Details of the Target

General Information of Target

Target ID LDTP11193
Target Name Metastasis-associated protein MTA3 (MTA3)
Gene Name MTA3
Gene ID 57504
Synonyms
KIAA1266; Metastasis-associated protein MTA3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDKGDPSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQLGLS
LRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASE
TRSGPQSASTAVKERPASSEKVKGGDDHDDTSDSDSDGLTLKELQNRLRRKREQEPTERP
LKGIQSRLRKKRREEGPAETVGSEASDTVEGVLPSKQEPENDQGVVSQAGKDDRESKLEG
KAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGIS
EARGRLLERNGEDYICPNCTILQVQDETHSETADQQEAKWRPGDADGTDCTSIGTIEQKS
SEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILK
HAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQAGIKISSVHKRPAPEKKETTVK
KAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRSEEK
AAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWL
SATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMS
AAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNR
YKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVME
SRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDT
TSQHRAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPDSAD
EVMPEAVPEVASEPGLESASHPNVDRTYFPGPPGDGHPEPSPLEDLSPCPASCGSGVVTT
VTVSGRDPRTAPSSSCTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSP
DPRYLSVPPSPNISTSESRSPPEGDTTLFLSRLSTIWKGFINMQSVAKFVTKAYPVSGCF
DYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYF
SSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGLESPRPNIILGLVICQKIK
RPANSGELDKMDEKRTRLQPEEADVPAYPKVATVPQSEKKPSKYPLCSADAAVSTTPPGS
PPPPPPLPEPPVLKVLSSLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQT
LFGKKKSFDPSAREPPGSTAGLPQEPKTTAEDGVPAPPLLDPIVQQFGQFSKDKALEEEE
DDRPYDPEEEYDPERAFDTQLVERGRRHEVERAPEAAAAEREEVAYDPEDETILEEAKVT
VDDLPNRMCADVRRNSVERPAEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLEEQEEAL
RQQRAAVGVSMAHFSVSDALMSPPPKSSLPKAELFQQEQQSADKPASLPPASQASNHRDP
RQARRLATETGEGEGEPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEPASSPWA
SGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPARRVLLPTPPCGALQPGFPLQHDGER
DPFTCPGFASQDKALGSAQYEDPRNLHSAGRSSSPAGETEGDREPQARPGEGTAPLPPPG
QKVGGSQPPFQGQREPGPHALGMSGLHGPNFPGPRGPAPPFPEENIASNDGPRGPPPARF
GAQKGPIPSLFSGQHGPPPYGDSRGPSPSYLGGPRGVAPSQFEERKDPHGEKREFQDAPY
NEVTGAPAQFEGTEQAPFLGSRGGAPFQFGGQRRPLLSQLKGPRGGPPPSQFGGQRGPPP
GHFVGPRGPHPSQFETARGPHPNQFEGPRGQAPNFMPGPRGIQPQQFEDQRVHSPPRFTN
QRAPAPLQFGGLRGSAPFSEKNEQTPSRFHFQGQAPQVMKPGPRPLLELPSHPPQHRKDR
WEEAGPPSALSSSAPGQGPEADGQWASADFREGKGHEYRNQTFEGRQRERFDVGPKEKPL
EEPDAQGRASEDRRRERERGRNWSRERDWDRPREWDRHRDKDSSRDWDRNRERSANRDRE
READRGKEWDRSRERSRNRERERDRRRDRDRSRSRERDRDKARDRERGRDRKDRSKSKES
ARDPKPEASRASDAGTASQA
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Uniprot ID
Q9BTC8
Ensemble ID
ENST00000405094.2
HGNC ID
HGNC:23784

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.K543N DBIA    Probe Info 
FTC133 SNV: p.Q448H DBIA    Probe Info 
HDQP1 SNV: p.S19N DBIA    Probe Info 
KYSE150 SNV: p.P154S DBIA    Probe Info 
SW948 SNV: p.F131L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.74  LDD0402  [1]
STPyne
 Probe Info  		K61(0.94)  LDD0277  [2]
BTD
 Probe Info  		C212(1.20)  LDD2152  [3]
AHL-Pu-1
 Probe Info  		C212(2.27)  LDD0169  [4]
HHS-475
 Probe Info  		Y22(0.41)  LDD0264  [5]
DBIA
 Probe Info  		C403(0.60); C406(0.60)  LDD0531  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C264(0.00); C109(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C109(0.00); C264(0.00); C403(0.00); C406(0.00)  LDD0037  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
AOyne
 Probe Info  		9.40  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C212(1.20)  LDD2152  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C212(2.27)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C403(0.60); C406(0.60)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C379(0.90); C382(0.90); C400(0.80); C403(0.97)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C379(0.44); C382(0.44); C400(0.44)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C379(0.54); C382(0.54); C400(0.54)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C379(1.02); C382(1.02); C400(1.02)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C379(0.54); C382(0.54); C400(0.54)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C379(0.66); C382(0.66); C400(0.66)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C379(0.54); C382(0.54); C400(0.54)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C379(0.51); C382(0.51); C400(0.51)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C379(0.66); C382(0.67); C400(0.66)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C379(0.38); C382(0.66); C400(0.38)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C379(0.59); C382(0.45); C400(0.59)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C379(0.84); C382(0.84); C400(0.90); C403(1.01)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C379(0.60); C382(0.43); C400(0.60)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C379(0.53); C382(0.59); C400(0.53)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C379(0.81); C382(0.59); C400(0.81)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C379(0.87); C382(0.99); C400(0.87); C403(0.82)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C379(0.69); C382(1.18); C400(0.84); C403(0.86)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C379(0.79); C382(0.71); C400(0.65); C403(0.85)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C379(0.99); C382(0.95); C400(0.89); C403(0.83)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C379(0.77); C382(0.85); C400(0.70); C403(0.80)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C379(0.91); C382(0.96); C400(0.78); C403(0.84)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C379(0.81); C382(0.94); C400(0.78); C403(0.87)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C379(0.81); C382(0.81); C400(0.87); C403(0.80)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C379(0.87); C382(1.22); C400(0.93); C403(0.84)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C379(0.73); C382(0.86); C400(0.73); C403(0.84)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C379(0.72); C382(1.26); C400(0.86); C403(0.86)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C379(0.74); C382(0.86); C400(0.69); C403(0.86)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C379(0.92); C382(0.90); C400(0.78); C403(0.89)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C379(0.93); C382(0.96); C400(0.87); C403(0.91)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C379(0.85); C382(1.00); C400(0.77); C403(0.90)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C379(0.70); C382(0.99); C400(0.73); C403(0.91)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C403(0.75); C406(0.75)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C403(1.28); C406(1.28)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C403(0.79); C406(0.79)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C403(1.32); C406(1.32)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C403(0.74); C406(0.74)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C403(0.69); C406(0.69)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C403(0.68); C406(0.68)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C403(0.63); C406(0.63)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C403(0.72); C406(0.72)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C403(0.80); C406(0.80)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C403(0.74); C406(0.74)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C403(0.75); C406(0.75)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C379(0.85); C382(0.85); C400(0.84); C403(0.87)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C403(0.70); C406(0.70)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C403(0.73); C406(0.73)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C403(0.78); C406(0.78)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C403(0.77); C406(0.92); C379(1.40); C382(1.40)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C403(0.75); C406(0.80); C379(1.05); C382(1.05)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C403(0.83); C406(0.88); C379(1.38); C382(1.38)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C403(0.75); C406(0.81); C379(0.98); C382(0.98)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C403(0.68); C406(0.77); C379(0.90); C382(0.90)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C403(0.66); C406(0.73); C379(1.38); C382(1.38)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C403(0.69); C406(0.75); C379(1.07); C382(1.07)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C379(1.01); C382(1.01); C400(1.06); C403(0.78)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C403(0.90); C406(0.94); C379(1.10); C382(1.10)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C403(0.89); C406(0.96); C379(1.05); C382(1.05)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C406(0.88); C403(0.89); C379(1.01); C382(1.01)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C403(0.76); C406(0.85); C379(1.32); C382(1.32)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C379(0.93); C382(0.93); C400(0.93); C403(0.81)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C379(1.11); C382(1.11); C400(1.11); C403(0.93)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C379(1.25); C382(1.25); C400(1.25); C403(0.92)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C379(1.16); C382(1.16); C400(1.16); C403(1.17)  LDD2161  [6]
 LDCM0276  AC17 HEK-293T C400(1.22); C403(0.80)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C400(1.20); C403(0.80)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C400(1.10); C403(0.86)  LDD0876  [6]
 LDCM0279  AC2 HCT 116 C403(0.53); C406(0.53)  LDD0596  [6]
 LDCM0280  AC20 HEK-293T C400(1.37); C403(0.76)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C400(1.17); C403(0.71)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C400(1.51); C403(0.78)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C400(1.66); C403(0.62)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C400(1.15); C403(0.99)  LDD0882  [6]
 LDCM0285  AC25 HCT 116 C403(0.98); C406(0.98)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C403(0.79); C406(0.79)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C403(0.86); C406(0.86)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C403(0.87); C406(0.87)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C403(0.89); C406(0.89)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C403(0.65); C406(0.65)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C403(0.88); C406(0.88)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C403(0.83); C406(0.83)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C403(0.75); C406(0.75)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C403(0.87); C406(0.87)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C403(0.77); C406(0.77)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C403(1.11); C406(1.11)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C403(0.75); C406(0.75)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C403(0.77); C406(0.77)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C403(0.90); C406(0.90)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C403(0.90); C406(0.90)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C403(0.63); C406(0.63)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C403(0.72); C406(0.72)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C403(0.72); C406(0.72)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C403(0.77); C406(0.77)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C403(0.89); C406(0.89)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C403(0.94); C406(0.94)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C403(0.72); C406(0.72)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C400(0.76); C403(0.73)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C400(0.88); C403(0.67)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C400(1.00); C403(0.71)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C400(1.25); C403(0.78)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C403(0.56); C406(0.56)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C400(0.93); C403(0.62)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C400(1.02); C403(0.49)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C400(1.01); C403(0.50)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C400(0.81); C403(0.64)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C400(1.04); C403(0.52)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C400(0.92); C403(0.65)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C400(0.85); C403(0.70)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C379(0.82); C382(0.82); C400(0.82)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C379(1.04); C382(1.04); C400(1.04)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C379(0.73); C382(0.73); C400(0.73)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C379(0.94); C382(0.94); C400(1.10); C403(1.18)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C379(1.04); C382(1.04); C400(1.04)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C379(1.42); C382(1.42); C400(1.42)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C379(1.26); C382(1.26); C400(1.26)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C379(0.80); C382(0.80); C400(0.80)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C379(0.95); C382(0.95); C400(0.95)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C379(0.68); C382(0.68); C400(0.68)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C379(1.05); C382(1.05); C400(1.05)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C379(0.67); C382(0.67); C400(0.67)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C406(0.81); C382(0.89); C379(0.97); C400(0.97)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C406(0.95); C379(1.30); C400(1.30); C382(1.36)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C379(0.99); C382(0.99); C400(1.06); C403(0.89)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C406(0.80); C382(0.86); C379(1.00); C400(1.00)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C406(1.12); C382(1.19); C379(1.43); C400(1.43)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C382(0.91); C406(1.03); C379(1.11); C400(1.11)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C382(0.81); C406(0.98); C379(1.06); C400(1.06)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C406(0.97); C382(1.17); C379(1.35); C400(1.35)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C382(0.85); C406(0.93); C379(1.05); C400(1.05)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C406(0.88); C382(1.07); C379(1.12); C400(1.12)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C406(0.77); C382(1.01); C379(1.03); C400(1.03)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C406(1.01); C382(1.06); C379(1.20); C400(1.20)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C406(1.03); C382(1.12); C379(1.31); C400(1.31)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C379(0.93); C382(0.93); C400(1.12); C403(0.81)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C406(0.98); C379(1.48); C400(1.48); C382(1.57)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C406(0.85); C379(1.25); C400(1.25); C382(1.40)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C382(0.96); C406(0.97); C379(1.11); C400(1.11)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C400(1.02); C403(0.97)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C400(1.34); C403(0.76)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C400(1.25); C403(0.94)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C400(1.05); C403(0.96)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C400(1.11); C403(0.87)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C400(1.18); C403(0.82)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C400(1.26); C403(0.71)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C400(1.27); C403(0.76)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C400(1.40); C403(0.89)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C400(1.24); C403(1.00)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C400(1.33); C403(0.82)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C400(1.16); C403(0.62)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C400(1.29); C403(0.80)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C400(1.47); C403(0.58)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C400(2.52); C403(0.30)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C379(0.40); C382(0.40); C400(0.40)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C379(0.65); C382(0.65); C400(0.65)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C379(0.89); C382(0.89); C400(1.00); C403(0.97)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C379(0.82); C382(0.82); C400(0.82); C403(0.71)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C379(0.82); C382(0.82); C400(0.82); C403(0.74)  LDD0873  [6]
 LDCM0367  CL1 PaTu 8988t C400(0.84); C379(0.94); C382(0.86)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C400(0.59); C379(0.65); C382(0.62)  LDD1247  [6]
 LDCM0369  CL100 HCT 116 C403(0.67); C406(0.67)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C379(0.92); C382(0.92); C400(0.97); C403(0.72)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C379(0.83); C382(0.83); C400(0.86); C403(0.72)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C379(1.02); C382(1.02); C400(0.90); C403(0.72)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C379(0.96); C382(0.96); C400(0.92); C403(0.89)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C400(1.27); C403(1.00)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C400(1.38); C403(1.02)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C400(1.16); C403(0.97)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C400(1.17); C403(0.93)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C400(1.16); C403(0.91)  LDD0976  [6]
 LDCM0379  CL11 PaTu 8988t C400(0.80); C379(0.87); C382(0.87)  LDD1258  [6]
 LDCM0380  CL110 HEK-293T C400(1.25); C403(0.80)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C400(1.18); C403(1.01)  LDD0979  [6]
 LDCM0382  CL112 HCT 116 C403(0.87); C406(0.87)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C403(0.83); C406(0.83)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C403(0.71); C406(0.71)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C403(0.85); C406(0.85)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C403(0.72); C406(0.72)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C403(0.93); C406(0.93)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C403(0.95); C406(0.95)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C403(0.76); C406(0.76)  LDD0706  [6]
 LDCM0390  CL12 PaTu 8988t C400(0.83); C379(0.98); C382(0.99)  LDD1269  [6]
 LDCM0391  CL120 HCT 116 C403(0.67); C406(0.67)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C400(0.86); C403(0.59)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C400(0.94); C403(0.66)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C400(0.77); C403(0.70)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C400(0.91); C403(0.75)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C379(1.53); C382(1.53); C400(1.53)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C379(1.42); C382(1.42); C400(1.42)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C379(0.97); C382(0.97); C400(0.97)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C379(1.52); C382(1.52); C400(1.52)  LDD0716  [6]
 LDCM0400  CL13 PaTu 8988t C400(0.74); C379(0.83); C382(0.77)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C400(0.78); C379(0.91); C382(0.81)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C400(0.90); C379(0.87); C382(0.85)  LDD1281  [6]
 LDCM0403  CL16 HEK-293T C379(0.90); C400(0.92); C403(1.20)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C379(0.97); C400(1.12); C403(0.88)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C379(1.09); C400(1.06); C403(0.76)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C379(0.92); C400(0.97); C403(1.08)  LDD1004  [6]
 LDCM0407  CL2 PaTu 8988t C400(0.76); C379(0.95); C382(0.90)  LDD1286  [6]
 LDCM0408  CL20 HEK-293T C379(1.04); C400(1.03); C403(0.89)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C379(1.15); C400(1.17); C403(0.66)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C379(0.84); C400(1.06); C403(0.77)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C379(0.82); C400(1.05); C403(0.87)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C379(0.82); C400(1.01); C403(0.88)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C379(0.86); C400(1.22); C403(0.73)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C379(0.91); C400(1.32); C403(0.67)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C379(0.86); C400(1.08); C403(0.82)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C379(0.87); C400(1.10); C403(0.93)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C379(1.10); C400(1.03); C403(0.90)  LDD1015  [6]
 LDCM0418  CL3 PaTu 8988t C400(0.79); C379(0.79); C382(0.81)  LDD1297  [6]
 LDCM0419  CL30 HEK-293T C379(1.16); C400(1.26); C403(0.49)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C379(1.18); C382(1.18); C400(1.18); C403(0.76)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C379(0.65); C382(0.65); C400(0.65); C403(0.71)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C379(1.08); C382(1.08); C400(1.08); C403(0.75)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C379(1.05); C382(1.05); C400(1.05); C403(0.88)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C379(1.08); C382(1.08); C400(1.08); C403(0.80)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C379(1.23); C382(1.23); C400(1.23); C403(0.86)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C379(1.04); C382(1.04); C400(1.04); C403(0.84)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C379(0.91); C382(0.91); C400(0.91); C403(0.88)  LDD0745  [6]
 LDCM0429  CL4 PaTu 8988t C400(0.83); C379(0.95); C382(0.81)  LDD1308  [6]
 LDCM0430  CL40 HCT 116 C379(1.25); C382(1.25); C400(1.25); C403(0.83)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C379(0.76); C382(0.76); C400(0.76); C403(0.92)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C379(0.87); C382(0.87); C400(0.87); C403(0.80)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C379(1.01); C382(1.01); C400(1.01); C403(1.17)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C379(1.07); C382(1.07); C400(1.07); C403(0.85)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C379(1.22); C382(1.22); C400(1.22); C403(0.98)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C379(0.89); C382(0.95); C400(0.92)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C379(1.24); C382(1.10); C400(1.17)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C379(1.26); C382(1.28); C400(1.27)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C379(1.08); C382(1.07); C400(1.08)  LDD0756  [6]
 LDCM0440  CL5 PaTu 8988t C400(0.74); C379(0.80); C382(0.82)  LDD1319  [6]
 LDCM0441  CL50 HCT 116 C379(1.16); C382(0.93); C400(1.05)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C379(1.08); C382(1.19); C400(1.14)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C379(1.41); C382(1.31); C400(1.36)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C379(1.06); C382(1.26); C400(1.16)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C379(1.21); C382(1.30); C400(1.25)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C379(1.27); C382(1.25); C400(1.26)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C379(1.16); C382(1.18); C400(1.17)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C379(0.83); C382(1.07); C400(0.95)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C379(1.28); C382(1.23); C400(1.26)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C379(0.98); C382(1.07); C400(1.03)  LDD0767  [6]
 LDCM0451  CL6 PaTu 8988t C400(0.79); C379(0.83); C382(0.79)  LDD1330  [6]
 LDCM0452  CL60 HCT 116 C379(1.05); C382(1.08); C400(1.07)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C379(1.51); C382(1.75); C400(1.39)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C379(1.34); C382(1.43); C400(1.40)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C379(1.19); C382(1.16); C400(1.29)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C379(1.07); C382(1.07); C400(1.08)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C379(1.23); C382(1.07); C400(1.26)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C379(1.18); C382(1.14); C400(1.30)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C379(1.21); C382(1.22); C400(1.29)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C379(1.19); C382(1.17); C400(1.34)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C379(1.17); C382(1.32); C400(1.31)  LDD1059  [6]
 LDCM0462  CL7 PaTu 8988t C400(0.84); C379(0.90); C382(0.86)  LDD1341  [6]
 LDCM0463  CL70 HEK-293T C379(1.30); C382(1.33); C400(1.35)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C379(1.24); C382(1.14); C400(1.34)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C379(1.26); C382(1.23); C400(1.10)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C379(1.23); C382(1.15); C400(1.30)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C379(1.83); C382(1.31); C400(1.64)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C379(0.91); C382(0.86); C400(1.11); C403(0.97)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C379(0.98); C382(0.99); C400(1.29); C403(0.87)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C379(0.64); C382(0.67); C400(1.44); C403(0.88)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C379(0.98); C382(1.01); C400(1.17); C403(0.83)  LDD1070  [6]
 LDCM0473  CL8 PaTu 8988t C400(0.68); C379(0.70); C382(0.72)  LDD1352  [6]
 LDCM0474  CL80 HEK-293T C379(1.11); C382(0.68); C400(1.22); C403(0.89)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C379(1.01); C382(1.22); C400(1.23); C403(0.84)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C379(1.02); C382(1.65); C400(1.04); C403(1.03)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C379(1.31); C382(1.32); C400(1.03); C403(0.88)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C379(0.81); C382(0.81); C400(1.30); C403(0.82)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C379(0.87); C382(0.71); C400(1.21); C403(0.82)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C379(0.82); C382(0.84); C400(2.00); C403(0.69)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C379(1.03); C382(1.18); C400(1.25); C403(0.79)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C379(1.00); C382(1.07); C400(1.06); C403(0.75)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C379(0.91); C382(0.84); C400(1.16); C403(0.81)  LDD1081  [6]
 LDCM0484  CL9 PaTu 8988t C400(0.72); C379(0.77); C382(0.71)  LDD1363  [6]
 LDCM0485  CL90 HEK-293T C379(1.26); C382(1.30); C400(1.06); C403(0.74)  LDD1083  [6]
 LDCM0486  CL91 HCT 116 C403(0.65); C406(0.65)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C403(0.63); C406(0.63)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C403(0.62); C406(0.62)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C403(0.56); C406(0.56)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C403(0.60); C406(0.60)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C403(0.62); C406(0.62)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C403(0.56); C406(0.56)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C403(0.53); C406(0.53)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C403(0.64); C406(0.64)  LDD0811  [6]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C532(4.30)  LDD0513  [12]
 LDCM0495  E2913 HEK-293T C532(1.87); C264(0.92); C406(1.01)  LDD1698  [13]
 LDCM0204  EV-97 T cell C532(5.54)  LDD0524  [12]
 LDCM0468  Fragment33 HEK-293T C379(1.33); C382(0.97); C400(1.47)  LDD1066  [6]
 LDCM0427  Fragment51 HCT 116 C379(1.12); C382(1.12); C400(1.12); C403(1.12)  LDD0744  [6]
 LDCM0116  HHS-0101 DM93 Y22(0.41)  LDD0264  [5]
 LDCM0118  HHS-0301 DM93 Y22(7.72)  LDD0266  [5]
 LDCM0022  KB02 HEK-293T C264(1.08); C109(0.87); C403(0.99); C406(0.99)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C264(1.05); C109(0.76); C403(1.04); C406(1.04)  LDD1497  [13]
 LDCM0024  KB05 G361 C229(3.62)  LDD3311  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) . P23771

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840