Details of the Target

General Information of Target

Target ID LDTP05586
Target Name Protein VAC14 homolog (VAC14)
Gene Name VAC14
Gene ID 55697
Synonyms
TAX1BP2; TRX; Protein VAC14 homolog; Tax1-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEF
ALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNI
VKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVL
GEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGI
LTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIA
VLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVILKDLEVLAEIASSPAGQTDDP
GPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS
ERKLLEVRGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTELF
QLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVD
FLAEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCV
PNPELLQTEDSLKAAPKSQKADSPSIDYAELLQHFEKVQNKHLEVRHQRSGRGDHLDRRV
VL
Target Bioclass
Other
Family
VAC14 family
Subcellular location
Endosome membrane
Function
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Uniprot ID
Q08AM6
Ensemble ID
ENST00000261776.10
HGNC ID
HGNC:25507

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G475V; p.R502I .
HT115 SNV: p.Q287R; p.Y296C .
Ishikawa (Heraklio) 02 ER SNV: p.L612P DBIA    Probe Info 
MCC13 SNV: p.E598K DBIA    Probe Info 
MEWO SNV: p.S738F DBIA    Probe Info 
REH SNV: p.D647H .
RL SNV: p.G481A DBIA    Probe Info 
SNGM SNV: p.P486A DBIA    Probe Info 
SNU1079 SNV: p.A470T DBIA    Probe Info 
SUPT1 Deletion: p.A474QfsTer33 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K21(2.22); K25(7.07); K27(0.19); K536(10.00)  LDD0277  [2]
MCL-2
 Probe Info  		1.80  LDD0048  [3]
AHL-Pu-1
 Probe Info  		C516(2.60); C114(2.25); C101(7.06)  LDD0170  [4]
HHS-482
 Probe Info  		Y111(0.18)  LDD0286  [5]
HHS-475
 Probe Info  		Y111(0.84); Y112(0.92)  LDD0264  [6]
HHS-465
 Probe Info  		Y111(10.00)  LDD2237  [7]
DBIA
 Probe Info  		C516(1.16); C619(0.88); C620(0.88)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C324(0.00); C114(0.00); C101(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C324(0.00); C516(0.00); C114(0.00); C79(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C324(0.00); C516(0.00); C114(0.00); C406(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		C101(0.00); C324(0.00); C719(0.00); C114(0.00)  LDD2156  [12]
VSF
 Probe Info  		C719(0.00); C324(0.00)  LDD0007  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C79(0.00); C324(0.00); C114(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C293
 Probe Info  		25.63  LDD1963  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C516(2.60); C114(2.25); C101(7.06)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C516(2.53); C114(3.37)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C114(0.82); C516(0.81); C619(1.09); C620(1.05)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C101(1.01); C114(0.63); C619(1.11); C620(1.03)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C101(1.15); C114(1.23); C324(0.84); C516(0.84)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C101(1.17); C114(0.98); C324(0.68); C516(0.88)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C101(1.03); C114(1.08); C324(0.70); C516(0.77)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C101(1.03); C114(1.08); C324(0.79); C516(0.88)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C101(1.03); C114(1.07); C324(0.78); C516(0.96)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C101(0.94); C114(0.86); C324(0.71); C516(0.91)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C101(1.04); C114(0.96); C324(0.74); C516(1.00)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C101(1.17); C114(1.27); C324(0.80); C516(0.87)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C101(1.08); C114(1.04); C324(0.69); C516(1.00)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C101(1.19); C114(1.00); C324(0.78); C516(1.11)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C101(1.14); C114(0.75); C619(1.14); C620(0.94)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C101(1.09); C114(1.07); C324(0.75); C516(0.97)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C101(1.12); C114(1.13); C324(0.64); C516(0.98)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C101(1.01); C114(0.95); C324(0.75); C516(1.00)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C101(0.83); C114(0.86); C516(1.08); C619(1.00)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C101(0.75); C114(0.78); C516(0.98); C619(1.00)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C101(0.57); C114(0.74); C516(1.03); C619(1.05)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C101(0.56); C114(0.78); C516(0.99); C619(1.10)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C101(0.64); C114(0.81); C516(0.96); C619(1.03)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C101(0.61); C114(0.79); C516(0.90); C619(0.88)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C101(0.63); C114(0.72); C516(0.99); C619(0.92)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C101(1.02); C114(0.92); C619(0.94); C620(0.92)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C101(0.58); C114(1.03); C516(1.22); C619(1.06)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C101(0.69); C114(0.86); C516(0.86); C619(1.04)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C101(0.63); C114(0.84); C516(0.90); C619(0.92)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C101(0.72); C114(0.98); C516(1.04); C619(1.01)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C101(0.88); C114(0.85); C516(0.92); C619(0.97)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C101(0.63); C114(1.11); C516(0.92); C619(1.07)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C101(0.62); C114(0.94); C516(0.93); C619(0.98)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C101(0.57); C114(0.87); C516(0.87); C619(1.01)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C114(1.92); C619(1.21); C620(1.21)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C114(1.19); C619(1.15); C620(1.07)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C114(1.03); C619(1.22); C620(1.16)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C114(1.28); C619(1.43); C620(1.13)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C114(0.75); C619(1.19); C620(1.14)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C114(0.94); C619(1.16); C620(1.13)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C114(1.33); C619(1.17); C620(1.10)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C114(0.80); C619(1.23); C620(1.04)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C114(1.03); C619(1.17); C620(0.87)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C114(1.41); C619(1.09); C620(0.92)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C114(1.81); C619(1.49); C620(1.11)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C114(0.88); C619(1.18); C620(1.07)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C101(1.11); C114(1.24); C619(1.07); C620(1.16)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C114(1.01); C619(1.33); C620(1.21)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C114(1.17); C619(1.41); C620(1.15)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C114(0.92); C619(1.09); C620(0.98)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C620(0.90); C619(0.91); C674(1.05); C516(1.09)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C620(0.91); C619(0.97); C516(1.21); C674(1.38)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C619(0.96); C620(0.99); C516(1.04); C674(2.82)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C620(1.03); C516(1.05); C619(1.09); C674(1.82)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C620(1.09); C619(1.10); C516(1.31); C674(1.41)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C620(1.31); C516(1.32); C619(1.34); C674(1.84)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C620(1.03); C619(1.11); C516(1.23); C674(3.50)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C674(0.87); C620(1.12); C101(1.19); C619(1.30)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C620(0.95); C619(1.02); C516(1.33); C674(1.55)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C620(0.88); C516(0.94); C619(0.95); C674(1.24)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C620(0.99); C619(1.08); C516(1.34); C674(1.44)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C620(1.30); C619(1.42); C516(1.43); C674(1.81)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C516(1.42); C619(1.14); C620(1.07); C674(1.22)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C516(1.16); C619(1.04); C620(1.04); C674(1.62)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C516(1.17); C619(0.94); C620(0.92); C674(0.90)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C516(1.12); C619(0.98); C620(1.01); C674(1.19)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C114(0.83); C324(0.94); C719(1.06); C516(1.07)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C516(0.74); C101(0.82); C114(0.97); C324(1.01)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C516(0.63); C101(0.93); C324(0.98); C114(1.05)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C114(0.69); C516(0.92); C674(1.12); C619(1.14)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C516(0.77); C324(0.93); C114(0.99); C719(1.02)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C516(0.79); C101(0.84); C324(0.86); C719(0.89)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C324(0.87); C719(0.87); C516(0.91); C114(0.94)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C516(0.72); C101(0.94); C324(1.00); C114(1.11)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C516(0.92); C324(0.94); C114(0.98); C101(1.13)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C516(0.71); C101(0.85); C620(0.95); C619(0.98)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C516(0.77); C101(1.00); C620(1.01); C619(1.05)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C516(0.76); C101(0.94); C620(0.97); C619(1.20)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C516(0.71); C620(0.84); C101(0.95); C619(1.15)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C516(0.89); C620(1.04); C101(1.14); C619(1.23)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C114(0.63); C516(0.82); C619(1.01); C620(1.09)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C620(0.96); C101(1.09); C516(1.11); C619(1.29)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C516(0.80); C101(1.00); C620(1.12); C619(1.25)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C516(0.89); C620(1.06); C101(1.15); C619(1.57)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C516(0.85); C101(0.91); C620(0.94); C619(1.65)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C516(0.94); C101(0.99); C620(1.26); C619(2.14)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C516(0.75); C114(0.95); C619(0.99); C101(1.00)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C516(0.76); C114(0.77); C101(0.87); C619(1.01)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C516(0.83); C114(0.88); C101(0.90); C619(0.92)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C114(0.88); C101(0.89); C516(0.96); C620(0.97)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C114(0.84); C516(0.87); C619(0.89); C101(0.97)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C114(0.61); C516(0.84); C620(1.07); C619(1.09)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C114(0.83); C101(0.83); C516(0.85); C619(1.16)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C101(0.87); C114(0.89); C516(0.91); C620(1.01)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C516(0.91); C620(0.95); C101(1.01); C619(1.15)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C101(0.79); C114(0.79); C516(0.91); C620(1.02)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C101(0.89); C516(0.92); C620(0.98); C114(1.07)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C114(0.77); C516(0.83); C101(0.86); C620(1.01)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C114(0.73); C324(0.91); C619(0.97); C516(0.97)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C114(0.76); C619(0.84); C101(0.86); C324(0.95)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C114(0.75); C324(0.86); C619(0.88); C516(0.89)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C324(0.89); C516(0.93); C101(0.97); C619(1.50)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C114(0.69); C516(0.89); C620(1.01); C674(1.15)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C114(0.75); C324(0.85); C516(0.95); C101(1.01)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C324(0.93); C620(0.93); C101(0.94); C516(1.03)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C324(0.82); C516(0.89); C619(0.94); C101(1.00)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C114(1.00); C324(1.07); C619(1.09); C101(1.10)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C114(0.81); C516(0.95); C324(0.96); C101(0.98)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C114(0.90); C101(0.98); C619(1.03); C516(1.20)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C101(0.85); C324(0.97); C114(1.19); C619(1.33)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C516(0.88); C719(0.94); C619(1.05); C620(1.12)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C719(0.81); C516(1.00); C620(1.18); C619(1.26)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C719(0.76); C516(1.05); C620(1.14); C619(1.25)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C114(0.87); C674(0.89); C101(1.10); C620(1.12)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C719(0.75); C516(0.99); C674(1.00); C620(1.03)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C516(0.94); C719(0.94); C620(0.96); C674(1.00)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C719(0.88); C516(0.95); C620(1.03); C619(1.25)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C719(0.82); C516(0.91); C620(1.03); C619(1.16)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C516(0.89); C719(0.97); C619(1.09); C620(1.10)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C719(0.99); C516(1.00); C620(1.14); C619(1.26)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C516(0.97); C620(1.04); C719(1.05); C619(1.24)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C516(1.00); C719(1.03); C620(1.18); C674(1.28)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C114(0.83); C619(0.95); C620(0.95); C101(1.17)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C114(0.92); C620(1.07); C101(1.14); C619(1.16)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C114(0.78); C674(0.83); C620(0.99); C101(1.00)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C114(0.79); C516(0.88); C101(1.10); C620(1.16)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C114(0.84); C619(1.16); C620(1.17); C516(1.17)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C114(0.94); C620(1.01); C619(1.05); C516(1.18)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C114(0.98); C101(1.22); C620(1.43); C619(1.53)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C114(1.00); C619(1.23); C101(1.24); C620(1.30)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C114(0.94); C101(1.14); C674(1.39); C619(1.48)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C114(0.83); C674(1.05); C101(1.12); C516(1.18)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C114(0.81); C674(0.82); C619(1.08); C620(1.12)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C619(0.80); C114(0.85); C620(0.86); C516(1.00)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C114(0.85); C619(0.95); C620(0.99); C516(1.18)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C114(0.86); C674(0.97); C620(1.05); C619(1.15)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C114(0.83); C619(1.09); C620(1.15); C101(1.20)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C674(0.40); C114(0.92); C620(1.10); C619(1.14)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C114(1.15); C101(1.30); C620(1.43); C619(1.47)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C101(0.83); C114(0.90); C620(1.13); C619(1.14)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C101(0.78); C114(0.83); C619(1.12); C620(1.13)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C114(0.69); C101(0.95); C619(0.95); C620(1.01)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C114(0.93); C101(0.94); C619(1.03); C620(1.08)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C101(0.86); C619(0.90); C114(0.91); C620(1.00)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C619(0.89); C101(0.90); C620(0.99); C114(1.06)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C114(0.86); C101(0.99); C619(1.02); C620(1.05)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C114(0.84); C619(0.86); C516(1.06); C620(1.09)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C114(0.72); C101(0.97); C619(1.10); C620(1.18)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C114(0.70); C101(0.89); C619(0.98); C620(1.08)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C114(0.75); C101(0.97); C619(1.02); C620(1.16)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C114(0.56); C619(0.99); C101(1.01); C620(1.15)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C114(0.75); C619(0.87); C620(0.91); C101(1.12)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C114(0.63); C619(0.96); C101(1.08); C620(1.10)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C114(0.56); C101(0.93); C619(1.13); C620(1.14)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C324(0.66); C114(0.86); C516(0.93); C620(0.99)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C324(0.68); C619(0.79); C620(0.79); C516(0.80)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C101(1.28); C114(0.78); C619(1.03); C620(1.08)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C674(0.85); C114(0.92); C101(0.98); C620(1.10)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C114(1.00); C674(1.02); C101(1.08); C620(1.28)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C516(1.16); C619(0.88); C620(0.88)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa C236(0.00); H754(0.00); C719(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C114(0.48)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C101(0.70); C619(0.82); C114(0.88); C620(0.98)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C114(0.55); C101(0.97); C324(1.06); C619(1.09)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C516(0.79); C114(0.80); C620(1.12); C674(1.12)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C674(0.82); C620(1.03); C114(1.04); C101(1.06)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C674(0.73); C114(0.74); C101(0.98); C620(0.99)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C674(0.76); C114(0.84); C620(0.88); C619(0.95)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C114(0.88); C674(0.90); C101(1.06); C620(1.11)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C101(0.96); C324(1.08); C619(1.10); C516(1.12)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C516(0.76); C101(0.86); C719(1.21); C619(1.23)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C101(0.90); C516(0.94); C719(0.95); C324(1.04)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C101(0.91); C516(0.99); C719(0.99); C619(1.02)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C516(0.94); C101(0.97); C324(1.00); C619(1.16)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C114(0.65); C101(0.93); C516(1.10); C324(1.20)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C101(0.85); C516(0.91); C324(0.99); C719(1.07)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C516(0.73); C324(0.90); C101(0.95); C719(0.98)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C516(0.89); C101(0.98); C620(1.04); C619(1.12)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C516(1.00); C101(1.11); C620(1.31); C619(1.97)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C620(1.00); C619(1.08); C516(1.10); C101(1.22)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C101(1.00); C516(1.00); C619(1.22); C620(1.33)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C516(0.84); C101(1.04); C620(1.11); C619(1.27)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C516(0.92); C620(0.98); C101(1.00); C619(1.08)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C114(0.88); C619(0.91); C516(0.95); C620(0.97)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C114(0.78); C516(0.88); C101(0.98); C619(0.98)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C114(0.55); C101(1.16); C516(1.20); C324(1.32)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C114(0.71); C101(0.87); C516(0.92); C620(0.98)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C114(0.85); C101(0.88); C324(0.90); C620(0.96)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C101(0.84); C324(0.85); C516(0.91); C114(1.04)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C101(0.89); C114(0.91); C324(0.93); C619(1.04)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C114(0.84); C324(0.98); C101(0.99); C619(1.10)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C719(0.90); C620(0.96); C619(0.98); C516(0.99)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C719(0.90); C674(1.01); C516(1.01); C620(1.05)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C620(0.93); C516(0.94); C719(0.97); C674(1.03)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C719(0.93); C516(0.99); C619(1.05); C620(1.14)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C101(1.02); C114(1.05); C516(1.06); C324(1.13)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C114(0.94); C101(0.98); C516(1.04); C620(1.10)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C516(0.91); C114(0.99); C101(1.06); C619(1.07)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C719(0.76); C674(0.80); C114(0.86); C620(0.89)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C719(0.66); C114(0.74); C619(0.87); C620(0.89)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C719(0.78); C114(0.85); C516(0.89); C620(0.90)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C719(0.73); C114(0.87); C619(0.99); C620(0.99)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C101(0.84); C114(0.95); C619(1.02); C324(1.02)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C114(0.79); C719(0.88); C620(1.07); C619(1.14)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C719(0.78); C114(0.85); C516(1.05); C674(1.10)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C719(1.00); C516(1.20); C620(1.39); C114(1.42)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C719(0.78); C619(1.02); C620(1.04); C114(1.08)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C114(0.95); C516(1.07); C619(1.05); C620(1.05)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C114(0.90); C516(1.06); C619(1.01); C620(1.02)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C114(0.91); C516(1.16); C619(0.96); C620(0.98)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C114(0.92); C516(1.15); C619(0.96); C620(0.93)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C114(0.83); C516(1.00); C619(1.13); C620(1.04)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C114(0.94); C516(1.49); C619(1.12); C620(1.07)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C101(1.00); C114(0.75); C324(1.14); C516(0.94)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C114(1.09); C516(1.42); C619(1.00); C620(0.93)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C101(1.01); C114(0.99); C324(0.95); C516(1.08)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C101(1.02); C114(1.00); C324(0.92); C516(1.24)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C101(0.98); C114(0.87); C324(0.78); C516(1.01)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C101(0.91); C114(0.94); C324(1.04); C516(1.23)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C101(1.05); C114(1.09); C324(0.98); C516(1.45)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C101(0.87); C114(0.97); C324(0.90); C516(1.24)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C101(0.94); C114(1.05); C324(0.92); C516(1.19)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C101(1.04); C114(1.07); C324(1.02); C516(1.25)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C101(0.94); C114(0.99); C324(1.02); C516(1.14)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C101(0.90); C114(1.02); C324(0.94); C516(1.26)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C101(0.71); C114(1.04); C324(0.91); C516(1.24)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C101(0.96); C114(1.22); C324(1.20); C516(1.56)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C101(1.10); C114(1.20); C324(1.01); C516(1.38)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C101(0.97); C114(1.03); C324(0.92); C516(1.25)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C101(0.99); C114(0.99); C324(1.01); C516(1.30)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C101(0.96); C114(0.98); C324(0.79); C516(1.03)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C101(1.11); C114(0.93); C324(0.82); C516(1.17)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C101(0.97); C114(1.13); C324(0.91); C516(1.04)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C101(1.28); C114(1.12); C324(1.26); C516(1.01)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C101(0.96); C114(1.11); C324(1.11); C516(0.90)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C101(0.90); C114(1.03); C324(1.06); C516(1.11)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C101(1.09); C114(0.99); C324(1.10); C516(1.09)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C101(0.98); C114(0.94); C324(0.99); C516(1.12)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C101(1.05); C114(1.17); C324(0.85); C516(1.56)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C101(1.03); C114(1.09); C324(0.94); C516(1.06)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C101(1.06); C114(1.05); C324(1.08); C516(1.09)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C101(1.11); C114(0.95); C324(0.87); C516(1.28)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C101(0.95); C114(1.07); C324(0.88); C516(1.18)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C101(1.04); C114(0.99); C324(0.96); C516(1.06)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C101(1.25); C114(0.93); C324(0.93); C516(1.03)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C101(0.95); C114(0.90); C324(1.05); C516(0.89)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C101(0.98); C114(0.96); C324(0.90); C516(1.13)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C101(0.88); C114(0.80); C619(1.25); C620(1.62)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C101(0.85); C114(0.72); C619(0.91); C620(0.91)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C101(1.00); C114(0.81); C619(0.96); C620(0.94)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C101(0.84); C114(0.83); C619(1.13); C620(1.01)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C101(1.27); C114(0.94); C619(1.05); C620(1.05)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C101(0.90); C114(0.84); C619(1.28); C620(1.11)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C101(0.88); C114(1.10); C619(1.22); C620(1.25)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C101(0.82); C114(1.25); C619(1.33); C620(1.50)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C101(1.03); C114(0.78); C619(1.10); C620(1.04)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C101(1.25); C114(0.73); C324(1.18); C516(0.91)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C101(1.13); C114(0.95); C619(1.13); C620(1.34)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C101(1.11); C114(0.94); C619(1.17); C620(1.37)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C101(0.77); C114(0.89); C619(0.95); C620(1.04)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C101(0.78); C114(0.93); C619(1.63); C620(1.13)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C101(0.82); C114(1.02); C619(1.44); C620(1.33)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C114(1.02); C324(0.94); C516(0.91); C619(1.19)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C114(2.42); C324(0.91); C516(1.11); C619(2.13)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C114(1.00); C324(0.99); C516(1.20); C619(1.24)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C114(1.02); C324(0.95); C516(1.12); C619(1.54)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C101(1.13); C114(1.76); C324(1.15); C516(0.91)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C114(1.04); C324(1.06); C516(0.86); C619(1.28)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C114(0.86); C324(0.92); C516(0.82); C619(1.35)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C114(1.07); C324(0.94); C516(0.95); C619(1.75)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C114(1.14); C324(0.97); C516(0.99); C619(1.61)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C114(1.24); C324(1.02); C516(1.35); C619(2.03)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C114(1.00); C324(0.96); C516(1.14); C619(1.23)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C114(1.13); C324(0.95); C516(1.05); C619(1.14)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C114(1.03); C324(1.11); C516(0.95); C619(1.24)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C114(1.33); C324(1.03); C516(0.95); C619(1.51)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C114(1.26); C324(1.17); C516(0.90); C619(1.91)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C101(0.87); C114(1.09); C324(1.15); C516(0.96)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C114(1.15); C324(0.86); C516(0.95); C619(0.99)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C114(0.64); C516(1.18); C619(1.12); C620(1.21)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C114(1.03); C516(1.08); C619(1.05); C620(1.08)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C114(1.18); C516(0.86); C619(1.18); C620(0.99)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C114(1.07); C516(0.98); C619(1.10); C620(1.02)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C114(0.80); C516(0.89); C619(1.22); C620(0.95)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C114(0.62); C516(0.95); C619(1.01); C620(1.15)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C114(0.65); C516(1.03); C619(1.18); C620(1.23)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C114(0.57); C516(0.95); C619(1.11); C620(0.93)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C114(0.60); C516(0.87); C619(1.00); C620(1.03)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C324(0.85); C516(0.86); C79(0.85); C114(0.91)  LDD1698  [16]
 LDCM0625  F8 Ramos C114(0.41); C101(0.71); C516(1.19); C719(0.57)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C101(1.84); C516(1.59); C719(1.00)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C114(2.39); C516(0.95); C719(0.12); C307(0.07)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C101(2.05); C516(1.25); C719(1.23)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C114(1.15); C101(0.81); C516(1.09); C719(1.51)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C101(5.12); C516(1.62); C719(1.24); C307(2.20)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C516(1.32); C719(0.82)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C114(0.75); C101(1.08); C516(1.16); C719(1.04)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C101(1.12); C516(1.12); C719(0.68)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C114(0.75); C101(0.74); C516(0.94); C719(1.13)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C114(4.01); C101(0.30); C516(0.80); C307(0.58)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C114(0.30); C101(1.09); C516(1.36); C719(1.39)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C101(1.17); C516(0.92)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C101(0.95); C516(1.56); C719(0.85)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C101(0.95); C114(0.79); C619(1.08); C620(1.15)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C114(0.96); C101(1.22); C516(0.78); C719(1.86)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C101(0.72); C516(0.54); C719(1.18)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C101(1.16); C114(1.13); C324(1.20); C516(1.48)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C114(0.48); C101(0.95); C516(1.19)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C114(0.38); C101(0.83); C516(1.38); C719(1.32)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C114(0.64); C101(0.92); C516(0.72); C719(1.17)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C101(2.93); C516(1.15); C719(1.04)  LDD2188  [17]
 LDCM0116  HHS-0101 DM93 Y111(0.84); Y112(0.92)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y112(0.69); Y111(0.82)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y111(0.75); Y112(0.78)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y112(0.93); Y111(1.01)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y111(2.27); Y112(2.58)  LDD0268  [6]
 LDCM0124  JWB142 DM93 Y111(0.18)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y111(0.19)  LDD0287  [5]
 LDCM0022  KB02 HCT 116 C619(1.53); C516(1.20)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C619(1.67); C516(1.13)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C619(1.91); C516(1.45)  LDD0082  [8]
 LDCM0006  Micheliolide M9-ENL1 1.80  LDD0048  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1) ATP-dependent AMP-binding enzyme family Q9NUB1
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) Cation transport ATPase (P-type) (TC 3.A.3) family P13637
Kynurenine--oxoglutarate transaminase 1 (KYAT1) Class-I pyridoxal-phosphate-dependent aminotransferase family Q16773
5-phosphohydroxy-L-lysine phospho-lyase (PHYKPL) Class-III pyridoxal-phosphate-dependent aminotransferase family Q8IUZ5
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Neuroglobin (NGB) Globin family Q9NPG2
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) HAD-like hydrolase superfamily Q9BSH5
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
EEF1A lysine methyltransferase 3 (EEF1AKMT3) METTL21 family Q96AZ1
Nitric oxide synthase 1 (NOS1) NOS family P29475
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Pellino family Q96FA3
Caspase-1 (CASP1) Peptidase C14A family P29466
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Rhomboid-related protein 1 (RHBDL1) Peptidase S54 family O75783
Phenazine biosynthesis-like domain-containing protein (PBLD) PhzF family P30039
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) PPP phosphatase family O00743
Ribosomal protein S6 kinase-related protein (RSKR) Ser/Thr protein kinase family Q96LW2
Myotubularin-related protein 9 (MTMR9) Protein-tyrosine phosphatase family Q96QG7
Ribonuclease H2 subunit C (RNASEH2C) RNase H2 subunit C family Q8TDP1
Tyrosyl-DNA phosphodiesterase 1 (TDP1) Tyrosyl-DNA phosphodiesterase family Q9NUW8
Metallophosphoesterase MPPED2 (MPPED2) UPF0046 family Q15777
Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) SMUG1 family Q53HV7
1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) . Q9Y2I7
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
Ester hydrolase C11orf54 (C11orf54) . Q9H0W9
Polyphosphoinositide phosphatase (FIG4) . Q92562
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) WD repeat G protein beta family P62873
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Hepatocyte nuclear factor 1-beta (HNF1B) HNF1 homeobox family P35680
Zinc finger and BTB domain-containing protein 49 (ZBTB49) Krueppel C2H2-type zinc-finger protein family Q6ZSB9
Zinc finger protein 34 (ZNF34) Krueppel C2H2-type zinc-finger protein family Q8IZ26
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
PHD finger protein 1 (PHF1) Polycomblike family O43189
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Homeobox protein VENTX (VENTX) . O95231
KRAB domain-containing protein 5 (KRBOX5) . Q7Z2F6
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sialic acid-binding Ig-like lectin 5 (SIGLEC5) SIGLEC (sialic acid binding Ig-like lectin) family O15389
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acyl carrier protein, mitochondrial (NDUFAB1) Acyl carrier protein (ACP) family O14561
Ankyrin repeat and SOCS box protein 13 (ASB13) Ankyrin SOCS box (ASB) family Q8WXK3
Beta-crystallin A2 (CRYBA2) Beta/gamma-crystallin family P53672
Beta-crystallin A3 (CRYBA1) Beta/gamma-crystallin family P05813
Coiled-coil domain-containing protein 103 (CCDC103) CCDC103/PR46b family Q8IW40
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) EIF-2-alpha family P05198
Eukaryotic translation initiation factor 6 (EIF6) EIF-6 family P56537
Protein FAM50B (FAM50B) FAM50 family Q9Y247
DNA replication complex GINS protein PSF3 (GINS3) GINS3/PSF3 family Q9BRX5
Keratin, type II cuticular Hb2 (KRT82) Intermediate filament family Q9NSB4
Vimentin (VIM) Intermediate filament family P08670
Keratin-associated protein 19-3 (KRTAP19-3) KRTAP type 19 family Q7Z4W3
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Otospiralin (OTOS) Otospiralin family Q8NHW6
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Proline-rich protein 20C (PRR20C) PRR20 family P86479
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Protein ripply1 (RIPPLY1) Ripply family Q0D2K3
Vacuolar-sorting protein SNF8 (SNF8) SNF8 family Q96H20
Telomerase Cajal body protein 1 (WRAP53) TCAB1 family Q9BUR4
UPF0462 protein C4orf33 (C4orf33) UPF0462 family Q8N1A6
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
von Hippel-Lindau-like protein (VHLL) VHL family Q6RSH7
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Neurobeachin-like protein 2 (NBEAL2) WD repeat neurobeachin family Q6ZNJ1
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
CD209 antigen (CD209) . Q9NNX6
CMT1A duplicated region transcript 4 protein (CDRT4) . Q8N9R6
Collagen alpha-1(VIII) chain (COL8A1) . P27658
GA-binding protein subunit beta-2 (GABPB2) . Q8TAK5
Oncoprotein-induced transcript 3 protein (OIT3) . Q8WWZ8
Proline-rich protein 13 (PRR13) . Q9NZ81
Protease-associated domain-containing protein 1 (PRADC1) . Q9BSG0
Protein SPMIP9 (SPMIP9) . Q96LM6
Putative apolipoprotein(a)-like protein 2 (LPAL2) . Q16609
Putative uncharacterized protein encoded by LINC00518 (LINC00518) . Q8N0U6
RNA binding protein fox-1 homolog 2 (RBFOX2) . O43251
SPRY domain-containing protein 7 (SPRYD7) . Q5W111
TP53-binding protein 1 (TP53BP1) . Q12888
Transcription elongation factor A N-terminal and central domain-containing protein (TCEANC) . Q8N8B7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578