Details of the Target

General Information of Target

Target ID LDTP03981
Target Name Phosphatidylinositol 4-kinase alpha (PI4KA)
Gene Name PI4KA
Gene ID 5297
Synonyms
PIK4; PIK4CA; Phosphatidylinositol 4-kinase alpha; PI4-kinase alpha; PI4K-alpha; PtdIns-4-kinase alpha; EC 2.7.1.67; Phosphatidylinositol 4-Kinase III alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMC
PVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARK
GRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPS
NLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYY
FSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHD
ADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLP
LLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLY
ISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQL
GCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI
QDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRR
LPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEP
LRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLE
YMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKEN
EEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLS
LSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHL
QEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFM
ASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAML
ISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTV
EQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIF
SSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYS
TAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDI
TVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEI
ERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPA
RFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTG
LSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKS
QLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNK
ITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAK
APYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDML
ALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYF
TRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMF
ESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTL
MLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDI
PY
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family, Type III PI4K subfamily
Subcellular location
Cytoplasm
Function Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
TTD ID
T99295
Uniprot ID
P42356
DrugMap ID
TTCUS9F
Ensemble ID
ENST00000255882.11
HGNC ID
HGNC:8983
ChEMBL ID
CHEMBL3667

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.D1045G DBIA    Probe Info 
CCK81 SNV: p.L549M DBIA    Probe Info 
DU145 SNV: p.A350T DBIA    Probe Info 
HCT15 SNV: p.G1004E; p.R1574C; p.G1620C DBIA    Probe Info 
HEC1 SNV: p.D420G DBIA    Probe Info 
HEC1B SNV: p.D420G .
HUH28 SNV: p.M902I DBIA    Probe Info 
IGROV1 SNV: p.L864I DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Y386C DBIA    Probe Info 
JURKAT Deletion: p.L481CfsTer2 Compound 10    Probe Info 
MCC13 SNV: p.G822E DBIA    Probe Info 
MCF7 SNV: p.D584E .
MEWO SNV: p.R779G DBIA    Probe Info 
MFE296 SNV: p.R1128H DBIA    Probe Info 
MFE319 SNV: p.L881F; p.D1242G DBIA    Probe Info 
MOLT4 SNV: p.R984G IA-alkyne    Probe Info 
NCIH1793 SNV: p.E961V DBIA    Probe Info 
SKOV3 SNV: p.R1577Q DBIA    Probe Info 
U937 SNV: p.F1057I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		11.53  LDD0066  [1]
STPyne
 Probe Info  		K1531(1.56); K1806(10.00); K432(10.00); K838(8.19)  LDD0277  [2]
BTD
 Probe Info  		C2081(1.11)  LDD2107  [3]
MCL-2
 Probe Info  		1.90  LDD0048  [4]
AHL-Pu-1
 Probe Info  		C918(3.46); C1206(3.46)  LDD0170  [5]
DBIA
 Probe Info  		C58(10.58)  LDD0209  [6]
Acrolein
 Probe Info  		N.A.  LDD0223  [7]
W1
 Probe Info  		C246(0.55)  LDD0239  [8]
ATP probe
 Probe Info  		K1800(0.00); K1531(0.00)  LDD0199  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C1774(0.00); C19(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		C19(0.00); C246(0.00)  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
Compound 10
 Probe Info  		C19(0.00); C246(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		C19(0.00); C246(0.00)  LDD2213  [15]
ENE
 Probe Info  		C1131(0.00); C19(0.00)  LDD0006  [14]
IPM
 Probe Info  		C19(0.00); C246(0.00)  LDD0005  [14]
PF-06672131
 Probe Info  		N.A.  LDD0017  [16]
VSF
 Probe Info  		C1893(0.00); C246(0.00); C19(0.00); C1131(0.00)  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		8.10  LDD0443  [18]
NAIA_5
 Probe Info  		C1761(0.00); C19(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C918(3.46); C1206(3.46)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C918(4.76); C246(2.77); C19(3.57)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C459(1.07); C574(0.98); C2081(0.96); C95(1.04)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C1131(1.08); C1812(1.02); C459(0.96); C574(1.01)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C1812(1.06); C459(0.90); C574(1.01); C2081(1.02)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C1131(0.96); C1812(1.00); C459(0.98); C574(0.95)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C1131(0.98); C459(1.02); C574(1.04); C2081(1.02)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C1131(1.04); C1812(1.06); C459(1.03); C574(0.95)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C459(1.10); C574(0.88); C2081(0.94); C95(0.91)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C1131(1.11); C1812(1.01); C459(0.94); C574(1.01)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C1812(1.20); C459(0.99); C574(1.13); C2081(0.83)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C1131(1.08); C1812(0.89); C459(1.02); C574(1.02)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C1131(0.92); C1812(1.09); C459(0.94); C574(1.04)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C1131(0.99); C1812(1.09); C459(1.01); C574(1.07)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C1131(0.98); C459(1.04); C574(1.04); C2081(1.00)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C1131(1.04); C1812(1.04); C459(1.10); C574(1.00)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C1131(1.03); C459(1.05); C574(1.07); C2081(1.01)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C459(1.02); C574(0.97); C2081(0.98); C95(1.04)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C1131(1.01); C1812(1.05); C459(0.99); C574(0.95)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C1812(0.92); C459(0.95); C574(0.92); C2081(1.18)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C1131(0.95); C1812(1.11); C459(0.97); C574(1.02)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C1131(1.01); C1812(0.98); C459(0.92); C574(1.02)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C1812(0.96); C459(1.00); C574(0.96); C2081(0.97)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C1131(1.01); C459(0.96); C574(0.98); C2081(1.05)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C1131(1.00); C1812(1.06); C459(1.05); C574(1.07)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C1131(1.08); C459(0.96); C574(1.10); C2081(0.97)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C459(1.11); C574(0.90); C2081(0.93); C95(0.99)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C1131(1.03); C1812(0.96); C459(0.96); C574(0.97)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C1812(1.05); C459(0.90); C574(0.97); C2081(0.85)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C1131(1.01); C1812(0.98); C459(1.05); C574(0.91)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C1131(1.00); C1812(0.82); C459(1.03); C574(1.08)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C1131(0.97); C459(1.07); C574(0.95); C2081(0.97)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C1131(1.06); C1812(0.94); C459(1.05); C574(0.98)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C1131(1.01); C1812(0.91); C459(0.95); C574(0.98)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C1131(1.02); C459(1.07); C574(1.19); C2081(0.97)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C459(1.07); C574(0.88); C2081(0.88); C95(0.96)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C1131(1.13); C1812(1.00); C459(1.03); C574(0.95)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C1812(0.92); C459(0.96); C574(1.00); C2081(0.94)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C1131(0.98); C1812(0.99); C459(1.01); C574(1.10)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C1131(1.03); C1812(0.93); C459(0.94); C574(1.10)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C1131(1.00); C459(0.99); C574(1.00); C2081(1.01)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C1131(1.20); C1812(0.91); C459(1.06); C574(1.01)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C1131(0.97); C459(1.05); C574(1.10); C2081(1.03)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C459(1.11); C574(0.88); C2081(0.93); C95(1.02)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C1131(1.05); C1812(0.93); C459(0.96); C574(1.02)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C1131(1.00); C1812(0.96); C459(0.95); C574(1.01)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C1812(0.98); C459(0.93); C574(1.01); C2081(0.90)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C1131(0.99); C1812(0.96); C459(1.01); C574(1.01)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C1131(0.98); C1812(0.93); C459(0.91); C574(1.09)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C1131(0.99); C459(0.99); C574(1.01); C2081(1.07)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C1131(1.17); C1812(0.98); C459(1.07); C574(0.97)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C1131(1.04); C459(1.00); C574(1.05); C2081(1.02)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C459(1.09); C574(0.97); C2081(0.92); C95(1.08)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C1131(1.03); C1812(0.92); C459(1.01); C574(0.99)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C1812(0.86); C459(0.96); C574(0.98); C2081(1.08)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C1131(1.12); C459(1.00); C574(0.97); C2081(1.02)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C1131(1.00); C1812(0.97); C459(0.96); C574(0.97)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C1131(1.12); C1812(0.95); C459(1.00); C574(1.03)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C1131(1.11); C459(1.00); C574(0.95); C2081(1.03)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C1131(1.21); C1812(0.91); C459(1.03); C574(0.97)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C1131(1.12); C459(0.96); C574(1.10); C2081(1.02)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C1131(1.19); C1812(0.91); C459(0.99); C574(0.95)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C1131(1.01); C459(1.00); C574(1.03); C2081(1.10)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C1131(0.96); C1812(0.95); C459(0.98); C574(1.09)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C459(1.14); C574(0.92); C2081(0.97); C95(1.02)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C1131(1.04); C459(0.96); C574(1.15); C2081(0.94)  LDD1514  [20]
 LDCM0632  CL-Sc Hep-G2 C2081(20.00); C95(2.95); C246(1.37); C19(0.85)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C1131(1.04); C1812(0.91); C459(1.03); C574(0.95)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C1131(1.53); C459(1.20); C574(1.07); C2081(0.83)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C1812(0.99); C459(0.94); C574(0.98); C2081(1.07)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C1131(0.87); C1812(0.97); C459(1.00); C574(0.87)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C1131(1.08); C459(1.02); C574(0.98); C2081(1.08)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C1131(0.97); C459(0.95); C574(0.99); C2081(0.92)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C1812(0.97); C459(1.06); C574(0.96); C2081(1.08)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C1131(0.96); C1812(0.93); C459(0.92); C574(0.95)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C1131(0.96); C459(0.99); C574(1.02); C2081(0.98)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C1131(0.96); C459(0.93); C574(1.01); C2081(1.00)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C1812(0.98); C459(1.01); C574(0.91); C2081(1.02)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C1131(0.89); C1812(1.13); C459(0.87); C574(0.96)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C1131(1.35); C1812(1.02); C459(1.35); C574(0.98)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C1131(1.14); C459(0.99); C574(0.96); C2081(0.99)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C1131(1.05); C459(1.01); C574(1.01); C2081(0.97)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C1812(0.95); C459(0.95); C574(0.96); C2081(1.13)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C1131(0.86); C1812(0.98); C459(0.96); C574(1.04)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C1131(1.13); C459(0.94); C574(1.02); C2081(0.95)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C1131(0.98); C459(0.96); C574(1.02); C2081(0.92)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C1812(0.86); C459(1.07); C574(1.04); C2081(1.12)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C1131(0.95); C1812(0.92); C459(0.96); C574(1.08)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C1131(0.99); C459(0.95); C574(1.03); C2081(1.06)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C1131(0.97); C459(0.94); C574(1.00); C2081(1.02)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C1131(1.06); C459(1.23); C574(1.13); C2081(0.83)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C1812(0.95); C459(0.99); C574(1.02); C2081(1.07)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C1131(0.94); C1812(0.84); C459(0.84); C574(1.00)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C1131(1.06); C459(1.00); C574(0.99); C2081(1.02)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C1131(1.21); C459(1.03); C574(1.17); C2081(0.87)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C1812(1.05); C459(1.00); C574(0.98); C2081(1.04)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C1131(1.02); C1812(0.89); C459(1.07); C574(0.96)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C1131(1.21); C459(1.00); C574(0.91); C2081(1.01)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C1131(1.19); C459(1.02); C574(1.01); C2081(0.98)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C1812(0.99); C459(0.93); C574(0.95); C2081(1.13)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C1131(1.14); C1812(0.86); C459(1.02); C574(0.86)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C1131(1.04); C459(1.00); C574(0.99); C2081(1.02)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C1131(1.34); C459(1.05); C574(1.06); C2081(0.80)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C1812(1.00); C459(1.16); C574(0.97); C2081(0.95)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C459(1.12); C574(0.95); C2081(0.77); C95(1.38)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C1131(1.04); C1812(1.06); C459(1.04); C574(0.99)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C1812(1.12); C459(1.07); C574(1.01); C2081(0.80)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C1131(1.08); C459(1.00); C574(1.00); C2081(1.06)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C1131(0.90); C1812(1.03); C459(1.16); C574(0.95)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C1131(1.08); C1812(1.09); C459(1.08); C574(1.06)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C1131(0.93); C459(1.22); C574(0.97); C2081(0.87)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C1131(1.13); C1812(1.00); C459(1.18); C574(0.91)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C1131(0.99); C459(1.15); C574(1.20); C2081(0.80)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C1131(1.25); C1812(0.85); C459(1.01); C574(0.96)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C1131(1.00); C459(0.97); C574(1.00); C2081(1.02)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C1131(1.05); C459(0.94); C574(0.95); C2081(0.91)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C1812(0.93); C459(1.00); C574(0.96); C2081(0.95)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C459(1.03); C574(1.00); C2081(0.87); C95(0.83)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C1131(1.06); C459(1.03); C574(1.05); C2081(0.89)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C1131(0.94); C1812(1.11); C459(1.04); C574(0.99)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C1812(1.07); C459(0.96); C574(0.96); C2081(0.83)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C1131(0.93); C1812(1.11); C459(1.01); C574(1.14)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C1131(1.69); C1812(1.62); C459(1.49); C574(1.13)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C1131(0.91); C459(1.20); C574(1.05); C2081(0.85)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C1131(0.90); C1812(1.16); C459(1.22); C574(0.99)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C1131(0.98); C459(1.16); C574(1.14); C2081(0.84)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C1131(1.21); C1812(0.94); C459(1.02); C574(0.93)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C1131(1.06); C459(1.07); C574(0.95); C2081(0.94)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C1812(0.93); C459(1.09); C574(1.00); C2081(0.97)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C1812(0.89); C459(1.03); C574(1.02); C2081(1.03)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C459(1.11); C574(0.87); C2081(0.92); C95(1.00)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C1131(0.90); C1812(0.99); C459(1.02); C574(1.07)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C1812(1.00); C459(0.98); C574(1.05); C2081(0.90)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C1131(0.87); C1812(1.05); C459(1.07); C574(1.03)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C1131(1.04); C1812(1.18); C459(1.20); C574(1.01)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C1131(0.85); C459(1.17); C574(1.05); C2081(0.89)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C1131(1.10); C1812(1.07); C459(1.36); C574(1.00)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C1131(0.92); C459(1.08); C574(1.12); C2081(0.85)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C1131(0.89); C1812(1.05); C459(1.01); C574(1.05)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C459(1.17); C574(0.91); C2081(0.90); C95(0.93)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C1131(1.06); C459(0.87); C574(1.06); C2081(0.95)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C1812(0.96); C459(1.02); C574(1.06); C2081(1.05)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C459(1.20); C574(0.93); C2081(0.88); C95(1.28)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C1131(1.19); C1812(0.96); C459(1.09); C574(1.06)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C1812(1.05); C459(0.98); C574(1.09); C2081(0.85)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C1131(0.96); C1812(0.99); C459(1.08); C574(1.06)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C1131(1.23); C1812(1.11); C459(1.10); C574(0.99)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C1131(1.36); C459(1.18); C574(1.08); C2081(0.88)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C1131(1.01); C1812(1.01); C459(1.19); C574(0.99)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C1131(1.22); C1812(0.89); C459(1.13); C574(0.92)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C1131(0.97); C459(1.13); C574(1.27); C2081(0.93)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C1131(0.99); C1812(0.93); C459(0.93); C574(1.07)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C1131(0.98); C459(1.05); C574(1.07); C2081(1.01)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C1131(1.00); C459(0.93); C574(1.01); C2081(1.03)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C1812(1.04); C459(0.99); C574(1.03); C2081(1.07)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C459(1.15); C574(1.00); C2081(0.90); C95(0.88)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C1131(1.16); C1812(0.94); C459(1.06); C574(1.01)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C1812(0.95); C459(1.02); C574(1.05); C2081(0.93)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C1131(0.98); C1812(0.94); C459(1.04); C574(1.09)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C1131(0.93); C1812(1.07); C459(1.12); C574(1.25)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C1812(1.15); C459(1.13); C574(0.97); C2081(0.81)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C1131(0.92); C459(1.16); C574(1.01); C2081(0.88)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C1131(1.02); C1812(1.01); C459(1.03); C574(0.97)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C1131(0.93); C459(1.24); C574(1.11); C2081(0.95)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C1131(1.21); C1812(1.03); C459(1.01); C574(0.98)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C1131(1.00); C459(1.03); C574(1.02); C2081(1.03)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C1812(0.92); C459(1.20); C574(0.96); C2081(1.12)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C459(1.08); C574(0.83); C2081(0.83); C95(1.30)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C1131(0.96); C1812(1.06); C459(1.08); C574(1.01)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C1812(1.06); C459(0.93); C574(0.98); C2081(0.94)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C1131(1.99); C1812(0.72); C459(1.36); C574(1.47)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C1131(0.84); C1812(0.96); C459(0.98); C574(1.02)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C1131(0.95); C1812(1.07); C459(1.12); C574(1.07)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C1131(0.91); C459(1.03); C574(1.03); C2081(0.88)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C1131(1.06); C1812(1.03); C459(1.15); C574(0.95)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C1131(1.04); C459(1.07); C574(1.08); C2081(0.90)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C1131(1.35); C1812(0.86); C459(1.08); C574(0.89)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C1131(1.28); C459(1.00); C574(1.04); C2081(1.11)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C1131(1.27); C459(0.91); C574(0.98); C2081(0.98)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C1812(0.88); C459(1.08); C574(1.05); C2081(1.16)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C459(1.10); C574(0.86); C2081(1.05); C95(1.06)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C1131(0.99); C1812(0.97); C459(1.11); C574(1.05)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C1131(1.95); C1812(1.35); C459(1.15); C574(0.94)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C1812(1.01); C459(1.01); C574(1.02); C2081(1.04)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C1131(1.17); C1812(0.92); C459(1.04); C574(1.12)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C1131(1.12); C1812(1.02); C459(1.22); C574(1.02)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C1131(0.98); C459(1.10); C574(1.03); C2081(0.90)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C1131(1.93); C1812(0.91); C459(1.19); C574(1.22)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C1131(1.06); C459(1.07); C574(1.19); C2081(0.93)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C1131(1.15); C1812(0.86); C459(1.13); C574(0.97)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C1131(1.09); C459(0.98); C574(1.04); C2081(1.00)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C1131(1.17); C459(0.94); C574(0.92); C2081(1.00)  LDD1697  [20]
 LDCM0634  CY-0357 Hep-G2 C1832(1.19); C19(0.60)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C1131(1.14); C459(0.94); C574(1.04); C2081(0.93)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C19(4.51); C1215(1.64)  LDD1702  [3]
 LDCM0625  F8 Ramos C2081(0.89); C186(0.53)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C2081(0.90); C186(1.50)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C2081(2.00); C186(0.72)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C2081(1.04); C186(0.39)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C2081(1.00); C186(2.36)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C2081(1.01)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C2081(2.41)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C2081(1.04); C186(3.30)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C2081(1.71); C186(9.60)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C2081(1.12); C186(2.57)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C2081(0.95); C186(0.70)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C2081(1.13); C186(2.77)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C2081(0.98); C186(6.29)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C2081(0.79); C186(1.97)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C1131(1.05); C459(0.88); C574(0.97); C2081(0.93)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C2081(1.00); C186(6.83)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C2081(1.72); C186(1.14)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C1131(1.12); C459(0.97); C574(1.04); C2081(1.03)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C2081(1.66); C186(4.60)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C2081(1.49); C186(1.98)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C2081(1.13)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C2081(3.39)  LDD2188  [21]
 LDCM0022  KB02 HEK-293T C19(0.89); C1832(0.92); C1131(0.99); C459(0.96)  LDD1492  [20]
 LDCM0023  KB03 Jurkat C58(10.58)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C19(2.15)  LDD3310  [22]
 LDCM0006  Micheliolide M9-ENL1 1.90  LDD0048  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C2081(1.11)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2081(0.79)  LDD2109  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2081(1.09)  LDD2125  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C19(0.49)  LDD2207  [23]
 LDCM0112  W16 Hep-G2 C246(0.55)  LDD0239  [8]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
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