General Information of Experiment

Probe Name EA-probe  Probe Info 
Probe concentration 40 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Ethacrynic acid  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 181 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 15.0
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) C194 6.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 4.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 3.3
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 2.9
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) C194 2.8
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) C185 2.7
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) C304 2.5
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C363 2.0
 LDTP09939  Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) C289 2.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.0
 LDTP06885  Glycerol-3-phosphate acyltransferase 3 (GPAT3) C306 1.9
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.8
 LDTP07967  Lysophosphatidylcholine acyltransferase 2 (LPCAT2) C223 1.8
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) . 1.8
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C166 1.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.7
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C343 1.7
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C42 1.6
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 1.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C376 1.6
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 1.6
 LDTP00492  Ras-related protein Rab-7L1 (RAB29) C120 1.6
 LDTP08217  Threonylcarbamoyl-AMP synthase (YRDC) C95 1.6
 LDTP10201  Atypical kinase COQ8B, mitochondrial (COQ8B) C335 1.5
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 1.5
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C360 1.4
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.4
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C166 1.4
 LDTP10049  FAST kinase domain-containing protein 4 (TBRG4) C335 1.3
 LDTP03726  Replication factor C subunit 2 (RFC2) C88 1.3
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C237 1.3
 LDTP02506  Microsomal glutathione S-transferase 1 (MGST1) C50 1.3
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) C163 1.3
 LDTP10049  FAST kinase domain-containing protein 4 (TBRG4) C335 1.3
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C164 1.3
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 1.2
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C23 1.2
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) C1076 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C376 1.2
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.2
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.2
 LDTP15219  Diphthine--ammonia ligase (DPH6) C88 1.2
 LDTP04243  Fatty acid synthase (FASN) C1448 1.2
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.2
 LDTP00293  Cytochrome c oxidase subunit NDUFA4 (NDUFA4) C44 1.2
 LDTP13285  Probable ATP-dependent RNA helicase DDX20 (DDX20) C577 1.2
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.1
 LDTP00492  Ras-related protein Rab-7L1 (RAB29) C120 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.1
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C62 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C4 1.1
 LDTP09396  Minor histocompatibility antigen H13 (HM13) C326 1.1
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) C18 1.1
 LDTP11311  Very long chain fatty acid elongase 1 (ELOVL1) C93 1.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) C499 1.1
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C467 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.1
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.1
 LDTP00293  Cytochrome c oxidase subunit NDUFA4 (NDUFA4) C44 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.1
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) C18 1.1
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C640 1.1
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.0
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.0
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB) C42 1.0
 LDTP09396  Minor histocompatibility antigen H13 (HM13) C326 1.0
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C579 1.0
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.0
 LDTP04874  Ubiquitin-conjugating enzyme E2 G2 (UBE2G2) C89 1.0
 LDTP01984  NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) C39 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) C215 1.0
 LDTP03401  Multifunctional protein CAD (CAD) C73 1.0
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) C131 1.0
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C143 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.0
 LDTP05289  AMP deaminase 2 (AMPD2) C230 1.0
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.0
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C411 1.0
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) C330 1.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.0
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C62 1.0
 LDTP01772  Cytochrome c oxidase subunit 1 (MT-CO1) C498 1.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C225 1.0
 LDTP03510  Peroxiredoxin-6 (PRDX6) C47 1.0
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) C111 1.0
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) C196 1.0
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C390 1.0
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.0
 LDTP11432  Inosine triphosphate pyrophosphatase (ITPA) C146 1.0
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.9
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C377 0.9
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB) C42 0.9
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 0.9
 LDTP03220  NAD-dependent malic enzyme, mitochondrial (ME2) C120 0.9
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 0.9
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.9
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C411 0.9
 LDTP02672  Elongation factor 2 (EEF2) C131 0.9
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C225 0.9
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) C705 0.9
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C257 0.9
 LDTP05503  Peroxiredoxin-1 (PRDX1) C71 0.9
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120 0.9
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 0.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C447 0.9
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C159 0.9
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 0.9
 LDTP14083  E3 ubiquitin-protein ligase RNF114 (RNF114) C8 0.9
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C329 0.9
 LDTP03518  Enoyl-CoA hydratase, mitochondrial (ECHS1) C62 0.9
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) C195 0.9
 LDTP03333  Proteasome subunit alpha type-4 (PSMA4) C107 0.9
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) C374 0.9
 LDTP03808  Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) C211 0.9
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C150 0.9
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C496 0.9
 LDTP02279  Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) C181 0.9
 LDTP01664  Serine/threonine-protein kinase OSR1 (OXSR1) C191 0.9
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C377 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.9
 LDTP02942  ADP-ribosylation factor 4 (ARF4) C159 0.9
 LDTP04986  ADP-ribosylation factor 6 (ARF6) C155 0.9
 LDTP13814  Phospholipase A-2-activating protein (PLAA) C605 0.9
 LDTP03770  Alpha-adducin (ADD1) C68 0.8
 LDTP02672  Elongation factor 2 (EEF2) C466 0.8
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.8
 LDTP00225  26S proteasome non-ATPase regulatory subunit 9 (PSMD9) C59 0.8
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C62 0.8
 LDTP00192  ATP-dependent RNA helicase DDX39A (DDX39A) C62 0.8
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) C53 0.8
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 0.8
 LDTP04876  Actin, cytoplasmic 1 (ACTB) C217 0.8
 LDTP10286  Corrinoid adenosyltransferase MMAB (MMAB) C119 0.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C247 0.8
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C119 0.8
 LDTP03008  Spermidine synthase (SRM) C25 0.8
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C81 0.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP10500  Lymphokine-activated killer T-cell-originated protein kinase (PBK) C22 0.8
 LDTP03411  Proteasome subunit beta type-8 (PSMB8) C120 0.8
 LDTP02672  Elongation factor 2 (EEF2) C131 0.8
 LDTP13814  Phospholipase A-2-activating protein (PLAA) C605 0.8
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) C453 0.8
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C4106 0.8
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.8
 LDTP04441  26S proteasome non-ATPase regulatory subunit 7 (PSMD7) C116 0.8
 LDTP02220  Adenine phosphoribosyltransferase (APRT) C140 0.8
 LDTP11090  Mitochondrial genome maintenance exonuclease 1 (MGME1) C79 0.8
 LDTP04561  ATP-citrate synthase (ACLY) C20 0.8
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.8
 LDTP02502  Thioredoxin (TXN) C73 0.8
 LDTP12646  ATP-dependent RNA helicase DDX19A (DDX19A) C392 0.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) C40 0.7
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C62 0.7
 LDTP00273  Dynamin-1-like protein (DNM1L) C361 0.7
 LDTP02521  S-formylglutathione hydrolase (ESD) C45 0.7
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) C429 0.7
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) C450 0.7
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C230 0.7
 LDTP00527  Phosphoribosylformylglycinamidine synthase (PFAS) C66 0.7
 LDTP03145  Catechol O-methyltransferase (COMT) C223 0.7
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) C155 0.7
 LDTP02261  ATP-dependent 6-phosphofructokinase, muscle type (PFKM) C334 0.7
 LDTP03145  Catechol O-methyltransferase (COMT) C119 0.7
 LDTP05193  ADP-ribosylation factor 5 (ARF5) C159 0.7
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) C145 0.6
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1) C234 0.6
 LDTP00192  ATP-dependent RNA helicase DDX39A (DDX39A) C197 0.6
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) C321 0.6
 LDTP03688  Serine hydroxymethyltransferase, cytosolic (SHMT1) C68 0.6
 LDTP05503  Peroxiredoxin-1 (PRDX1) C173 0.6
 LDTP14141  Mannose-1-phosphate guanyltransferase beta (GMPPB) C245 0.4
Transporter and channel
Click to Show/Hide to Show 92 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C160 15.0
 LDTP04787  Transmembrane protein 33 (TMEM33) C224 7.5
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) C257 3.4
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C257 3.2
 LDTP00434  Transportin-2 (TNPO2) . 2.8
 LDTP03869  Protein Mpv17 (MPV17) C59 2.3
 LDTP09515  Importin-4 (IPO4) C350 2.2
 LDTP12078  Mitochondrial glutamate carrier 1 (SLC25A22) C233 2.1
 LDTP15898  HIG1 domain family member 2A, mitochondrial (HIGD2A) C53 2.0
 LDTP04749  Peroxisomal biogenesis factor 3 (PEX3) C65 1.8
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) C257 1.7
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) C428 1.7
 LDTP04553  Tricarboxylate transport protein, mitochondrial (SLC25A1) C127 1.7
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C257 1.7
 LDTP09949  Transportin-1 (TNPO1) C386 1.6
 LDTP00810  Exportin-T (XPOT) C915 1.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C210 1.5
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) C136 1.5
 LDTP11292  BOS complex subunit TMEM147 (TMEM147) C23 1.5
 LDTP06242  Importin subunit beta-1 (KPNB1) C585 1.5
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) C477 1.4
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C129 1.4
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C39 1.3
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) C13 1.3
 LDTP01574  Importin-7 (IPO7) C401 1.3
 LDTP11213  Nucleoporin NDC1 (NDC1) C468 1.3
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) C136 1.3
 LDTP00434  Transportin-2 (TNPO2) C805 1.3
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.3
 LDTP06242  Importin subunit beta-1 (KPNB1) C585 1.3
 LDTP00592  Surfeit locus protein 4 (SURF4) C32 1.3
 LDTP09949  Transportin-1 (TNPO1) C142 1.3
 LDTP11310  Nuclear pore complex protein Nup85 (NUP85) C51 1.2
 LDTP00434  Transportin-2 (TNPO2) C789 1.2
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C467 1.2
 LDTP04801  Gasdermin-D (GSDMD) C268 1.2
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) C58 1.2
 LDTP04082  Ran GTPase-activating protein 1 (RANGAP1) C573 1.2
 LDTP09949  Transportin-1 (TNPO1) C103 1.2
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) C129 1.2
 LDTP00592  Surfeit locus protein 4 (SURF4) C32 1.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C47 1.2
 LDTP05305  Large neutral amino acids transporter small subunit 1 (SLC7A5) C496 1.2
 LDTP03869  Protein Mpv17 (MPV17) C59 1.2
 LDTP00501  Exportin-1 (XPO1) C164 1.2
 LDTP09825  Nuclear pore complex protein Nup205 (NUP205) C1662 1.2
 LDTP09949  Transportin-1 (TNPO1) C103 1.2
 LDTP12526  Oligosaccharyltransferase complex subunit OSTC (OSTC) C14 1.1
 LDTP04501  Importin subunit alpha-1 (KPNA2) C223 1.1
 LDTP00434  Transportin-2 (TNPO2) C93 1.1
 LDTP09515  Importin-4 (IPO4) C42 1.1
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) C13 1.1
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) C23 1.1
 LDTP11292  BOS complex subunit TMEM147 (TMEM147) C23 1.1
 LDTP04662  Exportin-2 (CSE1L) C853 1.1
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) C330 1.1
 LDTP00501  Exportin-1 (XPO1) C34 1.1
 LDTP01060  PRA1 family protein 2 (PRAF2) C28 1.1
 LDTP12526  Oligosaccharyltransferase complex subunit OSTC (OSTC) C14 1.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C47 1.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) C76 1.1
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) . 1.0
 LDTP00810  Exportin-T (XPOT) C38 1.0
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) C467 1.0
 LDTP00501  Exportin-1 (XPO1) C34 1.0
 LDTP04662  Exportin-2 (CSE1L) C344 1.0
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) C23 1.0
 LDTP04501  Importin subunit alpha-1 (KPNA2) C223 1.0
 LDTP01988  ATP synthase protein 8 (MT-ATP8) C59 1.0
 LDTP01037  Catenin delta-1 (CTNND1) C692 0.9
 LDTP11934  EH domain-containing protein 1 (EHD1) C138 0.9
 LDTP09949  Transportin-1 (TNPO1) C683 0.9
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) C366 0.9
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) C198 0.9
 LDTP04662  Exportin-2 (CSE1L) C853 0.9
 LDTP01631  Mitochondrial pyruvate carrier 2 (MPC2) C54 0.9
 LDTP06554  Dihydropyrimidinase-related protein 2 (DPYSL2) C179 0.9
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) C704 0.9
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) C199 0.8
 LDTP02010  Annexin A1 (ANXA1) C324 0.8
 LDTP06242  Importin subunit beta-1 (KPNB1) C436 0.8
 LDTP09949  Transportin-1 (TNPO1) C683 0.8
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) C589 0.8
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) C49 0.8
 LDTP04662  Exportin-2 (CSE1L) C325 0.8
 LDTP02010  Annexin A1 (ANXA1) C324 0.8
 LDTP01574  Importin-7 (IPO7) C757 0.8
 LDTP00266  Importin-5 (IPO5) C733 0.8
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 0.8
 LDTP01133  Copine-3 (CPNE3) C54 0.7
 LDTP04662  Exportin-2 (CSE1L) C344 0.2
Transcription factor
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04752  Transcription factor SOX-10 (SOX10) C71 2.1
 LDTP14241  eIF5-mimic protein 1 (BZW2) C97 1.7
 LDTP07940  eIF5-mimic protein 2 (BZW1) C96 1.6
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.4
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.1
 LDTP02500  Nuclear receptor subfamily 2 group F member 6 (NR2F6) C316 1.1
 LDTP04752  Transcription factor SOX-10 (SOX10) C190 0.9
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.7
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C115 1.0
Cytokine and receptor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10323  CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) C12 0.9
 LDTP10323  CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) C12 0.8
Other
Click to Show/Hide to Show 123 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 15.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 5.0
 LDTP05867  Treacle protein (TCOF1) C38 2.9
 LDTP00313  Nucleolar protein 56 (NOP56) C52 2.8
 LDTP03367  Elongation factor 1-gamma (EEF1G) C68 2.5
 LDTP13925  Nucleolar protein 58 (NOP58) C205 2.3
 LDTP00313  Nucleolar protein 56 (NOP56) C112 2.2
 LDTP00313  Nucleolar protein 56 (NOP56) C142 1.9
 LDTP11331  Sideroflexin-3 (SFXN3) C234 1.8
 LDTP00313  Nucleolar protein 56 (NOP56) C211 1.7
 LDTP03773  Metalloproteinase inhibitor 3 (TIMP3) C163 1.5
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C673 1.5
 LDTP14153  Trafficking protein particle complex subunit 1 (TRAPPC1) C115 1.5
 LDTP10864  Calponin-2 (CNN2) C175 1.4
 LDTP05867  Treacle protein (TCOF1) C38 1.3
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C196 1.3
 LDTP00313  Nucleolar protein 56 (NOP56) C384 1.3
 LDTP14069  WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) C393 1.3
 LDTP00720  Centromere/kinetochore protein zw10 homolog (ZW10) C568 1.2
 LDTP07718  MICOS complex subunit MIC27 (APOOL) C152 1.2
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C397 1.2
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C196 1.2
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.2
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.2
 LDTP02809  Small ribosomal subunit protein uS5 (RPS2) C229 1.2
 LDTP06383  Calponin-3 (CNN3) C173 1.1
 LDTP06383  Calponin-3 (CNN3) C173 1.1
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) C111 1.1
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C450 1.1
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) C60 1.1
 LDTP02205  Tubulin beta chain (TUBB) C303 1.1
 LDTP08387  Dynein axonemal assembly factor 5 (DNAAF5) C173 1.1
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.1
 LDTP05198  Histone H3.3 (H3-3A; H3-3B) C111 1.1
 LDTP15947  Mitochondrial fission regulator 1-like (MTFR1L) C52 1.1
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.1
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) C363 1.1
 LDTP05025  Large ribosomal subunit protein eL32 (RPL32) C91 1.1
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C49 1.1
 LDTP01285  TIP41-like protein (TIPRL) C87 1.1
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.1
 LDTP05049  Dynein light chain 1, cytoplasmic (DYNLL1) C56 1.1
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) C10 1.1
 LDTP14980  RRP12-like protein (RRP12) C763 1.1
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C511 1.1
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.0
 LDTP06367  Poly(rC)-binding protein 2 (PCBP2) C217 1.0
 LDTP02205  Tubulin beta chain (TUBB) C239 1.0
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) C60 1.0
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 1.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.0
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 1.0
 LDTP15101  Armadillo repeat-containing protein 6 (ARMC6) C297 1.0
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) C180 1.0
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) C33 1.0
 LDTP05778  Chromobox protein homolog 3 (CBX3) C177 1.0
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) C33 1.0
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) C468 1.0
 LDTP19499  UPF0598 protein C8orf82 (C8orf82) C98 1.0
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) C363 1.0
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) C468 1.0
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.0
 LDTP02059  Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) C112 1.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) C119 1.0
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70 1.0
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.0
 LDTP13170  COP9 signalosome complex subunit 7a (COPS7A) C110 1.0
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.0
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.0
 LDTP04105  Large ribosomal subunit protein uL15 (RPL27A) C70 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.0
 LDTP13424  Vacuolar protein sorting-associated protein 28 homolog (VPS28) C128 1.0
 LDTP05049  Dynein light chain 1, cytoplasmic (DYNLL1) C56 1.0
 LDTP03888  T-complex protein 1 subunit zeta (CCT6A) C406 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C205 1.0
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 1.0
 LDTP02205  Tubulin beta chain (TUBB) C201 1.0
 LDTP03244  Cofilin-1 (CFL1) C139 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C175 0.9
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C155 0.9
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14) C42 0.9
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C615 0.9
 LDTP02596  Proliferating cell nuclear antigen (PCNA) C81 0.9
 LDTP04504  Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) C85 0.9
 LDTP04249  T-complex protein 1 subunit gamma (CCT3) C455 0.9
 LDTP08902  CDGSH iron-sulfur domain-containing protein 2 (CISD2) C92 0.9
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C325 0.9
 LDTP11331  Sideroflexin-3 (SFXN3) C189 0.9
 LDTP03367  Elongation factor 1-gamma (EEF1G) C266 0.9
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.9
 LDTP03244  Cofilin-1 (CFL1) C139 0.9
 LDTP00619  Eukaryotic translation initiation factor 3 subunit D (EIF3D) C19 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C175 0.9
 LDTP05697  Heat shock protein 75 kDa, mitochondrial (TRAP1) C573 0.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.9
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.9
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.9
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C172 0.9
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) C119 0.8
 LDTP05002  Small ribosomal subunit protein eS6 (RPS6) C12 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.8
 LDTP10071  Protein mago nashi homolog 2 (MAGOHB) C133 0.8
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.8
 LDTP13991  Serine-threonine kinase receptor-associated protein (STRAP) C340 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP16107  TBC1 domain family member 13 (TBC1D13) C145 0.8
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C54 0.8
 LDTP04887  Destrin (DSTN) C163 0.8
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C155 0.8
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 0.8
 LDTP05055  Small ribosomal subunit protein eS21 (RPS21) C56 0.8
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP09811  Heat shock protein 105 kDa (HSPH1) C34 0.7
 LDTP02107  Large ribosomal subunit protein P1 (RPLP1) C61 0.7
 LDTP04708  NHP2-like protein 1 (SNU13) C30 0.7
 LDTP04504  Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) C85 0.6
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.6
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C269 0.6
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.6

References

1 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.