Details of the Target

General Information of Target

Target ID LDTP15019
Target Name Histone H3-7 (H3-7)
Gene Name H3-7
Synonyms
H3-2; HIST2H3PS2; Histone H3-7
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNNEEDLLQEDSTRDEGNETEANSMNTLRRTRKKVTKPYVCSTEVGETDMSNSNDCMRDS
SQILTPPQLSSRMKHIRQAMAKNRLQFVRFEATDLHGVSRSKTIPAHFFQEKVSHGVCMP
RGYLEVIPNPKDNEMNNIRATCFNSDIVLMPELSTFRVLPWADRTARVICDTFTVTGEPL
LTSPRYIAKRQLSHLQASGFSLLSAFIYDFCIFGVPEILNSKIISFPALTFLNNHDQPFM
QELVDGLYHTGANVESFSSSTRPGQMEISFLPEFGISSADNAFTLRTGVKEVARKYNYIA
SFFIETGFCDSGILSHSLWDVDRKKNMFCSTSGTEQLTITGKKWLAGLLKHSAALSCLMA
PSVSCRKRYSKDRKDLKKSVPTTWGYNDNSCIFNIKCHGEKGTRIENKLGSATANPYLVL
AATVAAGLDGLHSSNEVLAGPDESTDFYQVEPSEIPLKLEDALVALEEDQCLRQALGETF
IRYFVAMKKYELENEEIAAERNKFLEYFI
Target Bioclass
Other
Family
Histone H3 family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q5TEC6
Ensemble ID
ENST00000392948.5
HGNC ID
HGNC:32060

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		3.53  LDD0448  [1]
P2
 Probe Info  		1.62  LDD0449  [1]
DBIA
 Probe Info  		C111(0.79)  LDD1492  [2]
STPyne
 Probe Info  		K37(0.00); K57(0.00)  LDD0009  [3]
MPP-AC
 Probe Info  		N.A.  LDD0428  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
TPP-AC
 Probe Info  		N.A.  LDD0427  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C111(0.99)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C111(0.89)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C111(1.28)  LDD1512  [2]
 LDCM0277  AC18 HEK-293T C111(1.33)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C111(0.99)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C111(0.90)  LDD1518  [2]
 LDCM0282  AC22 HEK-293T C111(1.15)  LDD1521  [2]
 LDCM0284  AC24 HEK-293T C111(0.92)  LDD1523  [2]
 LDCM0286  AC26 HEK-293T C111(1.16)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C111(1.04)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C111(0.88)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C111(1.09)  LDD1530  [2]
 LDCM0293  AC32 HEK-293T C111(1.32)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C111(1.17)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C111(1.10)  LDD1535  [2]
 LDCM0299  AC38 HEK-293T C111(1.22)  LDD1538  [2]
 LDCM0302  AC40 HEK-293T C111(1.14)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C111(0.93)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C111(0.96)  LDD1544  [2]
 LDCM0308  AC46 HEK-293T C111(0.94)  LDD1547  [2]
 LDCM0310  AC48 HEK-293T C111(0.84)  LDD1549  [2]
 LDCM0313  AC50 HEK-293T C111(1.13)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C111(0.88)  LDD1553  [2]
 LDCM0317  AC54 HEK-293T C111(1.01)  LDD1556  [2]
 LDCM0319  AC56 HEK-293T C111(1.30)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C111(1.07)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C111(0.95)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C111(1.04)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C111(0.88)  LDD1565  [2]
 LDCM0328  AC64 HEK-293T C111(0.99)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C111(0.92)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C111(1.02)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C111(1.10)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C111(0.42)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C111(0.85)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C111(1.05)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C111(1.27)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C111(1.07)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C111(1.03)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C111(1.08)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C111(0.84)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C111(1.07)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C111(0.82)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C111(1.00)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C111(1.15)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C111(1.33)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C111(1.05)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C111(1.21)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C111(0.75)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C111(0.98)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C111(1.11)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C111(1.25)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C111(0.89)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C111(0.99)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C111(1.38)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C111(0.94)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C111(0.91)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C111(0.89)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C111(0.95)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C111(0.97)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C111(0.89)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C111(0.95)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C111(1.01)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C111(0.86)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C111(1.17)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C111(0.94)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C111(0.83)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C111(1.18)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C111(1.04)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C111(1.35)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C111(1.22)  LDD1611  [2]
 LDCM0410  CL22 HEK-293T C111(2.19)  LDD1614  [2]
 LDCM0412  CL24 HEK-293T C111(2.75)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C111(0.86)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C111(0.99)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C111(1.02)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C111(0.93)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C111(1.08)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C111(1.06)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C111(1.19)  LDD1624  [2]
 LDCM0423  CL34 HEK-293T C111(3.02)  LDD1627  [2]
 LDCM0425  CL36 HEK-293T C111(1.84)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C111(1.02)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C111(1.07)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C111(1.02)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C111(1.03)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C111(1.07)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C111(1.44)  LDD1637  [2]
 LDCM0436  CL46 HEK-293T C111(1.77)  LDD1640  [2]
 LDCM0438  CL48 HEK-293T C111(1.49)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C111(0.99)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C111(1.01)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C111(1.09)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C111(1.16)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C111(1.29)  LDD1649  [2]
 LDCM0449  CL58 HEK-293T C111(2.32)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C111(1.19)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C111(1.32)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C111(0.92)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C111(0.93)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C111(1.09)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C111(0.97)  LDD1659  [2]
 LDCM0458  CL66 HEK-293T C111(1.37)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C111(1.07)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C111(1.14)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C111(1.74)  LDD1666  [2]
 LDCM0465  CL72 HEK-293T C111(1.49)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C111(0.79)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C111(0.73)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C111(1.02)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C111(1.33)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C111(1.06)  LDD1675  [2]
 LDCM0476  CL82 HEK-293T C111(1.59)  LDD1679  [2]
 LDCM0478  CL84 HEK-293T C111(1.28)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C111(0.95)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C111(0.77)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C111(0.98)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C111(0.97)  LDD1685  [2]
 LDCM0485  CL90 HEK-293T C111(1.10)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C111(1.13)  LDD1689  [2]
 LDCM0489  CL94 HEK-293T C111(1.03)  LDD1692  [2]
 LDCM0491  CL96 HEK-293T C111(1.17)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C111(0.90)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C111(0.94)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C111(0.90)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C111(0.91)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C111(0.92)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C111(0.94)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C111(0.79)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C111(1.27)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C111(1.00)  LDD1502  [2]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264