Details of the Target

General Information of Target

Target ID LDTP02328
Target Name Gamma-enolase (ENO2)
Gene Name ENO2
Gene ID 2026
Synonyms
Gamma-enolase; EC 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGK
GVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCK
AGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRD
AMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKI
VIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDD
WAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLA
QENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDE
ARFAGHNFRNPSVL
Target Bioclass
Enzyme
Family
Enolase family
Subcellular location
Cytoplasm
Function
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.
Uniprot ID
P09104
Ensemble ID
ENST00000229277.6
HGNC ID
HGNC:3353

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
D283MED SNV: p.D297Y .
JURKAT SNV: p.R15H .
LS180 SNV: p.I231T .
MFE319 SNV: p.I240T DBIA    Probe Info 
NCIH446 SNV: p.G107R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH214
 Probe Info  		Y25(12.53)  LDD0258  [1]
TH216
 Probe Info  		Y189(12.95)  LDD0259  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K193(8.87)  LDD0277  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
BTD
 Probe Info  		C357(0.93)  LDD2091  [4]
DBIA
 Probe Info  		C337(16.16)  LDD0209  [5]
HHS-482
 Probe Info  		Y189(1.12); Y25(1.29)  LDD0285  [6]
HHS-475
 Probe Info  		Y44(0.93)  LDD0264  [7]
HHS-465
 Probe Info  		Y257(10.00); Y270(0.92); Y44(7.91)  LDD2237  [8]
5E-2FA
 Probe Info  		H68(0.00); H190(0.00)  LDD2235  [9]
m-APA
 Probe Info  		H68(0.00); H426(0.00); H190(0.00)  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C337(0.00); C339(0.00); C357(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C337(0.00); C339(0.00); C357(0.00)  LDD0037  [10]
WYneC
 Probe Info  		N.A.  LDD0014  [13]
OSF
 Probe Info  		N.A.  LDD0029  [14]
SF
 Probe Info  		K256(0.00); Y44(0.00)  LDD0028  [14]
NAIA_5
 Probe Info  		C337(0.00); C119(0.00); C357(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [16]
STS-1
 Probe Info  		N.A.  LDD0068  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C357(0.79)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C399(2.47)  LDD0371  [18]
 LDCM0214  AC1 HEK-293T C119(1.06); C389(0.98); C337(1.10); C339(0.75)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C119(1.00); C389(0.92); C337(0.89)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C119(0.98); C389(1.00)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C119(0.99); C389(0.99); C339(0.98)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C119(0.99); C389(1.01); C337(0.98); C339(0.78)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C119(0.93); C389(1.00); C337(0.99); C339(0.91)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C119(1.02); C389(0.94); C337(0.97); C339(0.88)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C119(1.00); C389(0.94); C337(0.98)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C119(0.95); C389(0.98)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C119(1.04); C389(0.97); C337(0.79)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C119(0.96); C389(0.95); C339(1.00)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C119(0.94); C389(0.98); C339(1.12)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C119(0.96); C389(0.99); C337(0.87); C339(1.07)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C119(0.94); C389(0.98); C337(0.95); C339(0.85)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C119(0.95); C389(0.98)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C119(1.02); C389(1.00); C337(1.00); C339(0.93)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C119(1.00); C389(0.99); C337(1.00)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C119(1.00); C389(0.97)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C119(0.97); C389(1.00); C339(0.99)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C119(0.95); C389(1.04); C339(1.00)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C119(0.94); C389(0.99)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C119(1.08); C389(1.02); C337(0.92); C339(1.09)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C119(1.03); C389(1.02); C337(0.98); C339(1.01)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C119(1.00); C389(0.98)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C119(0.97); C389(0.95); C337(0.99); C339(0.93)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C119(1.00); C389(0.94); C337(1.02)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C119(0.97); C389(0.99)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C119(0.98); C389(0.94); C339(1.09)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C119(0.93); C389(1.05); C339(1.00)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C119(0.94); C389(1.05); C337(1.02); C339(1.05)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C119(0.96); C389(0.96); C337(1.05); C339(0.92)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C119(1.00); C389(0.97); C339(1.01)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C119(0.92); C389(0.89)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C119(1.01); C389(0.95); C337(0.88); C339(0.95)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C119(0.98); C389(1.01); C337(0.86)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C119(0.91); C389(1.07)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C119(0.94); C389(0.95); C339(1.08)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C119(0.97); C389(1.07); C339(0.95)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C119(0.98); C389(0.98); C337(0.89); C339(0.98)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C119(0.99); C389(0.99); C337(0.70); C339(0.91)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C119(0.98); C389(0.99)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C119(0.99); C389(0.93); C337(0.85); C339(0.91)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C119(0.94); C389(1.04); C339(1.04)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C119(1.00); C389(0.96); C337(0.91)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C119(1.01); C389(1.01)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C119(0.91); C389(0.94); C339(1.02)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C119(0.92); C389(1.04); C339(1.04)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C119(0.91); C389(0.98); C337(0.77); C339(0.88)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C119(1.00); C389(0.97); C337(0.92); C339(0.89)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C119(0.94); C389(1.00)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C119(1.05); C389(0.94); C337(0.92); C339(0.84)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C119(1.10); C389(1.05); C337(0.87)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C119(1.02); C389(0.96)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C119(0.97); C389(0.97); C337(0.94); C339(1.10)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C119(1.00); C389(0.98); C339(1.00)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C119(0.96); C389(0.94); C339(0.99)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C119(0.98); C389(0.99); C337(0.90); C339(0.84)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C119(0.99); C389(0.93); C337(0.92); C339(1.01)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C119(0.98); C389(0.94)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C119(0.99); C389(0.97); C337(0.98); C339(0.98)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C119(0.98); C389(1.04)  LDD1569  [19]
 LDCM0520  AKOS000195272 MDA-MB-231 C357(0.52)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C119(0.92); C389(1.01); C339(0.95)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C119(1.03); C389(0.99); C337(1.00); C339(0.90)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C119(0.96); C389(0.96)  LDD1514  [19]
 LDCM0498  BS-3668 MDA-MB-231 C357(0.93)  LDD2091  [4]
 LDCM0367  CL1 HEK-293T C119(0.98); C389(0.96); C339(0.92)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C119(0.88); C389(1.08); C337(1.01); C339(0.80)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C119(0.96); C389(1.01); C337(1.11)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C119(1.05); C389(0.98); C339(0.93)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C119(1.03); C389(1.14)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C119(0.99); C389(1.03); C339(1.01)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C119(0.99); C389(1.04); C337(1.02)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C119(1.05); C389(0.96); C339(0.94)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C119(0.96); C389(1.03)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C119(0.97); C389(1.07); C339(1.24)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C119(0.97); C389(0.99); C337(0.97)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C119(1.02); C389(0.92); C339(0.95)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C119(0.91); C389(1.16); C337(1.01); C339(0.95)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C119(1.03); C389(1.14)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C119(0.98); C389(1.08); C339(0.98)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C119(1.03); C389(1.03); C337(0.96)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C119(1.01); C389(0.95); C339(1.03)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C119(0.99); C389(1.02)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C119(1.01); C389(1.01); C339(1.10)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C119(0.94); C389(1.00); C337(0.86)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C119(0.99); C389(0.97); C339(0.96)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C119(1.02); C389(1.01)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C119(0.97); C389(1.11); C339(1.05)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C119(0.84); C389(1.06)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C119(0.95); C389(1.06); C337(0.93)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C119(1.02); C389(0.95); C339(0.95)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C119(0.98); C389(1.01)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C119(0.97); C389(0.98); C339(1.03)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C119(0.93); C389(1.03); C337(0.88)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C119(1.31); C389(0.98); C339(0.98)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C119(1.04); C389(1.00)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C119(1.05); C389(1.02); C339(1.05)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C119(0.95); C389(0.94); C337(1.06)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C119(1.11); C389(0.96); C339(1.08)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C119(1.04); C389(1.06)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C119(0.97); C389(0.97); C339(0.87)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C119(0.96); C389(0.99); C337(1.08)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C119(1.07); C389(1.05); C337(0.97); C339(0.97)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C119(0.96); C389(1.09); C337(0.98)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C119(0.89); C389(1.13)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C119(0.96); C389(1.04)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C119(0.84); C389(1.10); C339(1.11)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C119(0.89); C389(1.12); C339(1.04)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C119(0.77); C389(1.10); C337(1.00); C339(0.91)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C119(0.84); C389(1.03); C337(1.01); C339(1.12)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C119(0.85); C389(1.06)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C119(1.08); C389(0.91); C339(0.93)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C119(0.96); C389(1.00)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C119(0.96); C389(1.03); C339(1.13)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C119(1.04); C389(1.00); C337(1.05)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C119(0.97); C389(0.96); C337(0.99); C339(0.95)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C119(1.05); C389(1.09); C339(1.18)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C119(0.90); C389(0.98); C337(0.92)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C119(0.83); C389(1.09)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C119(0.82); C389(1.02); C339(0.92)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C119(0.86); C389(0.91); C339(0.97)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C119(0.77); C389(1.09); C337(0.86); C339(0.90)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C119(0.76); C389(1.09); C337(0.86); C339(0.88)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C119(0.84); C389(1.02)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C119(1.05); C389(0.98); C339(0.95)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C119(0.96); C389(1.03); C339(1.20)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C119(0.98); C389(1.13); C337(1.19)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C119(1.02); C389(1.02); C337(1.08)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C119(1.07); C389(1.02); C337(1.08); C339(1.08)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C119(0.91); C389(0.96); C337(1.01)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C119(0.84); C389(0.99)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C119(0.78); C389(1.03); C339(1.05)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C119(0.87); C389(1.15); C339(0.90)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C119(0.79); C389(1.05); C337(0.83); C339(1.02)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C119(0.77); C389(1.05); C337(0.90); C339(1.01)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C119(0.82); C389(1.11)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C119(1.10); C389(0.98); C339(1.25)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C119(1.02); C389(1.08); C337(1.03); C339(1.12)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C119(0.94); C389(1.04)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C119(0.99); C389(1.07); C337(1.17)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C119(1.02); C389(0.99); C337(1.06); C339(0.95)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C119(0.96); C389(0.97); C337(1.02)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C119(0.81); C389(0.98)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C119(0.80); C389(1.03); C339(1.03)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C119(0.81); C389(1.12); C339(1.07)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C119(0.75); C389(1.06); C337(0.85); C339(0.91)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C119(0.78); C389(1.09); C337(0.98); C339(1.10)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C119(0.95); C389(1.09); C337(1.02)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C119(0.86); C389(1.14)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C119(1.03); C389(0.96); C339(1.00)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C119(0.95); C389(1.02)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C119(0.96); C389(1.14); C339(1.03)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C119(0.99); C389(1.04); C337(1.01)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C119(0.99); C389(1.03); C337(0.96); C339(0.86)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C119(0.90); C389(0.98); C337(0.93)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C119(0.83); C389(1.01)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C119(0.85); C389(1.03); C339(1.19)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C119(0.84); C389(1.18); C339(1.12)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C119(0.90); C389(1.05)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C119(0.73); C389(1.04); C337(0.89); C339(1.12)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C119(0.81); C389(1.05); C337(0.86); C339(0.98)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C119(0.87); C389(1.08)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C119(1.05); C389(0.99); C339(0.84)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C119(1.03); C389(1.03)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C119(0.95); C389(0.95); C337(1.18)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C119(1.07); C389(1.02); C337(1.08); C339(0.94)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C119(0.96); C389(0.97); C337(0.95)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C119(0.90); C389(1.06)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C119(0.98); C389(1.09); C339(1.03)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C119(0.84); C389(0.98); C339(1.11)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C119(0.84); C389(1.10); C339(1.10)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C119(0.77); C389(1.03); C337(0.82); C339(1.02)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C119(0.79); C389(1.10); C337(0.86); C339(0.91)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C119(0.89); C389(1.10)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C119(1.23); C389(0.90); C339(0.94)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C119(1.05); C389(0.93)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C119(1.03); C389(0.97); C339(1.21)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C119(0.98); C389(1.02); C337(1.10)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C119(1.05); C389(0.97); C337(1.08); C339(0.99)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C119(0.88); C389(1.14); C339(0.95)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C119(1.06); C389(1.04); C337(1.03)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C119(0.95); C389(1.00)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C119(0.90); C389(0.95); C339(1.02)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C119(0.86); C389(1.02); C339(0.93)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C119(0.83); C389(1.05); C337(0.94); C339(0.88)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C119(0.98); C389(0.98); C337(1.00); C339(0.92)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C119(0.99); C389(1.02)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C119(1.03); C389(1.00); C339(1.05)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C119(0.93); C389(1.06)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C119(1.06); C389(1.04); C339(1.03)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C119(1.06); C389(0.97); C339(1.13)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C119(0.93); C389(1.09); C339(0.88)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C119(0.96); C389(1.05)  LDD1631  [19]
 LDCM0116  HHS-0101 DM93 Y44(0.93)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y44(0.86)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y44(0.79)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y44(0.84)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y44(0.93)  LDD0268  [7]
 LDCM0123  JWB131 DM93 Y189(1.12); Y25(1.29)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y189(0.73); Y25(0.76)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y189(0.92); Y25(0.91)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y189(2.61); Y25(3.71)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y189(1.71); Y25(2.69)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y189(0.22); Y25(0.50)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y189(1.21); Y25(0.86)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y189(0.64); Y25(0.69)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C119(0.99); C389(0.97)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C337(16.16)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C76(1.23)  LDD3310  [20]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C357(1.94)  LDD2101  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C357(0.72)  LDD2109  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C357(0.37)  LDD2118  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C357(0.70)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C357(0.52)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C357(0.68)  LDD2125  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C357(0.57)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C357(1.17)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C357(0.73)  LDD2137  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C357(0.41)  LDD2148  [4]
 LDCM0131  RA190 MM1.R C357(1.34)  LDD0304  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-phosphoglycolic Acid Small molecular drug DB02726

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
18 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.