General Information of Experiment

Probe Name THZ1-DTB  Probe Info 
Probe concentration 2 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
iTRAQ
Competitor Name THZ531  Competitor Info 
Competitor Concentration 5 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Cervical cancer [ICD11: 2C77]
Model Name Human cervical adenocarcinoma cell lysate (HeLa S3)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) C186 2.5
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) C317 2.4
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C225 2.2
 LDTP02223  Cathepsin B (CTSB) C108 2.2
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP08817  Solute carrier family 35 member F6 (SLC35F6) C36 2.2
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) C48 2.0
Other
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03997  Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) C930 2.3
 LDTP12589  Bromodomain and WD repeat-containing protein 1 (BRWD1) C248 2.2
 LDTP05025  Large ribosomal subunit protein eL32 (RPL32) C91 2.2
 LDTP05697  Heat shock protein 75 kDa, mitochondrial (TRAP1) C573 2.1

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.