Details of the Probe

General Information of Probe

Probe ID
LDPC0014
Probe Name
WYneC
Synonyms
GZOJNGHPVJJRIK-UHFFFAOYSA-N; (3-Butinyl)-carbonylmethylenetriphenyl phosphorane
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 356.4
Lipid-water partition coefficient (xlogp) 4.1
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 1
Chemical Identifiers
Formula
C24H21OP
IUPAC Name
1-(triphenyl-lambda5-phosphanylidene)hex-5-yn-2-one
Canonical SMILES
C#CCCC(=O)C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
InChI
InChI=1S/C24H21OP/c1-2-3-13-21(25)20-26(22-14-7-4-8-15-22,23-16-9-5-10-17-23)24-18-11-6-12-19-24/h1,4-12,14-20H,3,13H2
InChIKey
GZOJNGHPVJJRIK-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

35 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 C447  LDD0014 
Aldo-keto reductase family 1 member B10 (AKR1B10) LDTP00912 C187  LDD0014 
ATP-citrate synthase (ACLY) LDTP04561 C20  LDD0014 
ATP-dependent RNA helicase A (DHX9) LDTP05550 C438  LDD0014 
Carbonyl reductase [NADPH] 1 (CBR1) LDTP02831 C150  LDD0014 
Catalase (CAT) LDTP02001 C460; C232  LDD0014 
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) LDTP01341 C662  LDD0014 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 C1312  LDD0014 
Elongation factor 2 (EEF2) LDTP02672 C41  LDD0014 
Fatty acid synthase (FASN) LDTP04243 C2202  LDD0014 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 C339  LDD0014 
Gamma-enolase (ENO2) LDTP02328 C357  LDD0014 
Glutamate dehydrogenase 1, mitochondrial (GLUD1) LDTP01768 C172  LDD0014 
Glutamate--cysteine ligase catalytic subunit (GCLC) LDTP04185 C501  LDD0014 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 C156; C152; C247  LDD0014 
Glycogen phosphorylase, brain form (PYGB) LDTP02552 C326  LDD0014 
GTP-binding nuclear protein Ran (RAN) LDTP05007 C120; C112  LDD0014 
Guanine nucleotide-binding protein-like 3-like protein (GNL3L) LDTP12687 C278  LDD0014 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 C603  LDD0014 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 C163  LDD0014 
L-lactate dehydrogenase B chain (LDHB) LDTP02179 C164  LDD0014 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 C147  LDD0014 
Microsomal glutathione S-transferase 1 (MGST1) LDTP02506 C50  LDD0014 
Myosin-9 (MYH9) LDTP03764 C671; C988  LDD0014 
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) LDTP05372 C107  LDD0014 
Phosphoglycerate kinase 1 (PGK1) LDTP01787 C367  LDD0014 
Pyruvate kinase PKM (PKM) LDTP02733 C49  LDD0014 
Ras-related C3 botulinum toxin substrate 3 (RAC3) LDTP04877 C157; C178; C6  LDD0014 
Ras-related protein Rab-1A (RAB1A) LDTP05006 C126  LDD0014 
Rho-associated protein kinase 2 (ROCK2) LDTP01127 C804; C649  LDD0014 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 C447  LDD0014 
Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) LDTP04392 C660  LDD0014 
Triosephosphate isomerase (TPI1) LDTP04851 C67  LDD0014 
Ubiquitin carboxyl-terminal hydrolase 5 (USP5) LDTP04074 C838  LDD0014 
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) LDTP02383 C152  LDD0014 
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⏷ Show the Full List of 35 Enzyme
7 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Annexin A2 (ANXA2) LDTP02199 C9  LDD0014 
Clathrin heavy chain 1 (CLTC) LDTP05252 C870  LDD0014 
Filamin-A (FLNA) LDTP03107 C1157; C2543  LDD0014 
Filamin-B (FLNB) LDTP01197 C2333; C1617; C2431  LDD0014 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 C129  LDD0014 
Talin-1 (TLN1) LDTP14031 C1199  LDD0014 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 C47  LDD0014 
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⏷ Show the Full List of 7 Transporter and channel
43 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenylyl cyclase-associated protein 1 (CAP1) LDTP05294 C93; C375  LDD0014 
Alpha-actinin-1 (ACTN1) LDTP02631 C480  LDD0014 
CASP8-associated protein 2 (CASP8AP2) LDTP13464 C1240  LDD0014 
Cleavage stimulation factor subunit 2 (CSTF2) LDTP03665 C150  LDD0014 
Clustered mitochondria protein homolog (CLUH) LDTP14486 C1196  LDD0014 
Cofilin-1 (CFL1) LDTP03244 C139  LDD0014 
Complexin-2 (CPLX2) LDTP07613 C90  LDD0014 
Coronin-1C (CORO1C) LDTP13580 C420; C190  LDD0014 
Destrin (DSTN) LDTP04887 C23; C135  LDD0014 
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) LDTP02101 C218  LDD0014 
Eukaryotic translation initiation factor 3 subunit A (EIF3A) LDTP06055 C478  LDD0014 
Far upstream element-binding protein 1 (FUBP1) LDTP10078 C148  LDD0014 
Galectin-1 (LGALS1) LDTP02341 C61  LDD0014 
General vesicular transport factor p115 (USO1) LDTP01048 C303  LDD0014 
Heat shock-related 70 kDa protein 2 (HSPA2) LDTP04621 C606  LDD0014 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 C34  LDD0014 
LanC-like protein 2 (LANCL2) LDTP12571 C169  LDD0014 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 C22  LDD0014 
Large ribosomal subunit protein eL8 (RPL7A) LDTP04990 C199  LDD0014 
Large ribosomal subunit protein uL10 (RPLP0) LDTP02109 C119; C27  LDD0014 
Large ribosomal subunit protein uL11 (RPL12) LDTP03517 C141; C17  LDD0014 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 C125  LDD0014 
Microtubule-associated protein 4 (MAP4) LDTP03404 C635  LDD0014 
Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13) LDTP14136 C50  LDD0014 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 C109  LDD0014 
Profilin-1 (PFN1) LDTP02218 C128  LDD0014 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 C91  LDD0014 
Rab GDP dissociation inhibitor alpha (GDI1) LDTP03574 C317  LDD0014 
RUN and FYVE domain-containing protein 1 (RUFY1) LDTP10834 C351  LDD0014 
Sequestosome-1 (SQSTM1) LDTP05898 C113  LDD0014 
Serine-threonine kinase receptor-associated protein (STRAP) LDTP13991 C305  LDD0014 
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) LDTP04982 C63  LDD0014 
Small ribosomal subunit protein eS1 (RPS3A) LDTP04913 C96  LDD0014 
Small ribosomal subunit protein eS17 (RPS17) LDTP02302 C35  LDD0014 
Small ribosomal subunit protein uS2 (RPSA) LDTP02312 C148  LDD0014 
Src substrate cortactin (CTTN) LDTP06094 C112; C246  LDD0014 
Tubulin beta chain (TUBB) LDTP02205 C12; C354  LDD0014 
Tubulin beta-3 chain (TUBB3) LDTP05904 C12  LDD0014 
Tubulin beta-4B chain (TUBB4B) LDTP05076 C354  LDD0014 
Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) LDTP05034 C115  LDD0014 
Vimentin (VIM) LDTP02297 C328  LDD0014 
Vinculin (VCL) LDTP02946 C313  LDD0014 
Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) LDTP08018 C272  LDD0014 
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⏷ Show the Full List of 43 Other

Full Information of The Labelling Profiles of This Probe

Qualitation: Labeling site identification
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
10 uM
Quantitative Method
Isotope tag
In Vitro Experiment Model
Model Type
Cell lysate
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cell lysate (HEK-293T)
Interaction Atlas ID
 LDD0014 
Download The Altas

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764