Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name MCL-2  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Micheliolide  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (M9-ENL1)

Interaction Altas of This Experiment [1]

Enzyme
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Target ID Target Name Binding Ratio
 LDTP08082  L-xylulose reductase (DCXR) 3.1
 LDTP03981  Phosphatidylinositol 4-kinase alpha (PI4KA) 1.9
 LDTP03470  Inositol monophosphatase 1 (IMPA1) 1.8
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB) 1.5
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12661  Exocyst complex component 1 (EXOC1) 5.1
Other
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13961  Small ribosomal subunit protein uS2m (MRPS2) 6.2
 LDTP03555  Guanine nucleotide-binding protein subunit alpha-15 (GNA15) 2.9
 LDTP04995  CCHC-type zinc finger nucleic acid binding protein (CNBP) 2.6
 LDTP05586  Protein VAC14 homolog (VAC14) 1.8

References

1 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455