP03617 5.13  LDD0473 
14-3-3 protein eta (YWHAH) LDTP05442 5.27  LDD0473 
26S proteasome non-ATPase regulatory subunit 11 (PSMD11) LDTP00223 7.01  LDD0473 
A-kinase anchor protein 8-like (AKAP8L) LDTP13591 20.00  LDD0473 
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) LDTP03871 6.38  LDD0473 
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) LDTP09843 6.30  LDD0473 
Acidic leucine-rich nuclear phosphoprotein 32 family member E (ANP32E) LDTP11207 12.10  LDD0473 
Alpha-2-macroglobulin (A2M) LDTP01814 20.00  LDD0473 
Alpha-actinin-1 (ACTN1) LDTP02631 6.74  LDD0473 
Alpha-actinin-4 (ACTN4) LDTP00843 6.52  LDD0473 
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 20.00  LDD0473 
Angio-associated migratory cell protein (AAMP) LDTP05966 20.00  LDD0473 
Annexin A7 (ANXA7) LDTP03030 5.67  LDD0473 
Beta-actin-like protein 2 (ACTBL2) LDTP14951 6.45  LDD0473 
BTB/POZ domain-containing protein KCTD12 (KCTD12) LDTP15705 8.27  LDD0473 
Calpain small subunit 1 (CAPNS1) LDTP02047 8.22  LDD0473 
Calumenin (CALU) LDTP00887 18.68  LDD0473 
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) LDTP02511 20.00  LDD0473 
cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A) LDTP02697 5.45  LDD0473 
Centrosomal protein 43 (CEP43) LDTP01652 8.82  LDD0473 
Coatomer subunit beta (COPB1) LDTP04570 12.23  LDD0473 
Coiled-coil domain-containing protein 6 (CCDC6) LDTP06515 20.00  LDD0473 
Desmocollin-1 (DSC1) LDTP05567 20.00  LDD0474 
Desmoglein-1 (DSG1) LDTP05353 20.00  LDD0474 
DNA fragmentation factor subunit alpha (DFFA) LDTP00239 13.63  LDD0473 
Drebrin (DBN1) LDTP06588 20.00  LDD0473 
Dynactin subunit 2 (DCTN2) LDTP05922 12.06  LDD0473 
Elongation factor 1-beta (EEF1B2) LDTP03283 5.82  LDD0473 
Endoplasmic reticulum resident protein 29 (ERP29) LDTP03509 12.06  LDD0473 
Endoplasmin (HSP90B1) LDTP02734 12.51  LDD0473 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 20.00  LDD0473 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 16.15  LDD0473 
Eukaryotic translation initiation factor 4B (EIF4B) LDTP03247 12.21  LDD0473 
Eukaryotic translation initiation factor 4H (EIF4H) LDTP06301 20.00  LDD0473 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 13.53  LDD0473 
Eukaryotic translation initiation factor 6 (EIF6) LDTP04743 5.48  LDD0473 
Galectin-3-binding protein (LGALS3BP) LDTP05558 20.00  LDD0473 
Ganglioside GM2 activator (GM2A) LDTP02927 20.00  LDD0473 
Golgi apparatus protein 1 (GLG1) LDTP09920 20.00  LDD0473 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 20.00  LDD0473 
Golgi membrane protein 1 (GOLM1) LDTP09054 20.00  LDD0473 
Growth factor receptor-bound protein 2 (GRB2) LDTP05035 9.27  LDD0473 
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) LDTP02306 12.31  LDD0473 
Heat shock protein beta-1 (HSPB1) LDTP02053 20.00  LDD0473 
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) LDTP04495 5.12  LDD0473 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 7.06  LDD0473 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 5.61  LDD0473 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 6.85  LDD0473 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 6.26  LDD0473 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 5.52  LDD0473 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 7.60  LDD0473 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 6.30  LDD0473 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 6.08  LDD0473 
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) LDTP02227 7.28  LDD0473 
Histone H1.3 (H1-3) LDTP02844 6.26  LDD0473 
Hornerin (HRNR) LDTP08425 20.00  LDD0473 
Hsc70-interacting protein (ST13) LDTP04367 6.20  LDD0473 
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) LDTP12904 5.53  LDD0473 
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) LDTP14272 9.75  LDD0473 
Junction plakoglobin (JUP) LDTP02756 8.54  LDD0473 
Keratinocyte proline-rich protein (KPRP) LDTP07136 20.00  LDD0473 
KIF-binding protein (KIFBP) LDTP10263 14.00  LDD0473 
Lamin-B2 (LMNB2) LDTP05400 12.01  LDD0473 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 5.54  LDD0473 
Large ribosomal subunit protein uL23 (RPL23A) LDTP05001 5.10  LDD0473 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 5.26  LDD0473 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 20.00  LDD0473 
Microtubule-associated protein 1B (MAP1B) LDTP04112 20.00  LDD0473 
Microtubule-associated protein 4 (MAP4) LDTP03404 5.17  LDD0473 
Microtubule-associated protein RP/EB family member 1 (MAPRE1) LDTP06444 7.65  LDD0473 
Myosin light polypeptide 6 (MYL6) LDTP04875 6.18  LDD0473 
Myosin regulatory light chain 12B (MYL12B) LDTP00487 8.95  LDD0473 
Neudesin (NENF) LDTP13630 12.25  LDD0473 
Neuferricin (CYB5D2) LDTP15623 20.00  LDD0473 
Nicastrin (NCSTN) LDTP09787 14.41  LDD0473 
Nucleobindin-1 (NUCB1) LDTP05375 16.52  LDD0473 
Nucleobindin-2 (NUCB2) LDTP05160 13.46  LDD0473 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 20.00  LDD0473 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 20.00  LDD0473 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 5.03  LDD0473 
Plectin (PLEC) LDTP06330 20.00  LDD0474 
Pregnancy zone protein (PZP) LDTP03071 20.00  LDD0473 
Prelamin-A/C (LMNA) LDTP01932 10.87  LDD0473 
Protein FAM3C (FAM3C) LDTP09773 6.41  LDD0473 
Protein SET (SET) LDTP05277 10.31  LDD0473 
Rab9 effector protein with kelch motifs (RABEPK) LDTP08130 20.00  LDD0473 
Ragulator complex protein LAMTOR1 (LAMTOR1) LDTP07401 9.71  LDD0473 
Reticulocalbin-1 (RCN1) LDTP06352 12.88  LDD0473 
Reticulocalbin-2 (RCN2) LDTP06097 15.50  LDD0473 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 5.79  LDD0473 
RNA-binding protein 14 (RBM14) LDTP10684 5.67  LDD0473 
RNA-binding protein FUS (FUS) LDTP03775 6.42  LDD0473 
Serine/arginine-rich splicing factor 10 (SRSF10) LDTP01239 5.53  LDD0473 
Serine/arginine-rich splicing factor 3 (SRSF3) LDTP05197 5.52  LDD0473 
Serine/arginine-rich splicing factor 7 (SRSF7) LDTP06583 6.25  LDD0473 
Serpin B3 (SERPINB3) LDTP03493 20.00  LDD0474 
Serpin B6 (SERPINB6) LDTP03719 12.50  LDD0473 
Serpin H1 (SERPINH1) LDTP04363 12.02  LDD0473 
Small ribosomal subunit protein eS1 (RPS3A) LDTP04913 5.16  LDD0473 
Small ribosomal subunit protein mS31 (MRPS31) LDTP09836 20.00  LDD0473 
Splicing factor 3B subunit 1 (SF3B1) LDTP01251 6.28  LDD0473 
Splicing factor 3B subunit 2 (SF3B2) LDTP05870 5.27  LDD0473 
Stathmin (STMN1) LDTP02869 16.04  LDD0473 
Synapse-associated protein 1 (SYAP1) LDTP10062 16.77  LDD0473 
Syntaxin-12 (STX12) LDTP08389 13.85  LDD0473 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 5.61  LDD0473 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 5.47  LDD0473 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 6.65  LDD0473 
Tetraspanin-6 (TSPAN6) LDTP14458 20.00  LDD0473 
Transcription elongation factor SPT5 (SUPT5H) LDTP00236 12.02  LDD0473 
Translationally-controlled tumor protein (TPT1) LDTP02683 5.24  LDD0473 
Tropomyosin alpha-3 chain (TPM3) LDTP02165 15.51  LDD0473 
Tropomyosin alpha-4 chain (TPM4) LDTP05068 14.41  LDD0473 
Tubulin beta chain (TUBB) LDTP02205 8.06  LDD0473 
Tubulin beta-4B chain (TUBB4B) LDTP05076 7.86  LDD0473 
Ubiquilin-1 (UBQLN1) LDTP13626 12.37  LDD0473 
Uncharacterized protein KIAA2013 (KIAA2013) LDTP17652 20.00  LDD0473 
Vesicle-associated membrane protein 7 (VAMP7) LDTP04468 17.29  LDD0473 
Vimentin (VIM) LDTP02297 11.28  LDD0473 
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⏷ Show the Full List of 119 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:200uM; negative probe:200uM
Quantitative Method
SILAC
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD0473 
Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:200uM; negative probe:200uM
Quantitative Method
SILAC
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Chronic myeloid leukemia [ICD-11:2A20]
Model Name
Human chronic myeloid leukemia cells (K562)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD0474 
Download The Altas
  
Experiment 3 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:20uM; negative probe:20uM
Quantitative Method
SILAC
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD0487 
Download The Altas

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.