Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name THL-R  Probe Info 
Probe concentration 20 uM
Criteria Other data
Competitor Name Orlistat  Competitor Info 
Competitor Concentration 100 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cells (Hep-G2)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name
 LDTP04243  Fatty acid synthase (FASN)
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name
 LDTP02199  Annexin A2 (ANXA2)
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1)
Other
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14)
 LDTP04990  Large ribosomal subunit protein eL8 (RPL7A)
 LDTP04109  Small ribosomal subunit protein uS4 (RPS9)
 LDTP02205  Tubulin beta chain (TUBB)

References

1 Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities. J Am Chem Soc. 2010 Jan 20;132(2):656-66. doi: 10.1021/ja907716f.