Probe Name	P1					Probe Info
Probe concentration	1 uM
Criteria	Quantification: Probe vs DMSO
Quantitative Method	LFQ
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Skin
	Disease Model		Skin squamous cell carcinoma [ICD-11:2C31]
	Model Name		Human skin squamous cell carcinoma cells (A431)

Target ID	Target Name					Binding Ratio
LDTP11701	5'-3' exoribonuclease 2 (XRN2)					10.0
LDTP08837	Cardiomyopathy-associated protein 5 (CMYA5)					10.0
LDTP05136	DNA-dependent protein kinase catalytic subunit (PRKDC)					10.0
LDTP14109	FACT complex subunit SPT16 (SUPT16H)					10.0
LDTP04665	Transitional endoplasmic reticulum ATPase (VCP)					10.0
LDTP12851	UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1)					10.0
LDTP01127	Rho-associated protein kinase 2 (ROCK2)					3.7
LDTP09890	Histone acetyltransferase KAT2A (KAT2A)					3.5
LDTP01785	Epidermal growth factor receptor (EGFR)					2.6
LDTP15093	Carboxylesterase 5A (CES5A)					1.9
LDTP05171	Dermcidin (DCD)					1.9
LDTP12752	NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11)					1.8
LDTP12397	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)					1.8
LDTP01806	Carbonic anhydrase 2 (CA2)					1.7
LDTP07932	Probable ATP-dependent RNA helicase DDX46 (DDX46)					1.6

Target ID	Target Name					Binding Ratio
LDTP05292	Fatty acid-binding protein 5 (FABP5)					10.0
LDTP08637	Serine/arginine repetitive matrix protein 1 (SRRM1)					3.3
LDTP06350	RNA-binding protein with serine-rich domain 1 (RNPS1)					2.7

Target ID	Target Name					Binding Ratio
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)					2.1

Target ID	Target Name					Binding Ratio
LDTP13312	Adhesion G protein-coupled receptor E2 (ADGRE2)					10.0

Target ID	Target Name					Binding Ratio
LDTP19752	Immunoglobulin superfamily member 22 (IGSF22)					2.0

Target ID	Target Name					Binding Ratio
LDTP19314	Coiled-coil domain-containing protein 38 (CCDC38)					10.0
LDTP17467	Coiled-coil domain-containing protein 81 (CCDC81)					10.0
LDTP03606	DnaJ homolog subfamily A member 1 (DNAJA1)					10.0
LDTP04743	Eukaryotic translation initiation factor 6 (EIF6)					10.0
LDTP03615	Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)					10.0
LDTP00991	Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)					10.0
LDTP08425	Hornerin (HRNR)					10.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)					10.0
LDTP02109	Large ribosomal subunit protein uL10 (RPLP0)					10.0
LDTP17003	Matrix-remodeling-associated protein 7 (MXRA7)					10.0
LDTP11223	Multiple myeloma tumor-associated protein 2 (MMTAG2)					10.0
LDTP00193	PDZ and LIM domain protein 1 (PDLIM1)					10.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)					10.0
LDTP09081	SERPINE1 mRNA-binding protein 1 (SERBP1)					10.0
LDTP11804	SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3)					10.0
LDTP04970	Small ribosomal subunit protein uS11 (RPS14)					10.0
LDTP02435	Heat shock 70 kDa protein 1B (HSPA1B)					7.1
LDTP03618	14-3-3 protein sigma (SFN)					4.6
LDTP05001	Large ribosomal subunit protein uL23 (RPL23A)					4.2
LDTP15019	Histone H3-7 (H3-7)					3.5
LDTP09705	Connector enhancer of kinase suppressor of ras 2 (CNKSR2)					3.3
LDTP04964	Small ribosomal subunit protein eS8 (RPS8)					3.2
LDTP05033	Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)					3.0
LDTP10999	Histone H2A type 1-J (H2AC14)					2.9
LDTP12826	Bcl-2-associated transcription factor 1 (BCLAF1)					2.7
LDTP02845	Histone H1.2 (H1-2)					2.6
LDTP17238	Coiled-coil domain-containing protein 18 (CCDC18)					2.4
LDTP02364	Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)					2.2
LDTP01139	Huntingtin-interacting protein 1-related protein (HIP1R)					2.1
LDTP04919	Large ribosomal subunit protein eL15 (RPL15)					1.8
LDTP03617	14-3-3 protein beta/alpha (YWHAB)					1.8
LDTP05509	Large ribosomal subunit protein eL18 (RPL18)					1.8
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)					1.8
LDTP19326	Putative ribosomal protein eL39-like 5 (RPL39P5)					1.8
LDTP12926	Aryl-hydrocarbon-interacting protein-like 1 (AIPL1)					1.7
LDTP02084	Plasminogen activator inhibitor 2 (SERPINB2)					1.7
LDTP04389	Large ribosomal subunit protein eL14 (RPL14)					1.7
LDTP13746	Serine/arginine repetitive matrix protein 2 (SRRM2)					1.7
LDTP05802	Serine/arginine-rich splicing factor 6 (SRSF6)					1.7
LDTP01534	Luc7-like protein 3 (LUC7L3)					1.7
LDTP07862	Ankyrin repeat and SAM domain-containing protein 3 (ANKS3)					1.6
LDTP15199	TOG array regulator of axonemal microtubules protein 2 (TOGARAM2)					1.6
LDTP06128	RNA-binding protein 39 (RBM39)					1.5
LDTP05188	Large ribosomal subunit protein eL42 (RPL36A)					1.5

1	Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.