Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Alk-rapa  Probe Info 
Probe concentration 20 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Rapamycin  Competitor Info 
Competitor Concentration 200 mM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Liver
Disease Model Hepatocellular carcinoma [ICD-11:2C12]
Model Name Human hepatocellular carcinoma cell lysate (JHH-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 69 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10049  FAST kinase domain-containing protein 4 (TBRG4) 41.7
 LDTP17417  UDP-glucuronosyltransferase 2A3 (UGT2A3) 12.2
 LDTP13720  Ubiquitin carboxyl-terminal hydrolase 24 (USP24) 11.4
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) 11.1
 LDTP11012  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1) 10.8
 LDTP02718  Glucosidase 2 subunit beta (PRKCSH) 9.9
 LDTP07283  E3 ubiquitin-protein ligase RNF213 (RNF213) 9.9
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.4
 LDTP12303  ATP-binding cassette sub-family B member 6 (ABCB6) 8.1
 LDTP06219  Chromodomain-helicase-DNA-binding protein 4 (CHD4) 7.6
 LDTP00536  Mitochondrial ribonuclease P catalytic subunit (PRORP) 7.4
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 7.2
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 7.1
 LDTP05795  Nucleoside diphosphate kinase 3 (NME3) 7.0
 LDTP13466  Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1) 7.0
 LDTP10038  Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) 6.9
 LDTP13285  Probable ATP-dependent RNA helicase DDX20 (DDX20) 6.7
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) 6.5
 LDTP12697  Androgen-induced gene 1 protein (AIG1) 6.5
 LDTP13408  Cell division cycle protein 23 homolog (CDC23) 6.5
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 6.4
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 6.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 6.2
 LDTP07092  Probable arginine--tRNA ligase, mitochondrial (RARS2) 6.1
 LDTP03628  Glycerol kinase (GK) 5.7
 LDTP12776  Sphingomyelin phosphodiesterase 4 (SMPD4) 5.6
 LDTP12773  Very long chain fatty acid elongase 2 (ELOVL2) 5.4
 LDTP08722  Retinol dehydrogenase 10 (RDH10) 5.3
 LDTP00294  26S proteasome non-ATPase regulatory subunit 14 (PSMD14) 5.3
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) 5.2
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) 5.0
 LDTP00502  TATA-binding protein-associated factor 172 (BTAF1) 4.9
 LDTP03401  Multifunctional protein CAD (CAD) 4.4
 LDTP03145  Catechol O-methyltransferase (COMT) 4.4
 LDTP03170  Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) 4.3
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 4.1
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) 4.0
 LDTP05914  Serine/threonine-protein kinase ATR (ATR) 3.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.9
 LDTP05000  Rho-related GTP-binding protein RhoB (RHOB) 3.8
 LDTP03911  Replication factor C subunit 3 (RFC3) 3.8
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 3.8
 LDTP16204  GPN-loop GTPase 3 (GPN3) 3.8
 LDTP00931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) 3.8
 LDTP00543  1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) 3.7
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 3.5
 LDTP07979  FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) 3.5
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 3.4
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 3.4
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 3.3
 LDTP07030  Diacylglycerol kinase kappa (DGKK) 3.3
 LDTP12647  Serine palmitoyltransferase 3 (SPTLC3) 3.3
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1) 3.1
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 2.9
 LDTP07967  Lysophosphatidylcholine acyltransferase 2 (LPCAT2) 2.9
 LDTP02231  Tyrosine-protein kinase Yes (YES1) 2.9
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 2.9
 LDTP03424  ATP-binding cassette sub-family D member 3 (ABCD3) 2.8
 LDTP00416  CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) 2.7
 LDTP03980  Serine/threonine-protein kinase mTOR (MTOR) 2.7
 LDTP04619  5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) 2.6
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 2.6
 LDTP05822  Serine-protein kinase ATM (ATM) 2.6
 LDTP09251  Atlastin-2 (ATL2) 2.4
 LDTP01372  Carboxypeptidase D (CPD) 2.4
 LDTP06779  Triokinase/FMN cyclase (TKFC) 2.3
 LDTP01430  E3 ubiquitin-protein ligase listerin (LTN1) 2.2
 LDTP03024  Plasma membrane calcium-transporting ATPase 1 (ATP2B1) 2.0
 LDTP06047  Ubiquitin conjugation factor E4 A (UBE4A) 2.0
Transporter and channel
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 11.9
 LDTP10343  Vacuole membrane protein 1 (VMP1) 10.7
 LDTP20002  Transmembrane protein 160 (TMEM160) 7.5
 LDTP01969  Transferrin receptor protein 1 (TFRC) 7.5
 LDTP06242  Importin subunit beta-1 (KPNB1) 7.3
 LDTP09180  Zinc transporter 7 (SLC30A7) 7.1
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.0
 LDTP05900  Metaxin-1 (MTX1) 6.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 6.7
 LDTP12695  Trimeric intracellular cation channel type B (TMEM38B) 6.1
 LDTP03506  Guanine nucleotide-binding protein subunit alpha-11 (GNA11) 6.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.0
 LDTP04866  Protein transport protein Sec61 subunit beta (SEC61B) 5.8
 LDTP11824  Sodium-coupled neutral amino acid symporter 1 (SLC38A1) 5.3
 LDTP10804  Chloride channel CLIC-like protein 1 (CLCC1) 5.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 4.9
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 4.7
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) 4.5
 LDTP05038  AP-2 complex subunit beta (AP2B1) 4.3
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 4.2
 LDTP05625  AP-1 complex subunit beta-1 (AP1B1) 4.1
 LDTP12510  Aladin (AAAS) 4.1
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) 4.0
 LDTP06573  Bcl-2 homologous antagonist/killer (BAK1) 3.9
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 3.8
 LDTP18177  Solute carrier family 35 member E1 (SLC35E1) 3.7
 LDTP13834  Sodium-dependent multivitamin transporter (SLC5A6) 3.6
 LDTP11844  Protein spinster homolog 1 (SPNS1) 3.4
 LDTP00287  Exocyst complex component 5 (EXOC5) 3.3
 LDTP07236  Protein GPR107 (GPR107) 3.2
 LDTP04787  Transmembrane protein 33 (TMEM33) 3.2
 LDTP07064  Nucleoporin NUP188 (NUP188) 3.2
 LDTP09279  THO complex subunit 2 (THOC2) 3.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 3.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 3.0
 LDTP13698  Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1) 2.9
 LDTP04512  Cationic amino acid transporter 2 (SLC7A2) 2.8
 LDTP05384  Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) 2.7
 LDTP00855  AP-1 complex subunit gamma-1 (AP1G1) 2.4
 LDTP00810  Exportin-T (XPOT) 2.4
 LDTP04013  Neutral amino acid transporter A (SLC1A4) 2.3
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 2.2
 LDTP11310  Nuclear pore complex protein Nup85 (NUP85) 2.0
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3) 9.4
 LDTP03828  Sterol regulatory element-binding protein 1 (SREBF1) 8.8
 LDTP12311  Carbohydrate-responsive element-binding protein (MLXIPL) 7.6
 LDTP05101  General transcription factor II-I (GTF2I) 6.5
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14610  Golgi pH regulator B (GPR89B) 3.2
Other
Click to Show/Hide to Show 96 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06681  Inverted formin-2 (INF2) 18.4
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 14.2
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 13.4
 LDTP04558  Arfaptin-1 (ARFIP1) 11.5
 LDTP03227  Glycine cleavage system H protein, mitochondrial (GCSH) 11.4
 LDTP12766  Mediator of RNA polymerase II transcription subunit 29 (MED29) 10.8
 LDTP01813  Angiotensinogen (AGT) 10.0
 LDTP15283  Nucleolar protein 9 (NOP9) 9.2
 LDTP04557  Arfaptin-2 (ARFIP2) 8.6
 LDTP00691  TELO2-interacting protein 1 homolog (TTI1) 8.2
 LDTP13559  Mediator of RNA polymerase II transcription subunit 23 (MED23) 8.1
 LDTP08578  SURP and G-patch domain-containing protein 2 (SUGP2) 7.4
 LDTP07814  Protein MMS22-like (MMS22L) 7.3
 LDTP06983  Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) 7.1
 LDTP06021  Cytoskeleton-associated protein 5 (CKAP5) 6.9
 LDTP14304  MAU2 chromatid cohesion factor homolog (MAU2) 6.7
 LDTP17034  Unhealthy ribosome biogenesis protein 2 homolog (URB2) 6.5
 LDTP00078  CCR4-NOT transcription complex subunit 1 (CNOT1) 6.5
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) 6.4
 LDTP00759  Tumor protein D54 (TPD52L2) 6.4
 LDTP11287  Nucleolar complex protein 4 homolog (NOC4L) 6.4
 LDTP14237  Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) 6.3
 LDTP00822  Trafficking protein particle complex subunit 3 (TRAPPC3) 6.3
 LDTP00517  U2 snRNP-associated SURP motif-containing protein (U2SURP) 6.1
 LDTP01307  Paralemmin-1 (PALM) 6.0
 LDTP15012  RNA-binding protein 26 (RBM26) 6.0
 LDTP12094  Conserved oligomeric Golgi complex subunit 4 (COG4) 5.8
 LDTP08785  Integrator complex subunit 1 (INTS1) 5.7
 LDTP13304  Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) 5.6
 LDTP16028  Protein Njmu-R1 (C17orf75) 5.5
 LDTP10353  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) 5.4
 LDTP08041  Protein MON2 homolog (MON2) 5.4
 LDTP12680  Fanconi anemia group I protein (FANCI) 5.3
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) 5.2
 LDTP01522  Reticulon-3 (RTN3) 5.1
 LDTP13851  Exocyst complex component 6B (EXOC6B) 5.0
 LDTP19505  Tetratricopeptide repeat protein 27 (TTC27) 5.0
 LDTP06181  Structural maintenance of chromosomes protein 1A (SMC1A) 4.9
 LDTP07574  Superkiller complex protein 3 (SKIC3) 4.9
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) 4.9
 LDTP13994  SH3 domain-binding protein 1 (SH3BP1) 4.8
 LDTP11948  HEAT repeat-containing protein 1 (HEATR1) 4.7
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 4.7
 LDTP05605  F-BAR domain only protein 2 (FCHO2) 4.7
 LDTP07551  Integrator complex subunit 5 (INTS5) 4.6
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 4.5
 LDTP10799  GPI transamidase component PIG-S (PIGS) 4.5
 LDTP05033  Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) 4.5
 LDTP05922  Dynactin subunit 2 (DCTN2) 4.5
 LDTP19992  FIGNL1-interacting regulator of recombination and mitosis (FIRRM) 4.4
 LDTP05765  Translation initiation factor eIF2B subunit epsilon (EIF2B5) 4.4
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 4.4
 LDTP08300  Reticulophagy regulator 3 (RETREG3) 4.1
 LDTP01652  Centrosomal protein 43 (CEP43) 4.1
 LDTP08950  ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) 4.0
 LDTP05098  Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 4.0
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) 4.0
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 3.9
 LDTP08842  Cohesin subunit SA-2 (STAG2) 3.9
 LDTP19951  CYFIP-related Rac1 interactor A (CYRIA) 3.9
 LDTP00900  Origin recognition complex subunit 5 (ORC5) 3.9
 LDTP05306  Protein Dr1 (DR1) 3.8
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 3.5
 LDTP04571  Coatomer subunit alpha (COPA) 3.5
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) 3.4
 LDTP04570  Coatomer subunit beta (COPB1) 3.4
 LDTP13338  Vacuolar protein sorting-associated protein 51 homolog (VPS51) 3.4
 LDTP15101  Armadillo repeat-containing protein 6 (ARMC6) 3.3
 LDTP01532  ZW10 interactor (ZWINT) 3.3
 LDTP09783  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) 3.2
 LDTP09773  Protein FAM3C (FAM3C) 3.2
 LDTP00212  AP-3 complex subunit beta-1 (AP3B1) 3.1
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 3.1
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 3.1
 LDTP00632  Syntaxin-7 (STX7) 3.0
 LDTP12277  Protein S100-A14 (S100A14) 3.0
 LDTP13110  Coatomer subunit gamma-2 (COPG2) 3.0
 LDTP04679  Afadin (AFDN) 2.9
 LDTP12762  Transmembrane protein 161A (TMEM161A) 2.9
 LDTP13656  Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) 2.9
 LDTP14000  Rab GTPase-activating protein 1 (RABGAP1) 2.8
 LDTP13924  Mediator of RNA polymerase II transcription subunit 16 (MED16) 2.8
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 2.8
 LDTP11890  Protein unc-45 homolog A (UNC45A) 2.7
 LDTP01970  Serotransferrin (TF) 2.7
 LDTP00513  Plexin-B2 (PLXNB2) 2.7
 LDTP04342  Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) 2.6
 LDTP02841  Intron Large complex component GCFC2 (GCFC2) 2.6
 LDTP16111  Integrator complex subunit 10 (INTS10) 2.5
 LDTP08062  CLIP-associating protein 1 (CLASP1) 2.5
 LDTP12678  Integrator complex subunit 7 (INTS7) 2.4
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) 2.3
 LDTP03727  Replication factor C subunit 1 (RFC1) 2.3
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 2.2
 LDTP02526  Clusterin (CLU) 2.0
 LDTP06055  Eukaryotic translation initiation factor 3 subunit A (EIF3A) 2.0

References

1 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.