Details of the Target

General Information of Target

Target ID LDTP04547
Target Name Nuclear pore complex protein Nup98-Nup96 (NUP98)
Gene Name NUP98
Gene ID 4928
Synonyms
ADAR2; Nuclear pore complex protein Nup98-Nup96; EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98; 98 kDa nucleoporin; Nucleoporin Nup98; Nup98; Nuclear pore complex protein Nup96; 96 kDa nucleoporin; Nucleoporin Nup96; Nup96)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPG
GLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLFSSQNNAFAQNKPTGFGNF
GTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVST
NISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGAGTTTGLFGSSPATSSATGL
FSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTQNTGF
SFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQTNTGFGAV
GSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFGNKPTLTLGTNTNTSNFGFGTNTSGNSIF
GSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTTTATLGFG
APQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAA
QKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKL
VLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYT
NPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDRE
EIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGD
VNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSP
DRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTS
TKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLD
TMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKA
DTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIP
STSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG
RSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEK
LSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDL
PEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEE
EVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLV
DWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTA
SISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYS
DRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEG
LWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAK
AVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERS
SLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKD
RLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAMDE
LRSLTQSYLRELAVGSL
Target Bioclass
Enzyme
Family
Nucleoporin GLFG family
Subcellular location
Nucleus membrane
Function
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body).; (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro).
Uniprot ID
P52948
Ensemble ID
ENST00000324932.12
HGNC ID
HGNC:8068

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.70  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y1337(20.00)  LDD0260  [3]
TH216
 Probe Info  		Y550(8.04)  LDD0259  [3]
STPyne
 Probe Info  		K1040(10.00); K1222(10.00); K1405(8.33); K1608(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y627(10.52)  LDD3495  [5]
BTD
 Probe Info  		C1347(1.91)  LDD1700  [6]
Jackson_1
 Probe Info  		10.43  LDD0120  [7]
AHL-Pu-1
 Probe Info  		C1312(2.24)  LDD0168  [8]
HHS-465
 Probe Info  		Y550(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C1068(1.19); C1711(1.06); C1727(1.00); C1312(1.00)  LDD0078  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
ATP probe
 Probe Info  		K831(0.00); K797(0.00); K551(0.00); K1040(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1492(0.00); C760(0.00); C1590(0.00); C1636(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C188(0.00); C1027(0.00)  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C1027(0.00); C1492(0.00); C1068(0.00); C1590(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		C1068(0.00); C1590(0.00); C1711(0.00); C1735(0.00)  LDD2226  [16]
TFBX
 Probe Info  		C1711(0.00); C1027(0.00); C1312(0.00); C1347(0.00)  LDD0027  [15]
WYneN
 Probe Info  		C1347(0.00); C1027(0.00); C760(0.00)  LDD0021  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
Compound 10
 Probe Info  		C1027(0.00); C1068(0.00); C1347(0.00); C760(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		C1027(0.00); C1068(0.00)  LDD2213  [19]
ENE
 Probe Info  		C1027(0.00); C1347(0.00)  LDD0006  [17]
IPM
 Probe Info  		C1312(0.00); C1027(0.00); C1711(0.00); C1068(0.00)  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
PF-06672131
 Probe Info  		C1027(0.00); C1068(0.00)  LDD0017  [20]
SF
 Probe Info  		N.A.  LDD0028  [21]
VSF
 Probe Info  		C1068(0.00); C1312(0.00); C1347(0.00); C1027(0.00)  LDD0007  [17]
Phosphinate-6
 Probe Info  		C1027(0.00); C1419(0.00); C1711(0.00); C1312(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		N.A.  LDD0228  [18]
Acrolein
 Probe Info  		C1347(0.00); C1711(0.00); C1068(0.00); C1027(0.00)  LDD0217  [23]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [23]
Crotonaldehyde
 Probe Info  		C1027(0.00); C1735(0.00); C1068(0.00); C188(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C1590(0.00); C1027(0.00); C1347(0.00); C1068(0.00)  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
AOyne
 Probe Info  		8.00  LDD0443  [25]
NAIA_5
 Probe Info  		C1735(0.00); C760(0.00); C1419(0.00); C835(0.00)  LDD2223  [16]
HHS-475
 Probe Info  		Y550(1.05)  LDD2238  [9]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		14.25  LDD0475  [26]
FFF probe2
 Probe Info  		14.00  LDD0463  [26]
FFF probe3
 Probe Info  		5.95  LDD0464  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
Alk-rapa
 Probe Info  		5.21  LDD0213  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1347(0.65)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1347(0.95); C188(0.67)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1492(2.12); C1727(0.82); C1347(0.95); C1027(1.24)  LDD2117  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1347(0.92)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1347(0.51)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1347(0.75)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C1312(2.24)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1027(2.39)  LDD0169  [8]
 LDCM0561  Abegg_cp(-)-10 HeLa C1347(4.51)  LDD0312  [15]
 LDCM0562  Abegg_cp(-)-11 HeLa C1347(6.39)  LDD0313  [15]
 LDCM0214  AC1 HCT 116 C1027(0.74); C1068(0.89); C1312(0.89); C1419(1.10)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C1027(1.16); C1068(1.16); C1312(1.15); C1419(1.10)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C1027(0.79); C1068(1.00); C1312(0.95); C1419(0.76)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C1027(1.09); C1068(1.29); C1312(1.00); C1419(0.68)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C1027(0.93); C1068(0.92); C1312(0.95); C1419(0.77)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C1027(0.90); C1068(1.29); C1312(1.32); C1419(0.71)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C1027(0.91); C1068(0.97); C1312(1.07); C1419(0.72)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C1027(1.40); C1068(0.96); C1312(1.08); C1419(0.68)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C1027(1.43); C1068(1.09); C1312(1.21); C1419(0.73)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C1027(1.00); C1068(1.06); C1312(1.11); C1419(0.89)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C1027(0.75); C1068(0.88); C1312(0.82); C1419(0.83)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C1027(0.79); C1068(1.05); C1312(0.86); C1419(0.73)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C1027(1.08); C1068(1.42); C1312(1.35); C1419(1.22)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C1027(1.02); C1068(0.88); C1312(0.96); C1419(0.71)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C1027(0.71); C1068(0.96); C1312(0.98); C1419(0.66)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C1027(0.93); C1068(1.17); C1312(1.14); C1419(0.79)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C1027(0.66); C1068(1.05); C1347(0.68); C1419(1.06)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C1027(1.11); C1068(1.11); C1347(0.53); C1419(1.04)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C1027(1.22); C1068(1.21); C1347(0.57); C1419(1.09)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C1027(1.21); C1068(1.30); C1347(0.74); C1419(1.10)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C1027(1.25); C1068(1.10); C1347(0.57); C1419(1.03)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C1027(1.11); C1068(1.08); C1347(0.60); C1419(0.97)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C1027(1.32); C1068(1.09); C1347(0.70); C1419(0.94)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C1027(0.82); C1068(1.05); C1312(1.20); C1419(1.10)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C1027(1.28); C1068(1.18); C1347(0.64); C1419(1.04)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C1027(1.47); C1068(0.93); C1347(0.65); C1419(1.04)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C1027(1.15); C1068(1.04); C1347(0.67); C1419(1.08)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C1027(1.01); C1068(1.01); C1347(0.44); C1419(1.03)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C1027(1.45); C1068(1.01); C1347(0.56); C1419(0.94)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C1027(1.04); C1068(1.08); C1347(0.55); C1419(1.02)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C1027(1.44); C1068(1.28); C1347(0.81); C1419(1.10)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C1027(1.15); C1068(1.39); C1347(0.71); C1419(1.03)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C1027(0.87); C1068(0.92); C1312(1.34); C1347(1.07)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C1027(0.89); C1068(0.80); C1312(0.86); C1347(0.63)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C1027(0.98); C1068(0.95); C1312(1.14); C1347(0.86)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C1027(0.90); C1068(0.78); C1312(0.95); C1347(0.92)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C1027(1.00); C1068(0.66); C1312(0.90); C1347(0.79)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C1027(0.88); C1068(0.81); C1312(1.02); C1347(0.87)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C1027(1.04); C1068(0.85); C1312(1.18); C1347(0.91)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C1027(0.84); C1068(0.87); C1312(1.19); C1347(0.93)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C1027(1.20); C1068(0.79); C1312(1.04); C1347(1.02)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C1027(1.05); C1068(0.71); C1312(0.96); C1347(0.87)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C1027(1.08); C1068(0.75); C1312(1.03); C1347(0.88)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C1027(1.42); C1068(0.79); C1312(1.12); C1347(0.99)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C1027(0.83); C1068(1.05); C1312(1.05); C1419(1.29)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C1027(1.37); C1068(0.79); C1312(1.11); C1347(0.95)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C1027(1.06); C1068(0.77); C1312(1.09); C1347(0.83)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C1027(1.84); C1068(0.74); C1312(0.84); C1347(0.90)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C1590(0.72); C1419(0.90); C1636(0.93); C1464(0.97)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C1347(0.83); C1419(0.92); C1476(0.93); C1735(0.93)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C1347(0.82); C1476(0.89); C1464(0.92); C1636(0.94)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C1347(0.97); C1636(1.00); C1590(1.03); C1476(1.04)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C1476(0.95); C1636(0.97); C1464(1.02); C1735(1.06)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C1636(1.21); C1419(1.22); C1476(1.28); C1735(1.30)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C1636(0.96); C1735(0.96); C1419(1.01); C1727(1.11)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C1464(0.84); C1492(0.90); C1027(0.92); C1476(0.95)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C1735(0.89); C1419(0.92); C1636(0.94); C1476(0.98)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C1347(0.83); C1735(0.86); C1636(0.88); C1068(1.02)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C1419(0.95); C1590(1.00); C1636(1.04); C1476(1.07)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C1347(1.17); C1735(1.23); C1636(1.25); C1419(1.26)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C1027(1.80); C1068(1.32); C1312(1.48); C1347(1.03)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C1027(2.00); C1068(1.45); C1312(1.57); C1347(0.81)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C1027(1.25); C1068(1.13); C1312(1.12); C1347(0.83)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C1027(1.39); C1068(1.11); C1312(1.23); C1347(0.87)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C1068(0.85); C1735(0.95); C1636(0.95); C1492(0.95)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C1727(0.69); C1068(0.88); C1492(1.02); C1711(1.02)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C1347(0.70); C1492(0.85); C1636(0.86); C1068(0.87)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C1735(0.70); C1027(0.73); C1492(0.78); C1068(0.84)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C1068(0.88); C1419(0.89); C1636(0.91); C1735(0.94)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C1347(0.72); C1727(0.93); C1636(0.94); C1419(0.95)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C1347(0.88); C1492(0.91); C1711(0.92); C1419(0.92)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C1492(0.84); C1068(0.89); C1636(0.91); C1347(1.00)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C1347(0.79); C1492(0.88); C1636(0.90); C1068(0.92)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C1312(0.72); C1492(0.76); C1636(0.87); C1464(0.88)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C1492(0.70); C1312(0.74); C1590(0.75); C1636(0.78)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C1312(0.70); C1590(0.78); C1027(0.78); C1492(0.79)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C1312(0.65); C1636(0.78); C1492(0.78); C1590(0.91)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C1590(0.71); C1312(0.76); C1636(0.77); C1492(0.84)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C1735(0.69); C1492(0.86); C1027(0.87); C1312(0.89)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C1492(0.65); C1590(0.66); C1636(0.80); C1419(0.86)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C1492(0.61); C1312(0.68); C1590(0.78); C1636(0.79)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C1492(0.59); C1312(0.72); C1590(0.72); C1636(0.80)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C1492(0.52); C1590(0.69); C1312(0.70); C1636(0.79)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C1492(0.63); C1590(0.67); C1636(0.82); C1312(0.89)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C1727(0.86); C1312(0.90); C1711(0.92); C1492(0.94)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C1727(0.83); C1312(0.85); C1492(0.95); C1068(0.96)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C1727(0.88); C1312(0.93); C1027(0.94); C1711(0.94)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C1027(0.65); C760(0.88); C1476(0.95); C1464(0.95)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C1027(0.84); C1492(0.93); C1636(0.96); C1727(0.99)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C1027(0.68); C1735(0.80); C1068(0.82); C1312(0.83)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C1027(0.96); C1492(1.03); C1711(1.06); C1727(1.06)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C1027(0.69); C1492(0.90); C1636(0.92); C1464(0.93)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C1027(0.87); C1492(0.96); C1636(0.97); C1727(0.98)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C1636(0.90); C1492(0.92); C1027(0.97); C1727(1.01)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C1027(0.88); C1636(0.96); C1464(0.99); C1492(0.99)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C1636(0.98); C1492(1.04); C1711(1.07); C1727(1.08)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C1027(0.87); C1590(0.88); C1735(0.92); C1492(0.92)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C1027(0.73); C1590(0.84); C1735(0.86); C1476(0.89)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C1735(0.82); C1590(0.86); C1027(0.89); C1312(0.92)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C1590(0.78); C1027(0.90); C1068(1.00); C1476(1.03)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C1027(0.62); C1735(0.74); C1068(0.80); C1312(0.85)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C1590(0.76); C1735(1.00); C1476(1.00); C1464(1.01)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C1590(0.75); C1492(0.82); C1312(0.83); C1476(0.85)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C1027(0.79); C1590(0.81); C1312(0.86); C1476(0.87)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C1590(0.82); C1027(0.84); C1492(0.94); C1636(0.96)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C1027(0.88); C1590(0.91); C1711(0.98); C1068(0.98)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C1590(0.93); C1027(1.03); C1735(1.06); C1419(1.07)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C1590(0.70); C1027(1.15); C1492(1.19); C1476(1.22)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C1068(0.79); C1312(0.90); C1492(0.98); C1027(1.00)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C1068(0.84); C1590(0.87); C1027(0.93); C1464(0.97)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C1068(0.75); C1492(0.98); C1027(1.00); C1735(1.04)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C1027(0.90); C1464(0.93); C1590(0.93); C1492(0.95)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C1068(0.85); C1476(1.03); C1735(1.04); C1636(1.07)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C1068(0.82); C1027(0.82); C1735(0.94); C1312(0.95)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C1068(0.77); C1590(1.08); C1492(1.10); C1476(1.12)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C1068(0.87); C1476(0.92); C1492(0.93); C1464(0.96)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C1068(0.79); C1027(0.84); C1492(0.98); C1312(1.14)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C1027(0.37); C1068(0.67); C1312(1.02); C1492(1.03)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C1027(0.39); C1068(0.69); C1735(1.00); C1492(1.00)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C1027(0.50); C1068(0.58); C1492(0.99); C1312(1.07)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C1727(0.77); C1027(0.87); C1711(0.88); C1068(0.91)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C1727(0.69); C1068(0.90); C1027(0.92); C1711(0.94)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C1464(0.84); C1476(0.86); C1735(0.97); C1590(0.99)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C1419(0.86); C1068(0.92); C1727(0.95); C1711(0.98)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C1727(0.80); C1068(0.90); C1027(0.95); C1711(1.04)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C1419(0.89); C1727(0.94); C1711(1.00); C1492(1.03)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C1590(0.92); C1727(0.93); C1492(1.05); C1419(1.16)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C1727(0.75); C1419(1.13); C1492(1.17); C1027(1.17)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C1727(0.97); C1590(1.07); C1492(1.13); C1419(1.18)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C1727(0.78); C1419(0.86); C1711(1.02); C1068(1.10)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C1727(0.72); C1590(0.89); C1419(0.96); C1711(0.98)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C1419(0.91); C1711(0.95); C1727(0.96); C1492(0.98)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C1727(0.81); C1492(0.94); C1027(0.94); C1419(0.95)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C760(0.75); C1027(0.91); C1492(0.95); C1636(0.99)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C1727(0.78); C1492(0.89); C1711(1.07); C1590(1.10)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C1727(0.76); C1027(0.89); C1419(0.91); C1711(1.02)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C1727(0.80); C1590(1.11); C1068(1.25); C1492(1.32)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C1492(0.84); C1590(0.86); C1727(0.88); C1347(1.02)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C1727(0.85); C1711(0.89); C1027(0.97); C1590(1.01)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C1492(0.75); C1027(0.79); C1735(0.86); C1347(0.86)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C1347(0.79); C1636(0.85); C1735(0.86); C1590(0.88)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C1347(0.75); C1492(0.88); C1735(0.88); C1636(0.90)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C1347(0.67); C1419(0.74); C1492(0.76); C1735(0.81)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C1347(0.72); C1492(0.78); C1590(0.88); C1636(0.90)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C1347(0.55); C1492(0.66); C1590(0.75); C1636(0.86)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C1492(0.78); C1027(0.82); C1347(0.84); C1727(0.97)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C1492(0.69); C1347(0.78); C1590(0.96); C1419(0.97)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C1492(0.69); C1347(0.79); C1590(0.82); C1419(0.89)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C1347(0.81); C1419(0.81); C1711(0.89); C1735(0.91)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C1492(0.66); C1590(0.79); C1347(0.80); C1727(0.89)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C1027(0.49); C1347(0.74); C1492(0.77); C1735(0.85)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C1492(0.66); C1590(0.70); C1027(0.85); C1636(0.87)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C1735(0.76); C1419(0.84); C1590(0.85); C1636(0.95)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C1419(0.70); C1735(0.71); C1464(0.81); C1068(0.82)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C1347(0.32)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C1347(0.78)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C1027(0.95); C1068(1.15); C1312(1.17); C1419(1.21)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C1027(0.79); C1464(0.84); C1476(0.96); C1735(0.97)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C760(0.94); C1727(0.99); C1735(1.04); C1590(1.05)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C1068(1.19); C1711(1.06); C1727(1.00); C1312(1.00)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C1347(0.48)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C1068(0.00); C1347(0.00); C188(0.00); C1027(0.00)  LDD0222  [23]
 LDCM0071  Cisar_cp14 MDA-MB-231 10.34  LDD0121  [7]
 LDCM0070  Cisar_cp37 MDA-MB-231 10.43  LDD0120  [7]
 LDCM0632  CL-Sc Hep-G2 C1711(1.40); C1027(0.55)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C1027(0.85); C1492(0.85); C1419(0.85); C1735(0.93)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C760(0.73); C1027(0.77); C1492(0.85); C1419(0.96)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C1027(0.75); C1492(0.87); C1312(0.94); C1727(1.04)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C1027(0.67); C1636(0.92); C1419(0.95); C1727(0.96)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C1027(0.88); C1492(0.94); C1735(0.95); C1727(0.95)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C1464(0.86); C1476(0.89); C1735(0.89); C1492(0.90)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C1464(0.88); C1419(0.90); C1636(0.91); C1476(0.93)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C1068(0.84); C1492(0.93); C1636(0.97); C1347(1.05)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C1068(0.87); C1727(0.99); C1492(1.01); C1636(1.12)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C1068(0.81); C1492(0.97); C1347(0.98); C1727(1.09)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C1068(0.86); C1727(0.90); C1347(0.97); C1492(1.01)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C1492(0.79); C1347(0.82); C1636(0.87); C1068(0.89)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C1027(0.64); C760(0.72); C1492(0.80); C1419(1.04)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C1492(0.82); C1068(0.83); C1419(0.94); C1636(0.95)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C1492(0.83); C1727(0.86); C1347(0.91); C1636(0.91)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C1312(0.73); C1636(0.79); C1492(0.84); C1590(0.86)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C1492(0.54); C1590(0.68); C1312(0.72); C1636(0.78)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C1492(0.50); C1590(0.63); C1636(0.75); C1419(0.93)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C1590(0.64); C1492(0.64); C1636(0.72); C1312(0.79)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C1492(0.49); C1590(0.68); C1636(0.76); C1312(0.80)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C760(0.88); C1068(1.03); C1735(1.12); C1727(1.21)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C1027(0.67); C1492(0.92); C1068(0.96); C760(1.02)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C1735(0.91); C1068(0.95); C1492(0.96); C760(0.97)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C760(0.64); C1027(0.89); C1492(0.93); C1068(1.01)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C1492(0.92); C760(0.93); C1636(0.94); C1068(1.00)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C1492(0.56); C1027(0.68); C1419(0.70); C1636(0.81)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C1027(0.83); C1590(0.85); C1476(0.90); C1312(0.96)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C1492(0.95); C1735(0.97); C1590(0.97); C1027(0.98)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C1590(0.90); C1027(0.93); C1735(0.99); C1419(0.99)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C1068(0.83); C1735(0.96); C1590(0.97); C1492(0.98)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C1068(0.80); C1312(0.85); C1590(0.92); C1735(0.93)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C1027(0.59); C1068(0.83); C1590(0.86); C1636(0.97)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C1068(0.80); C1492(0.89); C1735(0.95); C1590(0.97)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C1027(0.77); C760(0.84); C1492(0.90); C1419(0.97)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C1027(0.84); C1492(0.87); C1727(0.90); C1419(0.92)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C1027(0.71); C760(0.80); C1492(0.85); C1419(0.95)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C1590(0.82); C760(0.85); C1727(0.88); C1636(0.94)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C1492(0.57); C1419(0.92); C1735(0.92); C760(0.93)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C1492(0.55); C1590(0.90); C1727(0.91); C1636(0.92)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C1492(0.65); C1636(0.84); C1419(0.85); C1590(0.88)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C1027(0.82); C1068(0.91); C1464(0.93); C1419(0.93)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C1492(0.79); C1590(0.82); C1727(0.88); C1636(0.89)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C1492(0.69); C1727(0.91); C1419(0.96); C1636(0.96)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C1727(0.93); C1590(0.94); C760(0.97); C1312(1.03)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C1492(0.79); C760(0.84); C1636(0.87); C1590(0.91)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C1492(0.69); C760(0.96); C1419(0.98); C1636(0.99)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C1068(1.23); C1312(1.05); C1419(0.94); C1464(1.54)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C1068(1.10); C1312(1.10); C1419(0.93); C1464(1.46)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C1068(1.15); C1312(1.03); C1419(0.85); C1464(1.23)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C1068(1.18); C1312(1.05); C1419(0.85); C1464(1.79)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C1068(1.14); C1312(1.03); C1419(0.93); C1464(1.19)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C1027(0.83); C1068(0.89); C1312(1.01); C1419(0.95)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C1068(1.12); C1312(1.03); C1419(0.86); C1464(1.21)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C1068(1.13); C1312(1.17); C1419(1.02); C1464(1.36)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C1068(1.23); C1312(1.08); C1419(1.13); C1464(1.23)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C1068(1.25); C1312(1.14); C1419(1.03); C1464(1.46)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C1068(1.22); C1312(1.30); C1419(1.28); C1464(1.42)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C1068(1.05); C1312(1.42); C1419(0.99); C1464(1.36)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C1068(1.05); C1312(1.55); C1419(0.98); C1464(1.18)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C1068(1.03); C1312(2.70); C1419(1.18); C1464(1.40)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C1068(1.09); C1312(1.47); C1419(1.16); C1464(1.25)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C1027(0.79); C1068(0.95); C1312(1.06); C1419(0.90)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C1068(1.11); C1312(1.87); C1419(1.08); C1464(1.24)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C1068(1.05); C1312(1.45); C1419(1.10); C1464(1.07)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C1068(1.18); C1312(1.89); C1419(1.36); C1464(1.65)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C1068(1.14); C1312(1.53); C1419(1.17); C1464(1.30)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C1068(1.21); C1312(1.36); C1419(1.16); C1464(1.20)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C1068(1.24); C1312(1.52); C1419(1.18); C1464(1.67)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C1068(1.02); C1312(1.06); C1419(0.91); C1464(0.97)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C1068(0.90); C1312(1.08); C1419(0.91); C1464(0.92)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C1068(0.96); C1312(0.97); C1419(0.96); C1464(0.88)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C1068(1.02); C1312(1.05); C1419(1.06); C1464(1.00)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C1027(0.75); C1068(0.95); C1312(0.87); C1419(0.96)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C1068(0.98); C1312(1.11); C1419(0.90); C1464(0.92)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C1068(0.99); C1312(1.34); C1419(0.93); C1464(0.92)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C1068(1.16); C1312(1.16); C1419(0.79); C1464(0.87)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C1068(1.13); C1312(1.05); C1419(0.81); C1464(0.94)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C1068(1.03); C1312(0.95); C1419(0.94); C1464(1.00)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C1068(1.14); C1312(0.95); C1419(0.96); C1464(0.93)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C1068(0.89); C1312(1.00); C1419(0.95); C1464(0.97)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C1068(0.99); C1312(1.02); C1419(0.88); C1464(0.99)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C1068(1.08); C1312(0.91); C1419(0.89); C1464(0.90)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C1068(0.92); C1312(0.95); C1419(0.94); C1464(0.96)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C1027(0.91); C1068(1.19); C1312(1.06); C1419(1.01)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C1068(0.92); C1312(1.10); C1419(0.95); C1464(1.10)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C1068(0.98); C1312(1.08); C1419(0.95); C1464(1.12)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C1068(0.98); C1312(1.04); C1419(0.99); C1464(1.04)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C1068(0.99); C1312(1.13); C1419(1.00); C1464(1.00)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C1068(1.08); C1312(1.00); C1419(1.04); C1464(1.07)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C1068(0.99); C1312(1.04); C1419(0.93); C1464(1.08)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C1068(1.03); C1312(1.10); C1419(1.12); C1464(1.28)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C1068(0.99); C1312(0.88); C1419(1.15); C1464(1.11)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C1068(1.02); C1312(1.03); C1419(0.88); C1464(1.16)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C1068(1.39); C1312(1.20); C1419(0.89); C1464(1.13)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C1027(0.77); C1068(1.03); C1312(1.44); C1419(1.14)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C1068(1.26); C1312(1.11); C1419(1.05); C1464(1.03)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C1068(1.03); C1312(1.28); C1419(0.90); C1464(0.98)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C1068(0.94); C1312(1.15); C1419(0.99); C1464(1.05)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C1068(0.86); C1312(1.48); C1419(0.93); C1464(1.03)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C1068(0.96); C1312(1.07); C1419(0.90); C1464(1.07)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C1027(0.87); C1068(1.18); C1312(0.91); C1419(1.35)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C1027(0.62); C1068(0.85); C1312(1.11); C1419(0.89)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C1027(0.79); C1068(0.95); C1312(1.20); C1419(1.09)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C1027(0.86); C1068(0.93); C1312(0.94); C1419(1.32)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C1027(0.70); C1068(1.26); C1312(2.56); C1419(0.94)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C1027(0.86); C1068(1.20); C1312(1.02); C1419(1.28)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C1027(0.80); C1068(0.93); C1312(1.00); C1419(1.27)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C1027(0.71); C1068(1.06); C1312(1.03); C1419(1.37)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C1027(0.58); C1068(1.07); C1312(1.11); C1419(1.48)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C1027(0.99); C1068(1.11); C1312(1.05); C1419(1.40)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C1027(0.63); C1068(0.98); C1312(0.91); C1419(1.14)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C1027(0.68); C1068(0.91); C1312(0.93); C1419(1.30)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C1027(0.62); C1068(1.00); C1312(0.91); C1419(1.41)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C1027(0.68); C1068(1.03); C1312(0.85); C1419(1.36)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C1027(0.87); C1068(1.14); C1312(0.99); C1419(1.81)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C1027(0.79); C1068(1.02); C1312(1.15); C1419(0.97)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C1027(0.82); C1068(1.06); C1312(1.15); C1419(1.20)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C1027(0.65); C1068(1.03); C1312(1.03); C1419(1.03)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C1027(0.67); C1068(0.94); C1312(1.11); C1419(1.06)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C1027(0.66); C1068(0.87); C1312(0.92); C1419(0.97)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C1027(1.06); C1068(1.08); C1312(0.91); C1419(1.09)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C1027(0.62); C1068(1.12); C1312(1.86); C1419(1.15)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C1027(0.61); C1068(0.85); C1312(1.06); C1419(1.06)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C1027(0.70); C1068(0.81); C1312(1.08); C1419(1.00)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C1027(0.79); C1068(0.97); C1312(1.05); C1419(1.20)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C1027(0.78); C1068(0.87); C1312(0.92); C1419(1.15)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C188(0.86); C1347(1.30); C1711(0.85); C1590(1.01)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1711(2.21); C1727(1.75); C1590(0.13)  LDD1702  [6]
 LDCM0204  EV-97 T cell C1312(5.09)  LDD0525  [30]
 LDCM0625  F8 Ramos C1727(0.65); C1735(1.26); C1027(0.86); C1068(0.84)  LDD2187  [31]
 LDCM0572  Fragment10 MDA-MB-231 C1312(20.00)  LDD1465  [32]
 LDCM0573  Fragment11 Ramos C1727(0.13); C1735(2.29); C1027(16.70); C1068(0.39)  LDD2190  [31]
 LDCM0574  Fragment12 MDA-MB-231 C1312(20.00)  LDD1468  [32]
 LDCM0575  Fragment13 MDA-MB-231 C1312(1.20)  LDD1469  [32]
 LDCM0576  Fragment14 MDA-MB-231 C1312(1.67)  LDD1471  [32]
 LDCM0579  Fragment20 Ramos C1727(0.45); C1735(1.01); C1027(1.04); C1068(1.38)  LDD2194  [31]
 LDCM0580  Fragment21 MDA-MB-231 C1312(1.06)  LDD1473  [32]
 LDCM0582  Fragment23 Ramos C1727(0.72); C1735(0.60); C1027(1.70); C1068(0.98)  LDD2196  [31]
 LDCM0578  Fragment27 MDA-MB-231 C1312(1.32)  LDD1474  [32]
 LDCM0586  Fragment28 Ramos C1727(0.49); C1735(0.79); C1027(0.66); C1068(1.64)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C1727(1.34); C1735(1.20); C1027(1.44); C1068(1.06)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C1727(0.72); C1735(1.12); C1027(1.06); C1068(0.98)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C1727(0.48); C1735(0.82); C1027(1.29); C1068(1.29)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C1068(0.94); C1312(1.08); C1419(0.99); C1464(0.97)  LDD0785  [10]
 LDCM0596  Fragment38 MDA-MB-231 C1312(1.32)  LDD1480  [32]
 LDCM0566  Fragment4 Ramos C1727(0.77); C1735(0.97); C1027(1.07); C1068(1.00)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C1068(1.27); C1312(1.77); C1419(1.29); C1464(1.84)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C1727(0.98); C1735(1.26); C1027(1.26); C1068(1.11)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C1727(0.66); C1735(1.55); C1027(1.52); C1068(1.10)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C1727(0.31); C1735(1.05); C1027(1.09); C1068(1.30)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C1727(0.56); C1735(1.17); C1027(1.28); C1068(1.51)  LDD2188  [31]
 LDCM0107  IAA HeLa H1037(0.00); H1653(0.00); C188(0.00); C760(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C1312(13.41); C1735(2.45); C1068(2.13); C1464(2.80)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C1312(1.39); C1735(3.07); C1068(1.53); C1464(2.14)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C1312(3.14); C1735(2.97); C1068(2.95); C1464(2.18)  LDD0082  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1347(0.56)  LDD2121  [6]
 LDCM0109  NEM HeLa H1653(0.00); H1503(0.00); H1037(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1347(0.62)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1347(0.78); C188(1.40)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1727(1.03); C1347(0.74)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C188(2.96)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1347(0.27); C188(0.43); C1590(0.63)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1347(1.05); C188(1.00)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C188(1.13)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1347(0.99); C1027(1.05)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1347(0.71); C188(0.32)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1347(0.81)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1347(0.99); C188(0.46)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1347(1.24)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1347(0.67)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1347(1.10); C1027(1.13)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1347(0.58)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1492(0.61); C1347(0.50); C1068(0.72); C1711(0.61)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1347(0.60)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1347(1.08)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1492(0.79); C1347(0.64); C188(0.40)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1347(0.52)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C188(0.66)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1347(0.52)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1492(1.88)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1347(0.86)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C188(0.46)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1492(1.06); C1727(0.96); C1347(0.93); C1027(1.06)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1492(0.71); C1347(0.36)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1492(1.15); C1727(0.61); C1347(0.76); C1027(0.85)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1492(0.28)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1492(0.71); C1727(0.85)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1347(0.96)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1492(2.10); C1727(1.09); C1347(1.05)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1347(0.60)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1492(0.47); C1727(0.68); C1347(0.48)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1492(1.18); C1347(1.28)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1727(1.11); C1347(1.25)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1727(0.82); C1347(1.09); C1590(0.89)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1347(1.91)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1347(0.64)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1347(0.98)  LDD2143  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1347(0.17)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1727(1.20)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1347(0.50)  LDD2148  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1347(0.28)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1347(0.96)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C1068(0.91)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C1068(0.94); C1347(0.41); C1312(0.11)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C1068(2.85); C1312(1.86); C1476(1.69)  LDD0304  [34]
 LDCM0090  Rapamycin JHH-7 5.21  LDD0213  [28]
 LDCM0021  THZ1 HCT 116 C1068(0.95); C1711(1.13); C1312(0.95); C1735(1.08)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA export factor RAE1 (RAE1) WD repeat rae1 family P78406

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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