Details of the Target

General Information of Target

Target ID LDTP03849
Target Name Electron transfer flavoprotein subunit beta (ETFB)
Gene Name ETFB
Gene ID 2109
Synonyms
Electron transfer flavoprotein subunit beta; Beta-ETF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELRVLVAVKRVIDYAVKIRVKPDRTGVVTDGVKHSMNPFCEIAVEEAVRLKEKKLVKE
VIAVSCGPAQCQETIRTALAMGADRGIHVEVPPAEAERLGPLQVARVLAKLAEKEKVDLV
LLGKQAIDDDCNQTGQMTAGFLDWPQGTFASQVTLEGDKLKVEREIDGGLETLRLKLPAV
VTADLRLNEPRYATLPNIMKAKKKKIEVIKPGDLGVDLTSKLSVISVEDPPQRTAGVKVE
TTEDLVAKLKEIGRI
Target Bioclass
Enzyme
Family
ETF beta-subunit/FixA family
Subcellular location
Mitochondrion matrix
Function
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.
Uniprot ID
P38117
Ensemble ID
ENST00000309244.9
HGNC ID
HGNC:3482
ChEMBL ID
CHEMBL4105744

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K159N DBIA    Probe Info 
HEC1 SNV: p.G100S .
HEPG2 SNV: p.V208M NAIA_5    Probe Info 
HT3 SNV: p.T31K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.86  LDD0402  [2]
TH211
 Probe Info  		Y192(16.44)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K11(6.05); K110(10.00)  LDD0277  [5]
Probe 1
 Probe Info  		Y16(181.03); Y192(20.00)  LDD3495  [6]
BTD
 Probe Info  		C42(0.87)  LDD2098  [7]
MCL-2
 Probe Info  		1.50  LDD0048  [8]
EA-probe
 Probe Info  		C42(1.04); C42(0.93)  LDD2210  [9]
DBIA
 Probe Info  		C42(8.66)  LDD0204  [10]
ATP probe
 Probe Info  		K205(0.00); K116(0.00); K200(0.00); K202(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C42(0.00); C131(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C42(0.00); C66(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C71(0.00); C66(0.00); C42(0.00); C131(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
IPM
 Probe Info  		C71(0.00); C42(0.00)  LDD0025  [15]
JW-RF-010
 Probe Info  		C71(0.00); C66(0.00); C42(0.00)  LDD0026  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
TFBX
 Probe Info  		C66(0.00); C71(0.00); C42(0.00)  LDD0027  [15]
NHS
 Probe Info  		K19(0.00); K210(0.00); K248(0.00); K205(0.00)  LDD0010  [17]
PPMS
 Probe Info  		N.A.  LDD0008  [17]
SF
 Probe Info  		K19(0.00); Y16(0.00); Y192(0.00); K110(0.00)  LDD0028  [18]
Phosphinate-6
 Probe Info  		C42(0.00); C71(0.00)  LDD0018  [19]
1c-yne
 Probe Info  		K210(0.00); K221(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C66(0.00); C42(0.00); C71(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		C71(0.00); C66(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		C66(0.00); C71(0.00); C42(0.00)  LDD0218  [21]
W1
 Probe Info  		C66(0.00); C71(0.00)  LDD0236  [22]
AOyne
 Probe Info  		15.00  LDD0443  [23]
MPP-AC
 Probe Info  		N.A.  LDD0428  [24]
NAIA_5
 Probe Info  		C71(0.00); C42(0.00)  LDD2223  [16]
TER-AC
 Probe Info  		N.A.  LDD0426  [24]
TPP-AC
 Probe Info  		N.A.  LDD0427  [24]
HHS-465
 Probe Info  		N.A.  LDD2240  [25]
HHS-482
 Probe Info  		Y192(0.63)  LDD2239  [26]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C232
 Probe Info  		60.97  LDD1905  [27]
C274
 Probe Info  		23.26  LDD1944  [27]
FFF probe12
 Probe Info  		20.00  LDD0473  [28]
FFF probe3
 Probe Info  		12.47  LDD0464  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
DA-2
 Probe Info  		N.A.  LDD0070  [30]
STS-1
 Probe Info  		N.A.  LDD0068  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C42(0.50)  LDD2142  [7]
 LDCM0214  AC1 HEK-293T C42(1.07); C71(0.98)  LDD1507  [32]
 LDCM0215  AC10 HEK-293T C42(1.09); C71(0.99)  LDD1508  [32]
 LDCM0226  AC11 HEK-293T C42(1.11); C71(1.06)  LDD1509  [32]
 LDCM0237  AC12 HEK-293T C42(1.08); C71(1.03)  LDD1510  [32]
 LDCM0259  AC14 HEK-293T C42(1.05); C71(1.06)  LDD1512  [32]
 LDCM0270  AC15 HEK-293T C42(1.03); C71(0.99)  LDD1513  [32]
 LDCM0276  AC17 HEK-293T C42(1.07); C71(0.98)  LDD1515  [32]
 LDCM0277  AC18 HEK-293T C42(1.06); C71(0.98)  LDD1516  [32]
 LDCM0278  AC19 HEK-293T C42(1.02); C71(0.89)  LDD1517  [32]
 LDCM0279  AC2 HEK-293T C42(1.03); C71(0.92)  LDD1518  [32]
 LDCM0280  AC20 HEK-293T C42(1.02); C71(1.02)  LDD1519  [32]
 LDCM0281  AC21 HEK-293T C42(1.10); C71(1.02); C66(1.09)  LDD1520  [32]
 LDCM0282  AC22 HEK-293T C42(1.10); C71(0.96)  LDD1521  [32]
 LDCM0283  AC23 HEK-293T C42(0.95); C71(0.93)  LDD1522  [32]
 LDCM0284  AC24 HEK-293T C42(0.96); C71(0.99)  LDD1523  [32]
 LDCM0285  AC25 HEK-293T C42(1.10); C71(0.95)  LDD1524  [32]
 LDCM0286  AC26 HEK-293T C42(1.09); C71(0.90)  LDD1525  [32]
 LDCM0287  AC27 HEK-293T C42(1.06); C71(1.04)  LDD1526  [32]
 LDCM0288  AC28 HEK-293T C42(1.07); C71(1.00)  LDD1527  [32]
 LDCM0289  AC29 HEK-293T C42(1.10); C71(0.96); C66(1.12)  LDD1528  [32]
 LDCM0290  AC3 HEK-293T C42(1.04); C71(1.10)  LDD1529  [32]
 LDCM0291  AC30 HEK-293T C42(1.02); C71(0.98)  LDD1530  [32]
 LDCM0292  AC31 HEK-293T C42(1.04); C71(1.05)  LDD1531  [32]
 LDCM0293  AC32 HEK-293T C42(1.03); C71(0.98)  LDD1532  [32]
 LDCM0294  AC33 HEK-293T C42(1.11); C71(1.04)  LDD1533  [32]
 LDCM0295  AC34 HEK-293T C42(1.07); C71(1.01)  LDD1534  [32]
 LDCM0296  AC35 HEK-293T C42(1.05); C71(1.06)  LDD1535  [32]
 LDCM0297  AC36 HEK-293T C42(1.13); C71(0.98)  LDD1536  [32]
 LDCM0298  AC37 HEK-293T C42(1.08); C71(1.02); C66(1.11)  LDD1537  [32]
 LDCM0299  AC38 HEK-293T C42(1.00); C71(1.05)  LDD1538  [32]
 LDCM0300  AC39 HEK-293T C42(1.04); C71(1.00)  LDD1539  [32]
 LDCM0301  AC4 HEK-293T C42(1.06); C71(1.00)  LDD1540  [32]
 LDCM0302  AC40 HEK-293T C42(1.11); C71(0.98)  LDD1541  [32]
 LDCM0303  AC41 HEK-293T C42(1.00); C71(1.05)  LDD1542  [32]
 LDCM0304  AC42 HEK-293T C42(1.07); C71(1.00)  LDD1543  [32]
 LDCM0305  AC43 HEK-293T C42(1.04); C71(1.08)  LDD1544  [32]
 LDCM0306  AC44 HEK-293T C42(1.09); C71(1.04)  LDD1545  [32]
 LDCM0307  AC45 HEK-293T C42(1.13); C71(1.06); C66(0.98)  LDD1546  [32]
 LDCM0308  AC46 HEK-293T C42(1.03); C71(0.96)  LDD1547  [32]
 LDCM0309  AC47 HEK-293T C42(1.05); C71(1.04)  LDD1548  [32]
 LDCM0310  AC48 HEK-293T C42(1.00); C71(1.01)  LDD1549  [32]
 LDCM0311  AC49 HEK-293T C42(1.06); C71(1.03)  LDD1550  [32]
 LDCM0312  AC5 HEK-293T C42(1.11); C71(1.05); C66(1.00)  LDD1551  [32]
 LDCM0313  AC50 HEK-293T C42(1.05); C71(1.01)  LDD1552  [32]
 LDCM0314  AC51 HEK-293T C42(0.98); C71(1.07)  LDD1553  [32]
 LDCM0315  AC52 HEK-293T C42(1.10); C71(1.04)  LDD1554  [32]
 LDCM0316  AC53 HEK-293T C42(1.05); C71(0.92); C66(0.99)  LDD1555  [32]
 LDCM0317  AC54 HEK-293T C42(1.09); C71(0.99)  LDD1556  [32]
 LDCM0318  AC55 HEK-293T C42(1.01); C71(1.02)  LDD1557  [32]
 LDCM0319  AC56 HEK-293T C42(1.06); C71(1.06)  LDD1558  [32]
 LDCM0320  AC57 HEK-293T C42(0.97); C71(0.94)  LDD1559  [32]
 LDCM0321  AC58 HEK-293T C42(1.08); C71(0.88)  LDD1560  [32]
 LDCM0322  AC59 HEK-293T C42(1.10); C71(1.11)  LDD1561  [32]
 LDCM0323  AC6 HEK-293T C42(1.09); C71(0.94)  LDD1562  [32]
 LDCM0324  AC60 HEK-293T C42(1.02); C71(1.02)  LDD1563  [32]
 LDCM0325  AC61 HEK-293T C42(1.20); C71(1.07); C66(1.09)  LDD1564  [32]
 LDCM0326  AC62 HEK-293T C42(1.08); C71(1.00)  LDD1565  [32]
 LDCM0327  AC63 HEK-293T C42(1.13); C71(0.96)  LDD1566  [32]
 LDCM0328  AC64 HEK-293T C42(0.97); C71(0.96)  LDD1567  [32]
 LDCM0334  AC7 HEK-293T C42(1.02); C71(0.94)  LDD1568  [32]
 LDCM0345  AC8 HEK-293T C42(1.09); C71(0.91)  LDD1569  [32]
 LDCM0248  AKOS034007472 HEK-293T C42(1.04); C71(1.00); C66(1.13)  LDD1511  [32]
 LDCM0356  AKOS034007680 HEK-293T C42(1.04); C71(0.96)  LDD1570  [32]
 LDCM0275  AKOS034007705 HEK-293T C42(1.04); C71(1.00)  LDD1514  [32]
 LDCM0156  Aniline NCI-H1299 11.58  LDD0403  [2]
 LDCM0102  BDHI 8 Jurkat C42(8.66)  LDD0204  [10]
 LDCM0630  CCW28-3 231MFP C42(1.06)  LDD2214  [33]
 LDCM0108  Chloroacetamide HeLa C42(0.00); C66(0.00); C71(0.00); H36(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C42(20.00)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C42(1.52); C71(0.94)  LDD1571  [32]
 LDCM0368  CL10 HEK-293T C42(1.14); C71(1.54)  LDD1572  [32]
 LDCM0369  CL100 HEK-293T C42(1.03); C71(1.01)  LDD1573  [32]
 LDCM0370  CL101 HEK-293T C42(1.07); C71(1.08)  LDD1574  [32]
 LDCM0371  CL102 HEK-293T C42(1.09); C71(0.99); C66(1.07)  LDD1575  [32]
 LDCM0372  CL103 HEK-293T C42(1.08); C71(0.98); C66(0.92)  LDD1576  [32]
 LDCM0373  CL104 HEK-293T C42(1.03); C71(1.17)  LDD1577  [32]
 LDCM0374  CL105 HEK-293T C42(1.12); C71(1.09)  LDD1578  [32]
 LDCM0375  CL106 HEK-293T C42(1.05); C71(1.05); C66(1.08)  LDD1579  [32]
 LDCM0376  CL107 HEK-293T C42(1.13); C71(1.01); C66(0.85)  LDD1580  [32]
 LDCM0377  CL108 HEK-293T C42(1.21); C71(1.03)  LDD1581  [32]
 LDCM0378  CL109 HEK-293T C42(1.01); C71(1.03)  LDD1582  [32]
 LDCM0379  CL11 HEK-293T C42(1.45); C71(1.36)  LDD1583  [32]
 LDCM0380  CL110 HEK-293T C42(1.05); C71(1.07); C66(1.19)  LDD1584  [32]
 LDCM0381  CL111 HEK-293T C42(1.09); C71(1.16); C66(0.90)  LDD1585  [32]
 LDCM0382  CL112 HEK-293T C42(1.06); C71(1.10)  LDD1586  [32]
 LDCM0383  CL113 HEK-293T C42(1.09); C71(0.99)  LDD1587  [32]
 LDCM0384  CL114 HEK-293T C42(1.05); C71(1.04); C66(1.05)  LDD1588  [32]
 LDCM0385  CL115 HEK-293T C42(1.33); C71(1.07); C66(0.89)  LDD1589  [32]
 LDCM0386  CL116 HEK-293T C42(1.04); C71(1.02)  LDD1590  [32]
 LDCM0387  CL117 HEK-293T C42(1.16); C71(1.01)  LDD1591  [32]
 LDCM0388  CL118 HEK-293T C42(1.07); C71(1.09); C66(0.97)  LDD1592  [32]
 LDCM0389  CL119 HEK-293T C42(1.18); C71(1.00); C66(0.89)  LDD1593  [32]
 LDCM0390  CL12 HEK-293T C42(1.12); C71(1.14)  LDD1594  [32]
 LDCM0391  CL120 HEK-293T C42(1.06); C71(1.03)  LDD1595  [32]
 LDCM0392  CL121 HEK-293T C42(1.09); C71(1.04)  LDD1596  [32]
 LDCM0393  CL122 HEK-293T C42(1.05); C71(1.04); C66(0.95)  LDD1597  [32]
 LDCM0394  CL123 HEK-293T C42(1.33); C71(1.01); C66(0.98)  LDD1598  [32]
 LDCM0395  CL124 HEK-293T C42(1.05); C71(1.07)  LDD1599  [32]
 LDCM0396  CL125 HEK-293T C42(1.12); C71(0.92)  LDD1600  [32]
 LDCM0397  CL126 HEK-293T C42(1.13); C71(1.07); C66(1.19)  LDD1601  [32]
 LDCM0398  CL127 HEK-293T C42(1.05); C71(0.91); C66(0.95)  LDD1602  [32]
 LDCM0399  CL128 HEK-293T C42(1.07); C71(1.00)  LDD1603  [32]
 LDCM0400  CL13 HEK-293T C42(1.12); C71(1.64)  LDD1604  [32]
 LDCM0401  CL14 HEK-293T C42(1.10); C71(1.17); C66(1.26)  LDD1605  [32]
 LDCM0402  CL15 HEK-293T C42(1.09); C71(0.89); C66(0.89)  LDD1606  [32]
 LDCM0403  CL16 HEK-293T C42(1.04); C71(1.08)  LDD1607  [32]
 LDCM0404  CL17 HEK-293T C42(1.10); C71(0.97)  LDD1608  [32]
 LDCM0405  CL18 HEK-293T C42(1.11); C71(1.05)  LDD1609  [32]
 LDCM0406  CL19 HEK-293T C42(1.16); C71(1.09)  LDD1610  [32]
 LDCM0407  CL2 HEK-293T C42(1.11); C71(1.15); C66(1.13)  LDD1611  [32]
 LDCM0408  CL20 HEK-293T C42(1.14); C71(1.20)  LDD1612  [32]
 LDCM0409  CL21 HEK-293T C42(1.16); C71(1.63); C66(1.08)  LDD1613  [32]
 LDCM0410  CL22 HEK-293T C42(1.21); C71(1.17)  LDD1614  [32]
 LDCM0411  CL23 HEK-293T C42(1.12); C71(1.05)  LDD1615  [32]
 LDCM0412  CL24 HEK-293T C42(1.26); C71(1.07)  LDD1616  [32]
 LDCM0413  CL25 HEK-293T C42(1.02); C71(0.89)  LDD1617  [32]
 LDCM0414  CL26 HEK-293T C42(1.08); C71(1.04); C66(1.18)  LDD1618  [32]
 LDCM0415  CL27 HEK-293T C42(1.18); C71(0.94); C66(0.88)  LDD1619  [32]
 LDCM0416  CL28 HEK-293T C42(1.30); C71(1.14)  LDD1620  [32]
 LDCM0417  CL29 HEK-293T C42(1.07); C71(1.02)  LDD1621  [32]
 LDCM0418  CL3 HEK-293T C42(1.56); C71(0.98); C66(1.07)  LDD1622  [32]
 LDCM0419  CL30 HEK-293T C42(1.11); C71(1.05)  LDD1623  [32]
 LDCM0420  CL31 HEK-293T C42(1.21); C71(1.13)  LDD1624  [32]
 LDCM0421  CL32 HEK-293T C42(1.26); C71(1.01)  LDD1625  [32]
 LDCM0422  CL33 HEK-293T C42(1.65); C71(1.06); C66(1.20)  LDD1626  [32]
 LDCM0423  CL34 HEK-293T C42(1.24); C71(2.77)  LDD1627  [32]
 LDCM0424  CL35 HEK-293T C42(1.10); C71(1.09)  LDD1628  [32]
 LDCM0425  CL36 HEK-293T C42(1.11); C71(1.13)  LDD1629  [32]
 LDCM0426  CL37 HEK-293T C42(1.06); C71(0.86)  LDD1630  [32]
 LDCM0428  CL39 HEK-293T C42(1.20); C71(1.16); C66(0.88)  LDD1632  [32]
 LDCM0429  CL4 HEK-293T C42(1.18); C71(1.10)  LDD1633  [32]
 LDCM0430  CL40 HEK-293T C42(1.10); C71(1.03)  LDD1634  [32]
 LDCM0431  CL41 HEK-293T C42(0.99); C71(1.32)  LDD1635  [32]
 LDCM0432  CL42 HEK-293T C42(1.06); C71(1.09)  LDD1636  [32]
 LDCM0433  CL43 HEK-293T C42(1.21); C71(1.05)  LDD1637  [32]
 LDCM0434  CL44 HEK-293T C42(1.10); C71(1.09)  LDD1638  [32]
 LDCM0435  CL45 HEK-293T C42(1.12); C71(2.07); C66(1.19)  LDD1639  [32]
 LDCM0436  CL46 HEK-293T C42(1.39); C71(1.13)  LDD1640  [32]
 LDCM0437  CL47 HEK-293T C42(1.14); C71(1.05)  LDD1641  [32]
 LDCM0438  CL48 HEK-293T C42(1.13); C71(1.11)  LDD1642  [32]
 LDCM0439  CL49 HEK-293T C42(1.24); C71(0.86)  LDD1643  [32]
 LDCM0440  CL5 HEK-293T C42(1.09); C71(0.95)  LDD1644  [32]
 LDCM0441  CL50 HEK-293T C42(0.75); C71(1.11); C66(1.04)  LDD1645  [32]
 LDCM0443  CL52 HEK-293T C42(1.12); C71(1.14)  LDD1646  [32]
 LDCM0444  CL53 HEK-293T C42(1.03); C71(1.20)  LDD1647  [32]
 LDCM0445  CL54 HEK-293T C42(1.43); C71(0.94)  LDD1648  [32]
 LDCM0446  CL55 HEK-293T C42(1.13); C71(1.15)  LDD1649  [32]
 LDCM0447  CL56 HEK-293T C42(1.31); C71(1.23)  LDD1650  [32]
 LDCM0448  CL57 HEK-293T C42(1.09); C71(1.52); C66(1.22)  LDD1651  [32]
 LDCM0449  CL58 HEK-293T C42(1.28); C71(2.99)  LDD1652  [32]
 LDCM0450  CL59 HEK-293T C42(1.18); C71(1.09)  LDD1653  [32]
 LDCM0451  CL6 HEK-293T C42(0.98); C71(1.11)  LDD1654  [32]
 LDCM0452  CL60 HEK-293T C42(1.11); C71(1.18)  LDD1655  [32]
 LDCM0453  CL61 HEK-293T C42(1.07); C71(0.90)  LDD1656  [32]
 LDCM0454  CL62 HEK-293T C42(1.12); C71(1.04); C66(1.02)  LDD1657  [32]
 LDCM0455  CL63 HEK-293T C42(1.10); C71(1.10); C66(1.00)  LDD1658  [32]
 LDCM0456  CL64 HEK-293T C42(1.06); C71(1.01)  LDD1659  [32]
 LDCM0457  CL65 HEK-293T C42(1.11); C71(1.08)  LDD1660  [32]
 LDCM0458  CL66 HEK-293T C42(2.01); C71(1.17)  LDD1661  [32]
 LDCM0459  CL67 HEK-293T C42(1.08); C71(1.16)  LDD1662  [32]
 LDCM0460  CL68 HEK-293T C42(1.43); C71(1.39)  LDD1663  [32]
 LDCM0461  CL69 HEK-293T C42(1.23); C71(1.05); C66(1.10)  LDD1664  [32]
 LDCM0462  CL7 HEK-293T C42(1.12); C71(1.07)  LDD1665  [32]
 LDCM0463  CL70 HEK-293T C42(1.09); C71(1.00)  LDD1666  [32]
 LDCM0464  CL71 HEK-293T C42(1.02); C71(1.11)  LDD1667  [32]
 LDCM0465  CL72 HEK-293T C42(1.09); C71(1.12)  LDD1668  [32]
 LDCM0466  CL73 HEK-293T C42(1.09); C71(0.97)  LDD1669  [32]
 LDCM0467  CL74 HEK-293T C42(1.07); C71(1.11); C66(0.90)  LDD1670  [32]
 LDCM0469  CL76 HEK-293T C42(1.06); C71(1.08)  LDD1672  [32]
 LDCM0470  CL77 HEK-293T C42(1.03); C71(0.99)  LDD1673  [32]
 LDCM0471  CL78 HEK-293T C42(1.11); C71(1.03)  LDD1674  [32]
 LDCM0472  CL79 HEK-293T C42(1.13); C71(1.14)  LDD1675  [32]
 LDCM0473  CL8 HEK-293T C42(0.99); C71(1.46)  LDD1676  [32]
 LDCM0474  CL80 HEK-293T C42(1.18); C71(1.13)  LDD1677  [32]
 LDCM0475  CL81 HEK-293T C42(1.26); C71(1.07); C66(1.00)  LDD1678  [32]
 LDCM0476  CL82 HEK-293T C42(1.09); C71(1.09)  LDD1679  [32]
 LDCM0477  CL83 HEK-293T C42(1.30); C71(1.07)  LDD1680  [32]
 LDCM0478  CL84 HEK-293T C42(1.16); C71(1.23)  LDD1681  [32]
 LDCM0479  CL85 HEK-293T C42(1.21); C71(0.86)  LDD1682  [32]
 LDCM0480  CL86 HEK-293T C42(1.13); C71(1.11); C66(1.16)  LDD1683  [32]
 LDCM0481  CL87 HEK-293T C42(1.27); C71(1.39); C66(0.90)  LDD1684  [32]
 LDCM0482  CL88 HEK-293T C42(1.06); C71(1.07)  LDD1685  [32]
 LDCM0483  CL89 HEK-293T C42(1.07); C71(0.98)  LDD1686  [32]
 LDCM0484  CL9 HEK-293T C42(1.52); C71(0.99); C66(1.24)  LDD1687  [32]
 LDCM0485  CL90 HEK-293T C42(1.46); C71(0.79)  LDD1688  [32]
 LDCM0486  CL91 HEK-293T C42(1.22); C71(1.31)  LDD1689  [32]
 LDCM0487  CL92 HEK-293T C42(1.46); C71(1.45)  LDD1690  [32]
 LDCM0488  CL93 HEK-293T C42(1.56); C71(1.19); C66(1.20)  LDD1691  [32]
 LDCM0489  CL94 HEK-293T C42(1.20); C71(1.25)  LDD1692  [32]
 LDCM0490  CL95 HEK-293T C42(0.87); C71(1.27)  LDD1693  [32]
 LDCM0491  CL96 HEK-293T C42(1.11); C71(1.17)  LDD1694  [32]
 LDCM0492  CL97 HEK-293T C42(1.05); C71(1.04)  LDD1695  [32]
 LDCM0493  CL98 HEK-293T C42(1.24); C71(1.13); C66(1.37)  LDD1696  [32]
 LDCM0494  CL99 HEK-293T C42(1.23); C71(1.75); C66(0.93)  LDD1697  [32]
 LDCM0495  E2913 HEK-293T C42(1.54); C71(1.17); C66(0.99)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C42(1.18)  LDD1702  [7]
 LDCM0175  Ethacrynic acid HeLa C42(1.04); C42(0.93)  LDD2210  [9]
 LDCM0625  F8 Ramos 0.87; C42(1.64)  LDD2187  [34]
 LDCM0572  Fragment10 Ramos 0.76; C42(0.63)  LDD2189  [34]
 LDCM0573  Fragment11 Ramos 0.37; C42(0.05)  LDD2190  [34]
 LDCM0574  Fragment12 Ramos 0.61; C42(0.64)  LDD2191  [34]
 LDCM0575  Fragment13 Ramos 1.01; C42(0.55)  LDD2192  [34]
 LDCM0576  Fragment14 Ramos 0.80; C42(0.60)  LDD2193  [34]
 LDCM0579  Fragment20 Ramos 0.56; C42(0.40)  LDD2194  [34]
 LDCM0580  Fragment21 Ramos 0.87; C42(0.51)  LDD2195  [34]
 LDCM0582  Fragment23 Ramos 0.94; C42(0.86)  LDD2196  [34]
 LDCM0578  Fragment27 Ramos 1.12; C42(1.35)  LDD2197  [34]
 LDCM0586  Fragment28 Ramos 0.76; C42(0.64)  LDD2198  [34]
 LDCM0588  Fragment30 Ramos 1.34; C42(0.50)  LDD2199  [34]
 LDCM0589  Fragment31 Ramos 1.14; C42(1.09)  LDD2200  [34]
 LDCM0590  Fragment32 Ramos 0.51; C42(1.03)  LDD2201  [34]
 LDCM0468  Fragment33 HEK-293T C42(1.21); C71(0.97); C66(0.96)  LDD1671  [32]
 LDCM0596  Fragment38 Ramos 0.89; C42(1.17)  LDD2203  [34]
 LDCM0566  Fragment4 Ramos 0.89; C42(0.60)  LDD2184  [34]
 LDCM0427  Fragment51 HEK-293T C42(1.08); C71(1.05); C66(1.13)  LDD1631  [32]
 LDCM0610  Fragment52 Ramos 1.30  LDD2204  [34]
 LDCM0614  Fragment56 Ramos 1.24; C42(0.32)  LDD2205  [34]
 LDCM0569  Fragment7 Ramos 0.56; C42(0.53)  LDD2186  [34]
 LDCM0571  Fragment9 Ramos 0.82; C42(0.36)  LDD2188  [34]
 LDCM0107  IAA HeLa C66(0.00); C42(0.00); H36(0.00); H88(0.00)  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C42(0.99); C71(1.18); C66(0.93); C71(0.93)  LDD1492  [32]
 LDCM0023  KB03 HEK-293T C42(0.91); C71(1.02); C66(1.01); C71(1.01)  LDD1497  [32]
 LDCM0024  KB05 COLO792 C42(1.07)  LDD3310  [35]
 LDCM0006  Micheliolide M9-ENL1 1.50  LDD0048  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [21]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C42(0.87)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C42(1.07)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C42(0.65)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C42(0.66)  LDD2104  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C42(0.96)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C42(0.84)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C71(0.86)  LDD2111  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C42(0.70)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C42(0.79)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C42(0.65)  LDD2125  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C42(0.75)  LDD2137  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C42(0.75)  LDD2141  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C42(1.16)  LDD2144  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C42(0.92); C71(0.82); C42(0.60)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C42(0.86); C71(0.72); C42(0.65)  LDD2207  [36]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) ETF alpha-subunit/FixB family P13804
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Electron transfer flavoprotein regulatory factor 1 (ETFRF1) Complex I LYR family Q6IPR1

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
31 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
35 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.