Details of the Target

General Information of Target

Target ID LDTP03555
Target Name Guanine nucleotide-binding protein subunit alpha-15 (GNA15)
Gene Name GNA15
Gene ID 2769
Synonyms
GNA16; Guanine nucleotide-binding protein subunit alpha-15; G alpha-15; G-protein subunit alpha-15; Epididymis tissue protein Li 17E; Guanine nucleotide-binding protein subunit alpha-16; G alpha-16; G-protein subunit alpha-16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIK
QMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQD
PYKVTTFEKRYAAAMQWLWRDAGIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQ
DVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQ
CLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQG
PKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVR
DSVLARYLDEINLL
Target Bioclass
Other
Family
G-alpha family, G(q) subfamily
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Uniprot ID
P30679
Ensemble ID
ENST00000262958.4
HGNC ID
HGNC:4383

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C196(1.31)  LDD3315  [1]
MCL-2
 Probe Info  		2.90  LDD0048  [2]
MCL-4
 Probe Info  		4.20  LDD0049  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C345(0.00); C323(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C345(0.00); C323(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C345(0.00); C323(0.00); C196(0.00)  LDD0037  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C196(1.07)  LDD2245  [1]
 LDCM0023  KB03 697 C196(1.29)  LDD2662  [1]
 LDCM0024  KB05 IGR39 C196(1.31)  LDD3315  [1]
 LDCM0006  Micheliolide M9-ENL1 2.90  LDD0048  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.