Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name Dimethyl Fumarate(DMF)  Competitor Info 
Competitor Concentration 50 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 39 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP00475  Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) C464 15.5
 LDTP01026  Tyrosine-protein kinase JAK2 (JAK2) C243 13.3
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) C4045 12.5
 LDTP00267  DNA-directed RNA polymerase, mitochondrial (POLRMT) C726 10.4
 LDTP14535  6-phosphogluconolactonase (PGLS) C32, C33 9.0
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 8.7
 LDTP00536  Mitochondrial ribonuclease P catalytic subunit (PRORP) C367 8.6
 LDTP15785  Protein phosphatase 1M (PPM1M) C7, C9 8.5
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C315 8.2
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) C149 7.5
 LDTP13856  Little elongation complex subunit 1 (ICE1) C2094 7.3
 LDTP01803  Adenosine deaminase (ADA) C75 7.3
 LDTP00267  DNA-directed RNA polymerase, mitochondrial (POLRMT) C398 7.3
 LDTP13720  Ubiquitin carboxyl-terminal hydrolase 24 (USP24) C2160 7.0
 LDTP02971  DNA ligase 1 (LIG1) C895 6.9
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) C109 6.7
 LDTP12744  Interleukin-1 receptor-associated kinase 4 (IRAK4) C13 6.5
 LDTP00538  Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) C406 6.3
 LDTP03993  Probable helicase with zinc finger domain (HELZ) C100, C101 6.2
 LDTP07015  Alanine--tRNA ligase, mitochondrial (AARS2) C596, C609 6.1
 LDTP08156  Schlafen family member 11 (SLFN11) C150 5.9
 LDTP10828  2-aminoethanethiol dioxygenase (ADO) C18 5.7
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1) C492 5.5
 LDTP09004  Peroxisomal succinyl-coenzyme A thioesterase (ACOT4) C407 5.4
 LDTP10365  Methionine--tRNA ligase, mitochondrial (MARS2) C425 5.4
 LDTP00502  TATA-binding protein-associated factor 172 (BTAF1) C109 5.4
 LDTP09895  Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) C1088 5.1
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 5.1
 LDTP10030  Ribosome-releasing factor 2, mitochondrial (GFM2) C248 4.9
 LDTP00497  Cyclin-G-associated kinase (GAK) C87 4.7
 LDTP19669  Threonine synthase-like 1 (THNSL1) C324 4.7
 LDTP15246  Ubiquitin-protein ligase E3B (UBE3B) C75 4.7
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) C199 4.6
 LDTP14034  Transformation/transcription domain-associated protein (TRRAP) C555 4.6
 LDTP05822  Serine-protein kinase ATM (ATM) C532 4.5
 LDTP06848  Malonate--CoA ligase ACSF3, mitochondrial (ACSF3) C399 4.4
 LDTP12625  Palmitoyltransferase ZDHHC18 (ZDHHC18) C156 4.3
 LDTP07283  E3 ubiquitin-protein ligase RNF213 (RNF213) C4407 4.1
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13696  AP-4 complex subunit epsilon-1 (AP4E1) C1119 8.0
 LDTP10317  THO complex subunit 1 (THOC1) C49 6.1
 LDTP13243  Translocation protein SEC63 homolog (SEC63) C295 5.9
 LDTP01133  Copine-3 (CPNE3) C54 4.6
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 4.4
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05266  Interferon regulatory factor 9 (IRF9) C319 20.0
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 9.2
 LDTP05833  Nuclear body protein SP140 (SP140) C97 7.3
 LDTP19380  Zinc finger MYM-type protein 1 (ZMYM1) C989 7.3
 LDTP11193  Metastasis-associated protein MTA3 (MTA3) C532 4.3
Other
Click to Show/Hide to Show 36 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09702  Nesprin-2 (SYNE2) C568 16.0
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 14.9
 LDTP12830  U3 small nucleolar RNA-associated protein 6 homolog (UTP6) C370 13.6
 LDTP12285  Charged multivesicular body protein 1a (CHMP1A) C44 11.9
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C800 10.3
 LDTP09702  Nesprin-2 (SYNE2) C1032 9.9
 LDTP08707  Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) C71 9.0
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) C109 8.3
 LDTP11368  Oxysterol-binding protein-related protein 10 (OSBPL10) C615 6.4
 LDTP09790  RAB6A-GEF complex partner protein 2 (RGP1) C314 6.3
 LDTP06348  Ras GTPase-activating protein 2 (RASA2) C690 6.0
 LDTP12107  Non-homologous end-joining factor 1 (NHEJ1) C74 5.9
 LDTP07051  Rab GTPase-activating protein 1-like (RABGAP1L) C248 5.9
 LDTP01637  Pericentrin (PCNT) C2705 5.8
 LDTP13612  Spermatogenesis-associated protein 2 (SPATA2) C41 5.7
 LDTP15852  Protein FAM118B (FAM118B) C319 5.5
 LDTP14107  PAX3- and PAX7-binding protein 1 (PAXBP1) C597 5.5
 LDTP08248  NLR family member X1 (NLRX1) C155 5.4
 LDTP00239  DNA fragmentation factor subunit alpha (DFFA) C165 5.3
 LDTP10703  Leukocyte receptor cluster member 8 (LENG8) C547 5.2
 LDTP17715  S1 RNA-binding domain-containing protein 1 (SRBD1) C294 5.2
 LDTP10289  Cytoplasmic FMR1-interacting protein 2 (CYFIP2) C223 5.0
 LDTP09815  Dedicator of cytokinesis protein 2 (DOCK2) C1083 5.0
 LDTP00495  Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) C553 4.9
 LDTP13090  UV radiation resistance-associated gene protein (UVRAG) C239 4.9
 LDTP03238  Colorectal mutant cancer protein (MCC) C58 4.7
 LDTP08139  Centriolin (CNTRL) C1535 4.7
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) C266 4.5
 LDTP06348  Ras GTPase-activating protein 2 (RASA2) C567 4.5
 LDTP06431  Thyroid receptor-interacting protein 11 (TRIP11) C726 4.5
 LDTP01248  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) C15 4.4
 LDTP06166  Ras GTPase-activating protein 3 (RASA3) C662 4.4
 LDTP08795  GH3 domain-containing protein (GHDC) C502 4.3
 LDTP01440  Protein transport protein Sec24D (SEC24D) C1021, C1022 4.2
 LDTP06182  Ribosomal RNA processing protein 1 homolog B (RRP1B) C155 4.1
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C326 4.0

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.