Details of the Target

General Information of Target

Target ID LDTP11934
Target Name EH domain-containing protein 1 (EHD1)
Gene Name EHD1
Gene ID 10938
Synonyms
PAST; PAST1; EH domain-containing protein 1; PAST homolog 1; hPAST1; Testilin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW
LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT
FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP
PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP
SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG
PPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQ
SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW
GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA
QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW
GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRR
NQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTT
PYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPP
PRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQSSF
Target Bioclass
Transporter and channel
Family
TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, EHD subfamily
Subcellular location
Recycling endosome membrane
Function
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis.
Uniprot ID
Q9H4M9
Ensemble ID
ENST00000320631.8
HGNC ID
HGNC:3242
ChEMBL ID
CHEMBL4295942

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.59  LDD0402  [1]
A-EBA
 Probe Info  		3.02  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
ONAyne
 Probe Info  		K220(1.82); K32(2.50); K375(1.06); K468(0.49)  LDD0274  [4]
STPyne
 Probe Info  		K12(6.92); K13(6.42); K208(3.45); K213(10.00)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K220(4.05)  LDD3494  [5]
Probe 1
 Probe Info  		Y29(23.00)  LDD3495  [6]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [7]
THZ1-DTB
 Probe Info  		C138(1.10)  LDD0460  [7]
EA-probe
 Probe Info  		C138(0.93)  LDD2210  [8]
Acrolein
 Probe Info  		H346(0.00); H77(0.00); H102(0.00)  LDD0221  [9]
DBIA
 Probe Info  		C138(1.11)  LDD0547  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		7.94  LDD1977  [14]
FFF probe11
 Probe Info  		5.86  LDD0471  [15]
FFF probe12
 Probe Info  		13.97  LDD0473  [15]
FFF probe13
 Probe Info  		6.29  LDD0476  [15]
FFF probe15
 Probe Info  		5.68  LDD0478  [15]
FFF probe3
 Probe Info  		7.23  LDD0465  [15]
JN0003
 Probe Info  		8.45  LDD0469  [15]
STS-2
 Probe Info  		N.A.  LDD0139  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C138(0.39)  LDD1093  [10]
 LDCM0215  AC10 PaTu 8988t C138(0.69)  LDD1094  [10]
 LDCM0216  AC100 PaTu 8988t C138(0.64)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C138(0.83)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C138(0.83)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C138(0.70)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C138(0.87)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C138(0.89)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C138(0.71)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C138(0.88)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C138(0.70)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C138(0.74)  LDD1104  [10]
 LDCM0226  AC11 PaTu 8988t C138(0.73)  LDD1105  [10]
 LDCM0227  AC110 PaTu 8988t C138(0.64)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C138(0.74)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C138(0.84)  LDD1108  [10]
 LDCM0230  AC113 HCT 116 C138(1.11)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C138(0.79)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C138(0.84)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C138(0.77)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C138(0.88)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C138(0.83)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C138(0.85)  LDD0553  [10]
 LDCM0237  AC12 PaTu 8988t C138(0.69)  LDD1116  [10]
 LDCM0238  AC120 HCT 116 C138(0.79)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C138(0.89)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C138(0.78)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C138(0.88)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C138(0.93)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C138(0.90)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C138(0.89)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C138(0.86)  LDD0562  [10]
 LDCM0246  AC128 PaTu 8988t C138(0.92)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C138(0.91)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C138(1.00)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C138(1.00)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C138(0.88)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C138(0.99)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C138(0.85)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C138(1.05)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C138(0.88)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C138(0.92)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C138(0.88)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C138(1.04)  LDD1137  [10]
 LDCM0259  AC14 PaTu 8988t C138(0.84)  LDD1138  [10]
 LDCM0260  AC140 PaTu 8988t C138(0.87)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C138(0.97)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C138(0.91)  LDD1141  [10]
 LDCM0263  AC143 HCT 116 C138(0.84)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C138(0.84)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C138(0.82)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C138(0.92)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C138(1.06)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C138(0.91)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C138(0.88)  LDD0586  [10]
 LDCM0270  AC15 PaTu 8988t C138(0.74)  LDD1149  [10]
 LDCM0271  AC150 HCT 116 C138(1.16)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C138(0.88)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C138(0.77)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C138(0.95)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C138(0.75)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C138(0.86)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C138(1.07)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C138(1.28)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C138(1.10)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C138(1.18)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C138(0.92)  LDD0595  [10]
 LDCM0279  AC2 PaTu 8988t C138(0.49)  LDD1158  [10]
 LDCM0280  AC20 HCT 116 C138(0.93)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C138(0.78)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C138(1.06)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C138(1.28)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C138(1.13)  LDD0601  [10]
 LDCM0285  AC25 PaTu 8988t C138(1.04)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C138(0.83)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C138(0.85)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C138(0.81)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C138(0.77)  LDD1168  [10]
 LDCM0290  AC3 PaTu 8988t C138(0.48)  LDD1169  [10]
 LDCM0291  AC30 PaTu 8988t C138(0.92)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C138(1.08)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C138(0.88)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C138(0.79)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C138(0.95)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C138(0.79)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C138(0.64)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C138(0.73)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C138(0.63)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C138(0.63)  LDD1179  [10]
 LDCM0301  AC4 PaTu 8988t C138(0.53)  LDD1180  [10]
 LDCM0302  AC40 PaTu 8988t C138(0.59)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C138(0.78)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C138(0.65)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C138(0.78)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C138(0.68)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C138(0.67)  LDD1186  [10]
 LDCM0308  AC46 PaTu 8988t C138(0.81)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C138(0.75)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C138(0.69)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C138(0.66)  LDD1190  [10]
 LDCM0312  AC5 PaTu 8988t C138(0.43)  LDD1191  [10]
 LDCM0313  AC50 PaTu 8988t C138(0.63)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C138(0.56)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C138(0.65)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C138(0.61)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C138(0.65)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C138(0.62)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C138(0.61)  LDD1198  [10]
 LDCM0320  AC57 PaTu 8988t C138(0.90)  LDD1199  [10]
 LDCM0321  AC58 PaTu 8988t C138(0.92)  LDD1200  [10]
 LDCM0322  AC59 PaTu 8988t C138(0.92)  LDD1201  [10]
 LDCM0323  AC6 PaTu 8988t C138(0.75)  LDD1202  [10]
 LDCM0324  AC60 PaTu 8988t C138(0.94)  LDD1203  [10]
 LDCM0325  AC61 PaTu 8988t C138(0.99)  LDD1204  [10]
 LDCM0326  AC62 PaTu 8988t C138(0.88)  LDD1205  [10]
 LDCM0327  AC63 PaTu 8988t C138(0.91)  LDD1206  [10]
 LDCM0328  AC64 PaTu 8988t C138(1.00)  LDD1207  [10]
 LDCM0329  AC65 PaTu 8988t C138(1.09)  LDD1208  [10]
 LDCM0330  AC66 PaTu 8988t C138(0.91)  LDD1209  [10]
 LDCM0331  AC67 PaTu 8988t C138(0.96)  LDD1210  [10]
 LDCM0332  AC68 PaTu 8988t C138(1.23)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C138(0.96)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C138(0.91)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C138(1.11)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C138(1.01)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C138(1.28)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C138(1.28)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C138(1.27)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C138(1.00)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C138(1.01)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C138(1.11)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C138(1.27)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C138(0.96)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C138(0.79)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C138(1.35)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C138(1.27)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C138(1.25)  LDD1227  [10]
 LDCM0349  AC83 PaTu 8988t C138(1.14)  LDD1228  [10]
 LDCM0350  AC84 PaTu 8988t C138(0.99)  LDD1229  [10]
 LDCM0351  AC85 PaTu 8988t C138(1.18)  LDD1230  [10]
 LDCM0352  AC86 PaTu 8988t C138(1.23)  LDD1231  [10]
 LDCM0353  AC87 PaTu 8988t C138(1.29)  LDD1232  [10]
 LDCM0354  AC88 PaTu 8988t C138(1.29)  LDD1233  [10]
 LDCM0355  AC89 PaTu 8988t C138(1.10)  LDD1234  [10]
 LDCM0357  AC90 PaTu 8988t C138(1.41)  LDD1236  [10]
 LDCM0358  AC91 PaTu 8988t C138(1.23)  LDD1237  [10]
 LDCM0359  AC92 PaTu 8988t C138(1.13)  LDD1238  [10]
 LDCM0360  AC93 PaTu 8988t C138(1.42)  LDD1239  [10]
 LDCM0361  AC94 PaTu 8988t C138(1.25)  LDD1240  [10]
 LDCM0362  AC95 PaTu 8988t C138(1.17)  LDD1241  [10]
 LDCM0363  AC96 PaTu 8988t C138(1.64)  LDD1242  [10]
 LDCM0364  AC97 PaTu 8988t C138(1.20)  LDD1243  [10]
 LDCM0365  AC98 PaTu 8988t C138(0.68)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C138(0.83)  LDD1245  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C138(0.69)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C138(0.72)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C138(0.69)  LDD1154  [10]
 LDCM0108  Chloroacetamide HeLa H77(0.00); H346(0.00)  LDD0222  [9]
 LDCM0367  CL1 PaTu 8988t C138(0.98)  LDD1246  [10]
 LDCM0368  CL10 PaTu 8988t C138(0.77)  LDD1247  [10]
 LDCM0369  CL100 PaTu 8988t C138(0.48)  LDD1248  [10]
 LDCM0370  CL101 PaTu 8988t C138(0.79)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C138(0.80)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C138(0.78)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C138(0.75)  LDD1252  [10]
 LDCM0374  CL105 HCT 116 C138(0.91)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C138(0.71)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C138(0.69)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C138(0.78)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C138(1.07)  LDD0695  [10]
 LDCM0379  CL11 PaTu 8988t C138(0.66)  LDD1258  [10]
 LDCM0380  CL110 HCT 116 C138(0.72)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C138(0.79)  LDD0698  [10]
 LDCM0382  CL112 PaTu 8988t C138(0.91)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C138(0.95)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C138(0.89)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C138(1.05)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C138(0.62)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C138(0.83)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C138(0.70)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C138(0.72)  LDD1268  [10]
 LDCM0390  CL12 PaTu 8988t C138(0.76)  LDD1269  [10]
 LDCM0391  CL120 PaTu 8988t C138(0.74)  LDD1270  [10]
 LDCM0392  CL121 PaTu 8988t C138(0.75)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C138(0.75)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C138(0.64)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C138(0.65)  LDD1274  [10]
 LDCM0396  CL125 PaTu 8988t C138(1.04)  LDD1275  [10]
 LDCM0397  CL126 PaTu 8988t C138(0.99)  LDD1276  [10]
 LDCM0398  CL127 PaTu 8988t C138(0.96)  LDD1277  [10]
 LDCM0399  CL128 PaTu 8988t C138(0.86)  LDD1278  [10]
 LDCM0400  CL13 PaTu 8988t C138(0.93)  LDD1279  [10]
 LDCM0401  CL14 PaTu 8988t C138(0.83)  LDD1280  [10]
 LDCM0402  CL15 PaTu 8988t C138(0.96)  LDD1281  [10]
 LDCM0403  CL16 HCT 116 C138(0.82)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C138(0.91)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C138(1.00)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C138(0.99)  LDD0723  [10]
 LDCM0407  CL2 PaTu 8988t C138(0.92)  LDD1286  [10]
 LDCM0408  CL20 HCT 116 C138(1.15)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C138(1.15)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C138(1.58)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C138(1.17)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C138(1.04)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C138(1.00)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C138(1.00)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C138(0.89)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C138(0.91)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C138(1.21)  LDD0734  [10]
 LDCM0418  CL3 PaTu 8988t C138(0.69)  LDD1297  [10]
 LDCM0419  CL30 HCT 116 C138(1.00)  LDD0736  [10]
 LDCM0420  CL31 PaTu 8988t C138(0.81)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C138(0.77)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C138(0.71)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C138(0.69)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C138(0.74)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C138(0.23)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C138(0.73)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C138(0.75)  LDD1307  [10]
 LDCM0429  CL4 PaTu 8988t C138(0.92)  LDD1308  [10]
 LDCM0430  CL40 PaTu 8988t C138(0.82)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C138(0.83)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C138(0.77)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C138(0.70)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C138(0.63)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C138(0.67)  LDD1314  [10]
 LDCM0436  CL46 PaTu 8988t C138(0.76)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C138(0.69)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C138(0.68)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C138(0.66)  LDD1318  [10]
 LDCM0440  CL5 PaTu 8988t C138(0.82)  LDD1319  [10]
 LDCM0441  CL50 PaTu 8988t C138(0.63)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C138(0.71)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C138(0.73)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C138(0.54)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C138(0.66)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C138(0.63)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C138(0.42)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C138(0.73)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C138(0.67)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C138(0.77)  LDD1329  [10]
 LDCM0451  CL6 PaTu 8988t C138(0.80)  LDD1330  [10]
 LDCM0452  CL60 PaTu 8988t C138(0.72)  LDD1331  [10]
 LDCM0453  CL61 PaTu 8988t C138(0.91)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C138(0.82)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C138(0.93)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C138(0.84)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C138(0.92)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C138(0.83)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C138(0.89)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C138(0.77)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C138(0.76)  LDD1340  [10]
 LDCM0462  CL7 PaTu 8988t C138(0.77)  LDD1341  [10]
 LDCM0463  CL70 PaTu 8988t C138(0.80)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C138(0.87)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C138(1.04)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C138(0.65)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C138(0.79)  LDD1346  [10]
 LDCM0469  CL76 PaTu 8988t C138(0.95)  LDD1348  [10]
 LDCM0470  CL77 PaTu 8988t C138(0.61)  LDD1349  [10]
 LDCM0471  CL78 PaTu 8988t C138(0.61)  LDD1350  [10]
 LDCM0472  CL79 PaTu 8988t C138(0.67)  LDD1351  [10]
 LDCM0473  CL8 PaTu 8988t C138(0.85)  LDD1352  [10]
 LDCM0474  CL80 PaTu 8988t C138(0.65)  LDD1353  [10]
 LDCM0475  CL81 PaTu 8988t C138(0.62)  LDD1354  [10]
 LDCM0476  CL82 PaTu 8988t C138(0.79)  LDD1355  [10]
 LDCM0477  CL83 PaTu 8988t C138(0.54)  LDD1356  [10]
 LDCM0478  CL84 PaTu 8988t C138(0.74)  LDD1357  [10]
 LDCM0479  CL85 PaTu 8988t C138(0.73)  LDD1358  [10]
 LDCM0480  CL86 PaTu 8988t C138(0.67)  LDD1359  [10]
 LDCM0481  CL87 PaTu 8988t C138(0.56)  LDD1360  [10]
 LDCM0482  CL88 PaTu 8988t C138(0.61)  LDD1361  [10]
 LDCM0483  CL89 PaTu 8988t C138(0.76)  LDD1362  [10]
 LDCM0484  CL9 PaTu 8988t C138(0.87)  LDD1363  [10]
 LDCM0485  CL90 PaTu 8988t C138(0.56)  LDD1364  [10]
 LDCM0486  CL91 PaTu 8988t C138(0.56)  LDD1365  [10]
 LDCM0487  CL92 PaTu 8988t C138(0.48)  LDD1366  [10]
 LDCM0488  CL93 PaTu 8988t C138(0.44)  LDD1367  [10]
 LDCM0489  CL94 PaTu 8988t C138(0.50)  LDD1368  [10]
 LDCM0490  CL95 PaTu 8988t C138(0.40)  LDD1369  [10]
 LDCM0491  CL96 PaTu 8988t C138(0.43)  LDD1370  [10]
 LDCM0492  CL97 PaTu 8988t C138(0.49)  LDD1371  [10]
 LDCM0493  CL98 PaTu 8988t C138(0.38)  LDD1372  [10]
 LDCM0494  CL99 PaTu 8988t C138(0.51)  LDD1373  [10]
 LDCM0495  E2913 HEK-293T C138(1.01)  LDD1698  [17]
 LDCM0175  Ethacrynic acid HeLa C138(0.93)  LDD2210  [8]
 LDCM0625  F8 Ramos C138(0.60)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C138(0.52)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C138(4.25)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C138(0.55)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C138(0.62)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C138(1.78)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C138(0.51)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C138(0.78)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C138(0.63)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C138(0.56)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C138(0.59)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C138(0.70)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C138(0.67)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C138(1.07)  LDD2201  [18]
 LDCM0468  Fragment33 PaTu 8988t C138(0.84)  LDD1347  [10]
 LDCM0596  Fragment38 Ramos C138(0.42)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C138(0.82)  LDD2184  [18]
 LDCM0427  Fragment51 PaTu 8988t C138(0.68)  LDD1306  [10]
 LDCM0610  Fragment52 Ramos C138(0.47)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C138(0.56)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C138(1.08)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C138(0.96)  LDD2188  [18]
 LDCM0107  IAA HeLa H346(0.00); H77(0.00); H102(0.00)  LDD0221  [9]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [7]
 LDCM0022  KB02 HEK-293T C138(0.99)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C138(1.08)  LDD1497  [17]
 LDCM0024  KB05 G361 C138(2.17)  LDD3311  [19]
 LDCM0109  NEM HeLa H346(0.00); H77(0.00); H102(0.00)  LDD0223  [9]
 LDCM0021  THZ1 HeLa S3 C138(1.10)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EH domain-containing protein 3 (EHD3) Dynamin/Fzo/YdjA family Q9NZN3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EH domain-containing protein 1 (EHD1) Dynamin/Fzo/YdjA family Q9H4M9
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptosomal-associated protein 29 (SNAP29) SNAP-25 family O95721
MICAL-like protein 1 (MICALL1) . Q8N3F8
Rabankyrin-5 (ANKFY1) . Q9P2R3
Rabenosyn-5 (RBSN) . Q9H1K0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840