Details of the Target

General Information of Target

Target ID LDTP00947
Target Name Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
Gene Name MAST3
Gene ID 23031
Synonyms
KIAA0561; Microtubule-associated serine/threonine-protein kinase 3; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLD
SPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQP
TPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERF
PKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFL
EMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAA
EGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRR
KPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT
FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEY
LHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQV
CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWP
EGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLE
AEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTP
TFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNT
ISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSH
ARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVS
ALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKY
GFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVV
ELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKIS
KQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSA
SPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR
SPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERR
DSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD
Target Bioclass
Enzyme
Family
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Subcellular location
Cytoplasm
Uniprot ID
O60307
Ensemble ID
ENST00000262811.10
HGNC ID
HGNC:19036
ChEMBL ID
CHEMBL2417352

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C541(32.76)  LDD0209  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C762(2.13)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C762(1.06)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C762(0.51)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C762(0.48)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C762(0.58)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C762(0.70)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C762(0.76)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C762(0.89)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C762(1.96)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C762(0.49)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C762(0.40)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C762(0.46)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C762(0.99)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C762(0.73)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C762(0.66)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C762(0.52)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C762(1.31)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C762(1.32)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C762(1.27)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C762(1.33)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C762(1.19)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C762(1.20)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C762(1.13)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C762(1.19)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C762(1.41)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C762(1.12)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C762(1.15)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C762(0.96)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C762(0.98)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C762(1.18)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C762(1.37)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C762(1.23)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C762(0.81)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C762(0.95)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C762(0.98)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C762(0.82)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C762(1.05)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C762(1.22)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C762(0.90)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C762(1.44)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C762(1.29)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C762(1.55)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C762(1.86)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C762(1.34)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C762(1.12)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C762(1.26)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C762(1.49)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C762(1.09)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C762(1.19)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C762(1.42)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C762(1.67)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C762(1.50)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C762(1.95)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C762(2.88)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C762(1.21)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C762(1.32)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C762(1.50)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C762(1.40)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C762(1.36)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C762(1.58)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C762(1.13)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C762(1.27)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C762(2.42)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C762(2.59)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C762(1.20)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C762(1.04)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C762(0.95)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C762(1.34)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C762(1.07)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C762(1.31)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C762(1.06)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C762(1.47)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C762(0.80)  LDD0882  [4]
 LDCM0285  AC25 HCT 116 C762(1.47)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C762(1.31)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C762(1.53)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C762(1.23)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C762(1.68)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C762(1.11)  LDD0888  [4]
 LDCM0291  AC30 HCT 116 C762(1.38)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C762(1.20)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C762(1.81)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C762(1.22)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C762(1.23)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C762(1.22)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C762(0.91)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C762(0.78)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C762(0.97)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C762(1.13)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C762(1.00)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C762(1.28)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C762(0.83)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C762(1.40)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C762(1.19)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C762(1.05)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C762(1.38)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C762(1.20)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C762(0.92)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C762(1.22)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C762(1.98)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C762(1.06)  LDD0910  [4]
 LDCM0313  AC50 HCT 116 C762(1.57)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C762(1.01)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C762(1.20)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C762(1.85)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C762(1.18)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C762(1.75)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C762(1.91)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C762(0.80)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C762(0.85)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C762(1.43)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C762(0.74)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C762(1.05)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C762(1.09)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C762(1.42)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C762(1.00)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C762(1.54)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C762(0.70)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C762(0.62)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C762(0.88)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C762(0.81)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C762(1.11)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C762(1.18)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C762(1.13)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C762(0.89)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C762(1.30)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C762(1.36)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C762(1.54)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C762(1.58)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C762(1.26)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C762(1.12)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C762(1.02)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C762(1.38)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C762(1.13)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C762(1.11)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C762(1.23)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C762(1.71)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C762(1.51)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C762(1.39)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C762(1.05)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C762(1.34)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C762(0.89)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C762(0.83)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C762(1.32)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C762(0.68)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C762(1.17)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C762(1.35)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C762(1.80)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C762(1.84)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C762(1.26)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C762(1.68)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C762(1.30)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C762(0.85)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C762(0.42)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C762(1.18)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C762(1.34)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C762(1.12)  LDD0873  [4]
 LDCM0367  CL1 HCT 116 C762(1.06)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C762(2.00)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C762(1.05)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C762(1.01)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C762(1.12)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C762(1.18)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C762(1.03)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C762(0.66)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C762(0.97)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C762(0.95)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C762(0.94)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C762(0.95)  LDD0976  [4]
 LDCM0379  CL11 HCT 116 C762(1.24)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C762(1.01)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C762(0.91)  LDD0979  [4]
 LDCM0382  CL112 HCT 116 C762(1.45)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C762(1.36)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C762(2.30)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C762(1.08)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C762(1.25)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C762(1.60)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C762(1.23)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C762(1.21)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C762(2.24)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C762(1.15)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C762(1.09)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C762(0.96)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C762(1.30)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C762(1.67)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C762(0.66)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C762(0.80)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C762(1.59)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C762(1.29)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C762(2.01)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C762(1.65)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C762(1.91)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C762(0.94)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C762(1.02)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C762(0.92)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C762(0.92)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C762(0.97)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C762(1.04)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C762(1.69)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C762(1.75)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C762(1.14)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C762(1.70)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C762(1.31)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C762(1.33)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C762(1.13)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C762(1.16)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C762(1.03)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C762(1.94)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C762(1.00)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C762(2.10)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C762(1.26)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C762(1.27)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C762(1.59)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C762(2.60)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C762(0.99)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C762(2.51)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C762(1.36)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C762(1.21)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C762(1.41)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C762(1.43)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C762(2.26)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C762(1.89)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C762(1.27)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C762(1.69)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C762(0.95)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C762(0.95)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C762(0.89)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C762(1.15)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C762(1.42)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C762(1.49)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C762(1.10)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C762(0.77)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C762(0.80)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C762(1.17)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C762(0.99)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C762(0.99)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C762(0.75)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C762(1.04)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C762(1.15)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C762(1.58)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C762(1.50)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C762(1.30)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C762(1.20)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C762(1.47)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C762(1.52)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C762(1.01)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C762(1.94)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C762(1.33)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C762(1.12)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C762(1.26)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C762(1.62)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C762(1.79)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C762(1.64)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C762(1.16)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C762(1.29)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C762(1.56)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C762(0.86)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C762(0.79)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C762(0.81)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C762(1.03)  LDD1070  [4]
 LDCM0473  CL8 HCT 116 C762(1.78)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C762(1.06)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C762(1.06)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C762(1.18)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C762(1.05)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C762(0.85)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C762(1.04)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C762(1.30)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C762(1.04)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C762(1.20)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C762(1.09)  LDD1081  [4]
 LDCM0484  CL9 HCT 116 C762(1.31)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C762(0.85)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C762(0.59)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C762(0.72)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C762(0.72)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C762(0.76)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C762(0.99)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C762(0.83)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C762(0.84)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C762(0.85)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C762(0.91)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C363(0.71)  LDD1698  [5]
 LDCM0204  EV-97 T cell C541(5.54)  LDD0525  [6]
 LDCM0468  Fragment33 HCT 116 C762(1.37)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C762(2.76)  LDD0744  [4]
 LDCM0022  KB02 JeKo-1 C762(2.42)  LDD2403  [7]
 LDCM0023  KB03 Jurkat C541(32.76)  LDD0209  [1]
 LDCM0024  KB05 NALM-6 C762(3.19)  LDD3339  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) PTEN phosphatase protein family P60484

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840