Details of the Target

General Information of Target

Target ID LDTP03522
Target Name Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)
Gene Name PPP2R1A
Gene ID 5518
Synonyms
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; Medium tumor antigen-associated 61 kDa protein; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY
DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS
PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM
VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL
EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA
AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN
TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR
LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA
TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV
AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Target Bioclass
Enzyme
Family
Phosphatase 2A regulatory subunit A family
Subcellular location
Cytoplasm
Function
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability.
Uniprot ID
P30153
Ensemble ID
ENST00000322088.11
HGNC ID
HGNC:9302

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P2
 Probe Info  		10.00  LDD0449  [2]
A-EBA
 Probe Info  		2.92  LDD0215  [3]
CHEMBL5175495
 Probe Info  		8.04  LDD0196  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
CY4
 Probe Info  		100.00  LDD0244  [5]
N1
 Probe Info  		100.00  LDD0242  [5]
W1
 Probe Info  		14.03  LDD0235  [6]
TH211
 Probe Info  		Y495(15.32)  LDD0260  [7]
TH214
 Probe Info  		Y495(20.00)  LDD0258  [7]
TH216
 Probe Info  		Y261(7.14)  LDD0259  [7]
YN-1
 Probe Info  		100.00  LDD0444  [8]
STPyne
 Probe Info  		K188(3.85); K194(10.00); K266(10.00); K280(6.13)  LDD0277  [9]
BTD
 Probe Info  		C294(2.89)  LDD1699  [10]
ONAyne
 Probe Info  		K163(0.00); K133(0.00); K266(0.00); K107(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K107(3.25)  LDD3494  [11]
Probe 1
 Probe Info  		Y261(37.17)  LDD3495  [12]
JZ128-DTB
 Probe Info  		C294(0.00); C390(0.00); C504(0.00); C148(0.00)  LDD0462  [13]
THZ1-DTB
 Probe Info  		C390(1.05); C148(1.09)  LDD0460  [13]
DA-P3
 Probe Info  		6.29  LDD0183  [14]
AHL-Pu-1
 Probe Info  		C154(2.10)  LDD0168  [15]
EA-probe
 Probe Info  		C390(0.96); C377(0.94); C329(0.90); C377(0.88)  LDD2210  [16]
HHS-482
 Probe Info  		Y261(0.67)  LDD0285  [17]
HHS-465
 Probe Info  		Y261(4.85); Y495(9.47)  LDD2237  [18]
DBIA
 Probe Info  		C377(1.05); C294(1.00); C148(0.88); C317(0.85)  LDD0078  [19]
5E-2FA
 Probe Info  		H119(0.00); H117(0.00); H340(0.00); H454(0.00)  LDD2235  [20]
ATP probe
 Probe Info  		K475(0.00); K194(0.00); K307(0.00); K133(0.00)  LDD0199  [21]
4-Iodoacetamidophenylacetylene
 Probe Info  		C294(0.00); C377(0.00); C329(0.00); C390(0.00)  LDD0038  [22]
IA-alkyne
 Probe Info  		C390(0.00); C294(0.00); C310(0.00); C148(0.00)  LDD0032  [23]
IPIAA_H
 Probe Info  		C294(0.00); C377(0.00)  LDD0030  [24]
IPIAA_L
 Probe Info  		C390(0.00); C329(0.00); C294(0.00); C174(0.00)  LDD0031  [24]
Lodoacetamide azide
 Probe Info  		C294(0.00); C377(0.00); C329(0.00); C390(0.00)  LDD0037  [22]
ATP probe
 Probe Info  		K133(0.00); K416(0.00)  LDD0035  [25]
NAIA_4
 Probe Info  		C148(0.00); C174(0.00); C228(0.00); C377(0.00)  LDD2226  [26]
WYneN
 Probe Info  		C317(0.00); C329(0.00); C174(0.00); C390(0.00)  LDD0021  [27]
WYneO
 Probe Info  		C317(0.00); C329(0.00); C174(0.00)  LDD0022  [27]
1d-yne
 Probe Info  		N.A.  LDD0356  [28]
ENE
 Probe Info  		N.A.  LDD0006  [27]
IPM
 Probe Info  		C317(0.00); C329(0.00); C390(0.00)  LDD0005  [27]
PF-06672131
 Probe Info  		C154(0.00); C329(0.00); C390(0.00)  LDD0017  [29]
SF
 Probe Info  		K472(0.00); Y495(0.00)  LDD0028  [30]
TFBX
 Probe Info  		C294(0.00); C390(0.00); C329(0.00); C154(0.00)  LDD0148  [31]
VSF
 Probe Info  		C310(0.00); C329(0.00); C390(0.00)  LDD0007  [27]
Phosphinate-6
 Probe Info  		C377(0.00); C310(0.00); C390(0.00); C294(0.00)  LDD0018  [32]
Ox-W18
 Probe Info  		W140(0.00); W477(0.00)  LDD2175  [33]
1c-yne
 Probe Info  		K188(0.00); K546(0.00); K280(0.00); K202(0.00)  LDD0228  [28]
Acrolein
 Probe Info  		C329(0.00); H497(0.00); C174(0.00); H127(0.00)  LDD0217  [34]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [34]
Methacrolein
 Probe Info  		C310(0.00); C174(0.00); C317(0.00)  LDD0218  [34]
AOyne
 Probe Info  		10.10  LDD0443  [35]
NAIA_5
 Probe Info  		C294(0.00); C377(0.00); C329(0.00); C447(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		19.70  LDD1793  [36]
C193
 Probe Info  		6.02  LDD1869  [36]
C265
 Probe Info  		21.86  LDD1936  [36]
C328
 Probe Info  		5.24  LDD1992  [36]
FFF probe13
 Probe Info  		11.74  LDD0475  [37]
FFF probe14
 Probe Info  		14.28  LDD0477  [37]
FFF probe3
 Probe Info  		5.88  LDD0465  [37]
STS-1
 Probe Info  		N.A.  LDD0136  [38]
STS-2
 Probe Info  		N.A.  LDD0138  [38]
VE-P
 Probe Info  		N.A.  LDD0396  [39]
Alk-rapa
 Probe Info  		6.54  LDD0213  [40]
DA-2
 Probe Info  		N.A.  LDD0070  [41]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C377(1.55)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C377(1.34); C310(0.52)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C294(1.00); C174(0.61)  LDD2095  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C174(1.07)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C294(1.25); C174(1.05); C148(0.78); C377(1.38)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C174(1.22)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C310(0.92)  LDD2103  [10]
 LDCM0025  4SU-RNA HEK-293T C154(2.10)  LDD0168  [15]
 LDCM0026  4SU-RNA+native RNA HEK-293T C154(3.53); C294(2.11)  LDD0169  [15]
 LDCM0214  AC1 HCT 116 C174(0.89); C310(0.95); C317(1.06); C329(0.83)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C174(0.79); C310(0.91); C317(0.89); C377(1.25)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C174(0.64); C310(1.24); C317(1.32); C377(1.24)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C174(0.52); C310(1.31); C317(0.98); C377(1.14)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C174(0.52); C310(1.08); C317(1.25); C377(1.05)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C174(0.50); C310(0.88); C317(0.98); C377(1.31)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C174(0.45); C310(1.05); C317(1.21); C377(1.28)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C174(0.57); C310(0.92); C317(1.01); C377(1.40)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C174(0.50); C310(1.26); C317(1.29); C377(1.34)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C174(0.53); C310(1.16); C317(1.11); C377(1.31)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C174(0.62); C310(0.98); C317(1.20); C377(1.09)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C174(0.62); C310(1.03); C317(1.36); C377(0.83)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C174(0.77); C310(0.89); C317(0.95); C377(1.22)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C174(0.59); C310(1.00); C317(1.03); C377(1.13)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C174(0.55); C310(0.95); C317(0.91); C377(1.11)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C174(0.45); C310(0.85); C317(0.93); C377(1.27)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C174(1.13); C310(0.87); C317(0.88); C377(0.99)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C174(0.88); C310(0.84); C317(0.97); C377(1.16)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C174(0.85); C310(0.72); C317(0.70); C377(1.17)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C174(0.95); C310(0.67); C317(0.71); C377(1.12)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C174(1.01); C310(0.74); C317(0.85); C377(1.17)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C174(1.04); C310(0.87); C317(0.87); C377(1.04)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C174(1.09); C310(0.88); C317(0.86); C377(1.04)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C174(0.92); C310(1.02); C317(1.02); C377(1.06)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C174(0.82); C310(0.78); C317(0.87); C377(0.95)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C174(1.11); C310(0.89); C317(0.88); C377(1.01)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C174(1.17); C310(1.06); C317(0.99); C377(1.11)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C174(1.02); C310(0.95); C317(0.94); C377(1.06)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C174(1.22); C310(1.11); C317(1.10); C377(0.88)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C174(1.17); C310(0.80); C317(0.78); C377(1.07)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C174(1.02); C310(0.74); C317(0.77); C377(1.05)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C174(1.09); C310(0.77); C317(0.78); C377(1.12)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C174(1.02); C310(1.13); C317(1.12); C377(1.50)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C174(1.06); C310(1.20); C317(1.18); C377(1.20)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C174(0.94); C310(0.98); C317(1.02); C377(1.43)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C174(0.96); C310(1.13); C317(1.13); C377(1.03)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C174(1.01); C310(1.18); C317(1.22); C377(1.27)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C174(1.02); C310(1.06); C317(1.09); C377(1.39)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C174(0.89); C310(0.92); C317(1.04); C377(1.46)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C174(1.09); C310(0.96); C317(1.07); C377(1.47)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C174(0.99); C310(1.11); C317(1.12); C377(1.32)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C174(0.90); C310(1.13); C317(1.22); C377(1.26)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C174(0.75); C310(0.95); C317(1.11); C377(1.58)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C174(0.94); C310(0.97); C317(1.03); C377(1.51)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C174(0.80); C310(0.83); C317(0.91); C377(1.08)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C174(0.89); C310(0.92); C317(1.08); C377(1.60)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C174(0.87); C310(0.95); C317(1.12); C377(1.43)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C174(1.07); C310(1.14); C317(1.23); C377(1.37)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C174(0.70); C377(1.15); C317(1.25); C310(1.30)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C174(0.61); C317(0.70); C310(0.78); C377(1.40)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C317(0.66); C174(0.70); C310(0.88); C377(1.36)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C174(0.63); C317(0.80); C310(0.83); C377(1.44)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C317(0.75); C174(0.75); C310(0.82); C377(1.45)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C174(0.52); C317(0.69); C310(0.71); C377(2.07)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C174(0.63); C317(0.64); C310(0.73); C377(1.74)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C317(0.79); C174(0.84); C310(0.85); C377(1.12)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C174(0.71); C317(0.78); C310(0.83); C377(1.18)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C174(0.88); C317(1.15); C310(1.23); C377(1.30)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C174(0.58); C317(0.78); C310(0.90); C377(1.46)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C174(0.54); C317(0.68); C310(0.80); C377(2.44)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C174(0.61); C310(1.02); C317(0.89); C377(1.34)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C174(0.56); C310(0.86); C317(0.73); C377(1.24)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C174(0.84); C310(1.09); C317(1.03); C377(1.13)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C174(1.07); C310(1.05); C317(0.90); C377(1.07)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C317(0.99); C310(1.06); C377(1.07); C174(1.22)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C310(0.82); C317(0.88); C377(1.16); C174(1.23)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C317(0.82); C310(0.90); C377(1.14); C174(1.17)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C377(0.80); C329(0.95); C310(1.05); C317(1.10)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C317(0.98); C310(1.02); C377(1.05); C174(1.20)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C310(0.90); C317(1.04); C377(1.08); C174(1.26)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C310(0.92); C317(0.98); C377(1.08); C174(1.25)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C310(0.95); C174(1.01); C377(1.07); C317(1.09)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C377(0.96); C310(0.98); C174(1.00); C317(1.02)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C377(0.90); C174(0.90); C317(0.90); C310(0.96)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C317(0.80); C174(0.84); C310(0.85); C377(1.04)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C377(0.73); C317(0.76); C310(0.80); C174(0.98)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C329(0.75); C377(0.82); C174(0.90); C310(0.97)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C317(0.67); C174(0.79); C310(0.81); C377(0.87)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C329(0.96); C317(1.07); C310(1.10); C377(1.11)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C174(0.68); C317(0.69); C310(0.82); C329(1.03)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C317(0.73); C329(0.82); C310(0.86); C377(0.87)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C317(0.65); C174(0.72); C329(0.74); C310(0.79)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C329(0.54); C317(0.71); C310(0.77); C174(0.80)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C317(0.66); C310(0.71); C174(0.73); C329(0.89)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C377(0.81); C317(1.05); C310(1.07); C174(1.31)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C377(0.82); C317(0.94); C310(1.08); C174(1.15)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C377(0.89); C317(0.93); C310(0.98); C174(1.21)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C377(0.84); C317(0.94); C310(0.99); C174(1.06)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C377(0.99); C310(1.06); C317(1.07); C174(1.15)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C329(0.77); C174(0.89); C317(0.89); C310(0.91)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C317(0.94); C377(0.97); C310(0.98); C174(1.01)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C317(0.88); C377(0.95); C174(1.00); C310(1.00)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C377(0.88); C317(0.89); C174(0.95); C310(1.05)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C317(0.92); C377(0.96); C174(0.99); C310(1.05)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C377(0.88); C317(0.97); C174(0.99); C310(1.02)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C377(0.92); C174(0.98); C317(1.02); C310(1.04)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C310(1.00); C317(1.03); C174(1.17); C377(1.46)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C310(1.00); C174(1.00); C317(1.02); C377(1.16)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C377(1.06); C310(1.06); C317(1.11); C174(1.24)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C174(0.88); C310(0.94); C317(0.96); C377(1.17)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C329(0.79); C317(0.96); C174(0.97); C377(1.13)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C317(0.92); C310(0.93); C174(0.97); C377(1.14)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C317(1.07); C310(1.13); C377(1.13); C174(1.42)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C317(1.00); C377(1.01); C310(1.03); C174(1.28)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C310(0.99); C317(1.00); C377(1.08); C174(1.17)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C377(0.94); C174(0.98); C310(1.05); C317(1.10)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C310(0.99); C317(1.00); C174(1.03); C377(1.06)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C174(0.87); C310(1.01); C317(1.07); C377(1.12)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C174(0.70); C317(0.70); C310(0.76); C329(1.11)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C174(0.68); C317(0.68); C310(0.76); C329(1.02)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C317(0.66); C174(0.67); C310(0.71); C329(1.13)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C174(0.74); C317(0.82); C310(0.86); C377(1.32)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C317(0.62); C174(0.65); C310(0.66); C329(1.15)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C317(0.71); C174(0.72); C310(0.72); C329(0.99)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C317(0.66); C174(0.68); C310(0.69); C329(1.17)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C317(0.66); C174(0.73); C310(0.77); C377(1.26)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C317(0.70); C310(0.72); C174(0.73); C377(1.15)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C317(0.70); C174(0.75); C310(0.76); C329(0.99)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C317(0.69); C310(0.71); C174(0.79); C329(0.97)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C317(0.60); C310(0.64); C174(0.66); C329(1.10)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C329(0.78); C310(0.90); C174(0.96); C317(0.99)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C329(0.92); C310(0.94); C317(1.00); C174(1.16)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C174(0.88); C317(0.92); C310(0.97); C377(1.29)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C329(0.79); C310(0.84); C317(0.86); C174(0.89)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C310(0.94); C329(0.99); C317(1.02); C377(1.14)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C329(0.76); C317(0.88); C310(0.91); C377(1.41)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C317(0.75); C310(0.76); C329(0.78); C174(0.92)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C317(0.85); C310(0.87); C329(0.94); C174(0.95)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C310(0.76); C317(0.80); C329(0.84); C174(1.03)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C317(0.95); C310(0.96); C329(0.97); C174(1.24)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C329(0.81); C310(0.82); C317(0.88); C174(0.97)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C310(0.86); C329(0.87); C317(0.92); C174(1.02)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C329(0.76); C310(0.84); C317(0.88); C174(1.00)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C174(0.75); C317(0.83); C310(0.95); C377(1.21)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C310(0.91); C317(0.93); C329(1.05); C174(1.12)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C329(0.79); C174(1.07); C310(1.08); C377(1.13)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C310(0.89); C174(0.94); C317(0.94); C329(1.00)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C317(0.74); C174(0.76); C329(0.82); C310(0.83)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C174(0.73); C329(0.74); C317(0.79); C310(0.95)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C329(0.77); C174(0.79); C317(0.83); C310(0.92)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C317(0.85); C329(0.88); C174(0.89); C310(0.94)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C310(0.94); C174(0.95); C317(0.95); C329(1.05)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C329(0.80); C317(0.93); C174(1.00); C310(1.10)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C174(0.82); C329(0.86); C317(0.87); C310(0.88)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C317(0.90); C310(1.06); C377(1.20); C329(1.35)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C329(0.74); C174(0.86); C317(0.98); C310(1.01)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C329(0.83); C174(0.86); C317(0.87); C310(0.96)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C174(0.84); C329(0.87); C317(0.90); C310(0.91)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C329(0.85); C174(0.92); C377(1.02); C310(1.13)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C329(0.73); C174(0.87); C317(0.88); C310(1.02)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C329(0.65); C174(0.93); C377(1.06); C317(1.24)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C317(0.74); C174(0.75); C329(0.75); C310(0.80)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C174(0.35); C310(0.77); C317(0.96); C377(1.51)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C174(0.56); C310(1.13); C377(1.17); C317(1.33)  LDD0683  [19]
 LDCM0520  AKOS000195272 MDA-MB-231 C294(1.09)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C174(1.03); C310(1.10); C317(1.06); C377(1.02)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C174(0.83); C317(0.89); C310(1.03); C377(1.21)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C174(0.73); C317(0.80); C310(0.82); C377(1.64)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C377(1.05); C294(1.00); C148(0.88); C317(0.85)  LDD0078  [19]
 LDCM0630  CCW28-3 231MFP C377(32.14); C390(1.36)  LDD2214  [42]
 LDCM0108  Chloroacetamide HeLa C329(0.00); H497(0.00); C174(0.00); C310(0.00)  LDD0222  [34]
 LDCM0632  CL-Sc Hep-G2 C294(3.53); C390(1.83); C174(1.14); C329(1.05)  LDD2227  [26]
 LDCM0367  CL1 HCT 116 C310(0.86); C174(0.91); C317(0.91); C329(1.05)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C329(0.82); C310(0.96); C317(1.03); C174(1.11)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C329(0.79); C317(0.87); C174(0.94); C310(1.01)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C174(0.74); C317(0.87); C310(0.89); C377(1.21)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C174(0.89); C310(0.93); C317(0.97); C377(1.05)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C310(0.87); C317(0.95); C174(0.96); C377(1.04)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C174(0.91); C310(0.97); C317(0.99); C377(1.09)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C310(0.77); C317(0.93); C174(1.00); C377(1.21)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C310(0.91); C317(0.98); C377(1.28); C174(1.58)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C317(0.89); C310(0.91); C174(1.36); C377(1.42)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C310(0.89); C317(0.89); C377(1.23); C174(1.47)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C317(0.79); C310(0.90); C377(1.13); C174(1.15)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C329(0.89); C174(1.02); C310(1.05); C377(1.15)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C310(0.85); C317(0.98); C174(1.13); C377(1.15)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C310(0.83); C317(0.90); C174(0.93); C377(1.13)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C377(0.75); C317(0.87); C174(0.92); C329(0.96)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C174(0.60); C317(0.70); C310(0.73); C329(0.77)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C329(0.69); C317(0.71); C310(0.75); C174(0.78)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C317(0.69); C310(0.77); C377(0.78); C174(0.82)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C317(0.77); C310(0.84); C174(0.86); C377(0.89)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C174(1.00); C310(1.09); C317(1.22); C377(1.43)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C317(0.84); C310(0.95); C377(0.96); C174(1.13)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C317(0.87); C310(0.92); C377(0.96); C174(1.06)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C329(0.95); C317(1.04); C310(1.05); C174(1.29)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C317(0.86); C174(1.01); C377(1.02); C310(1.04)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C377(1.19); C317(1.32); C174(1.50); C310(1.76)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C310(0.97); C317(1.00); C174(1.04); C377(1.11)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C174(0.91); C310(1.03); C377(1.04); C317(1.10)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C310(0.93); C174(0.96); C317(1.00); C377(1.23)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C174(0.79); C317(0.87); C310(0.92); C377(1.08)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C174(0.73); C317(0.76); C310(0.78); C329(0.90)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C174(0.76); C317(0.82); C310(0.86); C329(1.01)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C317(0.72); C174(0.72); C310(0.72); C329(1.13)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C317(0.88); C329(0.88); C310(0.94); C174(1.07)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C317(0.82); C329(0.84); C310(0.87); C174(1.07)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C317(0.88); C329(0.90); C310(0.94); C174(1.09)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C310(0.72); C317(0.79); C329(0.90); C174(0.91)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C310(0.69); C317(0.72); C174(0.87); C329(0.88)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C329(0.62); C317(0.82); C310(0.87); C174(0.91)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C329(0.73); C310(0.79); C317(0.81); C174(0.92)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C310(0.91); C317(0.92); C174(0.96); C329(1.05)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C329(0.66); C317(0.71); C310(0.71); C174(0.83)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C329(0.69); C310(0.75); C317(0.81); C174(0.86)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C329(0.69); C310(0.74); C174(0.86); C317(0.91)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C329(0.64); C310(0.82); C174(0.82); C317(0.84)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C329(0.70); C317(0.77); C310(0.80); C174(0.87)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C174(0.87); C310(0.90); C317(0.99); C329(0.68)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C174(0.82); C310(0.94); C317(1.09); C329(0.78)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C174(1.00); C310(0.74); C317(0.79); C329(0.67)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C174(0.92); C310(0.75); C317(0.78); C329(0.67)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C174(0.92); C310(0.75); C317(0.78); C329(0.69)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C174(1.04); C310(1.05); C317(1.02); C329(1.03)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C174(0.96); C310(0.95); C317(0.97); C329(0.75)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C174(1.05); C310(1.05); C317(1.10); C329(1.04)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C174(0.99); C310(1.03); C317(0.97); C329(1.11)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C174(0.95); C310(1.10); C317(0.96); C329(1.05)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C174(1.04); C310(1.19); C317(0.93); C329(1.09)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C174(1.05); C310(1.08); C317(0.90); C329(1.03)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C174(1.03); C310(1.01); C317(1.04); C329(0.97)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C174(1.12); C310(1.22); C317(0.99); C329(1.11)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C174(1.10); C310(1.21); C317(1.12); C329(1.12)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C174(0.88); C310(0.89); C317(0.87); C329(1.03)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C174(0.88); C310(1.43); C317(1.06); C329(1.01)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C174(1.02); C310(1.01); C317(0.93); C329(1.11)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C174(1.09); C310(1.20); C317(1.13); C329(0.99)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C174(1.16); C310(1.30); C317(1.12); C329(1.17)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C174(1.23); C310(1.05); C317(0.96); C329(1.04)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C174(1.16); C310(1.09); C317(1.01); C329(1.02)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C174(1.25); C310(1.18); C317(1.18); C329(1.13)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C174(1.28); C310(0.93); C317(0.94); C329(1.05)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C174(1.20); C310(0.98); C317(1.01); C329(1.09)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C174(1.24); C310(0.81); C317(0.87); C329(0.86)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C174(1.18); C310(1.04); C317(1.07); C329(0.95)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C174(1.24); C310(1.08); C317(1.14); C329(0.92)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C174(1.55); C310(0.99); C317(0.99); C329(1.02)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C174(1.30); C310(1.18); C317(1.21); C329(0.98)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C174(1.10); C310(0.98); C317(1.02); C329(0.90)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C174(1.30); C310(0.86); C317(0.91); C329(0.98)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C174(1.22); C310(1.43); C317(1.44); C329(1.03)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C174(1.10); C310(0.95); C317(0.98); C329(0.87)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C174(1.26); C310(0.86); C317(0.89); C329(1.02)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C174(1.35); C310(0.91); C317(0.97); C329(1.07)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C174(1.24); C310(1.02); C317(1.06); C329(0.90)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C174(1.10); C310(0.79); C317(0.78); C329(0.86)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C174(1.19); C310(1.20); C317(1.21); C329(0.92)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C174(1.06); C310(1.12); C317(1.02); C329(1.04)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C174(0.93); C310(0.94); C317(0.94); C329(1.02)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C174(0.78); C310(0.80); C317(0.77); C329(0.88)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C174(0.95); C310(0.92); C317(0.83); C329(0.77)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C174(0.98); C310(1.06); C317(1.28); C329(0.86)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C174(0.97); C310(0.82); C317(0.83); C329(0.75)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C174(1.10); C310(0.96); C317(0.86); C329(0.82)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C174(1.15); C310(1.05); C317(1.06); C329(0.84)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C174(0.80); C310(0.87); C317(0.96); C329(0.77)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C174(1.23); C310(0.96); C317(0.99); C329(0.91)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C174(1.10); C310(0.96); C317(0.87); C329(0.84)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C174(0.89); C310(0.94); C317(0.91); C329(0.80)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C174(0.97); C310(1.01); C317(0.80); C329(1.07)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C174(0.98); C310(0.93); C317(0.87); C329(0.76)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C174(0.94); C310(0.82); C317(0.91); C329(0.74)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C174(0.99); C310(0.60); C317(0.77); C329(0.75)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C174(0.88); C310(0.77); C317(0.84); C329(0.80)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C174(1.03); C310(0.63); C317(0.77); C329(0.77)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C174(1.06); C310(0.64); C317(0.81); C329(0.69)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C174(0.92); C310(0.99); C317(1.07); C329(0.90)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C174(1.32); C310(0.57); C317(0.80); C329(0.75)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C174(1.38); C310(0.60); C317(0.79); C329(0.73)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C174(1.50); C310(0.64); C317(0.88); C329(0.68)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C174(1.19); C310(0.73); C317(0.97); C329(0.69)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C174(1.08); C310(0.72); C317(0.89); C329(0.69)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C174(1.14); C310(0.54); C317(0.71); C329(0.75)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C174(1.13); C310(0.62); C317(0.78); C329(0.86)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C174(1.45); C310(0.57); C317(0.78); C329(0.73)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C174(1.55); C310(0.61); C317(0.74); C329(0.68)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C174(1.23); C310(0.76); C317(0.98); C329(0.73)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C174(1.02); C310(0.96); C317(0.99); C329(0.90)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C174(1.02); C310(0.62); C317(0.89); C329(0.92)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C174(1.01); C310(0.92); C317(0.96); C329(0.94)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C174(0.95); C310(0.90); C317(0.93); C329(0.95)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C174(1.15); C310(1.28); C317(1.17); C329(0.94)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C174(0.90); C310(0.88); C317(0.83); C329(0.71)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C174(0.90); C310(0.96); C317(0.83); C329(0.78)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C174(0.92); C310(0.98); C317(0.94); C329(0.88)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C174(0.82); C310(0.86); C317(0.91); C329(0.83)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C174(0.95); C310(0.97); C317(1.00); C329(0.77)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C174(0.90); C310(0.90); C317(1.00); C329(0.79)  LDD0811  [19]
 LDCM0634  CY-0357 Hep-G2 C390(2.35); C377(1.88); C174(0.70)  LDD2228  [26]
 LDCM0495  E2913 HEK-293T C294(0.91); C377(1.06); C174(0.83); C329(0.94)  LDD1698  [43]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C317(12.32); C329(8.46); C154(2.42); C174(1.00)  LDD1702  [10]
 LDCM0031  Epigallocatechin gallate HEK-293T 6.29  LDD0183  [14]
 LDCM0175  Ethacrynic acid HeLa C390(0.96); C377(0.94); C329(0.90); C377(0.88)  LDD2210  [16]
 LDCM0625  F8 Ramos C174(1.03); 0.38; C329(0.92); C294(0.93)  LDD2187  [44]
 LDCM0572  Fragment10 Ramos C174(0.57); 1.09; C329(0.93); C294(0.71)  LDD2189  [44]
 LDCM0573  Fragment11 Ramos C174(0.17); 3.04; C329(0.15); C390(0.14)  LDD2190  [44]
 LDCM0574  Fragment12 Ramos C174(0.60); C329(2.27); C294(0.60); C390(0.69)  LDD2191  [44]
 LDCM0575  Fragment13 Ramos C174(1.18); 1.05; C329(1.08); C294(0.80)  LDD2192  [44]
 LDCM0576  Fragment14 Ramos C174(0.41); C329(2.33); C294(0.81); C390(0.86)  LDD2193  [44]
 LDCM0579  Fragment20 Ramos C174(0.55); 1.01; C329(1.73); C294(0.67)  LDD2194  [44]
 LDCM0580  Fragment21 Ramos C174(0.79); 0.84; C329(0.77); C294(0.91)  LDD2195  [44]
 LDCM0582  Fragment23 Ramos C174(0.69); C329(2.00); C294(2.13); C390(1.42)  LDD2196  [44]
 LDCM0578  Fragment27 Ramos C174(1.20); 1.22; C329(0.91); C294(0.93)  LDD2197  [44]
 LDCM0586  Fragment28 Ramos C174(0.76); 1.03; C329(0.39); C294(0.44)  LDD2198  [44]
 LDCM0588  Fragment30 Ramos C174(1.46); 1.15; C329(1.08); C294(0.66)  LDD2199  [44]
 LDCM0589  Fragment31 Ramos C174(0.87); C329(1.46); C294(0.84); C390(0.89)  LDD2200  [44]
 LDCM0590  Fragment32 Ramos C174(0.53); 1.13; C329(1.32); C294(0.70)  LDD2201  [44]
 LDCM0468  Fragment33 HCT 116 C174(1.11); C310(0.96); C317(0.96); C329(0.81)  LDD0785  [19]
 LDCM0596  Fragment38 Ramos C174(1.15); 1.07; C329(0.92); C294(0.52)  LDD2203  [44]
 LDCM0566  Fragment4 Ramos C174(0.81); 0.60; C329(0.76); C294(0.72)  LDD2184  [44]
 LDCM0427  Fragment51 HCT 116 C174(1.03); C310(1.18); C317(1.02); C329(1.20)  LDD0744  [19]
 LDCM0610  Fragment52 Ramos C174(1.27); 1.29; C329(1.36); C294(0.80)  LDD2204  [44]
 LDCM0614  Fragment56 Ramos C174(1.48); 1.31; C329(0.98); C294(0.69)  LDD2205  [44]
 LDCM0569  Fragment7 Ramos C174(0.57); C329(0.73); C294(0.69); C390(0.56)  LDD2186  [44]
 LDCM0571  Fragment9 Ramos C174(0.43); C329(1.68); C294(0.65); C377(0.10)  LDD2188  [44]
 LDCM0015  HNE MDA-MB-231 C329(1.08); C294(1.09)  LDD0346  [44]
 LDCM0107  IAA HeLa C174(0.00); H497(0.00); C310(0.00); C329(0.00)  LDD0221  [34]
 LDCM0123  JWB131 DM93 Y261(0.67)  LDD0285  [17]
 LDCM0124  JWB142 DM93 Y261(1.16)  LDD0286  [17]
 LDCM0125  JWB146 DM93 Y261(1.46)  LDD0287  [17]
 LDCM0126  JWB150 DM93 Y261(4.04)  LDD0288  [17]
 LDCM0127  JWB152 DM93 Y261(2.08)  LDD0289  [17]
 LDCM0128  JWB198 DM93 Y261(0.30)  LDD0290  [17]
 LDCM0129  JWB202 DM93 Y261(0.65)  LDD0291  [17]
 LDCM0130  JWB211 DM93 Y261(0.76)  LDD0292  [17]
 LDCM0179  JZ128 PC-3 C294(0.00); C390(0.00); C504(0.00); C148(0.00)  LDD0462  [13]
 LDCM0022  KB02 HCT 116 C310(3.36); C317(3.36); C329(1.78)  LDD0080  [19]
 LDCM0023  KB03 HCT 116 C310(1.34); C317(1.34); C329(1.29)  LDD0081  [19]
 LDCM0024  KB05 HCT 116 C310(4.48); C317(4.48); C329(0.96)  LDD0082  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C294(1.04); C310(0.92)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C174(1.10)  LDD2121  [10]
 LDCM0109  NEM HeLa H497(0.00); H117(0.00); H127(0.00); H340(0.00)  LDD0223  [34]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C377(0.77)  LDD2090  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C294(1.07); C329(0.70)  LDD2093  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C294(1.71); C174(1.02); C148(0.91); C377(1.34)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C377(1.78)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C294(0.91); C174(1.00); C329(0.92)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C377(1.33)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C294(0.37); C377(0.46); C310(0.85)  LDD2105  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C174(0.88); C148(1.10); C377(0.90); C329(0.79)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C310(0.48)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C174(0.80); C148(0.71); C329(0.76)  LDD2109  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C294(1.14); C174(1.23); C329(0.94)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C174(0.31)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C174(0.72); C310(0.65)  LDD2115  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C310(0.31)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C310(0.34)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C294(2.03); C329(1.62)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C310(1.00)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C310(0.30)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C174(0.98); C329(0.83)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C294(1.08); C174(0.87); C148(0.85); C329(0.69)  LDD2125  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C294(0.89); C174(0.94); C148(0.84); C329(0.96)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C310(0.54)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C294(0.88); C174(1.21); C148(1.39); C377(1.08)  LDD2129  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C294(0.42); C174(0.50); C329(0.47)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C294(1.19); C174(1.32); C148(0.82); C377(1.28)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C294(1.06); C174(1.35); C148(1.01)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C294(1.14); C174(0.94); C148(0.72); C329(0.73)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C377(2.41)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C294(1.39); C174(0.98); C377(1.03)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C377(1.63); C329(0.69)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C310(0.33)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C294(2.00); C174(1.95)  LDD2144  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C294(1.04); C174(0.95); C377(1.36); C329(0.85)  LDD2146  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C329(0.48)  LDD2148  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C310(0.87)  LDD2150  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C310(0.29)  LDD2151  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C317(1.15); C294(1.07)  LDD2206  [45]
 LDCM0628  OTUB2-COV-1 HEK-293T C294(0.75); C390(0.74); C317(0.32)  LDD2207  [45]
 LDCM0131  RA190 MM1.R C329(1.30); C310(1.04); C317(1.04)  LDD0304  [46]
 LDCM0090  Rapamycin JHH-7 6.54  LDD0213  [40]
 LDCM0021  THZ1 HeLa S3 C390(1.05); C148(1.09)  LDD0460  [13]
 LDCM0178  THZ531 HeLa S3 C317(2.39)  LDD0461  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipase A and acyltransferase 3 (PLAAT3) H-rev107 family P53816
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) Phosphatase 2A regulatory subunit A family P30154
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) Phosphatase 2A regulatory subunit B family P63151
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B) Phosphatase 2A regulatory subunit B family Q00005
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) Phosphatase 2A regulatory subunit B56 family Q15172
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PPP2R5B) Phosphatase 2A regulatory subunit B56 family Q15173
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) Phosphatase 2A regulatory subunit B56 family Q14738
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) Phosphatase 2A regulatory subunit B56 family Q16537
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) Phosphatase 2A regulatory subunit B56 family Q13362
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C) PPP phosphatase family P60510
Serine/threonine-protein phosphatase 5 (PPP5C) PPP phosphatase family P53041
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor p65 (RELA) . Q04206
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-G1 (CCNG1) Cyclin family P51959
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
. GOLGA8 family Q08AF8
Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1) WD repeat AMBRA1 family Q9C0C7
Striatin (STRN) WD repeat striatin family O43815
Calcium-regulated heat-stable protein 1 (CARHSP1) . Q9Y2V2
Cold shock domain-containing protein C2 (CSDC2) . Q9Y534
F-box only protein 43 (FBXO43) . Q4G163
Protein CIP2A (CIP2A) . Q8TCG1
Rho guanine nucleotide exchange factor 7 (ARHGEF7) . Q14155

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2s3s4e6e8s9s)-3-amino-9-methoxy-268-trimethyl-10-phenyldeca-46-dienoic Acid . DB06905
268-trimethyl-3-amino-9-benzyl-9-methoxynonanoic Acid . DB02506

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
12 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
13 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
14 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
15 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
16 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
17 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
21 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD039931
31 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
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Mass spectrometry data entry: PXD001377 , PXD005252
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