Details of the Target

General Information of Target

Target ID LDTP05136
Target Name DNA-dependent protein kinase catalytic subunit (PRKDC)
Gene Name PRKDC
Gene ID 5591
Synonyms
HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; EC 2.7.11.1; DNPK1; p460
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family
Subcellular location
Nucleus
Function
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome. Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism. Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 . Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation. Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1.
TTD ID
T81735
Uniprot ID
P78527
DrugMap ID
TTK3PY9
Ensemble ID
ENST00000314191.7
HGNC ID
HGNC:9413
ChEMBL ID
CHEMBL3142

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.S2883R DBIA    Probe Info 
ABC1 SNV: p.T2153A DBIA    Probe Info 
AN3CA SNV: p.R1136H; p.R3335M DBIA    Probe Info 
CALU6 SNV: p.A1067V DBIA    Probe Info 
CCK81 Insertion: p.N2830KfsTer16
SNV: p.Y651C		 DBIA    Probe Info 
CHL1 SNV: p.V2190L DBIA    Probe Info 
COLO320 SNV: p.V2190L DBIA    Probe Info 
ECC2 SNV: p.F4074C DBIA    Probe Info 
HCT116 SNV: p.Y2965C DBIA    Probe Info 
HDQP1 SNV: p.M3932L DBIA    Probe Info 
HEC1 SNV: p.A2161V DBIA    Probe Info 
HT115 SNV: p.E3448D DBIA    Probe Info 
IGROV1 SNV: p.C1455Y DBIA    Probe Info 
IM95 SNV: p.A1948T DBIA    Probe Info 
IPC298 SNV: p.S1162L DBIA    Probe Info 
JURKAT SNV: p.R1883H Compound 10    Probe Info 
KMS12BM SNV: p.Q1287H DBIA    Probe Info 
KMS27 SNV: p.P3175A DBIA    Probe Info 
KU1919 Deletion: p.T3415RfsTer37 DBIA    Probe Info 
KYM1 SNV: p.K2433I DBIA    Probe Info 
LNCaP clone FGC SNV: p.Q2587Ter DBIA    Probe Info 
LOXIMVI SNV: p.P2604S DBIA    Probe Info 
MCC13 SNV: p.N1568K DBIA    Probe Info 
MCC26 SNV: p.P494L DBIA    Probe Info 
MEC1 SNV: p.Y762C DBIA    Probe Info 
MELJUSO SNV: p.V2190L DBIA    Probe Info 
MEWO SNV: p.R2452Ter; p.P2548L DBIA    Probe Info 
MFE319 SNV: p.G3648S; p.L3695M DBIA    Probe Info 
MOLT4 SNV: p.G1789C IA-alkyne    Probe Info 
NCIH1793 SNV: p.A1647T DBIA    Probe Info 
NCIH358 SNV: p.D2073V DBIA    Probe Info 
NCIH446 SNV: p.T2645S DBIA    Probe Info 
RCC10RGB SNV: p.Q1584R DBIA    Probe Info 
REC1 SNV: p.K3873R DBIA    Probe Info 
RKO SNV: p.L2892R DBIA    Probe Info 
RL952 SNV: p.R1816C DBIA    Probe Info 
RVH421 SNV: p.P1723L DBIA    Probe Info 
SKMEL24 SNV: p.Q3133H DBIA    Probe Info 
SW620 SNV: p.A1302G DBIA    Probe Info 
SW948 Deletion: p.R1075GfsTer31 DBIA    Probe Info 
TE4 SNV: p.K832E DBIA    Probe Info 
UACC257 SNV: p.P2708S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 61 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.97  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0448  [2]
P2
 Probe Info  		10.00  LDD0449  [2]
A-EBA
 Probe Info  		3.39  LDD0215  [3]
11RK72
 Probe Info  		7.47  LDD0327  [4]
11RK73
 Probe Info  		7.08  LDD0328  [4]
8RK64
 Probe Info  		N.A.  LDD0039  [4]
CY-1
 Probe Info  		15.85  LDD0243  [5]
CY4
 Probe Info  		7.99  LDD0244  [5]
N1
 Probe Info  		26.14  LDD0242  [5]
W1
 Probe Info  		11.34  LDD0235  [6]
TH211
 Probe Info  		Y115(20.00); Y1411(20.00); Y2440(20.00); Y2772(20.00)  LDD0257  [7]
TH216
 Probe Info  		Y115(20.00); Y1411(20.00); Y2772(20.00); Y2775(20.00)  LDD0259  [7]
YN-4
 Probe Info  		100.00  LDD0445  [8]
ONAyne
 Probe Info  		K3753(0.00); K2694(0.00); K4085(0.00); K2908(0.00)  LDD0273  [9]
Probe 1
 Probe Info  		Y103(41.65); Y527(13.75); Y682(8.12); Y1874(75.69)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C232(0.00); C4061(0.00); C974(0.00); C223(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C223(1.13); C3347(1.13); C232(1.06); C2093(1.06)  LDD0460  [11]
Sulforaphane-probe2
 Probe Info  		2.22  LDD0042  [12]
AHL-Pu-1
 Probe Info  		C3837(2.45); C3403(3.46); C3014(2.08); C2342(2.14)  LDD0168  [13]
EA-probe
 Probe Info  		C42(1.61); C4106(0.78)  LDD2210  [14]
HHS-475
 Probe Info  		Y3715(0.45); Y3036(0.54); Y3280(0.82); Y2440(0.95)  LDD0264  [15]
HHS-465
 Probe Info  		Y2004(10.00); Y3280(7.51)  LDD2237  [16]
DBIA
 Probe Info  		C1499(1.13); C1507(1.13); C1312(1.11); C3837(1.05)  LDD0078  [17]
AMP probe
 Probe Info  		K3753(0.00); K4023(0.00)  LDD0200  [18]
ATP probe
 Probe Info  		K3753(0.00); K4023(0.00); K1057(0.00); K4019(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C3837(0.00); C1629(0.00); C1312(0.00); C25(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C478(0.00); C1742(0.00); C3683(0.00); C491(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C703(0.00); C2093(0.00); C3281(0.00); C3683(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C3281(0.00); C703(0.00); C2093(0.00); C4061(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C3837(0.00); C1629(0.00); C1312(0.00); C25(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K1869(0.00); K117(0.00); K2694(0.00); K1985(0.00)  LDD0035  [22]
BTD
 Probe Info  		C1904(0.00); C3837(0.00); C4061(0.00); C1127(0.00)  LDD0004  [23]
JW-RF-010
 Probe Info  		C3293(0.00); C2342(0.00); C4061(0.00); C3014(0.00)  LDD0026  [24]
NAIA_4
 Probe Info  		C25(0.00); C42(0.00); C123(0.00); C223(0.00)  LDD2226  [25]
TFBX
 Probe Info  		C3293(0.00); C223(0.00); C3014(0.00); C1312(0.00)  LDD0027  [24]
WYneC
 Probe Info  		N.A.  LDD0014  [23]
WYneN
 Probe Info  		C3837(0.00); C232(0.00); C1164(0.00); C3187(0.00)  LDD0021  [23]
WYneO
 Probe Info  		C111(0.00); C2469(0.00); C974(0.00); C1904(0.00)  LDD0022  [23]
aHNE
 Probe Info  		C1904(0.00); C2342(0.00)  LDD0001  [23]
Compound 10
 Probe Info  		C111(0.00); C1312(0.00); C1455(0.00); C1499(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		C1312(0.00); C1455(0.00); C1499(0.00); C1507(0.00)  LDD2213  [26]
ENE
 Probe Info  		C1507(0.00); C1742(0.00); C25(0.00); C223(0.00)  LDD0006  [23]
IPM
 Probe Info  		C90(0.00); C1128(0.00); C3781(0.00); C1164(0.00)  LDD0005  [23]
NHS
 Probe Info  		K3196(0.00); K1057(0.00); K3877(0.00); K3158(0.00)  LDD0010  [23]
NPM
 Probe Info  		C1312(0.00); C25(0.00); C4106(0.00)  LDD0016  [23]
OSF
 Probe Info  		N.A.  LDD0029  [27]
PF-06672131
 Probe Info  		C223(0.00); C232(0.00); C373(0.00); C795(0.00)  LDD0017  [28]
SF
 Probe Info  		Y3715(0.00); K2752(0.00); Y4077(0.00); K1407(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K117(0.00); K3753(0.00); K2829(0.00); K3710(0.00)  LDD0009  [23]
VSF
 Probe Info  		C123(0.00); C111(0.00); C1164(0.00); C3347(0.00)  LDD0007  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [29]
1c-yne
 Probe Info  		K1857(0.00); K810(0.00); K4023(0.00); K4050(0.00)  LDD0228  [30]
1d-yne
 Probe Info  		N.A.  LDD0357  [30]
Acrolein
 Probe Info  		C1904(0.00); H2642(0.00); C3347(0.00); C2342(0.00)  LDD0217  [31]
Cinnamaldehyde
 Probe Info  		C1455(0.00); C974(0.00); C2363(0.00); C3293(0.00)  LDD0220  [31]
Crotonaldehyde
 Probe Info  		C3014(0.00); H2642(0.00); C1904(0.00); C478(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		C1904(0.00); C3347(0.00); C3014(0.00); C1127(0.00)  LDD0218  [31]
NAIA_5
 Probe Info  		C3837(0.00); C1312(0.00); C25(0.00); C123(0.00)  LDD2223  [25]
TPP-AC
 Probe Info  		N.A.  LDD0427  [32]
HHS-482
 Probe Info  		Y2004(0.89); Y2440(0.97); Y2965(0.85); Y3280(0.84)  LDD2239  [16]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C219
 Probe Info  		6.36  LDD1893  [33]
FFF probe13
 Probe Info  		12.75  LDD0475  [34]
FFF probe14
 Probe Info  		12.69  LDD0477  [34]
FFF probe3
 Probe Info  		8.86  LDD0465  [34]
JN0003
 Probe Info  		12.06  LDD0469  [34]
STS-2
 Probe Info  		N.A.  LDD0138  [35]
VE-P
 Probe Info  		N.A.  LDD0396  [36]
DA-2
 Probe Info  		N.A.  LDD0070  [37]
OEA-DA
 Probe Info  		4.03  LDD0046  [38]
STS-1
 Probe Info  		N.A.  LDD0068  [39]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C3837(0.96); C491(0.73); C4061(0.73); C223(0.76)  LDD2142  [40]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C3837(1.15); C1742(0.60); C1364(0.93); C1455(0.84)  LDD2112  [40]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C3837(1.00); C1742(0.83); C1364(0.68); C1455(0.60)  LDD2095  [40]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C3837(0.97); C1364(0.84); C1455(1.08); C491(0.79)  LDD2130  [40]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C3837(1.02); C1742(1.09); C1364(0.96); C1455(0.95)  LDD2117  [40]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C3837(1.15); C1742(1.22); C1364(1.35); C1455(1.65)  LDD2152  [40]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C3837(1.36); C491(1.00); C974(0.76); C223(0.99)  LDD2103  [40]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C3837(0.66); C1455(0.42); C491(0.63); C4061(0.33)  LDD2132  [40]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1455(0.74); C491(0.47); C2435(0.46); C223(0.97)  LDD2131  [40]
 LDCM0025  4SU-RNA HEK-293T C3837(2.45); C3403(3.46); C3014(2.08); C2342(2.14)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C478(3.04); C42(3.64); C3837(2.35); C2342(2.15)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C1499(1.34); C1507(1.25); C4106(1.16); C974(1.55)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C1499(1.32); C1507(1.15); C4106(1.08); C974(0.78)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C1499(0.99); C1507(0.93); C4106(0.47); C974(0.71)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C1499(0.92); C1507(0.99); C4106(0.74); C974(0.68)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C1499(1.03); C1507(0.95); C4106(0.63); C974(0.94)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C1499(0.97); C1507(1.01); C4106(0.38); C974(0.68)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C1499(1.00); C1507(0.97); C4106(0.52); C974(1.22)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C1499(1.00); C1507(0.98); C4106(0.37); C974(0.88)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C1499(1.00); C1507(1.06); C4106(0.48); C974(0.65)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C1499(0.97); C1507(1.06); C4106(0.51); C974(0.77)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C1499(0.96); C1507(0.90); C4106(0.43); C974(0.76)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C1499(0.77); C1507(0.81); C4106(0.66); C974(1.35)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C1499(1.38); C1507(1.29); C4106(0.58); C974(0.73)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C1499(0.85); C1507(0.88); C4106(0.50); C974(0.78)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C1499(0.84); C1507(0.88); C4106(0.53); C974(0.58)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C1499(0.95); C1507(0.97); C4106(0.42); C974(0.57)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C1499(1.03); C1507(1.05); C4106(1.45); C974(0.93)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C1499(1.17); C1507(1.19); C4106(0.79); C974(0.79)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C1499(1.25); C1507(1.22); C4106(0.90); C974(0.65)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C1499(1.28); C1507(1.28); C4106(0.96); C974(0.72)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C1499(1.07); C1507(1.13); C4106(0.95); C974(0.71)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C1499(1.14); C1507(1.11); C4106(0.88); C974(1.28)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C1499(1.18); C1507(1.15); C4106(1.10); C974(1.10)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C1499(1.09); C1507(1.10); C4106(1.04); C974(0.86)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C1499(1.25); C1507(1.18); C4106(0.95); C974(0.74)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C1499(1.08); C1507(1.09); C4106(0.83); C974(1.04)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C1499(1.12); C1507(1.09); C4106(0.80); C974(1.26)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C1499(1.06); C1507(1.08); C4106(0.94); C974(1.04)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C1499(0.98); C1507(0.99); C4106(0.97); C974(1.34)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C1499(1.06); C1507(1.06); C4106(0.95); C974(0.87)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C1499(1.11); C1507(1.19); C4106(1.07); C974(0.50)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C1499(1.09); C1507(1.18); C4106(1.13); C974(0.70)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C1499(1.18); C1507(1.11); C974(0.40); C111(0.91)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C1499(0.92); C1507(0.99); C974(1.18); C111(1.14)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C1499(1.10); C1507(1.16); C974(0.66); C111(1.03)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C1499(0.95); C1507(1.01); C974(0.96); C111(0.93)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C1499(1.05); C1507(1.12); C974(1.41); C111(1.02)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C1499(1.09); C1507(1.14); C974(0.93); C111(0.98)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C1499(1.15); C1507(1.16); C974(0.70); C111(0.80)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C1499(1.23); C1507(1.12); C974(0.71); C111(0.88)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C1499(1.09); C1507(1.13); C974(0.92); C111(1.04)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C1499(1.07); C1507(1.09); C974(1.16); C111(0.99)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C1499(1.35); C1507(1.23); C974(0.96); C111(0.85)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C1499(1.11); C1507(1.17); C974(1.04); C111(0.99)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C1499(1.27); C1507(1.09); C4106(1.13); C974(0.87)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C1499(1.21); C1507(1.21); C974(0.76); C111(0.76)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C1499(1.22); C1507(1.17); C974(1.02); C111(0.87)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C1499(1.13); C1507(1.12); C974(1.77); C111(1.09)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C1499(1.15); C1507(1.17); C4106(0.62); C974(1.12)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C3293(0.15); C4106(0.20); C3281(0.22); C4061(0.31)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C3293(0.26); C3281(0.50); C4106(0.59); C4061(0.60)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C3293(0.24); C4106(0.36); C4061(0.43); C3281(0.48)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C3293(0.13); C4106(0.19); C3281(0.20); C4061(0.29)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C3293(0.13); C4106(0.18); C3281(0.19); C4061(0.27)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C3293(0.12); C3281(0.21); C4106(0.21); C4061(0.28)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C3281(0.48); C3293(0.49); C4061(0.54); C630(0.67)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C3293(0.33); C4106(0.42); C301(0.57); C3281(0.60)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C3293(0.37); C4106(0.64); C301(0.65); C3281(0.65)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C3293(0.14); C4106(0.16); C3281(0.19); C4061(0.28)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C3293(0.13); C4106(0.23); C3281(0.23); C795(0.27)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C1499(1.30); C1507(1.30); C4106(0.38); C974(0.84)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C1499(1.26); C1507(1.25); C4106(0.41); C974(1.00)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C1499(1.03); C1507(1.08); C4106(1.79); C974(1.04)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C1499(0.94); C1507(1.07); C4106(0.74); C974(0.91)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C301(0.73); C1128(0.78); C1127(0.78); C1135(0.80)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C3281(0.31); C4061(0.31); C2093(0.38); C1432(0.49)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C3281(0.73); C4061(0.76); C458(0.78); C1919(0.79)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C1432(0.59); C703(0.60); C2093(0.74); C111(0.80)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C1128(0.79); C1127(0.80); C974(0.82); C3281(0.84)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C3281(0.62); C1135(0.70); C1128(0.71); C1127(0.74)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C1919(0.63); C458(0.77); C2342(0.79); C90(0.82)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C630(0.73); C3281(0.77); C301(0.80); C1127(0.83)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C974(0.86); C1312(0.88); C1128(0.89); C1135(0.90)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C1919(0.50); C630(0.78); C3837(0.81); C4061(0.82)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C703(0.55); C1919(0.64); C630(0.66); C4061(0.68)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C1919(0.48); C3281(0.54); C3683(0.56); C1127(0.58)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C3281(0.47); C1919(0.50); C703(0.57); C1127(0.59)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C1919(0.44); C703(0.51); C1127(0.55); C1128(0.59)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C1432(0.56); C703(0.58); C2093(0.67); C111(0.79)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C3281(0.48); C3683(0.52); C4061(0.53); C2244(0.57)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C1919(0.50); C703(0.56); C3281(0.60); C1127(0.65)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C3281(0.29); C4061(0.38); C3683(0.39); C1127(0.40)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C3281(0.34); C3683(0.43); C4061(0.45); C1919(0.47)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C3281(0.25); C3683(0.36); C4061(0.37); C630(0.38)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C25(0.74); C1312(0.81); C1791(0.87); C3837(0.92)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C1432(0.89); C478(0.92); C25(0.94); C2342(0.94)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C25(0.87); C1432(0.87); C3293(0.96); C90(0.97)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C25(0.82); C1312(0.85); C478(0.88); C457(0.94)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C703(0.69); C3281(0.81); C25(0.81); C2093(0.85)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C1432(0.47); C703(0.60); C2093(0.61); C3281(0.79)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C1432(0.51); C1128(0.63); C2435(0.65); C301(0.67)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C1312(0.84); C478(0.89); C2248(0.89); C4061(0.90)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C1432(0.71); C25(0.83); C2435(0.84); C3683(0.84)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C478(0.78); C25(0.90); C3293(0.90); C2248(0.91)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C1432(0.69); C3281(0.81); C25(0.84); C4061(0.85)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C1432(0.60); C630(0.63); C301(0.63); C1919(0.68)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C1128(0.69); C1176(0.69); C478(0.69); C3293(0.78)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C1128(0.70); C703(0.70); C630(0.83); C1176(0.85)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C703(0.53); C1128(0.75); C3293(0.78); C478(0.79)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C2093(0.35); C630(0.35); C301(0.38); C974(0.42)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C1432(0.42); C2093(0.52); C703(0.56); C3781(0.67)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C630(0.33); C2093(0.39); C301(0.40); C703(0.43)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C1128(0.41); C1127(0.70); C3293(0.75); C478(0.77)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C1128(0.55); C1432(0.69); C478(0.73); C3293(0.74)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C2093(0.48); C630(0.49); C301(0.51); C703(0.55)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C2093(0.45); C630(0.45); C1432(0.49); C301(0.53)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C630(0.31); C2093(0.36); C301(0.36); C974(0.45)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C630(0.36); C2093(0.39); C301(0.39); C974(0.46)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C4061(0.32); C301(0.52); C2093(0.55); C2397(0.57)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C4061(0.34); C1135(0.41); C301(0.43); C3293(0.52)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C4061(0.21); C1135(0.30); C2093(0.31); C301(0.33)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C3293(0.41); C3281(0.51); C4061(0.59); C1135(0.64)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C4061(0.43); C2093(0.62); C2397(0.67); C301(0.69)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C301(0.48); C2093(0.61); C4061(0.65); C1135(0.74)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C301(0.22); C4061(0.23); C1135(0.23); C2397(0.31)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C4061(0.34); C1135(0.53); C301(0.57); C2093(0.57)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C4061(0.21); C301(0.22); C1135(0.26); C2093(0.28)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C4061(0.21); C2093(0.30); C4106(0.44); C1135(0.44)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C4061(0.26); C2093(0.37); C301(0.46); C4106(0.52)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C4061(0.17); C2093(0.17); C301(0.21); C1135(0.24)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C4061(0.38); C2093(0.62); C703(0.63); C1432(0.68)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C4061(0.45); C2093(0.57); C630(0.59); C703(0.60)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C3281(0.71); C1135(0.73); C3293(0.73); C4061(0.75)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C703(0.26); C2093(0.26); C630(0.26); C1919(0.29)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C4061(0.69); C3281(0.76); C630(0.78); C3014(0.85)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C4061(0.40); C630(0.53); C2093(0.55); C2397(0.56)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C630(0.32); C703(0.33); C301(0.33); C2093(0.34)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C630(0.32); C2093(0.33); C703(0.35); C4061(0.36)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C630(0.30); C703(0.37); C2093(0.39); C301(0.40)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C2093(0.34); C4061(0.36); C703(0.40); C630(0.40)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C2093(0.32); C703(0.34); C630(0.34); C4061(0.36)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C1432(0.59); C4061(0.72); C630(0.72); C703(0.75)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C4061(0.47); C3281(0.64); C630(0.66); C3014(0.67)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C3281(0.48); C4061(0.52); C1432(0.65); C630(0.69)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C4061(0.44); C2093(0.45); C2397(0.48); C630(0.48)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C1791(0.06); C1164(0.66); C630(0.69); C4061(0.79)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C630(0.30); C301(0.34); C703(0.37); C2093(0.39)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C703(0.24); C2435(0.27); C3281(0.28); C1919(0.30)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C3781(0.28); C3281(0.28); C703(0.30); C2435(0.32)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C703(0.43); C4106(0.55); C3281(0.55); C3781(0.59)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C703(0.41); C3683(0.49); C3281(0.50); C3781(0.54)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C703(0.55); C2363(0.68); C4106(0.69); C1742(0.71)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C3781(0.45); C703(0.50); C4106(0.54); C3683(0.55)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C3781(0.32); C3281(0.36); C1919(0.41); C703(0.41)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C703(0.60); C2363(0.63); C1176(0.75); C630(0.86)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C703(0.24); C2435(0.24); C3281(0.27); C3781(0.29)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C3281(0.25); C2435(0.26); C703(0.26); C3781(0.28)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C3281(0.42); C3781(0.45); C4106(0.51); C703(0.52)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C703(0.57); C232(0.62); C3781(0.68); C3281(0.69)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C703(0.48); C2363(0.67); C1432(0.73); C4106(0.75)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C703(0.45); C3781(0.46); C1919(0.52); C3281(0.53)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C3281(0.28); C3781(0.32); C703(0.33); C2435(0.35)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C630(0.12); C1919(0.13); C4061(0.13); C2093(0.20)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C1919(0.42); C630(0.49); C2248(0.56); C4061(0.59)  LDD0683  [17]
 LDCM0545  Acetamide MDA-MB-231 C1742(0.60); C1364(0.58); C491(0.38); C223(0.41)  LDD2138  [40]
 LDCM0520  AKOS000195272 MDA-MB-231 C1364(0.92); C1455(0.89); C491(0.74); C974(1.01)  LDD2113  [40]
 LDCM0248  AKOS034007472 HCT 116 C1499(1.08); C1507(1.04); C4106(1.19); C974(1.07)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C3281(0.69); C1135(0.74); C703(0.74); C630(0.75)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C3281(0.20); C4061(0.23); C3293(0.25); C630(0.27)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 C1791(0.00); C1904(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C1499(1.13); C1507(1.13); C1312(1.11); C3837(1.05)  LDD0078  [17]
 LDCM0102  BDHI 8 Jurkat C1499(26.99); C1507(26.99)  LDD0204  [41]
 LDCM0498  BS-3668 MDA-MB-231 C1742(0.87); C1364(0.61); C1455(0.81); C491(0.49)  LDD2091  [40]
 LDCM0630  CCW28-3 231MFP C1904(1.52); C1229(1.36)  LDD2214  [42]
 LDCM0108  Chloroacetamide HeLa H2642(0.00); C2342(0.00); C3347(0.00); C1432(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C2469(20.00); C491(20.00); C223(20.00); C3781(2.43)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C1176(0.62); C457(0.73); C458(0.73); C2244(0.75)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C1176(0.39); C3781(0.44); C795(0.60); C630(0.61)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C2093(0.52); C1432(0.57); C3281(0.64); C703(0.68)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C3281(0.40); C4061(0.46); C3293(0.50); C630(0.61)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C703(0.68); C2248(0.70); C3293(0.74); C4106(0.77)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C3293(0.63); C1432(0.64); C1135(0.69); C703(0.72)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C3293(0.71); C630(0.75); C703(0.79); C1364(0.80)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C3281(0.46); C2093(0.50); C4061(0.53); C630(0.68)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C3281(0.29); C2093(0.33); C4061(0.36); C630(0.47)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C3281(0.23); C4061(0.31); C2093(0.34); C630(0.48)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C3281(0.23); C4061(0.24); C2093(0.25); C1919(0.37)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C3281(0.44); C4061(0.57); C2093(0.65); C630(0.65)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C3781(0.39); C630(0.40); C1432(0.40); C795(0.46)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C3281(0.35); C4061(0.39); C2093(0.48); C630(0.51)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C3281(0.58); C630(0.66); C1919(0.67); C1128(0.67)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C1919(0.66); C3281(0.67); C2248(0.67); C1164(0.69)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C3281(0.34); C4061(0.44); C3683(0.45); C1127(0.48)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C2397(0.52); C2403(0.52); C1128(0.55); C1127(0.56)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C3281(0.53); C1127(0.56); C1128(0.58); C3683(0.58)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C3281(0.61); C3683(0.65); C1127(0.65); C630(0.66)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C630(0.52); C301(0.53); C2093(0.53); C1432(0.55)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C1432(0.74); C2248(0.80); C1455(0.81); C25(0.87)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C1312(0.64); C3781(0.70); C3281(0.72); C1432(0.76)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C630(0.37); C795(0.39); C1176(0.40); C1432(0.45)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C478(0.79); C25(0.86); C703(0.88); C3293(0.92)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C4106(0.44); C2093(0.62); C3683(0.66); C111(0.67)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C2093(0.61); C1128(0.64); C478(0.66); C1432(0.67)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C974(0.42); C2093(0.43); C630(0.43); C4106(0.44)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C630(0.37); C2093(0.37); C301(0.39); C974(0.40)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C301(0.62); C1176(0.72); C2093(0.75); C3014(0.82)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C301(0.56); C2093(0.63); C3683(0.65); C4061(0.66)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C301(0.55); C2093(0.70); C2363(0.77); C1455(0.82)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C4061(0.25); C1135(0.40); C2397(0.42); C2093(0.43)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C457(0.66); C458(0.66); C3281(0.67); C795(0.68)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C1176(0.66); C232(0.72); C457(0.82); C458(0.82)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C223(0.73); C2093(0.78); C232(0.79); C703(0.81)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C4061(0.53); C3683(0.60); C974(0.66); C3781(0.70)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C4061(0.57); C974(0.64); C1742(0.65); C3683(0.69)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C974(0.31); C457(0.52); C458(0.55); C1742(0.62)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C457(0.55); C4061(0.55); C4106(0.57); C3293(0.60)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C232(0.74); C1176(0.78); C2397(0.79); C457(0.80)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C974(0.21); C4061(0.25); C3781(0.26); C3293(0.33)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C974(0.18); C4061(0.21); C3781(0.26); C4106(0.26)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C974(0.21); C4061(0.27); C630(0.29); C457(0.30)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C974(0.26); C4061(0.31); C3781(0.31); C3293(0.46)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C974(0.19); C4061(0.23); C3781(0.25); C4106(0.27)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C1499(1.61); C1507(1.11); C4106(0.36); C974(0.19)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C1499(1.29); C1507(0.81); C4106(0.76); C974(0.43)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C1499(1.34); C1507(1.03); C4106(0.57); C974(0.49)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C1499(1.16); C1507(0.82); C4106(0.36); C974(0.29)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C1499(1.02); C1507(0.81); C4106(0.42); C974(0.25)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C1499(1.41); C1507(1.28); C4106(1.35); C974(1.18)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C1499(1.10); C1507(0.81); C4106(0.69); C974(0.45)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C1499(1.15); C1507(1.26); C974(0.70); C111(0.95)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C1499(1.59); C1507(1.45); C974(0.78); C111(0.87)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C1499(1.87); C1507(1.96); C974(0.68); C111(0.97)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C1499(1.42); C1507(1.82); C974(0.53); C111(0.99)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C1499(1.11); C1507(1.19); C974(0.51); C111(0.86)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C1499(1.59); C1507(1.63); C974(0.47); C111(1.02)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C1499(1.46); C1507(1.43); C974(0.53); C111(1.12)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C1499(1.38); C1507(1.49); C974(0.58); C111(1.08)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C1499(2.82); C1507(2.21); C4106(1.24); C974(1.06)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C1499(1.35); C1507(1.30); C974(0.50); C111(0.92)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C1499(1.15); C1507(1.35); C974(0.62); C111(0.93)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C1499(1.67); C1507(1.82); C974(0.50); C111(1.15)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C1499(1.14); C1507(1.39); C974(0.54); C111(1.10)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C1499(1.32); C1507(1.36); C974(0.60); C111(0.86)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C1499(1.34); C1507(1.30); C974(0.57); C111(1.05)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C1499(1.59); C1507(1.11); C4106(1.99); C111(1.33)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C1499(1.11); C1507(0.91); C4106(1.71); C111(1.23)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C1499(1.34); C1507(1.18); C4106(2.15); C111(1.18)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C1499(1.82); C1507(1.33); C4106(1.16); C111(0.96)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C1499(1.03); C1507(1.00); C4106(1.24); C974(1.18)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C1499(3.26); C1507(2.76); C4106(1.92); C111(1.15)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C1499(3.41); C1507(2.03); C4106(1.68); C111(1.17)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C1499(2.75); C1507(1.53); C4106(2.21); C111(0.96)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C1499(1.50); C1507(1.32); C4106(1.46); C111(1.04)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C1499(4.62); C1507(2.76); C4106(1.61); C111(1.02)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C1499(1.58); C1507(1.04); C4106(2.09); C111(0.98)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C1499(1.02); C1507(0.86); C4106(1.30); C111(1.02)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C1499(1.83); C1507(1.21); C4106(1.93); C111(0.96)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C1499(0.95); C1507(0.84); C4106(1.88); C111(1.05)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C1499(1.24); C1507(1.06); C4106(1.39); C111(1.03)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C1499(1.51); C1507(1.40); C4106(1.30); C974(0.99)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C1499(1.04); C1507(1.01); C4106(1.43); C111(1.11)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C1499(0.97); C1507(1.21); C974(0.76); C111(0.88)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C1499(1.10); C1507(1.21); C974(1.24); C111(0.76)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C1499(1.48); C1507(1.64); C974(1.17); C111(0.89)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C1499(2.19); C1507(2.54); C974(1.18); C111(0.73)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C1499(1.06); C1507(1.19); C974(0.59); C111(0.80)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C1499(1.31); C1507(1.33); C974(0.61); C111(0.66)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C1499(1.10); C1507(1.22); C974(0.79); C111(0.83)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C1499(1.11); C1507(1.41); C974(0.93); C111(0.95)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C1499(1.65); C1507(1.84); C974(1.07); C111(1.01)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C1499(2.50); C1507(2.19); C4106(0.90); C974(0.88)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C1499(1.64); C1507(1.80); C974(0.98); C111(0.86)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C1499(1.33); C1507(1.46); C974(1.03); C111(0.97)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C1499(0.96); C1507(1.05); C974(0.94); C111(0.81)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C1499(1.11); C1507(1.26); C974(0.79); C111(0.80)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C1499(1.02); C1507(1.20); C974(1.10); C111(0.86)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C1499(1.09); C1507(1.10); C4106(0.80); C974(0.26)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C1499(2.95); C1507(2.92); C4106(0.77); C974(0.44)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C1499(1.69); C1507(1.53); C4106(0.71); C974(0.27)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C1499(1.13); C1507(1.15); C4106(0.34); C974(0.12)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C1499(12.82); C1507(9.70); C4106(0.55); C974(0.55)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C1499(1.05); C1507(1.09); C4106(1.23); C974(0.39)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C1499(1.20); C1507(1.32); C4106(0.66); C974(0.27)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C1499(1.24); C1507(1.19); C4106(0.41); C974(0.10)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C1499(1.53); C1507(1.51); C4106(0.32); C974(0.10)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C1499(5.60); C1507(4.81); C4106(0.26); C974(0.12)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C1499(1.17); C1507(1.21); C4106(0.47); C974(0.32)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C1499(1.08); C1507(1.16); C4106(0.74); C974(0.40)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C1499(1.20); C1507(1.20); C4106(0.54); C974(0.22)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C1499(1.17); C1507(1.10); C4106(0.33); C974(0.10)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C1499(1.87); C1507(1.68); C4106(0.30); C974(0.13)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C1499(1.62); C1507(1.45); C4106(1.10); C974(0.86)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C1499(1.75); C1507(1.95); C4106(0.83); C974(0.29)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C1499(1.26); C1507(1.19); C4106(1.11); C974(0.75)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C1499(2.16); C1507(2.07); C4106(0.93); C974(0.92)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C1499(2.20); C1507(2.91); C4106(1.13); C974(1.29)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C1499(1.69); C1507(1.57); C4106(0.98); C974(1.54)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C1499(2.29); C1507(1.88); C4106(0.92); C974(0.91)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C1499(1.89); C1507(1.69); C4106(1.04); C974(1.03)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C1499(5.59); C1507(7.15); C4106(0.97); C974(0.92)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C1499(1.83); C1507(1.79); C4106(0.89); C974(1.33)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C1499(1.42); C1507(1.24); C4106(1.00); C974(1.62)  LDD0811  [17]
 LDCM0634  CY-0357 Hep-G2 C1312(1.26); C25(1.02); C1904(0.75); C4106(0.69)  LDD2228  [25]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C4045(12.49)  LDD0513  [43]
 LDCM0495  E2913 HEK-293T C1364(1.06); C1312(0.92); C111(0.83); C3837(1.05)  LDD1698  [44]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C223(21.74); C1904(10.62); C478(10.01); C2363(9.84)  LDD1702  [40]
 LDCM0175  Ethacrynic acid HeLa C42(1.61); C4106(0.78)  LDD2210  [14]
 LDCM0625  F8 Ramos C2435(0.80); C223(0.63); C1742(1.50); C111(1.05)  LDD2187  [45]
 LDCM0572  Fragment10 Ramos C2435(0.53); C223(0.56); C1742(0.62); C111(0.51)  LDD2189  [45]
 LDCM0573  Fragment11 Ramos C2435(0.70); C223(1.83); C1742(0.83); C111(16.25)  LDD2190  [45]
 LDCM0574  Fragment12 Ramos C2435(0.56); C223(0.43); C1742(0.66); C111(0.36)  LDD2191  [45]
 LDCM0575  Fragment13 Ramos C2435(0.96); C223(0.73); C1742(1.03); C111(1.06)  LDD2192  [45]
 LDCM0576  Fragment14 Ramos C2435(0.83); C223(0.68); C1742(0.93); C111(0.73)  LDD2193  [45]
 LDCM0579  Fragment20 Ramos C2435(0.50); C223(0.37); C1742(0.61); C111(0.32)  LDD2194  [45]
 LDCM0580  Fragment21 Ramos C2435(0.95); C223(0.64); C1742(0.80); C111(0.58)  LDD2195  [45]
 LDCM0582  Fragment23 Ramos C2435(0.86); C223(1.42); C1742(0.96); C111(0.32)  LDD2196  [45]
 LDCM0578  Fragment27 Ramos C2435(0.97); C223(1.15); C1742(0.86); C111(0.89)  LDD2197  [45]
 LDCM0586  Fragment28 Ramos C2435(1.56); C223(0.85); C1742(0.67); C111(0.83)  LDD2198  [45]
 LDCM0588  Fragment30 Ramos C2435(0.54); C223(1.04); C1742(1.19); C111(1.10)  LDD2199  [45]
 LDCM0589  Fragment31 Ramos C2435(1.09); C223(1.63); C1742(1.29); C111(1.01)  LDD2200  [45]
 LDCM0590  Fragment32 Ramos C2435(0.46); C223(0.36); C1742(0.66); C111(0.31)  LDD2201  [45]
 LDCM0468  Fragment33 HCT 116 C1499(1.22); C1507(1.30); C974(1.06); C111(0.86)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos C2435(0.88); C223(1.28); C1742(0.89); C111(1.06)  LDD2203  [45]
 LDCM0566  Fragment4 Ramos C2435(0.92); C223(0.72); C1742(0.97); C111(0.54)  LDD2184  [45]
 LDCM0427  Fragment51 HCT 116 C1499(1.44); C1507(3.87); C974(0.47); C111(1.19)  LDD0744  [17]
 LDCM0610  Fragment52 Ramos C2435(1.02); C223(1.49); C1742(1.19); C111(1.04)  LDD2204  [45]
 LDCM0614  Fragment56 Ramos C2435(0.85); C223(1.24); C1742(1.19); C111(1.46)  LDD2205  [45]
 LDCM0569  Fragment7 Ramos C2435(0.65); C223(0.62); C1742(0.60); C111(0.41)  LDD2186  [45]
 LDCM0571  Fragment9 Ramos C2435(0.53); C223(0.45); C1742(0.70); C111(0.32)  LDD2188  [45]
 LDCM0116  HHS-0101 DM93 Y3715(0.45); Y3036(0.54); Y3280(0.82); Y2440(0.95)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y3036(0.54); Y3715(0.56); Y2440(0.80); Y1411(0.82)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y3715(0.26); Y3280(0.58); Y1411(0.73); Y2440(0.73)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y3715(0.55); Y3036(0.79); Y2440(0.82); Y3280(0.97)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y3036(0.50); Y3715(0.77); Y2440(1.08); Y3280(1.34)  LDD0268  [15]
 LDCM0107  IAA HeLa H2642(0.00); C3014(0.00); H1901(0.00); C3347(0.00)  LDD0221  [31]
 LDCM0179  JZ128 PC-3 C232(0.00); C4061(0.00); C974(0.00); C223(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C1499(20.00); C1507(20.00); C457(4.09); C458(4.09)  LDD0080  [17]
 LDCM0023  KB03 HCT 116 C1499(20.00); C1507(20.00); C457(7.09); C458(7.09)  LDD0081  [17]
 LDCM0024  KB05 HCT 116 C1499(20.00); C1507(20.00); C457(3.98); C458(3.98)  LDD0082  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C3837(1.13); C1364(1.19); C491(1.05); C1904(0.92)  LDD2102  [40]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C3837(0.97); C1742(1.59); C1455(0.67); C491(0.53)  LDD2121  [40]
 LDCM0109  NEM HeLa H2642(0.00); H2077(0.00); H2464(0.00); H2777(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C3837(0.84); C1742(1.06); C1364(0.76); C1455(0.90)  LDD2089  [40]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C3837(1.26); C1455(1.17); C491(0.98); C1904(1.28)  LDD2090  [40]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C3837(0.86); C1364(0.78); C491(0.86); C4061(0.90)  LDD2092  [40]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1742(1.30); C1364(1.12); C491(1.01); C974(1.01)  LDD2093  [40]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C3837(0.98); C1364(1.02); C1455(1.77); C491(1.17)  LDD2094  [40]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C3837(0.55); C1364(0.61); C1455(0.07); C4061(0.53)  LDD2096  [40]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1364(0.97); C1455(1.00); C491(0.99); C373(0.83)  LDD2097  [40]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C3837(1.12); C1364(1.02); C491(1.04); C4061(0.79)  LDD2098  [40]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C3837(0.98); C1364(1.12); C1455(1.32); C491(0.74)  LDD2099  [40]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1455(0.62); C491(0.81); C974(0.80); C2435(0.94)  LDD2100  [40]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1364(1.14); C1455(0.87); C491(0.91); C1904(1.01)  LDD2101  [40]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C3837(1.32); C1742(0.96); C1364(0.68); C491(0.68)  LDD2104  [40]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C3837(1.44); C1742(0.99); C491(1.65); C974(1.24)  LDD2105  [40]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C3837(1.02); C1364(0.63); C491(0.59); C2435(1.00)  LDD2106  [40]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C3837(0.98); C1742(1.03); C1364(1.06); C1455(1.15)  LDD2107  [40]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1742(0.89); C1364(0.80); C1455(0.45); C491(0.71)  LDD2108  [40]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C3837(1.02); C1742(0.98); C1364(0.88); C1455(0.54)  LDD2109  [40]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C3837(5.13); C491(1.20); C2435(1.60); C1904(1.55)  LDD2110  [40]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C3837(0.88); C1742(1.37); C1364(1.30); C1455(1.12)  LDD2111  [40]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C3837(0.67); C1364(0.66); C491(0.53); C974(0.60)  LDD2114  [40]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1742(0.37); C1364(0.54); C491(0.52); C974(0.59)  LDD2115  [40]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C3837(1.05); C1742(0.47); C2435(0.83); C1904(0.85)  LDD2116  [40]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C3837(1.08); C1364(0.98); C491(0.93); C373(1.06)  LDD2118  [40]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C3837(1.76); C1742(1.63); C1364(2.10); C1455(2.76)  LDD2119  [40]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C3837(1.00); C1364(0.64); C1455(0.47); C491(0.81)  LDD2120  [40]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C3837(1.10); C1364(1.15); C1455(0.11); C491(0.83)  LDD2122  [40]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C3837(1.03); C1742(0.94); C1364(1.04); C1455(1.09)  LDD2123  [40]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C3837(0.99); C491(0.71); C373(0.96); C2435(0.62)  LDD2124  [40]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C3837(0.97); C1742(1.03); C1364(0.93); C1455(0.72)  LDD2125  [40]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C3837(1.33); C491(0.77); C373(1.23); C2435(0.38)  LDD2126  [40]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C3837(1.00); C1742(1.35); C1364(1.03); C1455(0.84)  LDD2127  [40]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C3837(1.08); C1455(0.68); C491(0.75); C373(1.33)  LDD2128  [40]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C3837(1.03); C1742(1.19); C1364(1.09); C1455(1.28)  LDD2129  [40]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1364(0.74); C1455(0.55); C491(0.79); C1904(0.52)  LDD2133  [40]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1742(0.50); C1364(0.55); C1455(0.45); C491(0.78)  LDD2134  [40]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C3837(0.97); C1742(1.22); C1364(1.48); C1455(1.87)  LDD2135  [40]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C3837(1.21); C1742(1.58); C1364(1.48); C1455(1.73)  LDD2136  [40]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C3837(1.00); C1742(1.11); C1364(0.99); C1455(1.23)  LDD2137  [40]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1455(3.04); C974(2.78); C1364(2.34); C1742(2.25)  LDD1700  [40]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C3837(0.97); C1742(1.03); C1364(1.12); C1455(0.71)  LDD2140  [40]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C3837(0.73); C1742(0.64); C1364(0.86); C491(0.66)  LDD2141  [40]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C3837(0.98); C1364(0.73); C1455(0.47); C491(0.95)  LDD2143  [40]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C3837(1.54); C1742(1.52); C1364(2.31); C1455(1.94)  LDD2144  [40]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C3837(13.01); C491(11.28); C223(6.78); C1183(6.47)  LDD2145  [40]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C3837(0.92); C1742(1.10); C1364(1.09); C1455(0.92)  LDD2146  [40]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C3837(2.10); C1455(1.57); C491(1.90); C373(1.22)  LDD2147  [40]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1742(0.46); C1364(0.64); C1455(0.49); C491(0.63)  LDD2148  [40]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C3837(0.95); C491(0.99); C1904(0.96); C223(0.68)  LDD2149  [40]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1742(0.50); C1364(0.70); C1455(0.60); C491(0.36)  LDD2150  [40]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C3837(1.56); C491(0.77); C2435(0.45); C1183(0.64)  LDD2151  [40]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C3837(1.79); C1455(1.43); C4061(1.80); C2435(2.50)  LDD2153  [40]
 LDCM0627  NUDT7-COV-1 HEK-293T C4106(2.71); C25(0.77); C1904(0.68); C478(0.48)  LDD2206  [46]
 LDCM0628  OTUB2-COV-1 HEK-293T C3781(1.29); C4106(0.98); C1904(0.97); C1432(0.94)  LDD2207  [46]
 LDCM0131  RA190 MM1.R C3781(1.33)  LDD0304  [47]
 LDCM0003  Sulforaphane MCF-7 2.22  LDD0042  [12]
 LDCM0021  THZ1 HeLa S3 C223(1.13); C3347(1.13); C232(1.06); C2093(1.06)  LDD0460  [11]
 LDCM0110  W12 Hep-G2 C1507(34.77)  LDD0237  [6]
 LDCM0112  W16 Hep-G2 C1507(4.46)  LDD0239  [6]
 LDCM0113  W17 Hep-G2 H2464(3.28); C1507(23.46)  LDD0240  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein artemis (DCLRE1C) DNA repair metallo-beta-lactamase (DRMBL) family Q96SD1
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
X-ray repair cross-complementing protein 5 (XRCC5) Ku80 family P13010
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B7 (HOXB7) Antp homeobox family P09629
ETS translocation variant 1 (ETV1) ETS family P50549
Protein C-ets-1 (ETS1) ETS family P14921
Transcription factor PU.1 (SPI1) ETS family P17947
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
Androgen receptor (AR) Nuclear hormone receptor family P10275
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Autoimmune regulator (AIRE) . O43918
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) SIN1 family Q9BPZ7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Caffeine Small molecular drug DB00201
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd7648 Small molecular drug DPNT63
M3814 . D0H3UR
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
M9831 . D02IKF
Investigative
Click To Hide/Show 104 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Shrna Molecule Silencing Dnapk Radiosensitizer Aptamer D04NVK
1-morpholin-4-yl-benzo[F]Chromen-3-one Small molecular drug D05SBJ
2-(1h-indol-5-yl)-6-morpholino-4h-pyran-4-one Small molecular drug D00MCG
2-(2-aminophenyl)-6-morpholino-4h-pyran-4-one Small molecular drug D03DJC
2-(2-fluoro-phenyl)-benzo[H]Chromen-4-one Small molecular drug D03IQX
2-(2-methoxyphenyl)-6-morpholino-4h-pyran-4-one Small molecular drug D02DDM
2-(2-methyl-morpholin-4-yl)-benzo[H]Chromen-4-one Small molecular drug D0X7TB
2-(3-acetylphenyl)-6-morpholino-4h-pyran-4-one Small molecular drug D04DQF
2-(3-fluoro-phenyl)-benzo[H]Chromen-4-one Small molecular drug D0KG0Z
2-(3-methoxyphenyl)-6-morpholino-4h-pyran-4-one Small molecular drug D0N2XO
2-(4-amino-phenyl)-benzo[H]Chromen-4-one Small molecular drug D02IDN
2-(4-chlorophenyl)-6-morpholino-4h-pyran-4-one Small molecular drug D02MPG
2-(4-fluorophenyl)-6-morpholino-4h-pyran-4-one Small molecular drug D08BRZ
2-(4-methoxyphenyl)-6-morpholino-4h-pyran-4-one Small molecular drug D00IRL
2-(Benzofuran-2-yl)-6-morpholino-4h-pyran-4-one Small molecular drug D0O5BC
2-(Furan-2-yl)-6-morpholino-4h-pyran-4-one Small molecular drug D02SMG
2-(Piperidin-1-yl)-4h-benzo[H]Chromen-4-one Small molecular drug D0B9EZ
2-biphenyl-4-yl-6-morpholin-4-yl-pyran-4-one Small molecular drug D08WQW
2-dibenzofuran-4-yl-6-morpholin-4-yl-pyran-4-one Small molecular drug D03FTE
2-morpholin-4-yl-6-phenyl-4h-thiopyran-4-one Small molecular drug D03MDA
2-morpholin-4-yl-6-phenyl-chromen-4-one Small molecular drug D0B4CJ
2-morpholin-4-yl-8-naphthalen-2-ylchromen-4-one Small molecular drug D04RAW
2-morpholin-4-yl-8-phenoxathiin-4-ylchromen-4-one Small molecular drug D0C8MK
2-morpholin-4-yl-8-styrylchromen-4-one Small molecular drug D04JGZ
2-morpholin-4-yl-8-thiophen-2-ylchromen-4-one Small molecular drug D0O3VF
2-morpholin-4-yl-8-thiophen-3-ylchromen-4-one Small molecular drug D0I1LR
2-morpholin-4-yl-benzo[H]Chromene-4-thione Small molecular drug D0W3QB
2-morpholin-4-yl-pyrido[1,2-a]Pyrimidin-4-one Small molecular drug D0V0SD
2-morpholin-4-yl-pyrimido[2,1-a]Isoquinolin-4-one Small molecular drug D0T0BY
2-morpholino-4h-benzo[G]Chromen-4-one Small molecular drug D0U7WU
2-morpholino-6-(Naphthalen-1-yl)-4h-chromen-4-one Small molecular drug D0XL6P
2-morpholino-6-(Naphthalen-1-yl)-4h-pyran-4-one Small molecular drug D0PO9X
2-morpholino-6-(Naphthalen-2-yl)-4h-pyran-4-one Small molecular drug D0QB9L
2-morpholino-6-(Quinolin-8-yl)-4h-pyran-4-one Small molecular drug D0Z3CC
2-morpholino-6-(Thianthren-1-yl)-4h-chromen-4-one Small molecular drug D00HXZ
2-morpholino-6-(Thiophen-2-yl)-4h-pyran-4-one Small molecular drug D01ZMP
2-morpholino-6-(Thiophen-3-yl)-4h-pyran-4-one Small molecular drug D0S5SG
2-morpholino-6-phenyl-4h-pyran-4-one Small molecular drug D0R7HM
2-morpholino-6-styryl-4h-pyran-4-one Small molecular drug D0F7ZK
2-morpholinobenzo[H]Quinolin-4(1h)-one Small molecular drug D0F5BD
2-pyridin-3-yl-benzo[H]Chromen-4-one Small molecular drug D0Q4GJ
2-pyrrolidin-1-yl-benzo[H]Chromen-4-one Small molecular drug D0V8VY
2-thiomorpholin-4-yl-pyrido[1,2-a]Pyrimidin-4-one Small molecular drug D02TCZ
2-thiomorpholino-4h-benzo[H]Chromen-4-one Small molecular drug D0AG8B
2-[1,4]Oxazepan-4-yl-benzo[H]Chromen-4-one Small molecular drug D0B0QS
3-(6-morpholino-4-oxo-4h-pyran-2-yl)Benzaldehyde Small molecular drug D01SXB
3-(6-morpholino-4-oxo-4h-pyran-2-yl)Benzoic Acid Small molecular drug D0KH8S
3-(6-morpholino-4-oxo-4h-pyran-2-yl)Benzonitrile Small molecular drug D09TJK
3-morpholino-1h-benzo[F]Chromen-1-one Small molecular drug D05SGV
4-(6-morpholino-4-oxo-4h-pyran-2-yl)Benzonitrile Small molecular drug D0K3VK
4-morpholin-4-yl-benzo[G]Chromen-2-one Small molecular drug D07NSR
4-morpholin-4-yl-benzo[H]Chromen-2-one Small molecular drug D0G4RG
4-morpholin-4-yl-chromen-2-one Small molecular drug D0J7BH
4-morpholino-6-phenyl-2h-pyran-2-one Small molecular drug D0M3RY
4-piperidin-1-yl-chromen-2-one Small molecular drug D0L3TX
4-thiomorpholin-4-yl-benzo[G]Chromen-2-one Small molecular drug D04ECT
6-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one Small molecular drug D03DGP
6-(3-hydroxyphenyl)-2-morpholino-4h-chromen-4-one Small molecular drug D03TQO
6-(4-chlorophenyl)-2-morpholin-4-ylpyridin-4-ol Small molecular drug D0LC5C
6-(4-chlorophenyl)-4-morpholino-2h-pyran-2-one Small molecular drug D0K5VE
6-(4-fluorostyryl)-2-morpholino-4h-chromen-4-one Small molecular drug D0I3IO
6-(4-hydroxyphenyl)-2-morpholino-4h-chromen-4-one Small molecular drug D0U4JL
6-(4-methoxyphenyl)-4-morpholino-2h-pyran-2-one Small molecular drug D0Y7WU
6-biphenyl-2-yl-2-morpholin-4-yl-chromen-4-one Small molecular drug D0JH9J
6-chloro-4-morpholin-4-yl-chromen-2-one Small molecular drug D04SCD
6-isopropyl-2-morpholin-4-yl-4h-thiopyran-4-one Small molecular drug D0C3SJ
6-methoxy-4-morpholin-4-yl-chromen-2-one Small molecular drug D06BDY
6-methyl-4-morpholin-4-yl-chromen-2-one Small molecular drug D0JB6H
6-tert-butyl-2-morpholin-4-yl-4h-thiopyran-4-one Small molecular drug D09YAL
7-benzoyloxy-2-(Morpholin-4-yl)-chromen-4-one Small molecular drug D02PBS
7-benzyloxy-2-(Morpholin-4-yl)-chromen-4-one Small molecular drug D0H2BL
7-ethyloxyethoxy-2-morpholin-4-yl-chromen-4-one Small molecular drug D0P4MU
7-hydroxy-2-(Morpholin-4-yl)Chromen-4-one Small molecular drug D0D9RN
7-methoxy-2-morpholin-4-yl-chromen-4-one Small molecular drug D0ZQ8Z
7-methoxy-4-morpholin-4-yl-chromen-2-one Small molecular drug D0O4KC
7-phenylethoxy-2-morpholin-4-yl-chromen-4-one Small molecular drug D06WCT
7-phenyloxyethoxy-2-morpholin-4-yl-chromen-4-one Small molecular drug D04XFN
7-propoxy-2-(Morpholin-4-yl)-chromen-4-one Small molecular drug D0O9OB
8-(1h-indol-5-yl)-2-morpholin-4-ylchromen-4-one Small molecular drug D01MXN
8-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one Small molecular drug D00MXW
8-(3-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one Small molecular drug D06TGR
8-(4-acetylphenyl)-2-morpholin-4-ylchromen-4-one Small molecular drug D00TUH
8-(4-chlorophenyl)-2-morpholin-4-ylchromen-4-one Small molecular drug D0V3XZ
8-(4-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one Small molecular drug D0S7NM
8-biphenyl-2-yl-2-morpholin-4-ylchromen-4-one Small molecular drug D0H9DB
8-dibenzofuran-4-yl-2-morpholin-4-ylchromen-4-one Small molecular drug D0K7LZ
8-furan-2-yl-2-morpholin-4-ylchromen-4-one Small molecular drug D06DAY
8-methoxy-2-morpholin-4-yl-chromen-4-one Small molecular drug D0R1BG
8-methoxy-4-morpholin-4-yl-chromen-2-one Small molecular drug D07AXO
8-methyl-2-morpholin-4-yl-chromen-4-one Small molecular drug D0F6ZC
8-methyl-4-morpholin-4-yl-chromen-2-one Small molecular drug D0U9ZW
8-phenyl-2-piperidin-1-yl-chromen-4-one Small molecular drug D0Q5FJ
8-phenyl-2-thiomorpholin-4-yl-chromen-4-one Small molecular drug D0N2LW
Alpha-naphthoflavone Small molecular drug D0I7GE
Ama37 Small molecular drug D03QQH
Ethyl 1-[(1h-benzimidazol-2(3h)One-5-yl)Sulfonyl]-1h-pyrrole-2-carboxylate Small molecular drug D0W1ST
Ic86621 Small molecular drug D06GNE
Ku-0060648 Small molecular drug D0R0TW
Ku-55933 Small molecular drug D05USL
Ly-292223 Small molecular drug D07APP
Nu-7432 Small molecular drug D0Y3OO
Pik-75 Small molecular drug D00HSJ
Pp121 Small molecular drug D03EHM
Sf1126 Small molecular drug DB05210

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