Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name P2  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
LFQ
In Vivo Experiment Model Model Type Living cell
Derived Tissue Skin
Disease Model Skin squamous cell carcinoma [ICD-11:2C31]
Model Name Human skin squamous cell carcinoma cells (A431)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) 10.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 10.0
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC) 10.0
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 10.0
 LDTP02162  Glucose-6-phosphate isomerase (GPI) 10.0
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) 10.0
 LDTP04898  NEDD8-conjugating enzyme Ubc12 (UBE2M) 10.0
 LDTP03216  Peptidyl-prolyl cis-trans isomerase B (PPIB) 10.0
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17) 10.0
 LDTP04134  Retinaldehyde dehydrogenase 3 (ALDH1A3) 10.0
 LDTP03522  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) 10.0
 LDTP02502  Thioredoxin (TXN) 10.0
 LDTP12851  UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) 10.0
 LDTP12923  EH domain-containing protein 2 (EHD2) 4.1
 LDTP01785  Epidermal growth factor receptor (EGFR) 3.9
 LDTP02541  Heat shock cognate 71 kDa protein (HSPA8) 3.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) 3.7
 LDTP03915  Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) 3.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) 2.8
 LDTP03669  Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) 2.7
 LDTP05812  Ras GTPase-activating protein-binding protein 1 (G3BP1) 2.7
 LDTP03764  Myosin-9 (MYH9) 2.5
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) 2.4
 LDTP03242  Adenosylhomocysteinase (AHCY) 2.2
 LDTP02637  Myosin-7 (MYH7) 2.2
 LDTP05171  Dermcidin (DCD) 2.0
 LDTP05503  Peroxiredoxin-1 (PRDX1) 1.9
 LDTP05059  Actin, cytoplasmic 2 (ACTG1) 1.8
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 1.8
 LDTP02179  L-lactate dehydrogenase B chain (LDHB) 1.8
 LDTP02159  Alpha-enolase (ENO1) 1.7
 LDTP05073  Actin, alpha skeletal muscle (ACTA1) 1.7
 LDTP02672  Elongation factor 2 (EEF2) 1.6
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) 1.6
 LDTP15029  Putative elongation factor 1-alpha-like 3 (EEF1A1P5) 1.5
 LDTP07932  Probable ATP-dependent RNA helicase DDX46 (DDX46) 1.5
 LDTP04851  Triosephosphate isomerase (TPI1) 1.5
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04969  14-3-3 protein epsilon (YWHAE) 10.0
 LDTP04953  14-3-3 protein gamma (YWHAG) 10.0
 LDTP02307  Annexin A5 (ANXA5) 10.0
 LDTP06203  Major vault protein (MVP) 10.0
 LDTP14031  Talin-1 (TLN1) 10.0
 LDTP02010  Annexin A1 (ANXA1) 5.7
 LDTP02199  Annexin A2 (ANXA2) 3.3
 LDTP04885  Protein S100-A10 (S100A10) 3.0
 LDTP03107  Filamin-A (FLNA) 2.8
 LDTP08637  Serine/arginine repetitive matrix protein 1 (SRRM1) 2.6
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) 2.4
 LDTP06350  RNA-binding protein with serine-rich domain 1 (RNPS1) 2.3
 LDTP01197  Filamin-B (FLNB) 2.2
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 2.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 2.1
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 2.0
 LDTP05043  14-3-3 protein zeta/delta (YWHAZ) 1.9
 LDTP05252  Clathrin heavy chain 1 (CLTC) 1.8
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02886  High mobility group protein HMG-I/HMG-Y (HMGA1) 10.0
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) 10.0
 LDTP03781  Transcription factor SOX-5 (SOX5) 10.0
Other
Click to Show/Hide to Show 90 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04931  10 kDa heat shock protein, mitochondrial (HSPE1) 10.0
 LDTP05294  Adenylyl cyclase-associated protein 1 (CAP1) 10.0
 LDTP14866  Adipogenesis regulatory factor (ADIRF) 10.0
 LDTP02631  Alpha-actinin-1 (ACTN1) 10.0
 LDTP12937  Calmodulin-like protein 5 (CALML5) 10.0
 LDTP06121  Caprin-1 (CAPRIN1) 10.0
 LDTP03499  Elongation factor 1-delta (EEF1D) 10.0
 LDTP04743  Eukaryotic translation initiation factor 6 (EIF6) 10.0
 LDTP02435  Heat shock 70 kDa protein 1B (HSPA1B) 10.0
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 10.0
 LDTP05689  Interleukin enhancer-binding factor 3 (ILF3) 10.0
 LDTP06137  Keratin, type I cuticular Ha3-II (KRT33B) 10.0
 LDTP05525  KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) 10.0
 LDTP05974  Laminin subunit beta-3 (LAMB3) 10.0
 LDTP05975  Laminin subunit gamma-2 (LAMC2) 10.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) 10.0
 LDTP02108  Large ribosomal subunit protein P2 (RPLP2) 10.0
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0) 10.0
 LDTP02990  Nucleolin (NCL) 10.0
 LDTP00193  PDZ and LIM domain protein 1 (PDLIM1) 10.0
 LDTP02691  Plastin-2 (LCP1) 10.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) 10.0
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) 10.0
 LDTP17266  Pre-mRNA-splicing factor 38B (PRPF38B) 10.0
 LDTP01932  Prelamin-A/C (LMNA) 10.0
 LDTP09145  Regulator of G-protein signaling 22 (RGS22) 10.0
 LDTP03864  Small ribosomal subunit protein eS19 (RPS19) 10.0
 LDTP05055  Small ribosomal subunit protein eS21 (RPS21) 10.0
 LDTP05002  Small ribosomal subunit protein eS6 (RPS6) 10.0
 LDTP04970  Small ribosomal subunit protein uS11 (RPS14) 10.0
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) 10.0
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 10.0
 LDTP01184  Tubulin-specific chaperone A (TBCA) 10.0
 LDTP03618  14-3-3 protein sigma (SFN) 8.1
 LDTP02125  Keratin, type II cytoskeletal 8 (KRT8) 7.3
 LDTP05001  Large ribosomal subunit protein uL23 (RPL23A) 6.1
 LDTP02845  Histone H1.2 (H1-2) 5.8
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 4.9
 LDTP02975  Keratin, type II cytoskeletal 4 (KRT4) 4.3
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14) 4.2
 LDTP12826  Bcl-2-associated transcription factor 1 (BCLAF1) 4.2
 LDTP00619  Eukaryotic translation initiation factor 3 subunit D (EIF3D) 4.0
 LDTP02227  Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) 3.8
 LDTP02675  Keratin, type I cytoskeletal 13 (KRT13) 3.7
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 3.7
 LDTP03617  14-3-3 protein beta/alpha (YWHAB) 3.3
 LDTP04875  Myosin light polypeptide 6 (MYL6) 3.2
 LDTP07954  Arginine/serine-rich coiled-coil protein 2 (RSRC2) 3.1
 LDTP10999  Histone H2A type 1-J (H2AC14) 3.0
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) 3.0
 LDTP02974  Keratin, type I cytoskeletal 15 (KRT15) 3.0
 LDTP11374  Rab11 family-interacting protein 5 (RAB11FIP5) 2.9
 LDTP04027  Matrin-3 (MATR3) 2.8
 LDTP02364  Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) 2.7
 LDTP02084  Plasminogen activator inhibitor 2 (SERPINB2) 2.7
 LDTP04964  Small ribosomal subunit protein eS8 (RPS8) 2.7
 LDTP06220  LIM and SH3 domain protein 1 (LASP1) 2.7
 LDTP03463  Protein S100-A2 (S100A2) 2.5
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 2.5
 LDTP02961  Large ribosomal subunit protein uL22 (RPL17) 2.4
 LDTP03899  Large ribosomal subunit protein uL13 (RPL13A) 2.4
 LDTP04982  Small nuclear ribonucleoprotein Sm D2 (SNRPD2) 2.4
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 2.4
 LDTP05027  Large ribosomal subunit protein uL2 (RPL8) 2.4
 LDTP16118  Arginine and glutamate-rich protein 1 (ARGLU1) 2.2
 LDTP05033  Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) 2.2
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 2.2
 LDTP03517  Large ribosomal subunit protein uL11 (RPL12) 2.1
 LDTP17238  Coiled-coil domain-containing protein 18 (CCDC18) 2.1
 LDTP04717  Small ubiquitin-related modifier 3 (SUMO3) 2.1
 LDTP06387  Splicing factor 3A subunit 2 (SF3A2) 2.0
 LDTP02779  Ezrin (EZR) 1.9
 LDTP04972  Small ribosomal subunit protein uS13 (RPS18) 1.9
 LDTP02884  Heat shock 70 kDa protein 6 (HSPA6) 1.9
 LDTP03620  Protein S100-A11 (S100A11) 1.9
 LDTP04990  Large ribosomal subunit protein eL8 (RPL7A) 1.8
 LDTP03364  Polypyrimidine tract-binding protein 1 (PTBP1) 1.7
 LDTP02843  Histone H1.5 (H1-5) 1.7
 LDTP05024  Large ribosomal subunit protein uL1 (RPL10A) 1.7
 LDTP13746  Serine/arginine repetitive matrix protein 2 (SRRM2) 1.7
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) 1.7
 LDTP05509  Large ribosomal subunit protein eL18 (RPL18) 1.6
 LDTP15019  Histone H3-7 (H3-7) 1.6
 LDTP03846  Transgelin-2 (TAGLN2) 1.6
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5) 1.6
 LDTP03244  Cofilin-1 (CFL1) 1.6
 LDTP06094  Src substrate cortactin (CTTN) 1.6
 LDTP04974  Small ribosomal subunit protein uS15 (RPS13) 1.5
 LDTP02164  Nucleophosmin (NPM1) 1.5
 LDTP05280  Serine/arginine-rich splicing factor 2 (SRSF2) 1.5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.