Details of the Target

General Information of Target

Target ID LDTP04990
Target Name Large ribosomal subunit protein eL8 (RPL7A)
Gene Name RPL7A
Gene ID 6130
Synonyms
SURF-3; SURF3; Large ribosomal subunit protein eL8; 60S ribosomal protein L7a; PLA-X polypeptide; Surfeit locus protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRY
IRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEK
KAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVP
YCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGN
VLGPKSVARIAKLEKAKAKELATKLG
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL8 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P62424
Ensemble ID
ENST00000323345.11
HGNC ID
HGNC:10364

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		1.83  LDD0449  [1]
P3
 Probe Info  		1.68  LDD0450  [1]
A-EBA
 Probe Info  		3.28  LDD0215  [2]
TH211
 Probe Info  		Y102(20.00); Y230(18.21); Y181(16.91)  LDD0260  [3]
C-Sul
 Probe Info  		6.06  LDD0066  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		K259(0.00); K20(0.00); K26(0.00); K125(0.00)  LDD0273  [6]
Probe 1
 Probe Info  		Y230(30.16)  LDD3495  [7]
AF-1
 Probe Info  		1.58  LDD0421  [8]
AHL-Pu-1
 Probe Info  		C182(2.20)  LDD0171  [9]
DBIA
 Probe Info  		C182(8.03); C182(11.87); C199(9.00)  LDD0209  [10]
ATP probe
 Probe Info  		K34(0.00); K37(0.00); K20(0.00); K21(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C174(0.00); C199(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
IPIAA_H
 Probe Info  		C174(0.00); C199(0.00)  LDD0030  [14]
IPIAA_L
 Probe Info  		C199(0.00); C174(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C174(0.00); C199(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		K20(0.00); K48(0.00); K11(0.00); K75(0.00)  LDD0035  [15]
BTD
 Probe Info  		N.A.  LDD0004  [16]
IPM
 Probe Info  		N.A.  LDD0025  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		C182(0.00); C199(0.00)  LDD0027  [17]
WYneC
 Probe Info  		N.A.  LDD0014  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
1d-yne
 Probe Info  		K245(0.00); K75(0.00)  LDD0356  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
ENE
 Probe Info  		N.A.  LDD0006  [16]
NHS
 Probe Info  		K37(0.00); K150(0.00); K217(0.00); K75(0.00)  LDD0010  [16]
PPMS
 Probe Info  		N.A.  LDD0008  [16]
SF
 Probe Info  		K125(0.00); K34(0.00); K25(0.00); K101(0.00)  LDD0028  [21]
STPyne
 Probe Info  		K48(0.00); K97(0.00); K75(0.00); K212(0.00)  LDD0009  [16]
Ox-W18
 Probe Info  		W237(0.00); W57(0.00)  LDD2175  [22]
1c-yne
 Probe Info  		K37(0.00); K75(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C199(0.00); H236(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C199(0.00); H236(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
NAIA_5
 Probe Info  		C174(0.00); C182(0.00); C199(0.00)  LDD2223  [18]
THL-R
 Probe Info  		N.A.  LDD0077  [25]
HHS-475
 Probe Info  		Y230(1.20)  LDD2238  [26]
HHS-482
 Probe Info  		Y230(0.93)  LDD2239  [26]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe4
 Probe Info  		5.05  LDD0466  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C199(0.68)  LDD2112  [30]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C182(0.53)  LDD2095  [30]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C182(0.99)  LDD2130  [30]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C182(0.93); C199(0.88)  LDD2117  [30]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C182(1.50)  LDD2152  [30]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C182(0.48)  LDD2132  [30]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C199(0.43)  LDD2131  [30]
 LDCM0026  4SU-RNA+native RNA DM93 C182(2.20)  LDD0171  [9]
 LDCM0214  AC1 HCT 116 C199(1.25)  LDD0531  [31]
 LDCM0215  AC10 HCT 116 C199(1.42)  LDD0532  [31]
 LDCM0216  AC100 HEK-293T C199(1.45); C174(0.64); C182(1.13)  LDD0814  [31]
 LDCM0217  AC101 HEK-293T C199(1.27); C174(1.21); C182(2.04)  LDD0815  [31]
 LDCM0218  AC102 HEK-293T C199(1.41); C174(0.71); C182(1.54)  LDD0816  [31]
 LDCM0219  AC103 HEK-293T C199(1.40); C174(0.69); C182(1.56)  LDD0817  [31]
 LDCM0220  AC104 HEK-293T C199(1.80); C174(0.71); C182(1.02)  LDD0818  [31]
 LDCM0221  AC105 HEK-293T C199(0.93); C174(0.98); C182(1.11)  LDD0819  [31]
 LDCM0222  AC106 HEK-293T C199(1.19); C174(1.15); C182(1.44)  LDD0820  [31]
 LDCM0223  AC107 HEK-293T C199(1.32); C174(0.63); C182(1.35)  LDD0821  [31]
 LDCM0224  AC108 HEK-293T C199(1.16); C174(0.70); C182(1.12)  LDD0822  [31]
 LDCM0225  AC109 HEK-293T C199(1.11); C174(0.82); C182(1.35)  LDD0823  [31]
 LDCM0226  AC11 HCT 116 C199(1.66)  LDD0543  [31]
 LDCM0227  AC110 HEK-293T C199(2.48); C174(0.26); C182(1.52)  LDD0825  [31]
 LDCM0228  AC111 HEK-293T C199(0.93); C174(0.18); C182(1.88)  LDD0826  [31]
 LDCM0229  AC112 HEK-293T C199(2.66); C174(0.20); C182(2.04)  LDD0827  [31]
 LDCM0230  AC113 HCT 116 C199(2.22)  LDD0547  [31]
 LDCM0231  AC114 HCT 116 C199(1.88)  LDD0548  [31]
 LDCM0232  AC115 HCT 116 C199(1.85)  LDD0549  [31]
 LDCM0233  AC116 HCT 116 C199(2.17)  LDD0550  [31]
 LDCM0234  AC117 HCT 116 C199(2.03)  LDD0551  [31]
 LDCM0235  AC118 HCT 116 C199(2.00)  LDD0552  [31]
 LDCM0236  AC119 HCT 116 C199(2.17)  LDD0553  [31]
 LDCM0237  AC12 HCT 116 C199(1.02)  LDD0554  [31]
 LDCM0238  AC120 HCT 116 C199(2.04)  LDD0555  [31]
 LDCM0239  AC121 HCT 116 C199(1.97)  LDD0556  [31]
 LDCM0240  AC122 HCT 116 C199(2.06)  LDD0557  [31]
 LDCM0241  AC123 HCT 116 C199(2.08)  LDD0558  [31]
 LDCM0242  AC124 HCT 116 C199(2.50)  LDD0559  [31]
 LDCM0243  AC125 HCT 116 C199(1.54)  LDD0560  [31]
 LDCM0244  AC126 HCT 116 C199(1.94)  LDD0561  [31]
 LDCM0245  AC127 HCT 116 C199(2.30)  LDD0562  [31]
 LDCM0246  AC128 HEK-293T C174(1.11); C182(1.22)  LDD0844  [31]
 LDCM0247  AC129 HEK-293T C174(0.59); C182(0.86)  LDD0845  [31]
 LDCM0249  AC130 HEK-293T C174(0.76); C182(0.92)  LDD0847  [31]
 LDCM0250  AC131 HEK-293T C174(1.02); C182(1.01)  LDD0848  [31]
 LDCM0251  AC132 HEK-293T C174(0.85); C182(1.14)  LDD0849  [31]
 LDCM0252  AC133 HEK-293T C174(0.44); C182(0.83)  LDD0850  [31]
 LDCM0253  AC134 HEK-293T C174(0.50); C182(1.11)  LDD0851  [31]
 LDCM0254  AC135 HEK-293T C174(0.66); C182(1.02)  LDD0852  [31]
 LDCM0255  AC136 HEK-293T C174(0.61); C182(0.79)  LDD0853  [31]
 LDCM0256  AC137 HEK-293T C174(0.22); C182(1.07)  LDD0854  [31]
 LDCM0257  AC138 HEK-293T C174(0.14); C182(1.07)  LDD0855  [31]
 LDCM0258  AC139 HEK-293T C174(0.26); C182(0.77)  LDD0856  [31]
 LDCM0259  AC14 HCT 116 C199(1.41)  LDD0576  [31]
 LDCM0260  AC140 HEK-293T C174(0.43); C182(0.96)  LDD0858  [31]
 LDCM0261  AC141 HEK-293T C174(0.21); C182(0.89)  LDD0859  [31]
 LDCM0262  AC142 HEK-293T C174(0.48); C182(0.81)  LDD0860  [31]
 LDCM0263  AC143 HEK-293T C199(0.76); C174(1.28); C182(1.29)  LDD0861  [31]
 LDCM0264  AC144 HEK-293T C199(1.05); C174(0.34); C182(0.97)  LDD0862  [31]
 LDCM0265  AC145 HEK-293T C199(0.65); C174(0.32); C182(1.74)  LDD0863  [31]
 LDCM0266  AC146 HEK-293T C199(0.80); C174(0.29); C182(1.50)  LDD0864  [31]
 LDCM0267  AC147 HEK-293T C199(0.79); C174(0.23); C182(2.05)  LDD0865  [31]
 LDCM0268  AC148 HEK-293T C199(0.61); C174(0.47); C182(2.21)  LDD0866  [31]
 LDCM0269  AC149 HEK-293T C199(0.60); C174(1.05); C182(0.80)  LDD0867  [31]
 LDCM0270  AC15 HCT 116 C199(1.32)  LDD0587  [31]
 LDCM0271  AC150 HEK-293T C199(0.56); C174(0.75); C182(1.61)  LDD0869  [31]
 LDCM0272  AC151 HEK-293T C199(0.66); C174(0.51); C182(1.79)  LDD0870  [31]
 LDCM0273  AC152 HEK-293T C199(1.00); C174(0.81); C182(0.88)  LDD0871  [31]
 LDCM0274  AC153 HEK-293T C199(0.97); C174(0.57); C182(1.01)  LDD0872  [31]
 LDCM0621  AC154 HEK-293T C199(0.91); C174(0.81); C182(1.26)  LDD2162  [31]
 LDCM0622  AC155 HEK-293T C199(0.86); C174(0.79); C182(0.93)  LDD2163  [31]
 LDCM0623  AC156 HEK-293T C199(0.87); C174(0.22); C182(1.18)  LDD2164  [31]
 LDCM0624  AC157 HEK-293T C199(0.98); C174(0.14); C182(1.03)  LDD2165  [31]
 LDCM0276  AC17 HCT 116 C199(1.10)  LDD0593  [31]
 LDCM0277  AC18 HCT 116 C199(0.75)  LDD0594  [31]
 LDCM0278  AC19 HCT 116 C199(0.83)  LDD0595  [31]
 LDCM0279  AC2 HCT 116 C199(1.09)  LDD0596  [31]
 LDCM0280  AC20 HCT 116 C199(0.97)  LDD0597  [31]
 LDCM0281  AC21 HCT 116 C199(0.92)  LDD0598  [31]
 LDCM0282  AC22 HCT 116 C199(1.21)  LDD0599  [31]
 LDCM0283  AC23 HCT 116 C199(0.89)  LDD0600  [31]
 LDCM0284  AC24 HCT 116 C199(0.98)  LDD0601  [31]
 LDCM0285  AC25 HEK-293T C199(1.29); C182(0.42)  LDD0883  [31]
 LDCM0286  AC26 HEK-293T C199(1.42); C182(0.55)  LDD0884  [31]
 LDCM0287  AC27 HEK-293T C199(1.13); C182(0.76)  LDD0885  [31]
 LDCM0288  AC28 HEK-293T C199(1.46); C182(0.78)  LDD0886  [31]
 LDCM0289  AC29 HEK-293T C199(1.37); C182(0.99)  LDD0887  [31]
 LDCM0290  AC3 HCT 116 C199(1.30)  LDD0607  [31]
 LDCM0291  AC30 HEK-293T C199(1.18); C182(0.77)  LDD0889  [31]
 LDCM0292  AC31 HEK-293T C199(1.04); C182(0.52)  LDD0890  [31]
 LDCM0293  AC32 HEK-293T C199(1.14); C182(0.46)  LDD0891  [31]
 LDCM0294  AC33 HEK-293T C199(1.32); C182(0.76)  LDD0892  [31]
 LDCM0295  AC34 HEK-293T C199(1.18); C182(0.44)  LDD0893  [31]
 LDCM0296  AC35 HCT 116 C199(1.23)  LDD0613  [31]
 LDCM0297  AC36 HCT 116 C199(2.65)  LDD0614  [31]
 LDCM0298  AC37 HCT 116 C199(3.37)  LDD0615  [31]
 LDCM0299  AC38 HCT 116 C199(1.24)  LDD0616  [31]
 LDCM0300  AC39 HCT 116 C199(1.15)  LDD0617  [31]
 LDCM0301  AC4 HCT 116 C199(1.64)  LDD0618  [31]
 LDCM0302  AC40 HCT 116 C199(0.88)  LDD0619  [31]
 LDCM0303  AC41 HCT 116 C199(0.79)  LDD0620  [31]
 LDCM0304  AC42 HCT 116 C199(0.84)  LDD0621  [31]
 LDCM0305  AC43 HCT 116 C199(1.91)  LDD0622  [31]
 LDCM0306  AC44 HCT 116 C199(0.80)  LDD0623  [31]
 LDCM0307  AC45 HCT 116 C199(0.55)  LDD0624  [31]
 LDCM0308  AC46 HCT 116 C199(1.33)  LDD0625  [31]
 LDCM0309  AC47 HCT 116 C199(1.06)  LDD0626  [31]
 LDCM0310  AC48 HCT 116 C199(1.07)  LDD0627  [31]
 LDCM0311  AC49 HCT 116 C199(0.74)  LDD0628  [31]
 LDCM0312  AC5 HCT 116 C199(1.72)  LDD0629  [31]
 LDCM0313  AC50 HCT 116 C199(0.75)  LDD0630  [31]
 LDCM0314  AC51 HCT 116 C199(1.17)  LDD0631  [31]
 LDCM0315  AC52 HCT 116 C199(0.92)  LDD0632  [31]
 LDCM0316  AC53 HCT 116 C199(1.05)  LDD0633  [31]
 LDCM0317  AC54 HCT 116 C199(0.89)  LDD0634  [31]
 LDCM0318  AC55 HCT 116 C199(0.99)  LDD0635  [31]
 LDCM0319  AC56 HCT 116 C199(0.75)  LDD0636  [31]
 LDCM0320  AC57 HCT 116 C199(1.29)  LDD0637  [31]
 LDCM0321  AC58 HCT 116 C199(1.12)  LDD0638  [31]
 LDCM0322  AC59 HCT 116 C199(1.16)  LDD0639  [31]
 LDCM0323  AC6 HCT 116 C199(0.96)  LDD0640  [31]
 LDCM0324  AC60 HCT 116 C199(1.13)  LDD0641  [31]
 LDCM0325  AC61 HCT 116 C199(1.20)  LDD0642  [31]
 LDCM0326  AC62 HCT 116 C199(1.01)  LDD0643  [31]
 LDCM0327  AC63 HCT 116 C199(1.09)  LDD0644  [31]
 LDCM0328  AC64 HCT 116 C199(1.23)  LDD0645  [31]
 LDCM0329  AC65 HCT 116 C199(1.21)  LDD0646  [31]
 LDCM0330  AC66 HCT 116 C199(1.21)  LDD0647  [31]
 LDCM0331  AC67 HCT 116 C199(1.16)  LDD0648  [31]
 LDCM0332  AC68 HEK-293T C199(0.86); C182(0.67)  LDD0930  [31]
 LDCM0333  AC69 HEK-293T C199(1.24); C182(0.71)  LDD0931  [31]
 LDCM0334  AC7 HCT 116 C199(1.32)  LDD0651  [31]
 LDCM0335  AC70 HEK-293T C199(1.42); C182(0.92)  LDD0933  [31]
 LDCM0336  AC71 HEK-293T C199(1.13); C182(0.64)  LDD0934  [31]
 LDCM0337  AC72 HEK-293T C199(1.27); C182(0.69)  LDD0935  [31]
 LDCM0338  AC73 HEK-293T C199(1.25); C182(0.89)  LDD0936  [31]
 LDCM0339  AC74 HEK-293T C199(1.29); C182(0.61)  LDD0937  [31]
 LDCM0340  AC75 HEK-293T C199(0.99); C182(0.44)  LDD0938  [31]
 LDCM0341  AC76 HEK-293T C199(0.99); C182(0.72)  LDD0939  [31]
 LDCM0342  AC77 HEK-293T C199(1.18); C182(0.76)  LDD0940  [31]
 LDCM0343  AC78 HEK-293T C199(1.24); C182(0.69)  LDD0941  [31]
 LDCM0344  AC79 HEK-293T C199(1.11); C182(0.69)  LDD0942  [31]
 LDCM0345  AC8 HCT 116 C199(0.80)  LDD0662  [31]
 LDCM0346  AC80 HEK-293T C199(1.21); C182(0.59)  LDD0944  [31]
 LDCM0347  AC81 HEK-293T C199(1.35); C182(0.66)  LDD0945  [31]
 LDCM0348  AC82 HEK-293T C199(1.23); C182(0.73)  LDD0946  [31]
 LDCM0349  AC83 HCT 116 C199(0.84)  LDD0666  [31]
 LDCM0350  AC84 HCT 116 C199(0.80)  LDD0667  [31]
 LDCM0351  AC85 HCT 116 C199(0.81)  LDD0668  [31]
 LDCM0352  AC86 HCT 116 C199(0.97)  LDD0669  [31]
 LDCM0353  AC87 HCT 116 C199(1.09)  LDD0670  [31]
 LDCM0354  AC88 HCT 116 C199(1.00)  LDD0671  [31]
 LDCM0355  AC89 HCT 116 C199(0.89)  LDD0672  [31]
 LDCM0357  AC90 HCT 116 C199(1.11)  LDD0674  [31]
 LDCM0358  AC91 HCT 116 C199(1.02)  LDD0675  [31]
 LDCM0359  AC92 HCT 116 C199(0.52)  LDD0676  [31]
 LDCM0360  AC93 HCT 116 C199(0.53)  LDD0677  [31]
 LDCM0361  AC94 HCT 116 C199(1.02)  LDD0678  [31]
 LDCM0362  AC95 HCT 116 C199(1.16)  LDD0679  [31]
 LDCM0363  AC96 HCT 116 C199(1.03)  LDD0680  [31]
 LDCM0364  AC97 HCT 116 C199(1.03)  LDD0681  [31]
 LDCM0365  AC98 HEK-293T C199(1.30); C174(0.83); C182(1.26)  LDD0963  [31]
 LDCM0366  AC99 HEK-293T C199(0.98); C174(0.82); C182(1.49)  LDD0964  [31]
 LDCM0545  Acetamide MDA-MB-231 C182(0.85); C199(0.46)  LDD2138  [30]
 LDCM0166  Afatinib A431 1.58  LDD0421  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C182(1.01); C199(0.59)  LDD2113  [30]
 LDCM0248  AKOS034007472 HCT 116 C199(1.38)  LDD0565  [31]
 LDCM0356  AKOS034007680 HCT 116 C199(1.32)  LDD0673  [31]
 LDCM0275  AKOS034007705 HCT 116 C199(0.99)  LDD0592  [31]
 LDCM0020  ARS-1620 HCC44 C199(1.04)  LDD2171  [31]
 LDCM0498  BS-3668 MDA-MB-231 C182(0.92); C199(0.48)  LDD2091  [30]
 LDCM0108  Chloroacetamide HeLa C199(0.00); H236(0.00); C182(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C199(0.80)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C199(1.20)  LDD0684  [31]
 LDCM0368  CL10 HCT 116 C199(0.82)  LDD0685  [31]
 LDCM0369  CL100 HCT 116 C199(1.34)  LDD0686  [31]
 LDCM0370  CL101 HCT 116 C199(1.18)  LDD0687  [31]
 LDCM0371  CL102 HCT 116 C199(1.81)  LDD0688  [31]
 LDCM0372  CL103 HCT 116 C199(1.58)  LDD0689  [31]
 LDCM0373  CL104 HCT 116 C199(1.44)  LDD0690  [31]
 LDCM0374  CL105 HCT 116 C199(0.92)  LDD0691  [31]
 LDCM0375  CL106 HCT 116 C199(0.94)  LDD0692  [31]
 LDCM0376  CL107 HCT 116 C199(0.68)  LDD0693  [31]
 LDCM0377  CL108 HCT 116 C199(0.68)  LDD0694  [31]
 LDCM0378  CL109 HCT 116 C199(0.83)  LDD0695  [31]
 LDCM0379  CL11 HCT 116 C199(0.66)  LDD0696  [31]
 LDCM0380  CL110 HCT 116 C199(0.67)  LDD0697  [31]
 LDCM0381  CL111 HCT 116 C199(0.87)  LDD0698  [31]
 LDCM0382  CL112 HEK-293T C199(1.41); C182(0.56)  LDD0980  [31]
 LDCM0383  CL113 HEK-293T C199(1.23); C182(0.40)  LDD0981  [31]
 LDCM0384  CL114 HEK-293T C199(1.74); C182(0.58)  LDD0982  [31]
 LDCM0385  CL115 HEK-293T C199(1.36); C182(0.43)  LDD0983  [31]
 LDCM0386  CL116 HEK-293T C199(1.47); C182(0.55)  LDD0984  [31]
 LDCM0387  CL117 HCT 116 C199(0.45)  LDD0704  [31]
 LDCM0388  CL118 HCT 116 C199(1.00)  LDD0705  [31]
 LDCM0389  CL119 HCT 116 C199(1.32)  LDD0706  [31]
 LDCM0390  CL12 HCT 116 C199(0.42)  LDD0707  [31]
 LDCM0391  CL120 HCT 116 C199(1.58)  LDD0708  [31]
 LDCM0392  CL121 HCT 116 C199(0.97)  LDD0709  [31]
 LDCM0393  CL122 HCT 116 C199(1.08)  LDD0710  [31]
 LDCM0394  CL123 HCT 116 C199(0.96)  LDD0711  [31]
 LDCM0395  CL124 HCT 116 C199(0.82)  LDD0712  [31]
 LDCM0396  CL125 HCT 116 C199(1.12)  LDD0713  [31]
 LDCM0397  CL126 HCT 116 C199(1.15)  LDD0714  [31]
 LDCM0398  CL127 HCT 116 C199(1.16)  LDD0715  [31]
 LDCM0399  CL128 HCT 116 C199(1.20)  LDD0716  [31]
 LDCM0400  CL13 HCT 116 C199(0.87)  LDD0717  [31]
 LDCM0401  CL14 HCT 116 C199(0.96)  LDD0718  [31]
 LDCM0402  CL15 HCT 116 C199(0.71)  LDD0719  [31]
 LDCM0403  CL16 HCT 116 C199(0.63)  LDD0720  [31]
 LDCM0404  CL17 HCT 116 C199(1.33)  LDD0721  [31]
 LDCM0405  CL18 HCT 116 C199(1.43)  LDD0722  [31]
 LDCM0406  CL19 HCT 116 C199(0.99)  LDD0723  [31]
 LDCM0407  CL2 HCT 116 C199(1.05)  LDD0724  [31]
 LDCM0408  CL20 HCT 116 C199(0.79)  LDD0725  [31]
 LDCM0409  CL21 HCT 116 C199(1.08)  LDD0726  [31]
 LDCM0410  CL22 HCT 116 C199(0.78)  LDD0727  [31]
 LDCM0411  CL23 HCT 116 C199(0.80)  LDD0728  [31]
 LDCM0412  CL24 HCT 116 C199(0.80)  LDD0729  [31]
 LDCM0413  CL25 HCT 116 C199(0.91)  LDD0730  [31]
 LDCM0414  CL26 HCT 116 C199(0.81)  LDD0731  [31]
 LDCM0415  CL27 HCT 116 C199(0.92)  LDD0732  [31]
 LDCM0416  CL28 HCT 116 C199(0.87)  LDD0733  [31]
 LDCM0417  CL29 HCT 116 C199(0.96)  LDD0734  [31]
 LDCM0418  CL3 HCT 116 C199(0.91)  LDD0735  [31]
 LDCM0419  CL30 HCT 116 C199(1.10)  LDD0736  [31]
 LDCM0420  CL31 HCT 116 C199(0.93)  LDD0737  [31]
 LDCM0421  CL32 HCT 116 C199(1.07)  LDD0738  [31]
 LDCM0422  CL33 HCT 116 C199(0.79)  LDD0739  [31]
 LDCM0423  CL34 HCT 116 C199(0.53)  LDD0740  [31]
 LDCM0424  CL35 HCT 116 C199(0.51)  LDD0741  [31]
 LDCM0425  CL36 HCT 116 C199(0.63)  LDD0742  [31]
 LDCM0426  CL37 HCT 116 C199(0.57)  LDD0743  [31]
 LDCM0428  CL39 HCT 116 C199(0.47)  LDD0745  [31]
 LDCM0429  CL4 HCT 116 C199(0.85)  LDD0746  [31]
 LDCM0430  CL40 HCT 116 C199(0.57)  LDD0747  [31]
 LDCM0431  CL41 HCT 116 C199(0.67)  LDD0748  [31]
 LDCM0432  CL42 HCT 116 C199(0.43)  LDD0749  [31]
 LDCM0433  CL43 HCT 116 C199(0.51)  LDD0750  [31]
 LDCM0434  CL44 HCT 116 C199(0.68)  LDD0751  [31]
 LDCM0435  CL45 HCT 116 C199(0.60)  LDD0752  [31]
 LDCM0436  CL46 HCT 116 C199(1.42)  LDD0753  [31]
 LDCM0437  CL47 HCT 116 C199(1.45)  LDD0754  [31]
 LDCM0438  CL48 HCT 116 C199(1.44)  LDD0755  [31]
 LDCM0439  CL49 HCT 116 C199(0.96)  LDD0756  [31]
 LDCM0440  CL5 HCT 116 C199(0.87)  LDD0757  [31]
 LDCM0441  CL50 HCT 116 C199(1.17)  LDD0758  [31]
 LDCM0442  CL51 HCT 116 C199(1.46)  LDD0759  [31]
 LDCM0443  CL52 HCT 116 C199(1.25)  LDD0760  [31]
 LDCM0444  CL53 HCT 116 C199(1.30)  LDD0761  [31]
 LDCM0445  CL54 HCT 116 C199(1.48)  LDD0762  [31]
 LDCM0446  CL55 HCT 116 C199(1.47)  LDD0763  [31]
 LDCM0447  CL56 HCT 116 C199(0.88)  LDD0764  [31]
 LDCM0448  CL57 HCT 116 C199(1.51)  LDD0765  [31]
 LDCM0449  CL58 HCT 116 C199(1.44)  LDD0766  [31]
 LDCM0450  CL59 HCT 116 C199(0.86)  LDD0767  [31]
 LDCM0451  CL6 HCT 116 C199(1.35)  LDD0768  [31]
 LDCM0452  CL60 HCT 116 C199(0.91)  LDD0769  [31]
 LDCM0453  CL61 HCT 116 C199(0.98)  LDD0770  [31]
 LDCM0454  CL62 HCT 116 C199(0.47)  LDD0771  [31]
 LDCM0455  CL63 HCT 116 C199(0.91)  LDD0772  [31]
 LDCM0456  CL64 HCT 116 C199(0.71)  LDD0773  [31]
 LDCM0457  CL65 HCT 116 C199(1.34)  LDD0774  [31]
 LDCM0458  CL66 HCT 116 C199(1.17)  LDD0775  [31]
 LDCM0459  CL67 HCT 116 C199(1.22)  LDD0776  [31]
 LDCM0460  CL68 HCT 116 C199(1.61)  LDD0777  [31]
 LDCM0461  CL69 HCT 116 C199(1.03)  LDD0778  [31]
 LDCM0462  CL7 HCT 116 C199(0.77)  LDD0779  [31]
 LDCM0463  CL70 HCT 116 C199(1.20)  LDD0780  [31]
 LDCM0464  CL71 HCT 116 C199(1.05)  LDD0781  [31]
 LDCM0465  CL72 HCT 116 C199(1.18)  LDD0782  [31]
 LDCM0466  CL73 HCT 116 C199(0.94)  LDD0783  [31]
 LDCM0467  CL74 HCT 116 C199(1.05)  LDD0784  [31]
 LDCM0469  CL76 HEK-293T C199(1.36); C174(0.70); C182(2.54)  LDD1067  [31]
 LDCM0470  CL77 HEK-293T C199(1.41); C174(0.49); C182(3.09)  LDD1068  [31]
 LDCM0471  CL78 HEK-293T C199(1.39); C174(0.59); C182(2.39)  LDD1069  [31]
 LDCM0472  CL79 HEK-293T C199(1.34); C174(0.35); C182(1.22)  LDD1070  [31]
 LDCM0473  CL8 HCT 116 C199(0.47)  LDD0790  [31]
 LDCM0474  CL80 HEK-293T C199(1.31); C174(0.59); C182(3.33)  LDD1072  [31]
 LDCM0475  CL81 HEK-293T C199(1.27); C174(0.46); C182(2.80)  LDD1073  [31]
 LDCM0476  CL82 HEK-293T C199(1.08); C174(0.73); C182(2.99)  LDD1074  [31]
 LDCM0477  CL83 HEK-293T C199(1.28); C174(0.69); C182(3.41)  LDD1075  [31]
 LDCM0478  CL84 HEK-293T C199(1.40); C174(0.42); C182(2.09)  LDD1076  [31]
 LDCM0479  CL85 HEK-293T C199(1.49); C174(0.79); C182(3.03)  LDD1077  [31]
 LDCM0480  CL86 HEK-293T C199(1.62); C174(0.52); C182(2.24)  LDD1078  [31]
 LDCM0481  CL87 HEK-293T C199(1.30); C174(0.59); C182(3.28)  LDD1079  [31]
 LDCM0482  CL88 HEK-293T C199(1.49); C174(0.72); C182(1.85)  LDD1080  [31]
 LDCM0483  CL89 HEK-293T C199(1.28); C174(0.86); C182(2.50)  LDD1081  [31]
 LDCM0484  CL9 HCT 116 C199(0.70)  LDD0801  [31]
 LDCM0485  CL90 HEK-293T C199(1.77); C174(0.61); C182(1.40)  LDD1083  [31]
 LDCM0486  CL91 HCT 116 C199(0.42)  LDD0803  [31]
 LDCM0487  CL92 HCT 116 C199(1.02)  LDD0804  [31]
 LDCM0488  CL93 HCT 116 C199(1.06)  LDD0805  [31]
 LDCM0489  CL94 HCT 116 C199(1.20)  LDD0806  [31]
 LDCM0490  CL95 HCT 116 C199(1.31)  LDD0807  [31]
 LDCM0491  CL96 HCT 116 C199(0.98)  LDD0808  [31]
 LDCM0492  CL97 HCT 116 C199(1.28)  LDD0809  [31]
 LDCM0493  CL98 HCT 116 C199(1.28)  LDD0810  [31]
 LDCM0494  CL99 HCT 116 C199(1.11)  LDD0811  [31]
 LDCM0495  E2913 HEK-293T C199(1.01); C182(0.70); C174(1.24)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C199(1.74)  LDD1702  [30]
 LDCM0625  F8 Ramos C182(1.09); C199(0.54)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C182(0.61); C199(0.74)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C182(0.05); C199(0.14)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C182(0.69); C199(1.02)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C182(1.33); C199(1.43)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C182(0.80); C199(1.01)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C182(0.71); C199(1.24)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C182(0.80); C199(1.36)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C182(0.99); C199(1.05)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C182(1.27); C199(1.28)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C182(1.11); C199(1.11)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C182(1.05); C199(0.79)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C182(1.29); C199(1.16)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C182(0.59); C199(0.90)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C199(0.69)  LDD0785  [31]
 LDCM0596  Fragment38 Ramos C182(1.08); C199(1.07)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C182(0.94); C199(0.61)  LDD2184  [33]
 LDCM0427  Fragment51 HCT 116 C199(0.38)  LDD0744  [31]
 LDCM0610  Fragment52 Ramos C182(1.30); C199(0.69)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C182(1.28); C199(0.83)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C182(0.72); C199(0.26)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C182(0.61); C199(0.56)  LDD2188  [33]
 LDCM0107  IAA HeLa C199(0.00); H236(0.00)  LDD0221  [23]
 LDCM0022  KB02 HEK-293T C199(0.98); C182(1.07); C174(1.10)  LDD1492  [32]
 LDCM0023  KB03 Jurkat C182(8.03); C182(11.87); C199(9.00)  LDD0209  [10]
 LDCM0024  KB05 G361 C174(1.50); C199(1.99)  LDD3311  [34]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C199(0.94)  LDD2102  [30]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C182(1.39); C199(0.99)  LDD2121  [30]
 LDCM0109  NEM HeLa C199(0.00); H236(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C182(0.98); C199(0.84)  LDD2089  [30]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C199(0.59)  LDD2092  [30]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C182(1.67)  LDD2093  [30]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C199(0.95)  LDD2094  [30]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C182(0.12)  LDD2096  [30]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C182(1.12); C199(0.83)  LDD2097  [30]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C199(0.68)  LDD2098  [30]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C182(1.10); C199(1.31)  LDD2099  [30]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C199(0.57)  LDD2100  [30]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C182(1.48); C199(0.87)  LDD2101  [30]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C199(0.64)  LDD2104  [30]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C199(1.26)  LDD2105  [30]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C199(0.43)  LDD2106  [30]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C182(1.02); C199(1.25)  LDD2107  [30]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C199(0.64)  LDD2108  [30]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C182(1.12); C199(0.86)  LDD2109  [30]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C182(1.19)  LDD2111  [30]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C199(0.80)  LDD2114  [30]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C182(0.64); C199(0.87)  LDD2115  [30]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C182(0.95)  LDD2118  [30]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C182(1.65); C199(2.15)  LDD2119  [30]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C182(0.75); C199(1.09)  LDD2120  [30]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C199(1.22)  LDD2122  [30]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C182(0.86)  LDD2123  [30]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C182(0.45); C199(1.21)  LDD2124  [30]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C182(1.01); C199(1.27)  LDD2125  [30]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C182(0.47); C199(2.94)  LDD2126  [30]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C199(1.07)  LDD2127  [30]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C182(1.04); C199(0.38)  LDD2128  [30]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C182(0.51); C199(0.77)  LDD2134  [30]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C182(1.88); C199(0.90)  LDD2135  [30]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C182(1.01); C199(1.06)  LDD2136  [30]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C182(0.96); C199(0.87)  LDD2137  [30]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C182(1.11); C199(1.11)  LDD2140  [30]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C199(0.71)  LDD2141  [30]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C182(0.75); C199(1.01)  LDD2143  [30]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C182(2.17); C199(5.92)  LDD2144  [30]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C199(0.22)  LDD2145  [30]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C182(1.33)  LDD2146  [30]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C182(1.36)  LDD2147  [30]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C182(0.66); C199(0.38)  LDD2148  [30]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C182(0.66); C199(1.84)  LDD2149  [30]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C182(1.03); C199(1.01)  LDD2150  [30]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C199(1.56)  LDD2151  [30]
 LDCM0018  Orlistat Hep-G2 N.A.  LDD0077  [25]
 LDCM0131  RA190 MM1.R C199(1.37)  LDD0304  [35]
 LDCM0021  THZ1 HCT 116 C199(1.04)  LDD2173  [31]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) . O95793

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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