Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name EV-97  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 35 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05409  Antigen peptide transporter 2 (TAP2) C641 20.0
 LDTP00697  Cytochrome b5 type B (CYB5B) C115 20.0
 LDTP09799  DCN1-like protein 4 (DCUN1D4) C219 20.0
 LDTP01430  E3 ubiquitin-protein ligase listerin (LTN1) C723 20.0
 LDTP13219  GTPase IMAP family member 2 (GIMAP2) C261 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 20.0
 LDTP00475  Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) C464 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) C110 20.0
 LDTP10874  Platelet-activating factor acetylhydrolase 2, cytoplasmic (PAFAH2) C72 14.7
 LDTP12319  Serine--tRNA ligase, mitochondrial (SARS2) C64, C66 13.0
 LDTP00577  Dihydroxyacetone phosphate acyltransferase (GNPAT) C54 12.9
 LDTP00536  Mitochondrial ribonuclease P catalytic subunit (PRORP) C507 12.8
 LDTP11678  Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) C748 9.1
 LDTP09904  Caspase-10 (CASP10) C16 8.5
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C204, C209 8.4
 LDTP00670  3-phosphoinositide-dependent protein kinase 1 (PDPK1) C21, C23 8.2
 LDTP05822  Serine-protein kinase ATM (ATM) C1396 8.1
 LDTP08564  E3 ubiquitin-protein ligase UBR1 (UBR1) C1603 7.6
 LDTP13511  Phospholipase A and acyltransferase 4 (PLAAT4) C113 6.7
 LDTP10676  Inositol polyphosphate-4-phosphatase type I A (INPP4A) C275, C286 5.7
 LDTP03401  Multifunctional protein CAD (CAD) C758 5.6
 LDTP14034  Transformation/transcription domain-associated protein (TRRAP) C555 5.6
 LDTP00947  Microtubule-associated serine/threonine-protein kinase 3 (MAST3) C541 5.5
 LDTP15154  Dehydrogenase/reductase SDR family member 13 (DHRS13) C174 5.5
 LDTP02748  Cytochrome c oxidase subunit 6B1 (COX6B1) C30 5.1
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1312 5.1
 LDTP08125  tRNA-splicing endonuclease subunit Sen54 (TSEN54) C486 4.9
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C302 4.7
 LDTP10532  E1A-binding protein p400 (EP400) C1820 4.7
 LDTP01686  Malonyl-CoA decarboxylase, mitochondrial (MLYCD) C206 4.5
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) C547 4.4
 LDTP11617  Myotubularin-related protein 12 (MTMR12) C152 4.3
 LDTP09729  Peroxynitrite isomerase THAP4 (THAP4) C360, C361 4.3
 LDTP19669  Threonine synthase-like 1 (THNSL1) C277 4.0
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10378  Nuclear envelope pore membrane protein POM 121 (POM121) C28 20.0
 LDTP04801  Gasdermin-D (GSDMD) C268 17.0
 LDTP07370  Multiple C2 and transmembrane domain-containing protein 2 (MCTP2) C497 14.6
 LDTP06152  Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) C379 14.6
 LDTP10073  Protein RFT1 homolog (RFT1) C448 12.8
 LDTP12548  Phospholipid scramblase 3 (PLSCR3) C125, C126 9.1
 LDTP07626  Rapamycin-insensitive companion of mTOR (RICTOR) C1608 6.4
 LDTP07456  Molybdate-anion transporter (MFSD5) C33 5.0
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11193  Metastasis-associated protein MTA3 (MTA3) C532 17.6
 LDTP19380  Zinc finger MYM-type protein 1 (ZMYM1) C989 12.7
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00671  Tapasin (TAPBP) C440 20.0
 LDTP09680  Palladin (PALLD) C964 4.7
Other
Click to Show/Hide to Show 27 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C28 20.0
 LDTP07522  Centrosomal protein of 85 kDa (CEP85) C281, C286 20.0
 LDTP08248  NLR family member X1 (NLRX1) C331 20.0
 LDTP09399  Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) C1266 20.0
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 20.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C532 20.0
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C157 20.0
 LDTP13090  UV radiation resistance-associated gene protein (UVRAG) C239 20.0
 LDTP00941  Zinc finger C3H1 domain-containing protein (ZFC3H1) C1778 20.0
 LDTP00687  Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) C1069 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 14.0
 LDTP11896  Kinetochore-associated protein DSN1 homolog (DSN1) C287 13.8
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C90 11.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C819 10.7
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 10.2
 LDTP13245  Zinc finger CCCH domain-containing protein 7B (ZC3H7B) C956 9.6
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C210, C213 7.8
 LDTP01750  Peroxisomal membrane protein 11B (PEX11B) C153 7.5
 LDTP14047  Plexin-D1 (PLXND1) C1363 7.5
 LDTP10140  Calcineurin B homologous protein 3 (TESC) C213 5.5
 LDTP15887  Lipase maturation factor 2 (LMF2) C659 5.4
 LDTP06210  Golgin subfamily B member 1 (GOLGB1) C3197, C3213 4.8
 LDTP19719  Solute carrier family 66 member 3 (SLC66A3) C135 4.8
 LDTP06276  MAD2L1-binding protein (MAD2L1BP) C247 4.5
 LDTP03994  Condensin-2 complex subunit D3 (NCAPD3) C631 4.5
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) C513 4.2
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) C38 4.0

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.